pulp dentin tissue engineering in operative dentistry

... both ‘cartilage’ and tissue engineering or ‘bone’ and tissue engineering were in 1991, accounting for 22% of all tissue engineering and ‘regenerative medicine’ entries Since that year, both ... ‘regenerative medicine’ can be found Since the first two PubMed entries for ‘cartilage’ and ‘bone tissue engineering were published in 1991 (accounting for 22% of all tissue engineering and ‘regenerative ... screening of antirheumatic drugs have been established [12] Joint tissue engineering: clinical applications The first entry for the key word tissue engineering , also termed ‘regenerative medicine’,...

Ngày tải lên: 09/08/2014, 01:22

... micromass culture technology in tissue engineering Head & Face Medicine 2007:4 Springer IN, Fleiner B, Jepsen S, Acil Y: Culture of cells gained from temporomandibular joint cartilage of non-absorbable ... arthroscopic and tomographic findings Int J Oral Maxillofac Surg 1988, 17:128-133 Martin JA, Buckwalter JA: The role of chondrocyte-matrix interactions in maintaining and repairing articular cartilage ... skeletal tissue substitute is bone, cartilage plays the most prominent role in orthopaedics [10] Cartilage engineering therapies were mainly invented and tested in the orthopaedic field but are now introduced...

Ngày tải lên: 12/08/2014, 00:20

... regeneration of dentin is feasible because dentin is in intimate contact with an underlying highly vascular and innervated pulpal tissue, forming a tightlyregulated "dentin -pulp complex" During primary ... canine pulp tissue was effective at promoting significant amounts of reparative dentin formation in vivo, with minimal pulpal inflammation or necrosis [43] Expression of dentin sialoprotein mRNA, ... common clinical scenario in which the dentin -pulp complex is destroyed by bacterialinduced inflammation Therefore, models have been developed in which pulpal inflammation is induced by the injection...

Ngày tải lên: 11/08/2014, 23:22

... 1.2 Tissue- Engineering Scaffolds The main goal of tissue engineering is to produce new tissue where it is needed Therefore, knowledge of the structure and functional limits of the regenerated tissue ... progenitor cells in a derivatized hyaluronan-gelatin composite sponge Tissue Engineering 5, 545–554 45 Doser, M (1999) Criteria for the selection of biomaterials for tissue engineering, in Polymers ... Sambanis, A (1995) Tissue engineering: from biology to biological substitutes Tissue Engineering 1, 3–13 23 Shors, E C and Holmes, R E (1993) Porous hydroxyapatite, in An Introduction to Bioceramics...

Ngày tải lên: 10/04/2014, 11:11

... (Figure 1) They include structural matrix proteins (collagens, laminin, fibronectin, fibrin, etc.) and molecules modulating cell migration (integrins), cell-cell and cell-substrate interactions ... cell; INK4a: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); iPS: inducible pluripotent stem cell; Klf4: Krueppel-like factor 4, a key transcription factor in maintaining pluripotency; ... and structure Types II and VI collagen bind matrix receptors (integrins) Type II collagen can also bind to anchorin CII, whereas fibronectin binds to integrins A large proteoglycan aggregate forms...

Ngày tải lên: 10/08/2014, 05:21

... References Anderer U, Libera J: In vitro engineering of human autogenous cartilage J Bone Miner Res 2002, 17(8):1420-1429 Hutmacher DW: Scaffolds in tissue engineering bone and cartilage Biomaterials ... 21(24):2529-2543 Lindenhayn K, Perka C, Spitzer R, Heilmann H, Pommerening K, Mennicke J, Sittinger M: Retention of hyaluronic acid in alginate beads: aspects for in vitro cartilage engineering J Biomed ... biophysical principles in extracorporal bone tissue engineering Part I Int J Oral Maxillofac Surg 2004, 33(4):325-332 Meyer U, Joos U, Wiesmann HP: Biological and biophysical principles in extracorporal...

Ngày tải lên: 11/08/2014, 23:22

... 1.4 Bone Tissue Engineering 1.4.1 Limitations in Bone Tissue Engineering 1.5 Importance of Vascularisation 1.5.1 Vascularisation in Bone Tissue Engineering 1.5.2 ... Cues .26 2.6 Bone Tissue Engineering 30 2.6.1 Four-Stage Bone Formation in Bone Tissue Engineering 30 2.6.2 Strategies in Bone Tissue Engineering .32 xi 2.6.2.1 Growth ... potentiates osteogenesis through paracrine activity in vitro and induces neovasculogenesis within tissue engineered bone grafts in vivo International Bone -Tissue- Engineering Congress (Bone-Tec), 7-10...

Ngày tải lên: 09/09/2015, 10:16

... PHIs in tissue engineering As reviewed in chapter 1, clinical applications of engineered tissues are currently limited mainly to thin or avascular tissues due to a difficulty in stimulating adequate ... for Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, ... preventing the realization of this goal 1.1.2 Vascularization is a major obstacle in tissue engineering While the field of tissue engineering has come a long way since its original conception in...

Ngày tải lên: 09/09/2015, 11:11

... proline into the wound [78] Providing additional proline or glutamine in the diet to enhance collagen biosynthesis, however, does not result in increased collagen accumulation In contrast, arginine, ... proline and hydroxyproline As a non-essential amino acid, proline is synthesized from arginine/ornithine via the urea cycle and glutamate (directly or indirectly from glutamine via glutaminase) ... 71 Chapter Peri-implantational fibrosis: a bottleneck in tissue engineering 72 4.1 Biomaterials in tissue engineering 73 4.2 Foreign body response 73 4.3 Biocompatibility...

Ngày tải lên: 10/09/2015, 15:52

... Chapter 1: Introduction   Chapter 1: Introduction The design of biomaterials is important in the field of tissue engineering and regenerative medicine Since the development of tissue engineering scaffolds, ... and new tissue formation Hence, the properties of the scaffolding materials are crucial in determining the success of many tissue engineering applications The general tissue engineering paradigm ... vascularised tissues that can integrate with the host native tissues 2.2 Biomaterials for Tissue Engineering Biomaterials is one important component in tissue engineering and regenerative medicine and...

Ngày tải lên: 11/09/2015, 09:10

... that restore, maintain or improve tissue function [3] By combining life sciences, engineering principles and innovation, tissue engineering holds enormous potential in confronting the supply crisis ... proteins were retained in this manner indicating minimal processing damage Investigations into the performance of this novel hybrid mesh as a three-dimensional (3D), bio-functional tissue engineering ... Chapter Two Introduction Scaffold-based tissue engineering Electrospinning and tissue engineering 12 Periosteum and bone healing 16 Chapter Three...

Ngày tải lên: 14/09/2015, 08:24

... potential in promoting angiogenesis in multi-layer membrane tissue engineering Through the understanding of the challenges faced in the use of biodegradable PCL film for membrane tissue engineering, ... failure Tissue engineering has been heralded as the new wave to revolutionize the healthcare-biotechnology industry It is a multidisciplinary field and involves the integration of engineering principles, ... Significance and importance of tissue engineering 12 2.3 Poly(ε-caprolactone) thin films and matrices 16 2.4 Current progress of poly(ε-caprolactone) in biomedical engineering 17 2.5 Introduction to lasers...

Ngày tải lên: 14/09/2015, 08:36

... AND CROSSLINKING OF COLLAGEN SCAFFOLDS AND THE POTENTIAL IN CORNEAL TISSUE ENGINEERING APPLICATION ZHONG SHAOPING (M.ENG INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMIC SCIENCES, BEIJING, PRC) ... a high-risk investment, more than $3.5 billion has been invested in worldwide research and development in tissue engineering [32, 33] Tissue engineering firms have increased spending at a compound ... goals in tissue engineering fields 2.2 Scaffold Materials The first issue with regard to tissue engineering is the choice of suitable materials for scaffolding The materials for tissue engineering...

Ngày tải lên: 14/09/2015, 09:33

... look into the field of bone tissue engineering for an ideal bone substitute 1.1.3 Strategies in BTE Tissue engineering is the restoration, improvement, maintenance and substitution of damaged tissues ... a heparin binding site in N-terminal region of mature BMP-2 polypeptide In pioneering work by Ruppert in 1996, it was shown that BMP-2 activity was increased upon interactions with heparins present ... present in ECM In the presence of N terminus of BMP-2 and heparin, there is a five-fold increased in bioactivity (Ruppert et al., 1996) This lead to various studies on heparin effects on BMP-2 in mind...

Ngày tải lên: 09/10/2015, 11:18

... rather than just the repair of skeletal tissue, and this treatment strategy was later coined as “bone tissue engineering A key component in tissue engineering for bone regeneration is the scaffold ... Tetrahydrofuran TV Tissue Volume xxi CHAPTER 1: INTRODUCTION 1.1 BACKGROUND This section aims to provide background information regarding bone tissue engineering strategy and the application in implant dentistry, ... respectively 1.1.1 Bone tissue engineering Loss of human tissues or organs is a devastating problem that can affect individuals of all ages Bone, a complex living tissue that provides internal support...

Ngày tải lên: 09/10/2015, 11:18

... modes of tissue engineering for tissue construction One is in vitro (ex vivo) tissue engineering and the other in vivo (in situ) tissue engineering In the beginning of tissue engineering research, ... impossible in the in vitro tissue engineering This may be the reason for very limited applications of in vitro tissue engineering mostly to epidermal production Tissue engineering below means the in ... have been used as scaffolds for tissue engineering, greatly contributing to the rapid progress of tissue engineering during the initial phase of tissue engineering research It is extremely difficult...

Ngày tải lên: 25/10/2013, 08:20

... files are in Windows installation directory (usually named \Windows or \Winnt) and are “Winmine.exe” and “Winmine.ini” We know that the exe file is the executable (or main program) and the ini file ... changes are available in three ways: " Windows upgrades (i.e Win 95 to Win 2000) " Windows updates (i.e Win 95 to Win 95b) " Service packs (i.e Win 2000 to Win 2000 sp1) Detailed information about ... pointer of a variable 25 Chapter 3: Windows Anatomy Chapter 3 Windows Anatomy 3.1 Windows API Windows are revolutionary in personal computers They brought multitasking and multiprocessing in...

Ngày tải lên: 05/11/2013, 20:15

... a discontinuity “Emerging” means rising up, coming into sight, and becoming apparent, important, or prominent Something that is emerging can be just coming into existence, or beginning to become ... educated in science and engineering exert disruptive effects decades later? At the time of this writing, petroleum -engineering graduates are becoming a hot commodity, commanding the top-paying engineering ... quality of the individuals it brings together and its effectiveness in integrating their combined judgment The endurance and continuing refinement of Techcast suggests it is becoming more useful...

Ngày tải lên: 12/02/2014, 19:20

... GEOENGINEERING This committee uses the term “geoengineering” to be inclusive of all types of engineering that deal with Earth materials such as geotechnical engineering, geological engineering, ... expanding applications of geotechnology In this report, the term “geoengineering” includes all types of engineering that deal with Earth materials, such as geotechnical engineering, geological engineering, ... other programs in the engineering directorate Finding The committee sees tremendous opportunities for advancing geoengineering through interaction with other disciplines, especially in the areas...

Ngày tải lên: 12/02/2014, 19:20

... straighter in the Dentinogenesis FIG 2-16 Dentinal tubules in cross-section, 1.2 mm from pulp Peritubular dentin (P is more mineralized than intertubular dentin (I) (From Brannstrom M: Dentin and pulp ... lined with a layer of peritubular dentin, which is much more mineralized than the surrounding intertubular dentin (Fig 2-16) The surface area of dentin is much larger at the dentinoenamel or dentinocemental ... Restoration, 837 Final Impression, 843 Working Casts and Dies, 846 Wax Patterns, 853 Spruing, Investing, and Casting, 856 Seating, Adjusting, and Polishing the Casting, 856 Trying -in the Casting, 858...

Ngày tải lên: 16/02/2014, 15:20