reactivation of epithelial mesenchymal transition in invasive and metastatic cancer

... RGZ and CGZ partially inhibited the maximum increase in N-cadherin expression in response to 2.5 ng/ml TGF-b1 (Figure 4B) The inhibitory effects of RGZ and CGZ were maintained in the presence of ... that RGZ and CGZ inhibit several TGF-b1-induced changes in markers of EMT and lung fibrosis, including cadherin proteins and collagen gene expression, to provide further support Page of 13 for ... concentrations of RGZ are of particular interest in the context of excessive collagen production by myofibroblasts in lung fibrosis Overall, the current findings suggest that the inability of PPARg ligands...

Ngày tải lên: 12/08/2014, 11:20

... immunostaining in DCIS of the breast 98 Figure 24 SPARC immunostaining in IDC of the breast 99 Figure 25 Keratin 14 immunostaining in normal breast and skin 107 Figure 26 Keratin 14 immunostaining in ... embryogenesis and in recent years, acquisition of invasiveness in malignant cells54 None of these findings hinted a link between these two sets of phenomena until the findings of Mani et al Indeed, ... culminating in phenotypic changes sufficient for cellular invasion and metastasis Beginning with subtle losses of epithelial markers such as claudins and cytokeratins in DCIS, followed by gain of...

Ngày tải lên: 05/10/2015, 21:24

... TGFβ-1 and the extracellular matrix protein laminin-5 induced EMT and hepatocellular carcinoma cell invasion by upregulating Snail and Slug, down regulating E-cadherin, translocating β-catenin into ... — approximately 25% of intimal lining cells and 7% in the sublining tissues Strong staining was seen at the advancing front of pannus and sites of bone erosions [90] Jones and colleagues [91] ... nucleus and engage LEF-1/TCF DNA binding proteins, transforming them into transcriptional activators of the genes central to EMT, including the down-regulation of E-cadherin genes Binding of TGF-β...

Ngày tải lên: 09/08/2014, 08:22

... βgal and immunofluorescent staining in lung tissues of α-SMA-Cre/R26R mice βgal and immunofluorescent staining in lung tissues of α-SMA-Cre/R26R mice In βgal stained sections (a, b, c, d, g), intrapulmonary ... deposition and βgal staining Effects of BLM on lung α-SMA protein levels, ECM deposition and βgal staining Panel A: βgal and Masson's trichrome-staining in sections of lung tissue shows βgal staining ... Foundation of China (NO 30230180) This funding covered all the cost in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript and in the decision...

Ngày tải lên: 12/08/2014, 16:20

... airway inflammation [5,6] The role of bacteria in the pathogenesis and acceleration of COPD remains the subject of some debate, but increasing evidence in recent years supports the importance of ... down-regulated in the nasal mucosa of smokers and in severe COPD in vivo Figure TLR4 mRNA expression is down-regulated in the nasal mucosa of smokers and in severe COPD in vivo Outpatients attending for ... LPS-induced IL-8 expression in the presence of CSE however, and similarly the "protective" effect of salmeterol on dexamethasone-induced inhibition of TLR4 signalling was lost in the presence of...

Ngày tải lên: 12/08/2014, 15:21

... localisation of desmoplakin, F-actin and βcatenin in P1, P2 and TGF-β1 treated P1 colonies 85 Figure 4.8B Sub-cellular localisation of desmoplakin, F-actin and βcatenin in P1, P2 and TGF-β1 treated ... staining profiles of sorted P1 and P2 subpopulations 47 Figure 3.5 Relative tumorigenicity of FACS-enriched P1 and P2 cells in nude mice allografts 48 Figure 3.6 Hoechst 33342 staining of P1 and ... Members of the RUNX group who helped and stimulated me in one way or another during the course of my PhD study The department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore...

Ngày tải lên: 09/09/2015, 18:57

... confluence and

Ngày tải lên: 16/10/2015, 15:37

... Care Resources (ARCCCR) maintains a database recording information on critical care resources, including the timing of introduction of METs In addition, ANZICS maintains an Adult Patient Database ... undertaken using the information contained within the database Assessment on timing of introduction of MET service We obtained information from a database maintained by the ANZICS ARCCCR and derived ... service introduction and the incidence and rate of ICU admissions due to ward CAs, (c) to assess the association between MET service introduction and the incidence and rate of ICU readmissions, and...

Ngày tải lên: 25/10/2012, 10:35

... concentrations of DEHP was much lower than 0.008 mg/l, the WHO guideline value of DEHP for drinking water quality, and 0.06 mg/l, the guideline value for monitoring items in Japanese drinking water standard, ... are expressed in total alkyl phenols in Figure 45 Sampling Points (Raw water and treated water) SPEED '98, individual styrenes, organic tin compounds, and hormones from human beings and livestocks ... selected treatment plants are conducting periodical monitoring of monitoring items included in Japanese water quality standard Sampling points were shown in Figure Analyzed Chemicals Target chemicals...

Ngày tải lên: 05/09/2013, 08:40

... metaphor in the writing and thinking of the time.⁴ Binding two nations together in an era of reform is less a matter of passing laws than of creating the institutional and affective links that ... cherished: In this, the dearest, most sacred, and most lasting of all human ties, let the names of Inismore and M— be inseparably blended, and the distinctions of English and Irish, of Protestant and ... of Union in Irish and English writing to the evidence of time, to the light of truth, and the corroboration of living testimony, in the study of a country which I am beginning to think would...

Ngày tải lên: 01/11/2013, 07:20

... English and Vietnamese idioms denoting work in term of the contrastive analysis and to classify them in accordance with their semantic and syntactic feature 3) Finding and making a comparison and ... ways of learning and teaching English idioms denoting work FINDINGS AND DISCUSSION 4.1 SYNTACTIC FEATURES OF ENGLISH AND VIETNAMESE IDIOMS DENOTING WORK 4.1.1 Syntactical Glimpse at English and ... newspapers and magazine in both denoting work in English and Vietnamese Typical examples and English and Vietnamese statistic tables of classification of idioms will be presented Using the 3.2.2...

Ngày tải lên: 26/11/2013, 13:16

... classify, and find What are the syntactic and pragmatic features of indirect interrogative directive in English and Vietnamese? How many typical types of indirect interrogative directive in English and ... and differences of indirect similarities and differences of requests, particularly in the field of interrogative directive in English and Vietnamese? pragmatics, use of language, in English and ... produced in a rising intonation, the sentence has the force of a question The tag in a rising intonation in English can be indicated in Vietnamese by the final particles h , 4.2.1.1 Indirect interrogative...

Ngày tải lên: 26/11/2013, 13:21

... acts role of culture in communication and in foreign language teaching in intra-cultural and cross-cultural communication However, the and learning, or to be more precisely, an insight into how ... gender and the thesis is useful and helpful in raising interactants’ awareness of relative status that might influence use of responses to dispraises similarities and differences of RD in English and ... effect of face-threatening activities Acts that appear to be respectful, both of which exist for the maintenance of face impede the addressees’ independence of movement and freedom of Following Goffman’s...

Ngày tải lên: 26/11/2013, 13:21

... Meanings of L NH in Vietnamese Vietnamese dictionary (2008) defines Cold as having lower temperature than usual, and often creating uncomfortable feeling When thinking of cold, we will think of ... storm in (2) has had a lot of transfers in their root meanings - Examine the metaphoric meanings of words denoting weather - Analyze and make a comparison of metaphoric meanings of English and ... METAPHORIC MEANINGS OF ‘COLD’ IN ENGLISH AND ‘L NH’ IN VIETNAMESE 4.2.1 Metaphoric Meanings of COLD in English In terms of temperature scale, Cold is opposite to Hot 4.1.2.12 Influx of money from...

Ngày tải lên: 26/11/2013, 13:23

... learners often have - identifying RCVs in English and in Vietnamese difficulties when dealing with RCVs For instance, a number of - examining the syntactic and semantic features of RCVs in Vietnamese ... indicating a change of religion 4.3.1.1 RCVs denoting the process of changing 4.3.1.8 RCVs indicating a change of occupation 4.3.1.2 RCVs denoting the result of changing 4.3.1.9 RCVs describing ... RCVs in terms of syntax, semantic and put into distinctive groups 13 14 - Calculating the frequency of occurrence to decide the focus CHAPTER of the study - Presenting, describing and analyzing...

Ngày tải lên: 26/11/2013, 13:23

... have been a number of writers making investigations into idioms with different points of view and objectives In English, What are the similarities and dissimilarities in syntactic and there are some ... 4.1.2 Semantic Features of Idioms Expressing Anger in English and Vietnamese 4.1.2.1 Insanity Table 4.3 Structures of Idioms Expressing Anger in English and Vietnamese in Insanity Field ENGLISH ... to insanity, heat, In the two languages, these idioms appear to be correspondent to fire, hot fluid in a container, swearing, withstanding and third party each other in terms of phrases venting...

Ngày tải lên: 26/11/2013, 13:24

... ensurance -Words in role of gerunds: the signing, the moving, the changing, the inspecting In Vietnamese official document, a good number of Vietnamese words of Chinese origin is used: kh i ... definitions and interpretations 2.4.2.3 Inclusiveness Binominal and multinominal phrases like “signed and sealed”, “works and services” “then or thereafter”, “directly or indirectly”, “out of ... begins to come into force The information of the contracting parties is necessary to state clearly their addresses, including number, name of the street or avenue, of district and of country in...

Ngày tải lên: 26/11/2013, 13:26

... features of English and Vietnamese 1.2 AIMS AND OBJECTIVES 1.2.1 Aims of the study The study will focus on: - examining linguistic features of English and Vietnamese idioms denoting family - involving ... this study life or in books and novels, in newspapers or films and so on Idioms comes into being investigated in an attempt to focus on semantic and denoting family contain the kinship That is, ... popular, indispensable and distinctive phenomenon of every language which reflects cultural and historical characteristics of the people speaking that language Understanding and using idioms proficiently...

Ngày tải lên: 26/11/2013, 13:28

... contain cases of meaning as follows: Firstly, Black denotes meaning of color defined as lacking hue and brightness; absorbing light without reflecting any of the rays composing it and it is used in ... adjectives Black and Đen - Giving contrastive analysis of Black and Đen in terms of frequency and semantic features 3.3 RELIABILITY AND VALIDITY Analysing and contrasting semantic and pragmatic of the ... analysis of semantic and pragmatic features of the adjective Black in English and Đen in Vietnamese - Find out similarities and differences of semantic and pragmatic features of the adjective Black in...

Ngày tải lên: 26/11/2013, 13:29

... frequencies of occurrence - Synthesizing, discussing the findings, and drawing conclusions - Suggesting some implications for teaching and learning as the analysis consisting of fifty samples in English ... generally 10 CHAPTER FINDINGS AND DISCUSSION 4.1 LAYOUT FEATURES OF ECAs and VCAs 4.1.1 The beginning section of ECAs and VCAs 4.1.1.1 The title of ECAs and VCAs The title of ECAs is optionally ... section of ECAs and VCAs The standard form of the beginning section of ECAs: COLLECTIVE AGREEMENT between nor numbered It introduces the time and the place of signing the agreement, the name and...

Ngày tải lên: 26/11/2013, 13:30