role of civil society organizations in governance
Báo cáo y học: " Role of Dietary Soy Protein in Obesity"
Ngày tải lên :
31/10/2012, 14:59
... Ten
proteins were detected as IgE-binding proteins and 8
proteins as IgG4-binding proteins, with high IgE de-
tection rate and specificity. Among the IgE-binding
proteins, the proteins with ... changes in fat intake since the
amount of dietary fat (30% of total energy) was main-
tained constant during the intervention. Similarly, in a
4-week randomized dietary intervention trial of male ...
food intake and gastric emptying [69]. These effects
were attributed in part to an increase in circulating
levels of cholecystokinin. Similarly, in rats fed a hy-
percholesterolemic diet, ingestion...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
Ngày tải lên :
13/02/2014, 06:20
... echo-planar MR imaging and
ADC mapping in the differential diag-
nosis of ovarian cystic masses: useful-
ness of detecting keratinoid substances
in mature cystic teratomas. J Magn
Reson Imaging 22:271–278
24. ... 2008
Published online: 7 October 2008
# European Society of Radiology 2008
Role of diffusion-weighted imaging
in the diagnosis of gynecological diseases
Abstract Recent technical advances
in diffusion-weighted ... the future of MRI in patients with
gynecological diseases.
Examination of the female pelvic region using DWI
DWI is obtained by measuring signal loss after a series of
two motion-providing gradient...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
Ngày tải lên :
18/02/2014, 16:20
... targeting of
CYP2E1
The role of PKA in mitochondrial targeting of
CYP2E1 was investigated using two approaches. The
first approach involved measuring the level of mito-
chondrial targeting of wild-type ... importance of PKA
in protein trafficking [47,48]. In this study, we used
PKA knockout mutants to determine the role of PKA
in mitochondrial targeting of CYP2E1. In mutants
lacking PKA, CYP2E1 was ... were resuspended in SEM
buffer containing indicated concentrations of digitonin
(0.05% to 0.4%, w ⁄ v) for 30 min on ice with occasional
mixing. Digitonin-soluble and digitonin-insoluble fractions
were...
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Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
Ngày tải lên :
19/02/2014, 12:20
... double-chain
insulin is synthesized in vivo as a single-chain precursor
(preproinsulin) and folded as proinsulin, in which a
connecting peptide of 35 residues links the C terminus of
the B chain and ... Sciences, Chinese Academy of Sciences, Shanghai, China
We have investigated the in vitro refolding process of human
proinsulin (HPI) and an artificial mini-C derivative of HPI
(porcine insulin precursor, ... character-
ization of the unfolding of insulin and proinsulin using the
reductive unfolding method has not been thoroughly
investigated. We have characterized the unfolding process
of an artificial porcine insulin...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
Ngày tải lên :
19/02/2014, 13:20
... fosfomycin binding due to charge–charge
repulsions. Most interestingly, the uncharged valine side
chain completely abolishes fosfomycin binding in the
absence of UDPNAG. Clearly, UDPNAG binding creates
additional ... not
interact with R124 in the ternary complex [20]. Hence, the
mechanism of binding of fosfomycin by reinforcement of an
initial binding site (mainly K22 and R397) through recruit-
ment of secondary ... Lysine 22 and arginine 120 in MurA (Eur. J. Biochem. 271) 2685
the positively charged side chain of K22 participates in
fosfomycin binding, thus providing a rationale for the loss of
fosfomycin...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
Ngày tải lên :
19/02/2014, 16:20
... that the N-terminal domain is involved in
protein–protein interactions with other hydrophilic domains
of neighboring integral membrane subunits, and interspecies
interactions are incompatible.
From ... the
bovine complex a large subdomain is made up of 20
integral membrane proteins contributing > 60 transmem-
brane segments. Some of these must be intimately involved
in proton pumping. Another ... one might expect a protein to be inserted
into the inner membrane, but it is missing a major portion
of the domain localized in the intermembrane space. A
comparison of all the known mammalian...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... family of thiolate-ligated
constitutive or inducible hemoprotein isoforms [281],
exhibiting insign ificant sequence identity with P450s in
the heme-binding region [282], but bearing a C-terminal
flavoprotein ... B. (1994) The pteridine b inding site of brain nitric oxide
synthase. Tetrahydrobiopterin binding k inetics, specificity, and
allosteric interaction w ith the substrate d omain. J. Biol. Chem.
269, ... cis-dihydroxylation of a romatic
rings, in itiating aerobic degradation of aromatic compounds
in soil bacteria, and are targets for bioengineering in
bioremediation [204]. They a re a consortium of two o...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
Ngày tải lên :
21/02/2014, 00:20
... periods of times (0–60 min)
at 37 °C. The concentration of the biotinylated Ig remaining
on the cell surface was then quantified by measuring the
binding of [
125
I]Streptavidin. In the absence of ... They
were then incubated with 0.25 mL of incubation medium
containing 2 lgặmL
)1
of biotinylated R5T-34 monoclonal
Ig [30] at 4 C for 30 min. In some cases, monensin 40 l
M
was added to the incubation ... domain and devoid of any tag was not
functional [27], while a mutant containing four amino acids
of the ectodomain and including a rhodopsine tag was
found constitutively activated [29]. In agreement...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
Ngày tải lên :
21/02/2014, 01:20
... University
Regional Learning Alliance – workforce development and
training/collaborations with business and industry; meeting the
training and education needs of businesses within 60 mile radius
in Northern ... $28,000 in average annual salary)
Preserving Value
Continuing education is important to preserving the market value
of specialized education – particularly in professional fields
Continuing education ... University
Small Business Initiative in the Frehn Center for Management;
offering information and assistance to individuals and groups
planning to start a new business
Indirect Contributions...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
Ngày tải lên :
21/02/2014, 03:20
... this
protease at pH9 [10]. Further interest in the aromatic
stacking is in the role of the electrostatic properties in
enzymatic catalysis of API, and in distinguishing the
functionally catalytic ... CH/, p interaction in the
packing of the adenine ring in protein structures. Advan. Protein
Chem. 39, 125–189.
20. Brandl, M., Weiss, M.S., Jabs, A.S., á hnel,J.&Hilgenfeld,R.
(2001) CH p-interaction ... a new way of thinking about
the functional role of the former ionizable aromatic amino
acid. The pH optimum mechanism in API results from two
things: (a) positively charged His210 interacts with...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
Ngày tải lên :
22/02/2014, 04:20
... respectively. By introducing an Ala residue in the place of
Gly it is expected that the conformational flexibility of the
main chain can be constrained with a minimum perturba-
tion of the local structure, ... our incomplete under-
standing of the relation between enzyme properties and
conformational flexibility limits the exploitation of the full
potential of protein engineering in the redesign of psychro-
philic ... the basis of side-chain packing criteria
from a modelled structure of the enzyme resulted in restor-
ation of the energy of activation to the levels of the native
enzyme and in an increased stability...
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HUMAN PERFORMANCE: Role of General Mental Ability in Industrial, Work, and Organizational Psychology docx
Ngày tải lên :
06/03/2014, 05:20
... Factor
Processing information (perceiving, retrieving,
manipulating, transmitting)
Compiling information, importance of 0.90 Seeing (DOT) 0.66 Work with complex things
Combining information, importance of ... importance of 0.36
Practical problem solving
Advising, importance of 0.86 Supervising nonemployees, importance of 0.64 Catering to people
Planning and scheduling, amount of 0.83 Catering and serving, ... Catering to people
Math, level of (DOT) 0.79
Math, level of 0.70
Quantitative information, extent of use 0.68
Coding and decoding, importance of 0.68
Oral information, extent of use 0.68
Talking...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
Ngày tải lên :
07/03/2014, 04:20
... in DptF is GLDSV,
indicating that this putative ACP domain is one of the
few ACPs in which valine replaces isoleucine (I) or
leucine (L) in the conserved sequence. To determine
whether DptF is ... remains to be clarified whether all
of the fatty acids activated by DptE can be incorpo-
rated into the final product or whether there is an
interfering specificity of the C
III
domain of the initia-
tion ... buffer A in 15 min, followed by a linear
gradient down to 5% buffer A in 2 min. 5% buffer A was
held for an additional 2 min and followed by a linear
gradient up to 95% buffer A in 6 min.
Determination...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
Ngày tải lên :
07/03/2014, 12:20
... clear
whether or not H39 is dominantly tuning the V
H
⁄ V
L
interaction of other Fvs, including HyHEL-10. In
addition, the effect of the H39 mutation on antigen
binding has not yet been analyzed. ... improved the antigen-binding affinity of Fv,
similarly to the level of scFv (Table 2).
Some single V
H
domains of anti-protein IgG, inclu-
ding HyHEL-10 and D1.3, were known to retain the
specificity ... determining the interdomain inter-
action strength.
Results
Construction of an FR2 combinatorial library
To investigate the possible relationship between anti-
gen-binding affinity and V
H
⁄ V
L
interaction...
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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
Ngày tải lên :
08/03/2014, 05:20
... Cardie, Vincent Ng, David Pierce,Chris Buckley. Ex-
amining the role of statistical and linguistic knowledge
sources in a general-knowledge que stion answering sys-
tem. In Proceedings of the 6th ... By relying on large, open-domain lin-
guistic resources such as WordNet we enabled a
more precise approach of searching and mining
answers from large collections of texts. Evalua-
tions indicate ... parse.
By implementing our own version of the pub-
licly available Collins parser (Collins, 1996), we
also learned a dependency model that enables the
mapping of parse trees into sets of binary rela-
tions...
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