role of neutrophil derived chemokines

... granules of neutrophils (Chapman, Hampton et al 2002; Rosen, Crowley et al 2002; Hirche, Gaut et al 2005; Rosen, Klebanoff et al 2009) 3.1 Functions of ROS of cells of the innate immune system Role( s) ... 2.6 Effect of chemokines on the recruitment of neutrophils into the peritoneal cavity To determine recruitment of neutrophils into the peritoneal cavity, mice were injected with 200 µl of KC, LIX ... looked for an involvement of NADPH oxidase derived ROS in the recruitment of neutrophils to sites of inflammation in vivo Since the gene coding for the gp91 subunit of the NADPH oxidase is on...

Ngày tải lên: 21/05/2016, 22:38

... generation of ROS, were investigated During neutrophil migration, activation of PtdIns3K and changes in [Ca2+]i occur as a results of chemoattractant Ó FEBS 2002 Role of Ca2+/calmodulin in human neutrophils ... Chemoattractant mediated neutrophil migration is abrogated by inhibition of calmodulin but not by inhibition of PtdIns3K In order to investigate the role of [Ca2+]i and calmodulin in neutrophil function, ... CXCL2, within the same family of the fMLP receptor [37] Migration of neutrophils was measured in the presence of IL-8 for 10 min, and the effect of specific inhibitors of calmodulin (W7) or PtdIns3K...

Ngày tải lên: 08/03/2014, 10:20

... AP.5/512, 514 AP.6/639 AP.10/1011, 1014 A score of -6.96 was used as a cut off for R5 strains and a score of -2.88 was used as a cutoff for X4 strains Most of these scores were higher than -6.96 especially ... likelihood of CXCR4 use In all of the Indian sequences in this study, lower numbers of positive charges, in the range of to 7, were found (Table 2) Thus, in an in-silico prediction model, all of the ... status of the patients (Table 1) Replication of subtype C chimeras in primary monocytederived macrophages While primary monocyte derived macrophages (MDM) express CD4 and CCR5 and a low level of...

Ngày tải lên: 18/06/2014, 18:20

... Figure Timing of the addition of inhibitor to NE affects concentration of SLPI Timing of the addition of inhibitor to NE affects concentration of SLPI The diagram shows the concentration of SLPI in ... preparation of the ELISA, and that this loss of SLPI was not enhanced in the presence of NE solely by increased binding to plastic rather than to cell membranes Proof of the concept of binding of SLPI ... presence of a molar excess of NE or CG, detection of SLPI by ELISA was not affected The studies described here did not examine the possibility of cleavage or degradation of SLPI by excess of proteinase,...

Ngày tải lên: 12/08/2014, 15:21

... to LPS reports Role of SLPI and elafin in innate immunity Role of SLPI and elafin in innate immunity A representation of the alveolar space (delineated by the epithelium) and some of the molecules ... review addresses mainly the role of SLPI and elafin in the lung SLPI Gene structure, protein and antiproteinase activity SLPI is one of the two members of the ALP superfamily of proteinase inhibitors ... down the unwanted effects of neutrophil histotoxic molecules such as elastase References Articles of particular interest have been highlighted as: • of special interest •• of outstanding interest...

Ngày tải lên: 12/08/2014, 18:20

... THE ROLE OF CHEMOKINES IN HAEMOPOIETIC STEM CELL QUIESCENCE Amy Sinclair BSc (hons), MRes Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy August 2013 Section of ... cells in the BM of WT and Cxcl4-/-animals 251 Figure 5-15 The numbers of HSC in the spleen of WT and Cxcl4-/-animals 252 Figure 5-16 The numbers of progenitors in the spleen of WT and Cxcl4-/-animals ... distinction are sex, expression of reporter genes or arguably the most commonly used, expression of cluster of differentiation (CD) cell surface markers including isoforms of CD45 (van Os et al., 2001,...

Ngày tải lên: 22/12/2014, 21:11

... 1.5.2 Receptors of LT 32 1.5.3 Role of LT in lymphoid tissue development 33 1.5.4 Pathological role of lymphotoxin (LT) in cancer 34 1.5.5 Anti-tumor role of lymphotoxin (LT) ... kinase Activity of this pathway is implicated by the presence of the phosphorylated form of AKT in HRS cells Inhibition of AKT causes death of HRS cell lines further supports its role in regulating ... clonogenic growth of HRS cells Recombinant neutralizing antibody of CCL5 can inhibit the basal proliferation of these HL -derived cell lines (Aldinucci et al., 2008) B cells of various maturation...

Ngày tải lên: 10/09/2015, 09:29

... Outline  Role of Power  Rules for Using Power Role of Power  Power defined:  • Ability or official capacity to exercise control;  authority • Ability to influence or control others  Sources of Power ... Find the Soft Spot  Encourage others to open up • Gain disclosure of something private or  personal about your counterpart • Expression of trust  Identify true motivations and sources  of objections ... Relationship between power &  dependence • Power A, B = Dependence B, A • Power of person A over B is equal to the  dependence of person B on A Rule #6: Power of Who You Know It’s not what you know but who you know...

Ngày tải lên: 22/08/2012, 22:07

... their required profitability The role of finance is thus to ensure that all profitable investments get adequate funding at the lowest possible costs The microeconomic nature of such role emerges ... efficiently, the reputational capital of an agent must equal the present value of the stream of future profits, or franchise value, of her business The concept of reputational capital is meaningful ... further exploring the implications of the time dimension in the economic process This will be one of the undertakings of this paper The paper analyzes the role of finance for economic growth and...

Ngày tải lên: 24/10/2012, 09:33

... of Foreign Trade 2.3 Faculty of Business English Functions & Main Activities of VIFFAS VIFFAS has the function of socio-professional associated organization of the enterprises, irrespective of ... lack of regulations and an incomplete legal framework on activities of freight forwarders, the quality of services has not met the requirements of the industry's development yet A lack of decrees ... the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam in the international freight...

Ngày tải lên: 27/10/2012, 16:42

... concentrations of isoflavones The amount of isoflavones in soybeans varies depending upon the type of soybean, geographic area of cultivation, and harvest years of soybeans [33-36] In addition, isoflavone ... prevention and treatment of obesity Nutrient composition of soy protein Soybeans provide one of the most abundant plant sources of dietary protein The protein content of soybeans varies from 36% ... with values of < 0.3 mg isoflavones/g soy protein Effect of dietary soy protein in animals and humans with obesity A number of studies in animals and humans suggest that consumption of soy protein...

Ngày tải lên: 31/10/2012, 14:59

... concentrations of ethanol (100 mM) induced the expression of genes involved in the metabolism of ethanol [16] In addition, the metabolism of ethanol 33 results in an increased production of toxic metabolites ... identification of potential targets in the diagnosis and treatment of human hepatocellular carcinoma Materials and methods Cell culture and reagents Based on the reported alteration of gene expression of ... with a SLR of 3.30, 2.61, 1.68 and 1.52, respectively ANK3 was the only significantly down-regulated gene with a SLR of -5.02 Figure Hierarchical clustering analysis of gene expression profile in...

Ngày tải lên: 31/10/2012, 15:28

... numbers of cells with apoptosis-associated alterations of the nuclei and without membrane barrier dysfunction were determined within a field of view at a magnification of X400 A total of 10 randomly ... inhibition of the GPCR signaling pathway as shown by phosphorylation of GRK2 and PKCα; with values of 109% and 104%, respectively, combined with dephosphorylation of ROKα, PKCδ and PKCμ; with values of ... Ethanol regulates the expression of genes of the Fas signaling cascade To further investigate the role of ethanol-induced apoptosis on gene expression, the mRNA level of Fas receptor, Fas ligand,...

Ngày tải lên: 31/10/2012, 15:37

... consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of pregnant women in Korea J Parasitol 2008; 94: 963-965 ... 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org ...

Ngày tải lên: 03/11/2012, 11:06

... the preserve of the few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which one of the languages ... perspective or needs of people from below At least one language of high status is used to exclude speakers of low status languages Marginalized groups are always at the disadvantage of the culture ... majority of people are left out In an education system where English dominates the majority of learners get little benefit from schooling, either in terms of acquiring the necessary language proficiency...

Ngày tải lên: 05/11/2012, 16:27

... billion, balance of call deposit account was VND 1,425 million Collected service fee of the last quarter of the year was zero because of free issuing card in this period However, accumulate of 12 months ... 1.- Quantity of ATM, EDC Source Report on result of 2009 card products and services The graph shows the quantity of ATM, EDC changing over period of four years In 2007, the quantity of EDC is lesser ... centre of the transaction process, maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the...

Ngày tải lên: 03/04/2013, 12:13

Ngày tải lên: 08/04/2013, 17:01

... Part I : General knowledge of advertising Some typical concepts of advertising Classifications of advertising Part II : The role of advertising in society Economic effects of advertising a On governments ... limitation of means of communication and citizens’ perception The most popular type of advertising is on TV Following is the advertising price chart of some typical types of advertising 65 Number of ... more profits it gains and the more it breaks into market Advertising is instrumental in sales promotion, which is one of the most vital tools in Marketing The appearance and the role of advertising...

Ngày tải lên: 16/04/2013, 11:05

... important role in the migration of atmospherically -derived, hazardous trace elements to streams during rain storms The present findings will contribute to current necessity of assessment of a risk of ... measurement, considering of their respective analytical errors A concept of two-component mixing was employed, in which it was assumed that runoff is composed of a mix of two components: one originating ... and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig...

Ngày tải lên: 05/09/2013, 09:08

... personal traits and characteristics of the job (Wexley and Yukl, 1984) To get deep understanding of employees, characteristics of jobs and their relation to the issue of job satisfaction various theories ... consists of several facets, including satisfaction with the supervisor, relationship with coworkers, present pay, nature of work, and opportunities for promotion 4.1 Nature of work The nature of the ... -3.67 as medium level of satisfaction and the means over 3.67 as high satisfaction Table shows the result of descriptive analysis for level of job satisfaction Examples of job satisfaction items...

Ngày tải lên: 11/09/2013, 11:44