... abnor-mal fruiting bodies with larger fruits.PARP involvement during oxidative stress- induced developmental changes in D. discoideumTo determine the roleof PARP inoxidative stress- induced developmental ... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidativestress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative ... animportant role under oxidativestress [21]; however,there is no report on the roleof PARP in D. discoideum development. We have investigated the roleof PARP in D. discoideum development by inhibiting...
... important rolein protection of neuronal cellsagainst stress- induced apoptosis [26]. In accordance withthese findings, ischemia/reperfusion in the rat forebraininduces the expression of HSP105/110 ... activation of p38 induced by oxidative stress, we further examined whether its activationis responsible for the induction of apoptosis in F9 cells usingSB202190, a potent inhibitor of p38. As shown in ... mitogen-activated protein kinase(p38). Furthermore, oxidative stress- induced apoptosis wassuppressed by SB202190, a potent inhibitor of p38, in F9cells. These findings indicated that the activation of p38...
... 8:20http://www.particleandfibretoxicology.com/content/8/1/20Page 8 of 14inflammatory response and IR development, were exam-ined in mice. As shown in Figure 3, PM2.5exposureinduced a marked increase in macroph age (F4/80+cells)infiltration in eWAT. ... effect of ambient PM2.5onWATandBATspecificgenesindifferent adipose depots. There are several major find-ings in this study. First, exposure to PM2.5resulted in oxidative stressin BAT. ... expression in iBAT(Relative to FA)FAPM2.5ABFigure 4 Immunohistochemical examination of uncoupling protein 1 (UCP1) in the iBAT. A. iBAT was stained by antibody against UCP1 andcounterstained...
... provide new informationabout the function of ANT proteins in the regulation of cell death⁄ survival processes. We analyzed the role of ANT1 and ANT2 isoforms in a human glioblas-toma cell line, the ... that silencing of ANT1, but not ANT2,strongly reduced ADF viability by inducing anincrease inoxidativestress that leads to cell death. Wealso demonstrated that the ANT1-silencing effect ... FEBSANT1-silencing effect on cell viability might be aresult of the onset of a programmed cell death process,we analyzed the effect of siRNA in the presence of theprotein synthesis inhibitor puromycin....
... use of vitamin E and vitamin C in combi-nation reduced the prevalence and incidence of AD in anelderly population; however, the use of either of thesevitamins alone had no effect [110]. Finally, ... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream signaling cascades responsible for activatingNADPH...
... response of the organism to particle-induced oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative ... only 10% of urate is excreted in the urine (theremaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The ... beenreported to increase the serum levels of uric acid in North Carolina police officers [4]. A similar increase of plasma antioxidants in response to an increased oxid a-tive stress was observed in newborns...
... Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-α- and interleukin-1β treated Role of the Adipocyte inDevelopment ... impair insulin signaling through activation of protein kinase C θ (PKCθ). PKCθ phosphorylates insulin receptor substrate I, thus preventing the phosphorylation involved in the insulin signal ... the Adipocyte inDevelopmentof Type 2 Diabetes 16effects (Tang et al., 2001), acting as co-adjuvants in the reduction of the incident ofdiabetes (Doggrell, 2002), increasing vascular function...
... significantly reduced (p < 0.05) in all groups compared to the control group. Similar finding have been reported in other study during oxidativestress [24]. No significant changes in GST activity was ... resistant strain of insect [38]. GST levels were also increased significantly after 30 days of exposure to protect RBCs from oxidative damage. Further significant decreases in GSH levels in our study ... oxidative damage [16]. Increased activity of GST was reported in Drosophila melanogaster after insecticide exposure [27]. Elevated GSTs were reported in Nilaparvata lugens, a pyrethroid insecticide...
... regulator of proper development and remodeling. Angiogenic factors areknown to play key roles in the maintenance of properspiral artery remodeling. Thus, the involvement of uterine NK cells in RPL ... Durak I: Role of oxidativestressin intrauterine growth restriction. Gynecol Obstet Invest2007, 64:187–192.228. Karowicz-Bilinska A: Lipid peroxides concentration in women withintrauterine growth ... JG: Roleofoxidativestress in endometriosis. Reprod Biomed Online 2006, 13:126–134.22. Agarwal A, Gupta S, Sharma RK: Roleofoxidativestressin femalereproduction. Reprod Biol Endocrinol...
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... analyzed models values ofstress intensity factor (KI) increased with the increase in crack size. The path of crack propagation in case of root crack is longer than that in cases of toe and cold-lab ... P.: A Finite Element Calculation of Stress Intensity Factors of Cruciform and Butt Welded Joints for Some Geometrical Parameters. Jordan Journal of Mechanical and Industrial Engineering. Vol. ... cold-lab cracks increased with the increase in crack size. The path of crack propagation in case of root crack is longer than that in cases of toe and cold-lab cracks. Journal of American...