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Báo cáo khoa học: The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme doc

Báo cáo khoa học: The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme doc

... group and the side chain SH group of the catalytic Cys89 are crucial for the correct positioning of substrate in the thiolase catalytic pocket. Furthermore, calorimetric assays indicate that the mutation ... OPP; furthermore, the structural changes of the protein part described for the OPP complex are seen as well in the Ac-OPP complex. Due to low occupancy of the com- pound in the structure, further ... identified in the thiolase fold. The core of the monomer is formed by the N-terminal domain (with the catalytic cysteine) and the C-terminal domain. The third domain, referred to as the loop domain,...

Ngày tải lên: 16/03/2014, 04:20

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Tài liệu Protest Fee Schedule for Thunder Cars: Protestor must verify with the INEX inspector that the proper tools are available to check protested items ppt

Tài liệu Protest Fee Schedule for Thunder Cars: Protestor must verify with the INEX inspector that the proper tools are available to check protested items ppt

... events. Suicide Doors - Doors with the latch on the A-Pillar and hinges on the B-Pillar rather than the traditional method of the latch on the B-Pillar and the hinges on the A-Pillar. Suicide doors are ... hood, holes in the front fenders and /or oil coolers are permitted. The maximum height for louvers is 3/8”. The size of the area for louvers or holes in the hoodmaynotexceed54squareinches(9”x6”).These components ... sponsor decals are optional, however contingency decals are mandatory and /or use of the product to be eligible for posted awards sponsored by the contingency sponsor. 15. DOOR PLATES: Doorplates...

Ngày tải lên: 19/02/2014, 04:20

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THE ART OF INTRUSION: The Real Stories Behind the Exploits of Hackers, Intruders & Deceivers

THE ART OF INTRUSION: The Real Stories Behind the Exploits of Hackers, Intruders & Deceivers

... and subheadings for sections within a chapter. When a program is compiled into the form that the machine can read, these road signs are ignored — the computer or microprocessor has no need for them. So ... user’s data. The team had discov- ered the same kind of error in the programming of the machine. At the same time the boys were working on a computer program that would let them win against their new ... working for the organization he or she claims? Did this person have the position he or she says? Does this person have documentation to back up the story, and can I verify that the documents are...

Ngày tải lên: 18/10/2013, 21:15

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Tài liệu THE ART OF INTRUSION: The Real Stories Behind the Exploits of Hackers, Intruders & Deceivers ppt

Tài liệu THE ART OF INTRUSION: The Real Stories Behind the Exploits of Hackers, Intruders & Deceivers ppt

... be ready for the action. At this point, the computer-in -the- pocket had found the place in the algorithm that represented the cards just dealt. Since its algorithm was the same as the one in the ... in the programming of the machine. At the same time the boys were working on a computer program that would let them win against their new target machine, they were pressing Alex for a no-more-running-to -the- payphone ... working for the organization he or she claims? Did this person have the position he or she says? Does this person have documentation to back up the story, and can I verify that the documents are...

Ngày tải lên: 17/01/2014, 16:20

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Tài liệu Preparing the Western Cape for the Knowledge Economy of the 21st Century ppt

Tài liệu Preparing the Western Cape for the Knowledge Economy of the 21st Century ppt

... regions in other parts of the world, they are subject to the proviso that there are no absolute "golden rules" for success. As Amin (1998), the World Bank (1999) and other observers ... environment for economic growth; ã To prepare the people of the province for the knowledge economy of the 21st century; ã To contain the spread of HIV/AIDS and TB; ã To empower the poor people ... and adds the need for the promotion of social equity through redistributive policies involving taxation, market reform and the reprioritisation of expenditure. To these important areas, the Provincial...

Ngày tải lên: 27/01/2014, 12:20

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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf

Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf

... clusters are depicted ( HADDOCK score). Surface residues of NarJT in brown form the bottom of the funnel-shaped cavity, residues represented in light orange form the entry, whereas the rest are in orange. Structural ... re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. S. ... HCl, 1 mM MgCl 2 , 100 mM NaCl. The upper panels show the raw data for the heat effect during the titrations; the lower panels are the binding isotherms. Table 2. Thermodynamic parameters of NarG(1–15)...

Ngày tải lên: 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: The elusive intermediate on the folding pathway of the prion protein pptx

Tài liệu Báo cáo khoa học: The elusive intermediate on the folding pathway of the prion protein pptx

... is more conducive to the formation of fibrillar material than are fully unfolded or native protein [18,46]. Therefore, a plausible scheme combining the normal folding pathway of PrP with the possible ... which linear portions of the plots inter- sect. It has been observed that phase diagrams are more informative if the two wavelengths are on different slopes of the spectrum, hence the wavelengths ... properties. The fluorescence curves reflect the breakdown of ter- tiary structure whilst no changes occur in the second- ary structure, as reported by the CD curve. Therefore, A B Fig. 7. Structure of the...

Ngày tải lên: 18/02/2014, 17:20

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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx

Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx

... wild-type enzyme, whereas the K22E mutant protein failed to form the covalent adduct. On the other hand, the K22V mutant protein requires the presence of UDPNAG for the formation of the adduct indicating ... wall biosynthesis are attractive targets for the development of new drugs [1]. The biosynthesis of the cell wall component peptidoglycan (or murein) commences with the transfer of the intact ... in the loop for binding interactions with the phosphonate group of fosfomycin (or with the phosphate group of phosphoenolpyruvate during normal catalysis). In order to investigate the importance...

Ngày tải lên: 19/02/2014, 13:20

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Tài liệu The Majors of Golf Complete Results of The Open, the U.S. Open, the PGA Championship and the Masters, 1860–2008 pdf

Tài liệu The Majors of Golf Complete Results of The Open, the U.S. Open, the PGA Championship and the Masters, 1860–2008 pdf

... The Majors of Golf Complete Results of The Open, the U.S. Open, the PGA Championship and the Masters, 1860–2008 MORGAN G. BRENNER Volume 1 (Introduction; Abbreviations; The Open; ... Charles Morris, H. Prideaux-Brunne, George E. A Rowe, Charles H. Saunders, Frederick Saunders, George Sherlock, James George Smith, Everard Reginald Martin A Walls, George Yeoman, Thomas 1900 1 Taylor, ... Thomas 171 1 Fernie, George 171 1 9T Fernie, Peter George 172 Kirkaldy, John 172 11T Allan, Matthew 173 Dunn, R. William, Jr. 173 13T Morris, James Ogilvie Fairlie 174 Morris, Thomas Mitchell,...

Ngày tải lên: 22/02/2014, 08:20

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Báo cáo "Evolution of holocene depositional environments in the coastal area from the Tien river to the Hau river mouths " pot

Báo cáo "Evolution of holocene depositional environments in the coastal area from the Tien river to the Hau river mouths " pot

... weathering crust (Q 1 3b ) to be formed. These deposits are spread from the land to -100m water depth on the shelf. The colorful clays contain a lot of laterites nodules likes texture of bread ... [11,12]. The elevation of these sand ridges is about 2-7m, their width varies from 100 to 3000m. They distributed parallel to the shore in the form of bows with a distance from each other about ... grayish brown to blackish gray. They were formed mainly by sedimentation of suspended materials during flooding of delta plain area. Therefore this deposits are bad sorted (So>3) and always...

Ngày tải lên: 05/03/2014, 16:20

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THE CONNECTED KINGDOM - HOW THE INTERNET IS TRANSFORMING THE U.K.ECONOMY pot

THE CONNECTED KINGDOM - HOW THE INTERNET IS TRANSFORMING THE U.K.ECONOMY pot

... consum- ers are willing to pay for a product and what they actu- ally pay. Ring  covers the impact of the Internet on productivity across the manufacturing and service sectors For exam- ple the Internet ... services The output method is theoretically the best way to meas- ure the Internet’s contribution. It is the approach used to calculate the contributions of most traditional sectors in the economy. ... among the nations of the Organisation for Economic Cooperation and De- velopment OECD  The United Kingdom does well among OECD nations scoring similarly to the Nether- lands Norway...

Ngày tải lên: 06/03/2014, 21:20

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Individual Rights and Liberties Under the U.S. Constitution The Case Law of the U.S. Supreme Court pot

Individual Rights and Liberties Under the U.S. Constitution The Case Law of the U.S. Supreme Court pot

... an inferior court within the Article III hierarchy is not the final word of the department (unless the time for appeal has expired), and it is the obli- gation of the last court in the hierarchy ... provided for prospective relief—a continuing injunction against the continuation or reconstruction of the bridge the ongoing validity of the injunctive relief depended on ‘whether or not the bridge ... an otherwise valid claim for injunctive relief, because the moratorium by its terms was not permanent. Id. at 101. The plain lesson of these cases is that there are circumstances in which the...

Ngày tải lên: 07/03/2014, 02:20

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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt

Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt

... which these proteins target mRNA for rapid degradation remains largely to be determined. It is not yet clear whether AREs are the actual targets for ribonucleases and /or whether trans-acting factors ... which is absent in class III AREs. One to three copies of the pentanucleotide AUUUA are either distributed over the entire 3Â-UTR,e.g.c-fos (class I) or three or more AREs are located in tandem, e.g. ... Additionally, the finding that many tumor cell lines have no or reduced MARCKS expression supports the hypothesis that MARCKS is a tumor and /or growth suppressor gene in some cell types [25–27]. The precise physiological...

Ngày tải lên: 08/03/2014, 08:20

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