regulation of transcriptional activation by wrn
báo cáo hóa học:" Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Chi Zhang" pptx
Ngày tải lên :
20/06/2014, 04:20
... determinant of craniofacial patterning and osteoblast differentiation Cell 2006, 125:971-986 11 Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH: Regulation of adult bone mass by the ... article as: Zhang, Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Journal of Orthopaedic Surgery and Research 2010, 5:37 Page of ... different mechanisms shown in Figure2: first, by being needed for the expression of a major Wnt antagonist and second, by inhibiting the transcriptional activity of β-catenin/Tcf We have shown that Osx...
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Báo cáo khoa học: Dual modulation of prothrombin activation by the cyclopentapeptide plactin pptx
Ngày tải lên :
07/03/2014, 00:20
... effects of cystatin, an inhibitor of DPP-I, on tcu-PA ⁄ T activation by U937 cells Cystatin effectively inhibited tcu-PA activation by U937 cells (Fig 3D) and prothrombin ⁄ Xa-mediated scu-PA activation ... prothrombin is one of the plasma cofactors participating in plactin D-promoted scu-PA activation on U937 cells Mechanism of prothrombin- and plactin-mediated enhancement of scu-PA activation The ... [12–14] Activation of prothrombin by the complex (prothrombinase complex) is > 105 times faster than activation by free Xa [15] Therefore, physiological coagulation is eventually catalyzed by the...
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Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot
Ngày tải lên :
07/03/2014, 12:20
... followed by an increase in ferritin synthesis [37] Such NO-dependent IRP2 degradation was caused by the S-nitrosylation of Cys178 which led to ubiquitination of the protein followed by its degradation ... that treatment of RAW 264.7 cells with the NO+ donor, SNP, causes the degradation of IRP2 associated with an increase of ferritin synthesis [20,37] Here, we examined the kinetics of ferritin synthesis ... RNA-binding activity of IRP1 remained largely unaffected (Fig 1B) Surprisingly, the rapid induction of ferritin synthesis by SNP in RAW 264.7 cells occurred much earlier than any decrease of IRP activities...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... polyamine in the regulation of apoptosis [21,22] Thus, the possibility that the antiviral effect of spermine is mediated by induction of apoptosis was analyzed For this purpose, the effect of spermine ... pathway of translational regulation mediated by eukaryotic initiation factor EMBO J 19, 6891–6899 Geiss G, Jin G, Guo J, Bumgarner R, Katze MG & Sen GC (2001) A comprehensive view of regulation of ... line following inducible expression of the constitutively active form of IRF-3, IRF-3 5D [14] Up -regulation of ArgII gene expression was observed after treatment of the tetracycline inducible cell...
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REGULATION OF INTEREST RATE BY THE STATE BANK OF VIETNAM (SBV) potx
Ngày tải lên :
15/03/2014, 01:20
... on loans on the basis of market capital supply – demand and the creditability of borrowers” Page of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) This ... Liberalization of interest rate From the year Page 18 of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) 1994, Credit limit mechanism was deleted, replacing by other ... Loc MBA Intake 13 CFVG, Hanoi, June 2006 Page of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) THE ROLES OF INTEREST RATE Interest Rate is a key economic...
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Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx
Ngày tải lên :
17/03/2014, 23:20
... Down -regulation of telomerase activity by induction of differentiation of HL-60 cells has been reported [24,25] To understand the role of each telomerase subunit in enzyme activity, we used downregulation ... enzyme activity, we used downregulation of telomerase by inducing differentiation of HL-60 cells, and up -regulation of telomerase by stimulating proliferation of peripheral blood mononuclear cells ... addition of 100 lL of tetramethylbenzidine substrate solution to each well Ten later, the reactions were stopped by the addition of 100 lL M HCl to each well Colorimetric signals were determined by...
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Molecular Regulation of Endocytosis Edited by Brian Ceresa pot
Ngày tải lên :
24/03/2014, 02:21
... satisfied Brian P Ceresa, Ph.D Department of Pharmacology University of Louisville, Louisville, Kentucky, USA Section Regulation of Tissue Homeostasis by the Endocytic Pathway Chapter Key Events ... heavy chain, Molecular Regulation of Endocytosis illumination followed by repetitive stimulation causes a complete loss of synaptic vesicles along with massive accumulation of plasma membrane folds ... has been determined by taking advantage of assembly-deficient mutants (66,67) Insight into the organization of assembled dynamin multimers has been gained by computer docking of domain crystal...
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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx
Ngày tải lên :
30/03/2014, 10:20
... effector [57,58], Ga ⁄ tubulin Agonist GPCR Gαβγ α Gα Activation of GTPase of tubulin by Gα, and inhibition of MT assembly Gβγ Loss of GTP cap on MT end by Gα promotes catastrophy in di and increase ... Effect GDPTubulin Effectors Promotion of MT assembly by Gβγ GTP-Tubulin γ-Tub Fig Model for the regulation of microtubule (MT) assembly by a and bc subunits of G proteins Based on in vitro results ... bound form of Gia and inhibit the exchange of GDP-bound for GTP-bound Ga [73–75] These signaling partners of G proteins might also be involved in the regulation of microtubule assembly by Gia or...
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Báo cáo khoa học: Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues pot
Ngày tải lên :
30/03/2014, 15:20
... Introduction of the Sfh2p into the sec14D cki1D strain does not change the transcriptional Ó FEBS 2004 Phosphatidylcholine turnover and INO1 regulation (Eur J Biochem 271) 4407 regulation of the INO1 ... steady-state levels of phospholipids using 32P-labelling, showed that deregulation of the INO1 gene correlates with higher steady-state levels of PA (Fig 6) The steady-state level of PA in the sec14D ... series of experiments it was shown that Opi1p, a negative transcriptional regulator of phospholipid biosynthesis, is inhibited by binding PA on the endoplasmic reticulum Following the addition of...
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Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John doc
Ngày tải lên :
30/03/2014, 15:20
... [22,23] Upon activation of naı¨ ve T cells by mitogenic stimulation, the expression of truncated Stat5a and Stat5b proteins disappears and is replaced by the expression and activation of the full-length ... of the exact cleavage site on Stat5 will be important in enhancing our understanding of the regulation of Stat5 function by proteolytic cleavage in peripheral T cells Proteolytic regulation of ... immediately preceeding the transactivation domain Fig Negative regulation of STAT signalling Cytokine-induced STAT activation can be inhibited by suppressors of cytokine signalling (SOCS) proteins,...
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Báo cáo khoa học: Regulation of ascidian Rel by its alternative splice variant pdf
Ngày tải lên :
30/03/2014, 20:20
... Ministry of Education, Science, Sports, Culture, and Technology of Japan References Fig Effect of Ci-IjB on transcriptional activity of As-rel1 Transcriptional activity of As-rel1 in the presence of ... overexpression of As-rel1 can be explained by its Ó FEBS 2003 Regulation of Rel by alternative splice variant (Eur J Biochem 270) 4467 the presence of the IjB protein, will modulate the function of As-rel1 ... amounts of transfected DNA were kept constant (1.5 lg) by adding an empty vector (pBIND or pCI-neo-Flag vector) The level of activity was normalized on the basis of the level of activity of control...
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Báo cáo sinh học: " Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc
Ngày tải lên :
18/06/2014, 22:20
... - + - + Figure overexpression of replication in response to exogenous Regulation of FeLVCBP Regulation of FeLV replication in response to exogenous overexpression of CBP K-562 cells were chronically ... Figure 1of the U3 region promoter (Pro) boxes) and transcriptional of the FeLV-945 LTR, indicating the transcriptional enhancer (hatched box), 21-bp triplication (open Diagram Diagram of the U3 ... expression of the firefly luciferase gene was driven by the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element Reporter gene constructs were introduced by lipid-mediated...
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báo cáo hóa học:" Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc
Ngày tải lên :
20/06/2014, 04:20
... - + - + Figure overexpression of replication in response to exogenous Regulation of FeLVCBP Regulation of FeLV replication in response to exogenous overexpression of CBP K-562 cells were chronically ... Figure 1of the U3 region promoter (Pro) boxes) and transcriptional of the FeLV-945 LTR, indicating the transcriptional enhancer (hatched box), 21-bp triplication (open Diagram Diagram of the U3 ... expression of the firefly luciferase gene was driven by the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element Reporter gene constructs were introduced by lipid-mediated...
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Báo cáo y học: " Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors" pptx
Ngày tải lên :
09/08/2014, 10:22
... localization of NF-κB p65 in the presence of both TNF-α and atRA More interestingly, acetylation of K310 is required for full NFκB transcriptional activity Hyperactivation of p300 induced by caMEKK1 ... reduction of Sox9 activity by atRA is independent of NF-κB activation Binding of protein complexes to the Col2a1 48-bp minimal enhancer and nuclear Sox9 levels Since Sox9 activity was decreased by TNF-α ... treated with both TNF-α and atRA Regulation of transcription factor activity by p300 Differences in the affinity for p300 may contribute to the pattern of regulation of transcription factor activity...
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Báo cáo y học: "Immune regulation of bone loss by Th17 cells" doc
Ngày tải lên :
09/08/2014, 13:21
... inhibits murine osteoclastogenesis by inducing the rapid degradation of the RANK adapter protein TRAF6, resulting in strong inhibition of RANKLinduced activation of NFκB and Jun N-terminal kinase ... Flavors of T-helper 17 cells The schematic concept of separate nonoverlapping T-cell lineages identified by their unique cytokine repertoire, however, is hampered by reality (Figure 1) A subset of ... differentiation of osteoclast precursor cells by the sequential expression of cFms and receptor activator of nuclear factor κB (RANK) receptors J Exp Med 1999, 190:1741-1754 25 Hofbauer LC, Khosla...
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Báo cáo y học: " Regulation of cardiac microRNAs by serum response factor" potx
Ngày tải lên :
10/08/2014, 05:21
... cardiac-specific overexpression of SRF leads to altered expression of cardiac miRNAs, especially the down -regulation of miR-1 and miR-133a, and up -regulation of miR-21, the dysregulation of which is known ... through transcriptional regulation where it controls the amount of pri-miRNA available for downstream miRNA maturation process We have proposed a model of miRNA regulation by SRF and its cofactors ... in the mouse heart resulted in altered expression of a number of miRNAs, including the down -regulation of mir-1 and mir-133a, and up -regulation of mir-21, which are usually dysregulated in cardiac...
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Báo cáo y học: "Preferential regulation of duplicated genes by microRNAs in mammals" ppt
Ngày tải lên :
14/08/2014, 20:22
... time Figure Dynamic simulation of regulation of duplucate genes by microRNA Dynamic simulation of regulation of duplucate genes by microRNA (a) A schematic diagram of a hypothetical microRNA-mediated ... until reaching a steady state Meanwhile, with upregulation of T1, after a transient down -regulation of P caused by the mutation of T2, the level of M is promptly restored to its original level ... pressure, we normalized rates of substitution for the 3'UTR of each gene by the corresponding rate of substitution of the coding region in the same gene Since the number of synonymous substitutions...
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REGULATION OF SRF ACTIVITY BY THE ATP-DEPENDENT CHROMATIN REMODELING ENZYME, CHD8
Ngày tải lên :
24/08/2014, 11:38
... 90 Curriculum Vitae x LIST OF TABLES Table Changes in apoptotic genes as a result of loss of CHD8 72 xi LIST OF FIGURES Figure Schematic of functional domains of serum response factor (SRF) ... cells 70 Figure Loss of CHD8 causes attenuated expression of Birc5/survivin 73 Figure Proposed model of CHD8’s regulation of apoptosis through mediation of survivin expression ... process of cellular differentiation can be divided into three main components: (a) activation of specific genes that are required for differentiation of a cell, (b) control of expression of these...
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK ERK IN CELL DYNAMICS
Ngày tải lên :
10/09/2015, 09:29
... Wittinghofer, 2001] The hydrolysis to bring about inactivation of RhoGTPases is mediated by the intrinsic, albeit slow, GTPase activity of the G-domain The exchange of the GDP for GTP starts off ... RhoGAP, one of the p190RhoGAP isoforms affects cell growth and differentiation, an effect seen by the reduction in size of mice thymus in the absence of p190B MgcRacGAP mediated downregulation of Cdc42 ... proved that hyperactivation of RhoA upon loss of DLC1 was a key factor in tumorigenesis [Xue et al., 2008] The effect of DLC1 GAP domain on RhoA activation was confirmed by the use of RhoA-Raichu...
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Regulation of NMDA receptors by serine proteases tissue plasminogen activator (tPA) and plasminogen plasmin
Ngày tải lên :
11/09/2015, 10:18
... NR2B-selective allosteric antagonists 1.6.2 Functional regulation by phosphorylation 1.6.2.1 Regulation by serine/threonine phosphorylation 1.6.2.2 Regulation by tyrosine phosphorylation 1.6.3 Proteases ... phosphorylation by Fyn is also implicated in regulation of surface expression of NMDA receptors (Nakazawa et al., 2001; Prybylowski et al., 27 2005) (Figure 1.6) and calpain-mediated cleavage of NMDA ... 1.7) Activation of astrocytic PAR-1 by thrombin can mediate Ca2+-dependent release of glutamate, which depolarizes adjacent neurons via NMDA receptors activation (Lee et al., 2007) Relief of the...
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