research advances and implications for clinical applications

... generated and expanded in vitro, might tip the balance and allow a true curative action in animal models of T1D [12], and much work is now directed to this area [20] Two recent studies in T1D and experimental ... withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation and the reinstatement of fully functional CD4+CD25+ Treg, RA is still not cured These strands of evidence seem to ... series of studies in RA and other chronic autoimmune joint inflammatory diseases such as juvenile idiopathic arthritis and spondyloarthropathies, in which phenotype, distribution and functional studies...

Ngày tải lên: 09/08/2014, 06:23

... well-known risk factor for knee OA, and to a lesser degree for hip OA and hand OA, and probably acts through a change in load distribution in the knee [72], and systemic and local inflammatory ... with implications for possible preventive treatments Bierma-Zeinstra and Verhagen Arthritis Research & Therapy 2011, 13:213 http://arthritis -research. com/content/13/2/213 Examples Lim and colleagues ... osteotomy for uni­ om­ c part­ ent malaligned knee OA However, to design such m trials for every suspected subgroup for the available treat­ ments would take many years of research, and resources...

Ngày tải lên: 12/08/2014, 15:22

... well-known process of RBC formation and destruction In so doing it shows the cause for hitherto unexplained observations [13] and predicts other clinical applications for routine blood analysis ... Biology and Medical Modelling 2006, 3:34 describe a computer simulation model that follows the formation and destruction of red blood cells (RBC) When standard assumptions about red cell formation and ... unexplained changes in the MCV and RDW-CV% and their clinical significance For simplicity, I have Page of (page number not for citation purposes) Theoretical Biology and Medical Modelling 2006,...

Ngày tải lên: 13/08/2014, 23:20

... toxicities, and 18 (51%) and 11 (32%) of the 86 cited reasons for ART discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related ... visits, but standardized data collection forms were used, and there was additional information collected on sexual behaviour, adherence and quality of life On average, about 15 research cohort ... the research cohort and clinic databases was 24.1 (20.5-28.2) and 13.2 (10.8-16.2), respectively, and 10.4 (9.1-11.9) for the 1233 patients in the clinic database This represents a 1.8- and 2.3-fold...

Ngày tải lên: 20/06/2014, 08:20

... T time slices, and N and are computed for each slice t Figure illustrates why such a modication is useful It depicts the frequency of the terms neural networks and expert system for each year ... the community, but would be necessary for an outsider to fully understand the discourse Take, for example, the terms backpropagation and hidden layer If a researcher of neural networks uses these ... words and phrases are coined or take on new meanings (Bauer, 1994; Jeffers and Lehiste, 1979) Below we describe an application in document clustering and point toward a theoretical framework for...

Ngày tải lên: 08/03/2014, 04:22

... that to be the case for most list and newsbrief documents and for many transcripts Beyond news data, this holds for case law documents, many types of financial documents, and others matic Condensation ... acceptability rate for magazine LEADs climbed to 92.50/0, still lower than for any other source Document length was a factor for LEAD acceptability for the entire test corpus, but list, newsbrief and transcript ... rating and assigning attributes to the 2,727 test corpus documents and LEADs I would also like to thank Breck Baldwin, Afsar Parhizgar, David Schmeer and Paul Zhang for their comments and suggestions...

Ngày tải lên: 17/03/2014, 07:20

... tolerance by expanding methadone maintenance treatment (MMT) and needle and syringe programs (NSPs), removing the requirement for viral hepatitis testing before school and job entry, and lifting ... applied [58,59], and empirical data are lacking Future randomized trials and operational research must address the potential for over-testing, over-treatment, side effects, resistance, and risk behavior ... such as vaccine and microbicide development, expanding HIV testing and treatment, discovering and developing new ARV drugs, optimizing the ART delivery system, and improving therapy for non-AIDS...

Ngày tải lên: 10/08/2014, 05:21

... cancer and local lymph node metastases: implications for clinical practice Journal of Experimental & Clinical Cancer Research 2011 30:30 Submit your next manuscript to BioMed Central and take ... therapeutic implications for EGFR-targeted therapy strategy For NSCLC patients with metastases, determining the KRAS and EGFR mutation status in both primary and metastatic tumors may be critical for ... Diagnosis and Therapy Center of Lung Cancer, Tianjin 300060, China Authors’ contributions ZZ, CW and BS designed the study; LS and QZ performed experiments; LS and HL analyzed data and prepared...

Ngày tải lên: 10/08/2014, 10:21

... (2003), European Unilateralism-Environmental Trade Barriers and the Rising Threat to Prosperity through Trade Website 16 http://www.census.gov/foreign-trade/statistics/index.html 17 http://vietnamese.vietnam.usembassy.gov/ambassador.html ... http://environment-safety.com/courses/EnvManagement/envStandards.htm 44.http://vea.gov.vn/vn/khoahoccongnghe/nhanxanh/gioithieunhansinthai/Pages 45 http://www.census.gov/foreign-trade 46.http://www.customs.gov.vn/Lists/TinHoatDong ... biết, Nxb Hà Nội Tiếng Anh 13 Adam McCarty (2001), Vietnam in ASEAN, Regional Intergration Process and Challenges, Hanoi 14 Damien J Neven (2000), Evaluating the effects of non-tariff barriers, University...

Ngày tải lên: 06/02/2014, 20:27

... into Efforts to Improve YRH By providing students with information and skills, sexuality education complements other efforts to provide quality reproductive health information and services and to ... youth-friendly services, and policy dialogue and advocacy School and livelihood opportunities complement and reinforce these approaches Table Effective YRH Program and Policy Actions Program and Policy Action ... nontreatment or delayed treatment; the need for early and effective treatment; the need to inform sexual partners and to treat them for STIs; and the effective methods for preventing STIs, especially correct...

Ngày tải lên: 14/02/2014, 14:20

... Congressional Research Service 12 China’s Economic Rise: History, Trends, Challenges, and Implications for the U.S Foreign Direct Investment (FDI) in China China’s trade and investment reforms and incentives ... machinery and equipment and parts thereof; sound recorders and reproducers, television image and sound recorders and reproducers, and parts and accessories of such articles Congressional Research ... China, and discusses the implications of China’s economic rise for the United States Congressional Research Service China’s Economic Rise: History, Trends, Challenges, and Implications for the...

Ngày tải lên: 20/02/2014, 20:20

... rigorous peer review to ensure high standards for research quality and objectivity Unfolding the Future of the Long War Motivations, Prospects, and Implications for the U.S Army Christopher G Pernin, ... and Doctrine Command, Army Capability Integration Center, and was conducted within RAND Arroyo Center’s Force Development and Technology Program RAND Arroyo Center, part of the RAND Corporation, ... Szayna, and Derek Eaton for substantial feedback on interim ideas and products, and Lauren Caston for input into regular meetings Critical reviews of this document by Karl Mueller (of RAND) and Douglas...

Ngày tải lên: 06/03/2014, 20:20

... Data for China for years 1998 and 2001 are taken from Zhang and Liang (2006); Data for Vietnam are adapted from Nguyen Thi Kim Anh and Pham Thi Hoang Oanh (2007) for 1998, 2001 and 2004, and are ... forward rate allowed and the forward rate that would equate supply and demand Currency options were first introduced by Eximbank into Vietnam’s forex market in 2003 However, trading in this form ... Institutional and Structural Problems of China's Foreign Exchange and Implications for the New Exchange Rate Regime', China: an Internatinal Journal, Vol 4, No 1, p 26 30 NOTES The data for NEER and REER...

Ngày tải lên: 07/03/2014, 18:20

... Psychosocial influences on the development and course of coronary heart disease: Current status and implications for research and practice Journal of Consulting and Clinical Psychology, 70, 548-568 Spanier, ... Psychological and modifiable Sociodemographic and somewhat modifiable Biological and not modifiable Figure A gender and health model that exemplifies how health education researchers and practitioners ... men and women, disparity reduction (political, social, and economic) is ignored For example, gender is a powerful predictor of premature cardiovascular morbidity and mortality (Kannel, Hjortland,...

Ngày tải lên: 14/03/2014, 21:20

... statistics and distribution of score ranges for the files from this region, and from California specifically, were virtually identical to those for the entire sample Therefore, the researchers ... not given useful and timely information about their credit 41 Standardized, generic explanations not provide sufficient information for consumers to address inconsistencies and contradictions, ... requirements for complete and accurate reporting of account information to credit repositories, and maintenance of consumer data by the repositories, with adequate oversight and penalties for non-compliance...

Ngày tải lên: 15/03/2014, 07:20

... published for prokaryotic ABC exporters are summarized in Table Resolution is highest for the ADP-bound form of Sav1866, and ˚ decreases to < A for the MsbA structures in the unliganded state (unliganded ... between TM helices and and between TM helices and provide noncovalent interactions with sites on the NBD These latter two linker regions, called intracellular loops and (ICL1 and ICL2) can both ... distances, residue accessibility and conformational transitions [38] For MsbA, several studies have attempted to determine the likelihood of the extreme conformations observed, and to verify the structures...

Ngày tải lên: 22/03/2014, 21:20

... organisms and organelles Some eukaryotes (land plants and various protists) use the multicomponent System I [also called the cytochrome c maturation (Ccm) system], and others (animals, fungi, and many ... in ball and stick representation, as are the methionine and histidine side chains that coordinate the heme iron, and the cysteine side chain that forms a thioether bond between heme and protein ... structure determination and refinement was collected at the Diamond Light Source, UK Integration and scaling were performed using denzo and scalepack [37] Subsequent data handling was carried out...

Ngày tải lên: 23/03/2014, 04:21

... R&D and research alone, the compound annual growth rates are positive Table Compound Annual Growth Rates for Federal Research and Development and for Federal Research Federal Outlays for Research ... Congressional Research Service Economics and National Security: Issues and Implications for U.S Policy overhead, gaining efficiency, and closing the Joint Forces Command in Norfolk, Virginia.19 (For further ... Specialist in Industry and Trade, Foreign Affairs, Defense, and Trade Division Congressional Research Service Economics and National Security: Issues and Implications for U.S Policy “rich man’s”...

Ngày tải lên: 23/03/2014, 21:20

... services and settings, the populations that need care, and the providers who comprise the formal and informal workforce Next I review the major issues that affect financing, delivery, and workforce ... long-term care policy— financing, delivery, and workforce and identifies some of the major demographic and policy trends that will affect the demand for, and supply of, long-term care in the future ... program for the poor, is the major public program covering long-term care for the elderly and for disabled people of all ages Despite the public’s tremendous interest in, and demand for, care...

Ngày tải lên: 28/03/2014, 17:20