role of inflammation and oxidative stress mediators in gliomas
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... a subset of NSAIDs (e.g. ibuprofen, flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the dep- osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug- gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: " Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators" pdf
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation" pps
Ngày tải lên: 12/08/2014, 18:21
gjerstad & smith - rethinking housing bubbles; the role of household and bank balance sheets in modeling economic cycles (2014)
Ngày tải lên: 01/11/2014, 18:18
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... imposing a continuous load of calcium to the neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase ... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... for a role of Trp proteins in the oxidative stress- induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res 42, 543– 549. 236 Wehage E, Eisfeld J, Heiner I, Jungling E,...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Yeast oxidative stress response Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state pot
... a DNA-binding protein that binds to elements in the vicinity of Yap1 binding site [52]. Alternatively, the increased reducing power of tsa1 mutant, achieved by the expression elevation of GSH1, ... (2001) Role of the glutathione ⁄ glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 39, 533–541. 5 Collinson EJ & Grant CM (2003) Role of yeast ... carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae. Mol Cel Biol 21, 8483–8489. 17 Guo J & Lemire BD (2003) The ubiquinone-binding site of the Saccharomyces...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. CYP2E1 causes apoptosis of cardiomyocytes ... College, Beijing, China 2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical ... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxi- dation (e.g. 4-hydroxynonenal and malondialdehyde), as...
Ngày tải lên: 22/03/2014, 16:20
Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt
... (1999) Photodynamic crosslinking of proteins. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl) methacrylamide ... modifica- tions of the side chains of amino acids within a protein. In particular, the side chains of cysteine, histidine, methionine, tryptophan and tyrosine are susceptible to ROS-induced modifications ... Western blotting are shown in (A) and (B). Silver stainingisshownin(C )and( D)inblue superimposed with the spots of oxidized pro- teins shown in red. Protein labels: 1, a-tubulin; 2, b-tubulin;3,actin;4,PDI;5,BiP;6, GRP58. 4862...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam- matory ... reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine and suggest a functional role to citrulline –NO cycle enzymes in anoxia....
Ngày tải lên: 26/10/2012, 09:07
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... involved in fosfomycin binding, and in view of the multitude of interactions, it was assumed that deletion of a single interaction would not lead to a complete loss of fosfomycin binding. Therefore ... fosfomycin binding due to charge–charge repulsions. Most interestingly, the uncharged valine side chain completely abolishes fosfomycin binding in the absence of UDPNAG. Clearly, UDPNAG binding creates additional ... UDP-N-acetylmuramic acid) (A) and inactivation mechanism of MurA by fosfomycin as a result of the covalent linkage between Cys115 of MurA and fosfomycin (B). Ó FEBS 2004 Lysine 22 and arginine 120 in MurA (Eur....
Ngày tải lên: 19/02/2014, 13:20
Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... periods of times (0–60 min) at 37 °C. The concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [ 125 I]Streptavidin. In the absence of ... image. Ó FEBS 2003 Role of cleavage and shedding in TSHR function (Eur. J. Biochem. 270) 3491 Role of cleavage and shedding in human thyrotropin receptor function and trafficking Myle ` ne Quellari 1 , ... five amino acids of the extracellular domain and devoid of any tag was not functional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag was found...
Ngày tải lên: 21/02/2014, 00:20
The Role of Small and Large Businesses in Economic Development doc
... recruiting large enterprises with tax breaks, financial incentives, and other induce- ments. Instead, they are relying on building businesses from the ground up and supporting the growth of existing ... growth from the second quarter of 2000 into job classes using beginning size of firm, mean size of firm over the period, and end size of firm. If the beginning size of the firm is used to classify firms, ... efficient at innovation. Small firms are the great innovators in some industries, while large firms are the great innovators in others. Moreover, small and large businesses interact in innovative...
Ngày tải lên: 06/03/2014, 19:20
Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... buffer A in 15 min, followed by a linear gradient down to 5% buffer A in 2 min. 5% buffer A was held for an additional 2 min and followed by a linear gradient up to 95% buffer A in 6 min. Determination ... °C: loading 5% buffer B, after 5 min linear gradient up to 95% buffer B in 37 min, and then holding 100% buffer B for 5 min. The product was identified by UV detection at 215 nm and by on-line ESI-MS ... domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence. To determine whether DptF is the putative partner of DptE, we expressed dptF using...
Ngày tải lên: 07/03/2014, 04:20