purinergic signaling in wound healing and airway remodeling
A novel role of hydrogen sulfide in wound healing and a new approach to wound dressing in rat model
Ngày tải lên :
26/09/2015, 09:39
... role of H2S in skin wound healing in rats Dermal wound healing is a complex phenomenon involving inflammation, re-epithelialization, granulation tissue and tissue remodeling Square wounds (15 ... the wound healing process H2S synthesizing activities in liver and skin for both wounded and non-wounded animals were examined [Fig.4.2] - 45 - Chapter H2S synthesizing activity in wounded and ... administration on MPO activity in wound healing We measured the fold increase in MPO activity in control animals after wounding In vehicle pretreated animals, surgery induced wounding caused inflammation,...
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Báo cáo y học: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling" pptx
Ngày tải lên :
12/08/2014, 16:20
... engines [2], decreases pulmonary function, increases AHR, and induces airway inflammation in dogs [3], guinea pigs [4], and humans [5-7] Chronic airway inflammation is associated with airway remodeling ... the increase in airway smooth muscle mass and airway inflammation, as shown in the present study In conclusion, we have demonstrated that the airway physiology and airway structure are altered in ... mice were maintained on an ovalbumin (OVA)-free diet and were individually housed in rackmounted stainless steel cages with free access to food and water Ovalbumin-induced allergic airway disease...
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Tạp chí y khoa Quá trình lành thương Journal vol12no3102012 Organisation in wound healing
Ngày tải lên :
26/12/2013, 13:05
... that the wound filler may determine the effects on wound healing Bacteria and fungus binding mesh (Sorbactđ) may constitute an interesting alternative (Figure and 3) The pathogen binding mesh ... to incise the abdominal skin and peritoneum Scalpel incisions included those in which all major layers of abdominal wall including skin, subcutaneous tissue, and musculoaponeurosis, were incised ... screening and administration of an antiplatelet agent, statin and antihypertensive where indicated Vascular Intervention The importance of a multidisciplinary decision involving clinicians offering...
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THE EPIDERMIS IN WOUND HEALING pdf
Ngày tải lên :
29/03/2014, 08:20
... Epidermis in Wound Healing fibronectin from degradation by neutrophil elastase in chronic wounds α1-Antitrypsin is intact and functional in acute wounds, but it is degraded and inactive in chronic wounds ... after wounding While few BrdU-nuclei are seen shortly after wounding (A), a sharp increase in proliferative activity is seen in both the wound and in the adjacent wound margins 24 h after wounding ... Aberrant integrin expression during epidermal wound healing and in psoriatic expression, J Clin Invest., 89, 1892, 1992 24 Martinez, I.R., Fine structural studies of migrating epidermal cells following...
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báo cáo hóa học:" BMP-2 signaling in ovarian cancer and its association with poor prognosis" pot
Ngày tải lên :
20/06/2014, 07:20
... using diaminobenzidine containing 0.3% H2O2 as a substrate for peroxidase and nuclei were counterstained with diluted hematoxylin Epithelial zones were scored according to the intensity of staining ... [26] Since BMP-2 and BMP-4 bind the same type I and type II BMP receptors, it is not surprising to notice similarities in their induction of signaling pathways A strategy based on the single inhibition ... pancreatic carcinoma cells and prostate cancer cells in absence of androgen [18,19] On the other hand, BMP-2 clearly inhibits the growth of tumor cells of many origins including cancers arising from...
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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx
Ngày tải lên :
21/06/2014, 19:20
... 3A) and a reversible inhibition of both ERK (Figure 3B and C) and mTOR signaling (Figure 3D–H) Hence, resveratrol dose- and time-dependently activates AMPK and inhibits ERK and mTOR signaling in ... phosphorylation of ERK and eIF4E in TG cultures (Figure 5) These findings indicate that resveratrol blocks IL6-induced signaling in sensory neurons Figure Resveratrol blocks IL-6 induced signaling in sensory ... potently and efficaciously inhibits ERK and mTOR signaling in sensory neurons in vitro The mTOR [39-42] and ERK pathways [43] have been linked to pathology in multiple preclinical pain models and...
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Wound Healing and Ulcers of the Skin - part 1 pps
Ngày tải lên :
10/08/2014, 18:20
... the essential and fundamental aspects of wound healing Due to its very nature, wound healing overlaps into the many disciplines of medicine in general Internists, diabetologists, and geriatricians ... phase includes the most prominent events of wound healing It begins about 4–5 days after wounding and lasts for a few weeks thereafter in the case of a normal, ‘healthy’ healing process The main ... factors in the wound area Leptin, a protein produced primarily in the adipose tissue, is involved in processes of wound Natural Course of Wound Repair healing Leptin regulates various metabolic and...
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Wound Healing and Ulcers of the Skin - part 2 pptx
Ngày tải lên :
10/08/2014, 18:20
... described in this tablet are: washing the wound, applying dressings/plasters, and bandaging the wound These constitute the basic principles of wound treatment today In his book The Healing Hand: Man and ... now being made in gene therapy is opening new possibilities in the field of wound healing In certain respects, the significant progress in the field of wound healing is rapidly approaching the ... pathway of normal wound healing References Mehendale F, Martin P: The cellular and molecular events of wound healing In: Falanga V (ed) Cutaneous Wound Healing, 1st edn London: Martin Dunitz 2001;...
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Wound Healing and Ulcers of the Skin - part 3 ppsx
Ngày tải lên :
10/08/2014, 18:20
... deficient in vitamin C In these cases, vitamin C supplementation may improve wound healing Shai A, Halevy S: Direct triggers for ulceration in patients with venous insufficiency Int J Dermatol (in press) ... Heggers JP: Wound healing alterations caused by infection Clin Plast Surg 1990; 17 : 485–492 Rietchel RL, Fowler JF: The role of age, sex and color of skin in contact dermatitis In: Rietchel ... to the following phenomena: Sensory neuropathy may conceal symptoms of intermittent claudication and rest pain An ischemic foot may nevertheless be warm and pink on clinical examination, due...
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Wound Healing and Ulcers of the Skin - part 4 pot
Ngày tải lên :
10/08/2014, 18:20
... ulcer healing process On rare occasions it is possible to diagnosis zinc or vitamin C deficiency on the basis of clinical skin findings (as detailed in Chap 19) In addition to the routine blood ... blood count and blood chemistry, other tests are advisable: tests for iron (and additonal indicators of iron status, e.g., transferrin iron-binding capacity and ferritin), albumin, and zinc levels ... and will be discussed separately The diagnosis of PG is based mainly on clinical findings: clinical appearance of an ulcer surrounded by an undermined violet margin, positive pathergy, and, in...
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Wound Healing and Ulcers of the Skin - part 5 pot
Ngày tải lên :
10/08/2014, 18:20
... (including hepatic and renal function tests) ¼ Serum iron (and additonal indicators for iron status e.g., transferrin iron-binding capacity and ferritin), zinc, albumin Measurements: ¼ Obtain ... smoking on wound healing (as well as the detrimental effects of smoking in general) Ulcer Measurement and Patient Assessment 7.3.5.1 Hypoxia In the initial stages of healing, hypoxia may, in fact, ... changing and cleansing can inflict a certain amount of trauma on the granulation tissue and newly forming epithelium The main argument for changing the dressing more frequently, on the other hand,...
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Wound Healing and Ulcers of the Skin - part 6 docx
Ngày tải lên :
10/08/2014, 18:20
... 1934; 19 : 586–581 81 Robinson W: Stimulation of healing in non -healing wounds by allantoin occurring in maggot secretions and of wide biological distribution J Bone Joint Surg 1935; 17 : 267–271 ... distinguish between nonlimb-threatening infections and infections which are limb threatening In non-limb-threatening infections the erythema surrounding the ulcer is less than cm in diameter and ... al: Infection and wound healing Wounds 2001; 13 : 127–131 100 Davis SC, Mertz PM, Eaglstein WH: The wound environment: implications from research studies for healing and infection In: Krasner D,...
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Wound Healing and Ulcers of the Skin - part 7 ppsx
Ngày tải lên :
10/08/2014, 18:20
... fingerprinting and the disappearance of Y chromosomes in sexmatched grafts [51] Accumulating evidence suggests that the main factor in wound healing using allogeneic keratinocyte grafts lies in ... impression in the medical literature nowadays is that allogeneic keratinocyte grafting, containing an epithelial component of living keratinocytes does, in fact, enhance wound healing in chronic ... complete healing and closure of the lesion On the other hand, in larger ulcers it is unreasonable, in most cases, to expect complete healing following allogeneic keratinocyte grafting In this...
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Wound Healing and Ulcers of the Skin - part 8 pdf
Ngày tải lên :
10/08/2014, 18:20
... also actually initiate and enhance the wound healing process The effect of certain therapeutic modalities in wound healing involving living cell grafting, such as cultured keratinocyte grafts ... Anstead GM: Steroids, retinoids, and wound healing Adv Wound Care 1998; 11 : 277–285 121 Pollack SV: Wound healing: A review Systemic medications affecting wound healing J Dermatol Surg Oncol ... 46 : 155–169 38 Lynch SE, Colvin RB, Antoniades HN: Growth factors in wound healing: Single and synergistic effects on partial thickness porcine skin wounds J Clin Invest 1989; 84 : 640–646 39...
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Wound Healing and Ulcers of the Skin - part 9 pdf
Ngày tải lên :
10/08/2014, 18:20
... an increased demand for certain ingredients, including zinc, within tissues in an ulcer One should distinguish between the effect of the zinc itself on the healing process and the formulation and ... Ruberg RL: Role of nutrition in wound healing Surg Clin North Am 1984; 64 : 705–714 26 Lindstedt E, Sandblom P: Wound healing in man: tensile strength of healing wounds in some patient groups Ann ... shown to be effective in debriding and cleansing unclean and foul-smelling ulcers and in inducing granulation and epithelialization They summarized their findings by reporting a “remarkable improvement”,...
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Wound Healing and Ulcers of the Skin - part 10 pdf
Ngày tải lên :
10/08/2014, 18:20
... process of wound healing Winter et al [14], followed by Hinman and Maibach [15], demonstrated the importance of moist healing on wounds and cutaneous ulcers It is now understood that creating a moist ... the fresh dressing to the wound Enter information into the patient’s record after completing the dressing procedure, removing the gloves, and washing your hands Between one patient and the next, ... guideline for hand washing and hand antisepsis in health-care settings Am J Infect Control 1995; 23 : 251–269 Hugonnet S, Pittet D: Hand hygiene revisited: Lessons from the past and present Curr Infect...
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Báo cáo y học: " Regional differences in the pattern of airway remodeling following chronic allergen exposure in mice" pptx
Ngày tải lên :
12/08/2014, 16:20
... staining B) Medium airway α-SMA staining C) Small airway Picrosirius Red (PSR) staining D) Medium airway PSR staining E) Small airway fibronectin staining F) Medium airway fibronectin stainingData ... [18] A) Large airway fibronectin staining B) Medium airway fibronectin staining C) Small airway fibronectin staining Representative histology images for large, medium, and small airways are located ... differences in airway remodeling between small and medium airways To further investigate the heterogeneity of airway remodeling we compared remodeling events between large (primary bronchus), medium, and...
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Báo cáo y học: "Wound healing and inflammation genes revealed by array analysis of ''''macrophageless'''' PU.1 null mice" ppt
Ngày tải lên :
14/08/2014, 14:21
... back skin results in rapid healing with or without an associated inflammatory response Resin histology of healing incisional wounds in neonatal mouse skin reveals closure of the wound commencing ... Materials and methods Mice and wounding Resin histology and c-fms in situ hybridization Wound tissues were processed for resin histology with sections cut at µm and stained with Toluidine Blue ... extended wound repair time course and to distinguish repair genes from those involved in, or a consequence of, inflammation, we have developed an incisional wound model in neonatal mice where healing...
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Role of nitric oxide in wound healing facilitatory effects of nitrosoglutathione a nitric oxide donor on the extracellular matrix deposition characteristics of wound healing
Ngày tải lên :
17/09/2015, 17:19
... metalloproteinases and in wound healing In: Wound Healing Society Conference, Institute of health, Singapore, Oct 1999 5) Achuth HN, WTL Tan, R Mahendran, SM Moochhala The effect of aminoguanidine (nitric ... Hydrocolloids, alginates and foams maintain the moist wound environment by absorbing exudates, and hydrogels and films donate or maintain moisture Infection-controlling properties of some wound dressings ... in wound healing 51 1.5.2.1 Coagulation and Inflammation 51 1.5.2.2 Cell proliferation and Matrix deposition 52 1.5.2.3 Matrix remodeling 54 1.5.3 Pharmacological studies of NO in wound healing...
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A review of herbal medicines in wound healing
Ngày tải lên :
08/06/2016, 00:00
... result, delays in wound closure and an increase in pain sensation in and beside the wound commonly appear, leading to even more hindered healing. 12 Considering the aforementioned, the anti-inflammatory ... Herbal medicines in wound healing Does scarring occur in the inflammation phase of wound healing? a True b False What are the characteristics of an ideal medicine for prevention of wound infection? ... Pain and wound healing in surgical patients Ann Behav Med 2006; 31: 165–172 18 Price P, Fogh K, Glynn C, et al Why combine a foam dressing with ibuprofen for wound pain and moist wound healing? ...
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