reducing the immune response to increase duration of expression
Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... concurrent analysis of the phenotype and proliferative response of antigen-specific T cells was used to study the immune response to a specific antigen [17] We employed a similar method to demonstrate ... levels of Th1 cytokines [29] CD28neg expression may reflect autoreactive properties of these cells, as has been demonstrated in other autoimmune diseases [30,31] However, we cannot exclude the possibility ... Multiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants (b) An excess of Th1 over Th2 cytokines was detected PE, phycoerythrin; TNF, tumour necrosis factor...
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study on the immune response of orange spotted grouper (epinephelus coioides hamilton, 1822) cultured in khanh hoa province to bacteria vibrio parahaemolyticus
... causing the ulcerative disease in grouper Study on the effect of oral administration β-glucan on the native immune response of orange-spotted grouper Study on the specific immune response of orange-spotted ... Influence factors for fish immune responses Factors affecting fish immune responses include factors related to fish ontogenesis Among environmental factors, temperature has been shown to greatly ... Observation of phagocytic activity was based on the ability to ingest the fluorescent beads of HKL according to Yeh et al (2008); The respiratory burst activity of HKL were measured according to Cheng...
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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65" pptx
... secretion of anti-inflammatory cytokines over proinflammatory cytokines in response to Bhsp65 To test and compare the T cell proliferative and cytokine response to the disease-related antigen Bhsp65 of ... turn generate some of the critical mediators of the inflammatory response [14,15,35] In fact, some of the active components of Celastrus have been shown to serve as inhibitors of the NF-κB pathway ... deviation) of the cytokine response to an anti-inflammatory type [26] This relative deviation of the cytokine response, caused either by decreased Th1-type cytokines and/or by enhanced Th2-type cytokines...
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Báo cáo y học: " Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma" pdf
... is Chief of the Division of Allergy/Immunology and Director of the Asthma Clinical Research Center at the University of California Competing interests SDA is the inventor of the mannitol test ... reproducibility of the exercise response in relation to the different NAEPPII scores is given in Table There was no relationship between the NAEPII score and the severity of the response to exercise ... reproducibility of the airway response to exercise in the type of individual most likely to be referred for exercise testing for EIB Exercise testing to identify EIB in the laboratory is affected by the...
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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx
... aspiration of either gastric fluid or normal saline are shown The ratio of macrophages in the left to the macrophage in the right lung is shown as a function of time In the inset, the ratio of macrophages ... (Figure 5) On the other hand, when all rats receiving gastric fluid were compared to all rats receiving normal saline, regardless of the duration of treatment, the ratio of T cells in the left (treated) ... phenotypic response It is also quite possible that, in the setting of a pulmonary allograft, the development of these inflammatory mediators could recruit and/or exacerbate immune responses that...
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Báo cáo y học: "Using an agent-based model to analyze the dynamic communication network of the immune response" docx
... ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per node for the first 400 ticks of the simulation for the given ... to set one of the challenges to the immune system at the top of the list “Set_ViralInfection:” and “Set_Bacti:” are the verified choices A ‘1’ must be typed in to replace the ‘0’ for one of the ... distributions of contacts for each immune agent type at 1000 ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per...
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INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
... The heterogeneous consequences of M tuberculosis infection The implications of the heterogeneity of the host immune response to M tuberculosis infection are becoming increasingly recognised The ... crucial to the delivery of antigen from the site of infection to the draining LN, where the initial activation of T cells occurs (Wolf et al., 2008) In addition, DCs are unique in their ability to ... dissemination is initiated by the migration of infected DCs to the draining LN (Humphreys et al., 2006) Taken together, these studies suggest that the migratory properties of infected DCs is 18 Chapter...
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báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx
... effect of overnight shipping on inhibition of internalization of AF488-MCP-1 by the receptor antagonist a direct comparison of the effect of overnight storage on the IC50 of the CCR2 inhibitor was ... important to demonstrate the ability of the CCR2 antagonist to inhibit the saturating concentration of the AF488-MCP-1 used in the assay To accomplish this CCR2 antagonist was titrated into the assay ... day period there is relatively little change in the overall expression of the CCR2 receptor as well as the cell's capacity to internalize the ligand The inter-person reproducibility of the assay...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
... is given to the orchestration of these events with respect to their timing and magnitude, and to the identity of the cells that produce them Timing differs between species (see below) Therefore, ... fibroblasts to upregulate the expression of cytokines IL-6 and GM-CSF mRNAs and the production and secretion of their proteins within to hours after the injury Inflammatory IL-1b mRNA expression ... Faculty of Medicine, Jerusalem, Israel innate -immune response of the PNS to traumatic nerve injury (e.g recruitment of macrophages, phagocytosis of degenerated myelin, and production of cytokines...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
... determine if the increased cell death observed in the injured brains of MT-I/II-/mice is due to the absence of the neuroprotective effects of MT-I/II in the CNS or the absence of the modulatory effects ... neurotoxic and can impede the resolution of brain injury [19-21] It is feasible that the number of immune cells entering the CNS can influence the progression of brain injury but the phenotype of ... expose the cranium and the steel rod was then applied directly to the skull for seconds The stereotaxic coordinates for the injury site were mm anterior of lambda and mm right of the midline The...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... examined the expression of p15INK4, p21WAF1/Cip1 and p27Kip1, which are known to prevent cell cycle progression under the growth inhibitory effect of TGF1 [29-32] The aim of the present study was therefore ... was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposus cells The study was designed to (1) analyze the effect of TGF1 on cell proliferation and the cell cycle ... cells in the S phase differ among individuals, these inhibitors both seem to block the mitogenic effect of TGF1 completely The statistical significance by the repeated measures ANOVA of the cell...
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Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnove" doc
... Ovariectomy was performed using a dorsal midline incision and the entrance into the abdominal cavity was made with a small cut in to the muscle half to two-thirds of the way down the side of the ... Overall, there are a series of situations where CTXII behaves distinctly to other markers The present study adds to these series the unique response of CTX-II to oestrogen deficiency There are ... levels of ovariectomy-rats were back to the control levels of sham-operated rats The present study aims to investigate the relevance of CTX-II to cartilage collagen metabolism in situations of oestrogen...
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Báo cáo y học: "Mactinin: a modulator of the monocyte response to inflammation" pps
... decided to pursue this further Owing to the autoimmune nature of rheumatoid arthritis, we examined whether mactinin was present in immune complexes That is, antibody-bound mactinin might not bind to ... material at the top of the gel (data not shown) Hence, the R313 Arthritis Research & Therapy Vol No Luikart et al Figure Dissociation of immune complexes in rheumatoid arthritis fluid An aliquot of rheumatoid ... maturation There, increased numbers of mature monocytes might increase cartilage and bone destruction These results lead us to speculate that inhibitors of mactinin might be of benefit in the treatment...
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Báo cáo y học: "Application of in vivo microscopy: evaluating the immune response in living animals" pps
... scattering of light by most tissues limits the depth of penetration into the tissue to 80 to 100 µm on average, which for lymph nodes allows the penetration of about only one-quarter of the whole ... than by a single photon of visible light as in confocal microscopy Each of the two photons contributes half of the energy required to induce fluorescence The energy of a photon decreases with ... accessible is the inguinal lymph node of the mouse by folding back a broad flap of abdominal skin or the popliteal lymph nodes of the feet [25] A rubber ring is glued on the inner surface of the exposed...
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Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover" doc
... Ovariectomy was performed using a dorsal midline incision and the entrance into the abdominal cavity was made with a small cut in to the muscle half to two-thirds of the way down the side of the ... Overall, there are a series of situations where CTXII behaves distinctly to other markers The present study adds to these series the unique response of CTX-II to oestrogen deficiency There are ... levels of ovariectomy-rats were back to the control levels of sham-operated rats The present study aims to investigate the relevance of CTX-II to cartilage collagen metabolism in situations of oestrogen...
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Báo cáo y học: "Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model" pdf
... was added to the wells A colored product was formed in proportion to the amount of cytokine present in the sample The reaction was terminated by the addition of N sulphuric acid and the absorbance ... developed in vitro model and therefore the study requires the development of an animal model The other limitation in the present model is inability to observe the immune response in PBMC after a ... very important to measure IgG response to nonrelated immunogen (control Ag) to rule out any non-specific immune response Secondly, the risk of development of TB cannot be studied with the developed...
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Báo cáo y học: "Role of TRPV3 in immune response to development of dermatitis" doc
... counted the number of mast cells in the skin of five or six mice at 15 weeks of age, and measured serum total IgE levels The number of mast cells in the skin of NC/ Nga-Nh mice significantly increased ... congenic strain to evaluate the contribution of TRPV3 to the development of AD in NC/Nga mice The penetrance of the Page of 10 (page number not for citation purposes) Journal of Inflammation ... exacerbation of eczema in AD [24] These findings suggest that binding of S aureus to the skin plays an important role in the development of AD Transduction of the TRPV3Gly573Ser gene into DS mice...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... consented to the immune response kinetic study (Table 1) and just two of them agreed to have an oral booster vaccination 42 days after primary immunisation Of these subjects, gave a history of contact ... capable of mounting humoral and cellular immune responses to the antigens tested The data presented here will form the basis for further studies with larger numbers of subjects, with the aim of studying ... immunoglobulins isotypes, other cytokines of importance in mucosal immune responses as well as responses to purified secreted proteins Competing interests The kinetics of lymphoproliferative response described...
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báo cáo khoa học: " Public health the leading force of the Indonesian response to the HIV/AIDS crisis among people who inject drugs" doc
... (two of the main provinces of Indonesia) is to lead the response and use the infrastructure of the health system to scale the response to the level of the epidemic The expansion was based on ... 2007, 4:9 motion of safe sex than to the promotion of safer use of drugs Advocacy of the police is the most difficult part of the job Indonesia has a history of militarization of the street police ... accurate; there is as well the need to increase quality of data collection and flux of the information Currently, there are many bodies of the Government playing a role in the control of the HIV/AIDS...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25