regulation of stem cells by the endocannabinoid system

... instead of lowering the interest rate according to the policy adopted by the Conference of Bankers at the beginning of the year, the State Bank preserved the status quo on the grounds that the inflation ... war” of interest rate in Banking System, to prevent failure of banking system (crisis of the Financial Market); c) Keep an eye on the inflation; in the case of Vietnam, this may be to control the ... also noted that the interest rates of all state-owned banks are nearly same On the other hand, the utility package offered by the banks to the investors mainly includes the low cost of capital, service...

Ngày tải lên: 15/03/2014, 01:20

... mechanism of the temporal and spatial regulation of Osx for bone formation and homeostatic regulation of skeletal system The need to develop novel drugs that stimulate bone formation and thereby elevate ... Osx-null embryos the number of TRAP-positive cells appear to be reduced compared to wild-type embryos In long bones of Osxnull embryos cells from the periosteum invade the zone of the hypertrophy ... expression of type I collagen (Col1a1) in the condensed mesenchyme of the membranous skeleton and the periosteum and mesenchyme of the endochondral skeleton is severely reduced Expressions of the osteoblast-specific...

Ngày tải lên: 20/06/2014, 04:20

... costimulators of cells of the adaptive immune system TLR-2 engagement therefore influences the differentiation of T cells not only by the activation of DCs (indirect pathway R439 Arthritis Research & Therapy ... Therapy Vol No Sobek et al control of innate and adaptive immunity [7] Recent observations have shown that TLRs are expressed not only by cells of the innate immune system but also by cells of ... state of the lipoprotein [3641,53,54] In addition, little is known about feedback regulation after engagement of TLRs and the consequences of the absence of particular TLRs on effector cells The...

Ngày tải lên: 09/08/2014, 01:23

... 1993) Systems such as the skeleton (bone and cartilage), the muscles (skeletal, smooth and cardiac), the circulatory system, the excretory system, the reproductive system, the inner layer of the ... (dermis), the outer layers of the digestive system and the respiratory system are all derived from the mesoderm germ layer (Solomon, 1993) The lining of the digestive tract and the respiratory system ... allowing them to become migratory and to form the precursors of the smooth muscle cells in the coronary vessels The final group of stem cells from which smooth muscle cells are derived is the endothelial...

Ngày tải lên: 24/08/2014, 11:38

... Dendritic cells, derived from bone marrow stem cells, are the most potent antigen-presenting cells of the immune system They play a central role in the initiation of primary immune response and in the ... one of the enzymes mostly involved in endocannabinoid inactivation The heterogeneous distribution of CB2 receptors among cells of the immune system suggests that these receptors might exert their ... (R&D Systems) (200 UÆmL)1) For dendritic cell activation, LPS (1 lgÆmL)1) or the Der p antigen (a major allergen of the house dust mite Ó FEBS 2002 The endocannabinoid system in human dendritic cells...

Ngày tải lên: 22/02/2014, 07:20

... neuropathologic alterations of the endocannabinoid system, such those detected after MCAo, are instrumental for its modulation by estrogen The modulation of the endocannabinoid system by E2 in the ischemic ... 2007 The Authors Journal compilation ª 2007 FEBS 4465 Endocannabinoid system modulation by E2 after MCAo D Amantea et al modulation of the endocannabinoid system is implicated in the mechanisms of ... mechanism involving altered endocannabinoid metabolism To the best of our knowledge, there is no information on the putative modulation of the endocannabinoid system by E2 in the brain under pathophysiologic...

Ngày tải lên: 23/03/2014, 07:20

... Although there is an apparent ED between ES cells and EG cells, the ED of TS cells to ES cells (77) is greater than that of EG cells to ES cells (49), confirming the similarity of EG cells to ES cells ... study of embryonic stem cells Differences in DNA methylation profiles between ES and other stem cells Comparing ES cells with other stem cells established from developing embryos revealed the uniqueness ... is the establishment of embryonic stem (ES) cells, which maintain the ability to form all types of cells in the body, and can differentiate into a variety of cell types in vitro [8] The use of...

Ngày tải lên: 23/03/2014, 07:20

... zone of cartilage could be clearly separated by the proximity of the cells to the joint space and the bone Page 10 of 15 (page number not for citation purposes) respectively, alignment of the ... along the arcades of Benninghoff [29] and by the appearance of hypertrophic cells Analyses of lacunae surface areas in the different growth plate zones revealed mean lacunae surface areas ± SD of ... formation, of 541.3 ± 166.3 μm2 in the center and 386.1 ± 108.7 μm2 the periphery of the Ad.BMP-2 transduced aggregates, and of 307.8 ± 75.6 μm2 in the center and 248.7 ± 65.4 μm2 the periphery of the...

Ngày tải lên: 09/08/2014, 14:22

... exemplified by the fertilized zygote and the cells of the blastomeres up to the 8-cell stage Pluripotent stem cells can differentiate into all cell types of the three germ layers of an organism ... Examples of pluripotent stem cells include the embryonic stem (ES) cells, embryonic germ (EG) cells and embryonal carcinoma (EC) cells Multipotent stem cells can give rise to cells of certain ... these cells, the modulators regulated by Nanog can be identified and the interconnection of Nanog with the LIF and BMP signals can be dissected One of the potential applications of the gain -of- function...

Ngày tải lên: 12/09/2015, 08:19

... Nevertheless, the cells and molecules are able to act in concert to maintain the integrity of the immune system Cells of the immune system originate from their hemapoietic progenitors in the bone ... refer to all the cells that play an active role in innate immunity These cells include epithelial cells, eosiniphils, DCs, mast cells, phagocytic cells, NK cells and γδ T cells The natural flora ... 2002) The innate immune system is mainly made up of mechanical, chemical and cellular components (Basset et al., 2003) The mechanical components of the innate immunity consist of epithelial cells...

Ngày tải lên: 16/10/2015, 11:59

... dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic and degradative enzymes, the endocannabinoid ... fact, the large amounts of nitric oxide (NO) generated by pathological expression of NO synthase isoforms are certainly neurotoxic, whereas homeostatic levels of NO produced by the endothelial isoform ... aided the comprehension of the neurobiology of this system CB1 receptors, which mediate the psychotropic effects of D9-tetrahydrocannabinol (D9-THC) and other CBs, are highly expressed in the central...

Ngày tải lên: 07/03/2014, 03:20

... polyamine in the regulation of apoptosis [21,22] Thus, the possibility that the antiviral effect of spermine is mediated by induction of apoptosis was analyzed For this purpose, the effect of spermine ... in the induction of spermine, which inhibits virus replication and mediates apoptosis Together, these results illustrate a new mechanism by which IRF-3 may contribute to the development of the ... intestinal epithelial IEC6 cells, thereby delaying TNF-a-induced apoptosis [38] As both NF-jB and JNK pathways are activated by virus infection, these pathways may be targets of the pro-apoptotic...

Ngày tải lên: 07/03/2014, 21:20

... to stem cells In the first, stem cells themselves are implanted in a diseased or injured organ in the hope that they will give rise to the mature cells needed by that organ In the second, the stem ... or the brain, in the adult body They can renew themselves in the body, making identical copies of themselves for the lifetime of the organism, or become specialized to yield the cell types of the ... specialized cells of different tissue types are rare in the adult In contrast, the seemingly unlimited potential of the undifferentiated cells of the early embryo has made embryonic stem cells the focus...

Ngày tải lên: 15/03/2014, 09:20

... capacity of B cells Effect of3 Effect of CP-870,893 on T cell stimulatory capacity of B cells Purified CD19+ B cells from each of donors were stimulated as described in Figure 2, irradiated, then ... immune surveillance and immunotherapy are enhanced in the absence of B cells [15-19], potentially due to the elimination of suppressive or regulatory B cells [18,20] B cells have been shown to be ... effects of CP-870,893 on peripheral blood B cells from normal donors, including both memory and naïve B cells as defined by the presence or absence of CD27 expression We studied the effect of CP-870,893...

Ngày tải lên: 18/06/2014, 15:20

... cells in the presence of a monoclonal anti-c-Myb antibody The results clearly showed decreased mobility of the specific complex in the presence of the c-Myb antibody (Figure 3A), but not in the ... contain the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element The U3 region of the FeLV-A/ 61E LTR, containing one copy of the 21-bp element, was cloned into the firefly ... possibility further Binding sites were identified for the transcription factor, c-Myb, that crossed the repeat junctions of the triplication Further, once cMyb was bound to the triplication, the transcriptional...

Ngày tải lên: 18/06/2014, 22:20

... cells in the presence of a monoclonal anti-c-Myb antibody The results clearly showed decreased mobility of the specific complex in the presence of the c-Myb antibody (Figure 3A), but not in the ... contain the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element The U3 region of the FeLV-A/ 61E LTR, containing one copy of the 21-bp element, was cloned into the firefly ... possibility further Binding sites were identified for the transcription factor, c-Myb, that crossed the repeat junctions of the triplication Further, once cMyb was bound to the triplication, the transcriptional...

Ngày tải lên: 20/06/2014, 04:20

... induced by Th1 cells was not significantly affected by any of the inhibitors used, but the MCP-1 levels induced by Th2 cells were affected strongly by both U-0126 and PSI and weakly by the JNK ... inhibition of IL-8 mRNA induced by Th1 but not by Th2 cells Involvement of JNK in IL-8 induction has been demonstrated in other cell types [63,64] In our system Th2 cells induced higher levels of IL-8 ... Several of the findings reported here are new First, the pattern of chemokines produced by fibroblasts was shown to depend on the type of Th cell that stimulates them This is consistent with the...

Ngày tải lên: 09/08/2014, 07:20

... the number of days for the treated tumors to reach ten times the initial tumor volume minus the number of days for the control group to reach the same size The mean size of tumors receiving the ... reach the same size ‡ The number of days for the tumors in the BO-1051+IR group to reach 10 times the initial tumor volume minus the number of days for tumors in the BO-1051only group to reach the ... may in part account for the effects of BO-1051 on the enhancement of radiosensitivity of glioma cell line Enhancement of radiosensitivity by BO-1051 treatment is not caused by apoptosis or mitotic...

Ngày tải lên: 09/08/2014, 09:20

... confluence by day 14 The yield of cells by the end of passage was typically 107 cells at confluence from g of IPFP tissue (proliferation rate 0.14 ± 0.01 doublings per day (mean ± SEM) [8]) Cells ... citation purposes) ing the synthesis and assembly of matrix by IPFP-derived stem cells as they undergo chondrogenesis and that this has important implications for the use of the IPFP in cartilage ... Chondrogenic culture of IPFP cells and the effect of low oxygen tension The cultured cell aggregates of IPFP cells with chondrogenic medium showed evidence of induction of chondrogenesis under...

Ngày tải lên: 09/08/2014, 10:20

... hampered by reality (Figure 1) A subset of Th17 cells defined by their expression of the signature cytokine IL-17A also produce IFNγ, albeit less than that produced by Th1 cells [53] The IL-17A/IFNγ ... dampen the immune response to minimize tissue destruction There are a number of mechanisms by which the Treg dampens the immune system, including some requiring cell-to-cell contact, but the present ... brief overview of four T-cell subsets and the factors that drive their differentiation into these subsets, and we then concentrate on how the signature cytokine(s) of these T cells impact inflammationdriven...

Ngày tải lên: 09/08/2014, 13:21