role of capital market authority in the economy

... managing and protecting digital identities, with a view to strengthening confidence in the online activities crucial to the growth of the Internet Economy. The primer is a product of the Working ... protection of individuals and their digital identities. As a key factor in increasing trust in online activities, IdM is also a key factor in fostering the growth of the Internet economy. Given the ... maintained in multiple accounts within the organisation. The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information....

Ngày tải lên: 23/03/2014, 23:21

... a well-defined hyperintensity mass in the cervical area. The shape of the uterine cervix is distorted in the DWI (arrowhead). d On the ADC map the tumor is hypointense (arrow) and the normal ... imaging technique (SENSE factor of 2). Imaging time of DWI was 90 s for 20 slices. Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue. On the other ... with uterine leiomyomas and a bleeding cyst. a Axial T2-WI shows an area of hypointensity in the center of the cystic component (arrow). b On T1-WI with fat suppression the area in the cystic...

Ngày tải lên: 13/02/2014, 06:20

... of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of mito- chondrial ... microsomes requires the co- translational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the protein interacts with a ... mitochondria-targeting signal in the yeast system. Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into...

Ngày tải lên: 18/02/2014, 16:20

... provided further insight into the molecular mechanism driving the formation of the covalent C115–fosfomycin adduct. A conservative exchange of K22 to arginine maintains fosfo- mycin binding, while ... form of the protein. The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the conformational process occurring during catalysis. Therefore, ... a rationale for these findings: the side chain amino group of K22 engages in a salt-bridge interaction with the phospho- nate group of fosfomycin (Fig. 5). Clearly, the guanidinium group of arginine can,...

Ngày tải lên: 19/02/2014, 13:20

... dependence of the pH-activity curve of API The pH-activity profiles depending on NaCl concentration were determined as part of the investigation into the shielding from solvent of the electrostatic interaction between ... position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table 1 and Fig. 3A). However, the ASAs of Asp113 ... size of the side-chain at residue 169 and the pK 2 showed a clear linear relationship (Fig. 3B). The pK 2 increased as the size of the residue at position 169 increased. The effect of the size of...

Ngày tải lên: 21/02/2014, 03:20

... by the C domain of the initiation module of dapto- mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al. [1]. In their work, the daptomycin ... is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence. To determine whether DptF is the putative ... [37]. Interestingly, in the case of the lipopeptide surfactin, neither an acyl CoASH ligase-like domain nor an ACP could be identified within the biosynthetic gene cluster using bioinformatic tools...

Ngày tải lên: 07/03/2014, 04:20

... documents and find that the fea- ture vectors corresponding to some of these docu- ments (particularly the short ones) have all zeroes in them. In other words, none of the bigrams from the training set ... cap- turing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie. The over- generalization resulting from these “stemmed” ... available. 612 Proceedings of the COLING/ACL 2006 Main Conference Poster Sessions, pages 611–618, Sydney, July 2006. c 2006 Association for Computational Linguistics Examining the Role of Linguistic Knowledge...

Ngày tải lên: 17/03/2014, 04:20

... used to describe the binding isotherms obtained previously for the b-casein 1–25 phos- phopeptide in this pH range, and the same model was adapted to fit the binding isotherm of OPN 1–149 mea- sured ... mixture of scattering from copolymer micelle-like nanoclus- ters and free peptide. The scattering of the nanoclusters was obtained by subtracting the scattering of the free peptide from the total ... solutions containing high concentrations of Ca, P i and the phospho- peptide, the concentration gradients generated and their persistence during inefficient mixing can allow the inital ACP to mature into...

Ngày tải lên: 29/03/2014, 23:20

... dur- ing lipid raft isolation. Moreover, these studies have provided some insights into the significance of the localization of the P2X 7 receptors in lipid rafts regard- ing the regulation of intracellular ... (glycero-)sphingolipids. In addition the fatty acid chains of the phospholipids composing these rigid domains are generally more saturated than those in the lipids of the surrounding membrane. In fact, this ... muscarinic receptors, endo- thelin receptors, rhodopsin) are located in lipid rafts [65–70] where they are in close proximity to their transducing GTP-binding protein (Gs, Gi, Go, Gq and transducin...

Ngày tải lên: 30/03/2014, 02:20

... Properties of the iron-binding site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal ... Archimedesweg, Leiden, the Netherlands Lactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linked glycosylation in protection of LF against proteolysis, ... such as the pancreatic enzyme trypsin has been suggested [19,20]. The experiments described herein further elucidate the role of N-linked glycosylation in the protection of lactofer- rin against...

Ngày tải lên: 30/03/2014, 13:20

Ngày tải lên: 30/03/2014, 14:20

Ngày tải lên: 18/06/2014, 15:20

Ngày tải lên: 08/08/2014, 20:23

Ngày tải lên: 09/08/2014, 02:21

Ngày tải lên: 10/08/2014, 10:20

Ngày tải lên: 11/08/2014, 08:20

Ngày tải lên: 11/08/2014, 21:21

Ngày tải lên: 12/08/2014, 11:22

Ngày tải lên: 12/08/2014, 18:20

Ngày tải lên: 13/08/2014, 13:20