restoring after losing one member of the multiplexed group
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
Ngày tải lên :
19/02/2014, 00:20
... to the residue in the midpoint of the respective loop, as shown in Fig To the east of the active site the 37- and 60-loops border the S2¢ pocket of the proteinase The observed differences in the ... below) The southern boundary of the active site cleft of DESC1 is formed by the 145 autolysis loop The backbone of this loop differs markedly from the other serine proteinases, making the active ... Lys224– Tyr228 (the back of the pocket) and the disulfide bridge Cys191–Cys220 (the front of the pocket) (Fig 4A) The backbones of these segments form a deep hydrophobic pocket with the negatively...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
Ngày tải lên :
07/03/2014, 04:20
... 1B) The partial phosphorylation of Grx4p still observed in the case of the two mutants (corresponding to 30–40% of that of the wild-type) could be explained either by the intervention of another ... in the phosphorylation of Bud32p at Ser258 In order to investigate the impact of Ser258 substitution in vivo, we compared the growth of the S258A mutant with that of the wild-type strain and of ... recognizes the same target sequence as human Akt ⁄ PKB, further supporting the assumption of the similarity between the two protein kinases This raises the question of whether phosphorylation of Bud32p...
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Báo cáo khoa học: O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner doc
Ngày tải lên :
08/03/2014, 02:20
... acetyl-CoA synthetase (AceCS) family was much less (20–30%) These observations indicate that the O-MACS protein is a novel member of the acyl-CoA synthetase family, belonging to the subtree of the MACS ... in these types of cells [23,30–33] Another possibility for the function of O-MACS is that it may play a role in generating the zonal segregation of the OE during development Unlike other zone-specific ... of OMP, OCAM and o-macs The o-macs gene is specifically expressed in the zone (OCAM negative) of the OE The sense probe of o-macs was used as a negative control Enlarged regions are boxed in the...
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Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
Ngày tải lên :
08/03/2014, 22:20
... parasites of the genus Giardia are one of the earliest lineages of eukaryotic cells, and the Giardia protease is the earliest known branch of the cathepsin B family [23] Its phylogeny confirms that the ... concentrating the allergen according to the isoelectric point (pI) of the molecule A pH gradient from to 11 was established for the characterization of Phl p After completion of the run, the individual ... further explore the biochemical function of group I allergens Expression of glycosylated and nonglycosylated rPhl p reveals differing stability of these allergens The expression of rPhl p in the...
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Báo cáo khoa học: Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family pptx
Ngày tải lên :
17/03/2014, 10:20
... performed immunoblotting of the 33.5 kDa Ubi-L adduct using an antibody against synthetic peptide based on the sequence of Bcl-G The results of the Fig Primary structure of Bcl-G (A) The predicted amino ... the gene products of Bcl-G and Ubi-L The fourth column indicates the number of the first and last amino acid of the identified Bcl-G and Ubi-L peptides, whereas the fifth shows the corresponding ... bonds between the C terminal of the glycine residue of Ubi-L and the lysine of Bcl-G The 33.5 kDa Ubi-L adduct was digested by V8 protease and subjected to MALDI-MS analysis The data in the first column...
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Báo cáo khoa học: The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity pot
Ngày tải lên :
22/03/2014, 17:20
... excitotoxicity BNIP3 is a BH3-only proapoptotic member of the Bcl-2 family However, unlike in other members of the Bcl-2 family, the BH3 domain of BNIP3 is not required for its death-inducing ... striatal areas adjacent to the site of injection (Fig 1A) High levels of BNIP3 immunostaining were found in the cytoplasm of striatal neurons affected by the KA, and almost all of the BNIP3positive neurons ... agonist for the kainate receptor (a subtype of the ionotrophic glutamate receptor) that mimics the effect of glutamate Of the 15 rats that received KA injections, five were used for preparation of brain...
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Báo cáo khoa học: Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily ppt
Ngày tải lên :
23/03/2014, 03:20
... for other members of the superfamily Results Conservation of L6 sequence in the superfamily The VRGY motif is located at the tip of L6 of FhaC, which reaches the periplasm Alignments of the FEBS ... subtypes of TPS system have been identified, which differ by the sequences of the TPS domains of the TpsA proteins and by those of their TpsB transporters [16,18] Nevertheless, the structure of the ... 1) Furthermore, the analysis of the sequences of a large number of predicted Toc75, Sam50 and Omp85 homologues indicated the presence of a closely related tetrad in the vast majority of these...
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THE WESTMINSTER KENNEL CLUB (Member of the American Kennel Club) JUDGING PROGRAM 2013 pptx
Ngày tải lên :
23/03/2014, 04:20
... ready to bring into the judging ring promptly The owner of the dog or the handler is responsible for the presence of their dog in the judging ring There is no rule of this Club or the American Kennel ... at the show is in the care and custody and control of its owner or handler during the time the dog is on the show premises See also the agreement on the reverse of the entry form The welfare of ... show, the grounds, site and show areas for whatever purpose so entirely at their own risk By virtue of entering the show, the entrant has indicated their acceptance of the terms listed in the premium...
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Báo cáo khoa học: Identification of a copper-repressible C-type heme protein of Methylococcus capsulatus (Bath) A member of a novel group of the bacterial di-heme cytochrome c peroxidase family of proteins docx
Ngày tải lên :
23/03/2014, 11:20
... located in the core of the CCP structure (Fig 3A) Furthermore, all of the additional insertions of the extended MCA2590 sequence are introduced in loop regions on the surface of the structure, thereby ... Detection of C-type heme Because of the sequence similarity of SACCP to members of the BCCP family of proteins and the prediction of heme-binding motifs in the primary sequence, it was of interest ... located on the cellular surface of the bacterium Furthermore, expression of MCA2590 also responded to the availability of copper, and was abundant when copper was scarce in the growth medium The MCA2590...
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Báo cáo Y học: A functionally conserved member of the FTZ-F1 nuclear receptor family from Schistosoma mansoni doc
Ngày tải lên :
23/03/2014, 21:20
... to the alternative splicing of the two 5¢ exons of the gene (see below) The 3¢ end of the sequence is not supported by the presence of a classical consensus polyadenylation signal upstream of the ... from the platyhelminth human parasite, Schistosoma mansoni [22] We are now studying the properties of these receptors to determine the level of conservation of their function and their role in the ... analysis of SmFTZ-F1 We aligned the peptide sequences of the conserved C and E domains of a variety of members of the FTZ-F1 family, including SmFTZ-F1, and constructed phylogenetic trees rooted to the...
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Báo cáo khoa học: Extrinsic proteins of photosystem II An intermediate member of the PsbQ protein family in red algal PS II ppt
Ngày tải lên :
31/03/2014, 07:20
... similarities of the PsbQ protein within the same group are reasonably high However, the sequence similarities of the PsbQ protein among different groups are relatively low One may therefore ask whether the ... from the thermophilic cyanobacteria as long as the 33-kDa protein is present On the other hand, the full binding and functioning of the 12-kDa protein and cyt c-550 requires the presence of the ... from the 5¢- and 3¢-RACE, respectively Sequencing of these cDNA fragments confirmed that they contained the cDNA for the 20-kDa protein These sequences were combined with the partial sequence of the...
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Báo cáo Y học: Characterization of a Saccharomyces cerevisiae NADP(H)-dependent alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol dehydrogenase family pptx
Ngày tải lên :
31/03/2014, 08:20
... built from the zinc-containing MDR enzymes from yeast, had placed Ymr318p and Ycr105p in a subgroup of one of the three branches of the tree [2] This grouping was consistent with the phylogenetic ... was obtained with the CLUSTALW program Thin arrows mark the aminoacids involved in the binding of the Ôcatalytic zincÕ The thick arrows point the Cys involved in the binding of the Ôstructural ... this case, with the purpose of regenerating NADP The manipulation of the levels of ADHVI and ADHVII could be used by the fermentation industry to alter the organoleptic properties of the fermented...
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– ANSWERS – Set 26 (Page 66) 390. a. Since one-half of the four children are girls, two must potx
Ngày tải lên :
18/06/2014, 17:20
... largest theaters Also, the theater never shows a foreign film in the largest theater Theaters and must show the movies that are rated G and PG, so the movies that are there must stay there The most ... logical choice is to put Mist in theater and Fly in theater 422 a “Honey” and “Sittin’ on the Dock of the Bay” are either and or and The Rascals appear on the list right after Otis Redding, who cannot ... so “Honey” is #3 and “Sittin’ on the Dock of the Bay” is #4; therefore, choices c and e are incorrect The Rascals are #5 (because they are right after Otis Redding), and Cream appears right after...
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– THE GRE ANALYTICAL WRITING SECTION – Leave about one-quarter of the time allotted to go over pdf
Ngày tải lên :
18/06/2014, 17:20
... alone is not responsible for the outcome of city council decisions—other members have say in the decisions and intentions of other members of the town council Furthermore, the information the ... telecommunication The relatively simple change to portable phones enabled us to roam around the house while chatting, unlimited by the length of the cord that attaches the receiver to the base of the telephone, ... than 140 years, the public library has endured a cycle of change We are in the middle of one of these cycles today as librarians try to be responsive to the trends of the times The Internet and...
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Báo cáo hóa học: " The genome and proteome of the Kluyvera bacteriophage Kvp1 – another member of the T7-like Autographivirinae" docx
Ngày tải lên :
20/06/2014, 01:20
... profile (Fig 3) in which most of the protein bands can be assigned based upon the extensive knowledge of these phages, and the mass of the protein bands compared with the in silico analysis of ... basis of its mass, to a product of one of the morphogenesis genes One of the characteristics of some T7-like phages is that they display, on SDS-PAGE, two "versions" of the major capsid protein which ... (Lane A) The masses of the proteins are indicated in the adjacent lanes The tentative identification based on in silico analysis of the properties of the gene products (Gp) are indicated on the right...
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Alexey a zaslavsky, one property of the jerabek hyperbola and its corollaries
Ngày tải lên :
18/07/2014, 22:48
... are the reflections of this point in the midpoints of the sides of ABC Therefore, the triangles ABC and A2 B2 C2 are centrosymmetric B2 A2 A1 C B1 C2 A B C1 Fig Note also that the center of perspective ... reflections of A1 , B1 , C1 in the midpoints of BC, CA, AB, respectively Then the lines AA2 , BB2 , CC2 are concurrent Proof The isogonal conjugate, Q, of P lies on the Jerabek hyperbola Let CQ meet the ... B Fig Proof It suffices to apply homothety of center the centroid of ABC and coefficient − to the configuration of the previous claim Statement Let O, I be the circumcenter and incenter of ABC An...
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roadshow mexico city on 7 8 may 2014 thomas aebischer holcim group cfo and member of the executive committee urs birri cfo holcim mexico thomas rueger treasury relationship manager angel garcía de quevedo treasure
Ngày tải lên :
29/07/2014, 12:42
... has been a subsidiary of Holcim since 1964 • In 2004, Holcim Group acquired 31% of the remaining shares of Holcim México, becoming the sole shareholder • In 2013, the name of the company changed ... Mio t cement (18% of Holcim Group) 10.2 Mio t aggregates (7% of Holcim Group) 8.0 Mio m3 ready-mix concrete (20% of Holcim Group) • Net Sales: CHF 3’349 Mio (17% of Holcim Group) • Op EBITDA: ... to achieve the savings (one- off) Additional CAPEX net 2) 239 48 3) 100-180 1) The base line is the financial year 2011 amounting to CHF 2,308 million (excluding one- off charges 2011 of CHF 375...
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holcim in latin america andreas leu member of the executive committee 2012 holicim ltd
Ngày tải lên :
30/07/2014, 21:47
... (17% of Holcim Group) 14.5 Mio t AGG (8% of Holcim Group) 11.0 Mio m3 RMX (23% of Holcim Group) • Net Sales: CHF 3’310 Mio (16% of Holcim Group) • Op EBITDA: CHF 888 Mio (22% of Holcim Group) ... Commercial Director of Holcim Argentina • “Besides the enriching personal and professional experience within the Group, the opportunities offered by Holcim rewarded me with a number of external acknowledgments” ... because they trusted me and gave me the opportunities, which allowed me to grow personally and professionally thereby supporting me all the way ” Plant Manager of Holcim Argentina • “During the 19...
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holcim in south asia asean paul hugentobler member of the executive committee 2012 holcim ltd
Ngày tải lên :
30/07/2014, 21:49
... Singapore • The Centre of Excellence (CoE) was built with the support from the Singapore Economic Development Board (EDB) • Aligned with Government of Singapore economic development priorities • The ... 2012 Holcim Ltd In the past ten years Holcim Group rapidly increased its exposure to South Asia and ASEAN… Indexed development of Holcim Group vs Holcim South Asia / ASEAN (excl the Philippines), ... Indonesia: 6.6% p.a Vietnam: 9.6% p.a Global: 5.2% p.a • India’s will be the world’s third largest construction market by 2020E (7% of global share) • India and Indonesia as main contributors of...
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