reconciling the roles of inflammation and ``degeneration amp rd
Báo cáo y học: " The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus" doc
Ngày tải lên :
12/08/2014, 15:22
... into whether interactions between endothelial cells and SLE autoreactive T cells result in endothelial damage and an increased risk of atherosclerosis should be considered The roles of other T-cell ... perpetuation of atherosclerotic lesions in the general population It increases the level of adhesion molecules on the surface of vascular endothelium and promotes enhanced levels of chemotactic ... stress Endothelial damage and the initiation of the atherogenic cycle may be influenced by the redox environment SLE patients have increased levels of reactive oxygen and nitrogen species and antibodies...
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The roles of rac1 and syncollin in regulated exocytosis insulin secreting INS 1 cells as a model
Ngày tải lên :
16/09/2015, 17:11
... hyperglycemia Study of the exocytosis using the insulin secretion model will benefit to the understanding of both the fundamental mechanism of regulated exocytosis and the pathogenesis of diabetes development ... features allowing them to be sorted at the level of the TGN For proinsulin, it has been shown that residues 16 (Leu) and 17 (Glu) of the A-chain and 13 (Glu) and 17 (Leu) of the B-chain serve ... Several regions, including the position of cysteins that form the disulfide bond, the N- and C-terminal regions of A chain and the hydrophobic residues at the C-terminal of B chain, are highly conserved...
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Effects of apolipoprotein e on n methyl d aspartate receptor signalling the roles of ageing and chicken extract
Ngày tải lên :
30/09/2015, 06:42
... the first lane and the size of the rectangular box is standardized for the rest of the lanes Lane profiles were plotted and a straight horizontal line was drawn defining the x-axis (the background) ... plasticity Activation of NMDARs facilitates formation of both LTP and LTD (Bear and Malenka, 1994; Bliss and Collingridge, 1993) and there are several hypotheses regarding the roles of NMDAR in bidirectional ... exclude the unusually bright staining (artefacts) at the periphery of the sections The total area of staining over the threshold within the ROIs was computed by the software and this total area of...
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Investigating the roles of neuroscience and knowledge management in higher education
Ngày tải lên :
03/06/2017, 21:37
... TERMS AND DEFINITIONS Brain: The soft convoluted mass of nervous tissue within the skull of vertebrates that is the commanding and coordinating center of the nervous system and the seat of thought, ... DIRECTIONS The classification of the extensive literature in the domains of neuroscience and KM will provide the potential opportunities for future research Neuroscience is the study of the brain and the ... emphasizes the current trends in higher education, the overview of neuroscience, the multifaceted applications of neuroscience, the overview of KM, the perspectives of KM, the significance of neuroscience...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish ... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene ... serves to maintain a level of AP-2a expression that limits the size of the hand plate and the associated number of digit primordia [72] AP-2 function was also analyzed in other species A similar...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
Ngày tải lên :
20/02/2014, 01:20
... ATnI130)252, and ATnI232)292 did not migrate into the gels, while free ATnI-52K and ATnI1)128 exhibited a band near the origin and at the middle of the gel, respectively The bands corresponding to the ... PAGE Lanes a and d, in the absence of both TnC and Ca2+; lanes b and e, in the presence of TnC and the absence of Ca2+; lanes c and f, in the presence of both TnC and Ca2+ Ac, actin; Tm, tropomyosin; ... actin and TnC in the absence and presence, respectively, of Ca2+ These phenomena should directly reflect the mechanism of Ca2+ switching involving the alternative binding of the C-terminal region of...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
Ngày tải lên :
20/02/2014, 02:21
... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and ... proximity of the N5 atom A putative flipping motion of the progesterone molecule along an axis parallel to the FMN plane aligns the C1-C2 with the 4666 plane of the isoalloxazine ring and in close ... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site The active sites of the enzymes are shown in stick format with the sigmaA...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
Ngày tải lên :
15/03/2014, 11:20
... promote the transfer of the p-HB moiety onto PKS15 ⁄ [16,18] To examine the involvement of FadD29 in the biosynthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of an ... the activation of the various intermediates in DIM and PGL biosynthesis has not been analyzed This study was undertaken to dissect the roles of FadD22, FadD26 and FadD29 in the biosynthesis of ... knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 in the...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
Ngày tải lên :
15/03/2014, 21:20
... implications among these alternative of small business finance is a growing of small business finance For example, the impact of the U.S of the early 1990s and the effect of the consolidation of the banking ... businesses and academics in the nature and behavior of the financial At the core of this issue are questions about the type of financing need and receive at various stages of their growth, the nature of ... credit, and other sources of funds These data allow for tests of research regarding the cost and availability of different types of external finance and how the cost and availability vary with the...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
Ngày tải lên :
16/03/2014, 13:20
... influences the rate of auto-oxidation and the redox potential of the heme iron, but, surprisingly, they had less effect on the characteristics of O2 and CO binding Finally, we discuss the roles of these ... the polarity of the heme distal side, the direction of the heme-bound O2 molecule, and the redox potential of the heme iron [5] The reason why the auto-oxidation rate of the Leu99 and Leu115 mutants ... accompany the redox change Specifically, there is a switch in the heme axial ligand and changes in the flexibility of the FG loop (residues 86–96) in the protein when the redox state of the heme...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... HD These processes may not be independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we specifically focus on the role of ... (45 kDa) and the activated caspase-1 (20 kDa) are shown by the arrows on the left The bar diagram (right panel) shows the average (n = 3) of integrated optical density (IOD) of the bands obtained ... elegans model of HD [45] The increased functional role of NMDAR in HD and the involvement of HIP-1 in NMDAR-mediated phosphorylation of Htt [18] further indicate the possible participation of HIP-1...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
Ngày tải lên :
23/03/2014, 21:20
... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33], VR ¼ ðSSE2 ... to the protein concentration of the membrane vesicles, and all data were corrected for the amount of radiolabelled substrate bound to the filter in the absence of vesicle protein The substrate and...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
Ngày tải lên :
29/03/2014, 21:20
... the roles of PrRP in the control of stress responses may depend upon the nature of stressful stimuli used Stressful stimuli affect food intake and increase energy expenditure On the other hand, ... in the brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the ... Y Takayanagi and T Onaka PrRP and RFRPs in metabolism and stress Table Summary of mammalian RFamide peptides and their receptors The effects of administration of RFamide peptides upon...
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Báo cáo khoa học: Tracking interactions that stabilize the dimer structure of starch phosphorylase from Corynebacterium callunae Roles of Arg234 and Arg242 revealed by sequence analysis and site-directed mutagenesis doc
Ngày tải lên :
31/03/2014, 01:20
... elements of rmGP [4] and EcMalP [3] onto the linear sequence of StP and thus measures the extent of conservation of the respective ÔsitesÕ in StP As in other GPs, the catalytic site and the PLP ... selected and the inserts sequenced The bottom of the figure (B) indicates the positions of BamHI and HindIII fragments, relative to the entire StP structural gene they represent prototypes of regulated ... responsible for the observed tetramer : dimer ratio of % 0.2 in Histagged StP, and likewise the Arg fi Ala mutants thereof The results suggest that if the occurrence of tetrameric and dimeric forms of His-tagged...
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Báo cáo sinh học: " Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse" pdf
Ngày tải lên :
18/06/2014, 18:20
... Since the latter Abs are a fraction of the Figure Composition of MAPs Composition of MAPs The amino acid (aa) composition of the scaffolds of G39d and G40d is shown in single letter code The triple ... of Health The help of Marion Sacks in the preparation of the manuscript and of Soheila Nikpour in the preparation of the figures is gratefully acknowledged References Determination of M2e-specific ... airways [24-26] The reason for this appears to be the lower rate of transudation of serum IgG through the pseudostratified columnar epithelium of upper airways than the thinner epithelium of respiratory...
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báo cáo hóa học:" Unsaturated phosphatidylcholines lining on the surface of cartilage and its possible physiological roles" potx
Ngày tải lên :
20/06/2014, 00:20
... µl The standard curves for all five PC species were all linear over the ranges of 5–25 mg/L and their correlation coefficients (r) were > 0.98 No internal standard was used The interassay and ... measured and recorded until no further movement of fluid was seen At the end of each experiment, the final pressure difference, ∆P, was recorded as the difference in the heights between the two ... ~60 % of all PC species in the lung regions of the body The present results offer further support to the Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research...
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Báo cáo hóa học: " Biosynthesis of Gold Nanoparticles by Foliar Broths: Roles of Biocompounds and Other Attributes of the Extracts" pptx
Ngày tải lên :
21/06/2014, 17:20
... i.e., the smallest observation, the lower quartile and the upper quartile cutting off the lowest and highest 25% of the data, respectively, the median which is the middle value of the data and the ... denotes the conversion of the Au(III), X the value of any of the five parameters of each broth, Cov(X, Y) the covariance value and rxy the correlation coefficient of X and Y with a range of [-1, ... those of the other and so was the case of the proteins The difference in the pH value (Fig 6b) was slight, which is also in accordance with what discussed in the prior section That is, in the biosynthesis...
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Business Change - The Roles of Change Agents and Subject Matter Experts in Organization Change potx
Ngày tải lên :
28/06/2014, 17:20
... ask for the opinions and reactions of their subordinates to the proposals, to make the changes beneficial to all of the members of a particular corporation or organization The Use of the ADKAR ... be given the chance to offer input in the technical aspects of the project They can focus on the technical side of the process, know what the competition is up to, the technology that the business ... until the AS9101 Standard is also launched, and the sanctioned training materials are released to the certification bodies Once the Assessment Standard has been released, the primary thrust of the...
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Báo cáo lâm nghiệp: "Roles of European and Japanese larch in the genetic control of growth, architecture and wood quality traits in interspecific hybrids (Larix × eurolepis Henry)" pot
Ngày tải lên :
08/08/2014, 01:22
... computed as 4Vf /Vp They mostly fit into these ranges but for total height, they rather stand in the upper range while for stem form, they stand in the lower range of 32 L.E Pâques these values Similar ... Branching density was estimated as the ratio of the number of branches on the 1988stem increment to the length of that increment and expressed as the number of branches per 10 cm long shoot; A ... categories according to the relative importance of the female and male variance components The first group includes traits with a quite equivalent contribution of the female and the male components,...
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