restoration of correct splicing in mutant pre mrnas in genetic disorders
late neoclassical economics restoration of theoretical humanism in contemporary mainstream economics
Ngày tải lên :
03/06/2014, 02:05
... […] The methods of voting and the market are methods of amalgamating the tastes of many individuals in the making of social choices […] Can we find other methods of aggregating individual tastes ... And finally, I finished a first complete draft of my dissertation in the loving presence of Ryvka Bar Zohar The communal home that we formed together in, of all places, Saratoga Springs during ... numerous schools of thought within the discipline of economics, including even, for instance, some skeins of Marxian economics (e.g., Analytical Marxism) as well as other disciplines of social theory.5...
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Báo cáo lâm nghiệp: "Effects of soil mechanical treatments combined with bramble and bracken control on the restoration of degraded understory in an ancient beech forest" pptx
Ngày tải lên :
07/08/2014, 16:20
... by the intermediary of an arm allowing its individual raising, as well as a lateral displacement in case of encountering an obstacle The disc plough turns the soil down to a maximum depth of 30 ... Agricultural engineering of the Agronomical Research Centre of Gembloux (Belgium) on the basis of models developed by the National Forest Office (ONF) in France Finally, the benefit of using the land ... method combines information on the concentration of species abundance in a particular group of samples (represented here by one treatment) and the faithfulness of occurrence of a species in that...
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Báo cáo y học: "Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts" ppt
Ngày tải lên :
09/08/2014, 20:22
... length All introns Proportion of bases 50% All intron Proportion of introns (b) Repartition of bases within the codons Insertion of introns within the CDS Number of introns Proportion of introns ... (36) Introns were detected in 5' UTRs The number of 5' UTR introns or of genes containing 5' UTR introns is indicated in parentheses motifs (Figure S2a,b in Additional file 2) This finding was previously ... examples of regulated splicing, in which the protein inhibits the splicing of its own pre- mRNA, include RPL30 [40] and YRA1 [27,41,42] Thus, the AS of mRNA generates two types of transcript: mRNAs...
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Báo cáo y học: "Coding potential of the products of alternative splicing in human" docx
Ngày tải lên :
09/08/2014, 22:23
... different sets of domains [18,19] On the other hand, a domain that is truncated in an isoform is more likely to be the result of incorrect splicing than of a regulated event As described in Materials ... AS Of all the isoforms encoded by the remaining genes, 31,618 are classified as non-protein coding according to the Ensembl annotations In the remaining genes, we found 7,467 isoforms differing ... median of normalized expression values in the 11 tissues in the panel Isoform expression is estimated as the median expression of all probe sets falling in the isoform-specific regions Page of 10...
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Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot
Ngày tải lên :
10/08/2014, 09:20
... autoradiographs of Bmal1 expression in one or more whole coronal sections of the brain, showing expression in the target structure and no expression outside of this structure in brain regions that ... contained an error, a result of mistakenly using an incorrect file to make the plot The incorrect file was an incomplete working file obtained from the same animal and experiment as shown in Fig ... restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized...
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Báo cáo y học: "Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies" docx
Ngày tải lên :
14/08/2014, 21:20
... detection of differential splicing is the complexity of the splicing process Several types of splicing events have been observed, such as exon inclusion/exclusion, alteration of exon length, intron ... splicing may be required as the understanding of the splicing process evolves As the aim of the present study was to demonstrate the benefits of using directly the probe-level data in detecting ... PLIER-LM and FIRMA in detecting differential splicing in the colon cancer data The ability of the methods to detect the same candidate splicing events in independent subsamples was investigated at...
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Báo cáo khoa học: "Parental attitudes and opinions on the use of psychotropic medication in mental disorders of childhood" docx
Ngày tải lên :
08/08/2014, 23:20
... members of the multidisciplinary team, according to the specific request and needs of each case Finally, the case is presented in the weekly case conference, where all members of the multidisciplinary ... characteristics of the sample are presented in Table 1; the diagnosis concerning the child's presenting problem according to ICD-10 [13] is shown in Table 2, Table shows the general views and beliefs of the ... structure of the question, concerning the distinction of psychoagents, led to the correct answer Most of them are afraid of potential dependency, and are affected by anti-drug public opinion The prevalence...
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báo cáo khoa học: " Tailoring the process of informed consent in genetic and genomic research" doc
Ngày tải lên :
11/08/2014, 12:20
... 31 Clayton EW: Incidental findings in genetics research using archived DNA J Law Med Ethics 2008, 36:286-291, 212 32 Cho MK: Understanding incidental findings in the context of genetics and genomics ... uncertain clinical relevance of research findings It is, however, becoming increasingly difficult to justify this position, especially in the context of large-scale medical genotyping and sequencing ... scientists in developed countries For this reason, MalariaGen investi gators have instituted a policy that includes capacity building and training for scientists in low-income settings involved in their...
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NOVEL RESTORATION TECHNOLOGY FOR PUZRIFICATION OF WATER QUALITY IN CLOSED WATER BODY BY HIGH CONCENTRATED OXYGEN WATER
Ngày tải lên :
05/09/2013, 08:40
... the outlet of the lab scale high concentrated oxygen dissolver By adjusting this valve, the pressure in the high concentrated oxygen dissolver can be increased However, increasing the pressure ... concentration of DO and temperature every depth in the dam (sampling point is under the machine) concentrati of on di ve oxygen ssol tem perature depth of w ater (m ) The production of high concentrated ... concentration of DO and temperature every depth in the dam (sampling point is upper buoy) concentrati of on di ve oxygen ssol tem perature depth of w ater (m ) 10 20 30 40 10 15 20 25 concentrati of di...
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Tài liệu Báo cáo khoa học: Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast doc
Ngày tải lên :
18/02/2014, 14:20
... Coq7 in fission yeast [38] Whereas induction of ctt1+ and apt1 occurred in all ubiquinone-deficient strains, induction of gpx1+ was not observed in any of the tested strains (Fig 6) However, in the ... Southern blotting B LN902/pREP1TP-COQ7 LN902/pREP1-coq7Sp b LN902/pREP1 SP66 /pREP1 Respiration deficiency of Dcyc1, Dcoq7 and Dcoq3 mutants LN902 /pREP1 SP66/pREP1 LN902 /pREP1 -coq7Sp LN902/ pREP1 TPCOQ7 ... consequences for demethoxyubiquinone function, as the binding sites of quinones are present in complex I, but it is not clear whether they are present in the NADH–ubiquinone reductase of yeasts S cerevisiae...
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
Ngày tải lên :
19/02/2014, 17:20
... ubiquitinated in the presence of the inhibitor of proteasome function Furthermore, the extent of ubiquitination of TNSALP (1559delT) was further augmented in the cells expressing ubiquitin, strongly ... oligosaccharide chains of glycoproteins [31] The involvement of EDEM and ⁄ or SCFFbs2 in the degradation of TNSALP mutant proteins is currently being investigated The aggregate form of TNSALP (1559delT) ... Cytohistochemical staining for alkaline phosphatase Cells expressing TNSALP or TNSALP (1559delT) were stained for alkaline phosphate activity in the absence or presence of saponin FEBS Journal 272...
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Báo cáo khoa học: Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region pdf
Ngày tải lên :
06/03/2014, 00:21
... suppressor may act in a different manner from the processing stem mutations As a deletion in rnc acts as a suppressor of JB69, a D7-derived IF1 mutant strain, it was of interest to determine ... rRNA termini are present in both the 50S and the 70S fractions We then investigated whether the observed extended termini present in the 23S processing stem mutants were incorporated into the ... mechanism of suppression of cold sensitivity in these double mutants is indirect, resulting from rRNA maturation defects According to structural data, the mature form of the processing stem of 23S...
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Báo cáo Y học: Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli doc
Ngày tải lên :
08/03/2014, 09:20
... strain CE1512, using processing as a criterion for translocation The prlA4 phenotype of the strain was confirmed by studying the processing kinetics of (G-10R)prePhoE The translocation of this mutant ... allele, we determined the effect of several other prlA suppressor mutations with the aminoacid substitutions being located in distinct topological domains of SecY [25] Again, suppression of the translocation ... kinetics of prePhoE and mutant derivatives in wild-type and prlA mutant strains (A) Cells of prlA+ strain CE1511 (prlA+) or prlA4 mutant CE1512, carrying plasmids encoding wild-type PhoE (WT) or mutant...
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Báo cáo khoa học: Systemic RNAi of the cockroach vitellogenin receptor results in a phenotype similar to that of the Drosophila yolkless mutant ppt
Ngày tải lên :
16/03/2014, 14:20
... the beginning of the last nymphal instar, steadily declining along the instar, and reaching the lowest values of the instar before the imaginal moult (Fig 3A) In the adult, mRNA levels remained ... high at the beginning of the adult stage, at previtellogenic period, declining on day after the adult emergence, and remaining low during the vitellogenic phase [8] In the ant S invicta, VgR mRNA ... mm proteases inhibitor cocktail (Roche, Barcelona, Spain) After measuring the protein contents of homogenates [34], suramine (5 mm) was added to inhibit the binding of vitellogenin to its receptor...
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Báo cáo khoa học: Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues ppt
Ngày tải lên :
23/03/2014, 13:20
... N-termini of RGS8 protein [19,20] The N-terminal deletion of RGS8 resulted in a remarkable decrease in the inhibitory effects of RGS8 on Gaq-coupled responses The nine amino acids in the N-termini ... Corp., Inc., Indianapolis, IN, USA), according to manufacturer’s instructions In brief, cells were washed twice and resuspended in mL of DMEM One microgram of plasmid DNA in mL of DMEM containing ... proteins T, total protein; M, membrane protein; C, cytosolic protein Arrows indicate a 26 kDa protein of RGS5 and a 13 kDa protein of RGS5s 794 -10 Fig Effects of RGS5 and RGS5s on Ca2+ signaling...
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Báo cáo khoa học: Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family pdf
Ngày tải lên :
30/03/2014, 20:20
... [3H]Thiamine uptake in NIH3T3 cell transfectants expressing the wild-type and mutant D93H THTR1 proteins [3H]Thiamine uptake was determined in NIH3T3 cells expressing the indicated proteins Net thiamine ... protein bands of 52 kDa These results suggest that the Myc tag fusion in the C-terminus of THTR1 protein may interfere with the cellular expression and/or stability of the protein In view of these ... necessarily result in lack of protein expression and/or rapid degradation; introduction of an enhanced green fluorescent protein (EGFP) tag at the C-terminus of THTR1 neither resulted in interference...
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Báo cáo Y học: Chemical structure and immunoreactivity of the lipopolysaccharide of the deep rough mutant I-69 Rd–/b+ of Haemophilus influenzae docx
Ngày tải lên :
31/03/2014, 21:21
... specificity of the epitope as no binding was observed with antigens containing Kdo-5P instead of Kdo-4P or with antigens containing nonphosphorylated Kdo Fig Binding curves of mAbs S42-16 (A and B), S42-21 ... recognition of charged carbohydrate epitopes by antibodies We are interested in this aspect to better understand protein–carbohydrate interactions in general and the binding of antibodies against bacterial ... final proof that both phosphates are made by the bacterium was provided recently when we coexpressed the monofunctional Kdo transferase and a phosphokinase of H in uenzae in E coli resulting in LPS...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
Ngày tải lên :
18/06/2014, 16:20
... results in the destruction of the insulin-producing beta (b) cells of pancreatic islets of Langerhans, resulting in insulin deficiency and persistent hyperglycemia Development of diabetes in NOD ... [61,62] Defining Treg cells in human is much more challenging than in mouse due to the lack of stringency of FOXP3 expression as a marker of Treg cells Indeed, in humans, FOXP3 is expressed by ... have yet to be examined Page of 12 In humans, exposing CD4+ T cells to both IL-2 and rapamycin in vitro leads to an increase in the cellular frequency of FOXP3+ T cells, originating from nTreg cells...
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USE THE CORRECT FORM OF THE WORDS IN BRACKETS pdf
Ngày tải lên :
21/07/2014, 21:20
... poisoning He is interested in the of old buildings A) preservation B) preserve C) preserved D) preserves Getting such a well-paid job is beyond my _ A) expect B) expected C) expecting D) ... means of …… A) communicate B) communication C) communicative D) communicatively 22 These countries are …… in exporting shrimps A) prefer B) preference C) preferential D) preferentially 23 Nothing ... saving money A) provide B) provision C) providing D) provided Daisy has been out of work for months She stays at home and does the housework A) disappoint B) disappointed C) disappointing...
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