ptld in liver and small bowel transplant recipients
Identification of baboon microRNAs expressed in liver and lymphocytes pptx
... region harboring human and rat QTLs including a QTL encoding serum cholesterol trait The chromosome X cluster is localized to 146,059,514-146,180,617 bp and includes QTLs encoding insulin and stress ... atropine (0.025 mg/kg) and intubated Anesthesia was induced and maintained with isoflurane (1-2%) Blood pressure was measured by automated arm cuff (Collin) and oxygen saturation, heart rate, and ... miRNAs in various species and in some cases shown that miRNA influences disease susceptibility For quantification and identification of miRNAs, cloning and sequencing, northern blotting and primer...
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Tuberculosis in Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Individual Patient Data doc
... regimens including pyrazinamide, 31% received drug regimens including a fluoroquinolone, and 17% received drug regimens including streptomycin Induction drug regimens consisted of drugs in 5% of ... fluoroquinolone in 52%, pyrazinamide in 18%, and streptomycin in 14% Most maintenance regimens consisted of 2-drug (46%) or 3-drug (29%) regimens No patients received single-drug MTB therapy during induction ... previous randomized studies of isoniazid LTBI treatment in 184 and 85 renal transplant candidates showed similar reductions in active MTB infection.118,119 In our review, clinically LIVER TRANSPLANTATION.DOI...
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báo cáo khoa học: "Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients" potx
... nuclear staining was interpreted as positive, and the pattern of the nuclear staining was classified as diffuse, punctated, and mixed [13] “Diffuse pattern” was defined as a pattern in which the ... between high-risk HPV and infiltrating cervical carcinoma punctate Page of ISH, in situ hybridization arising from the use of immunosuppressants increased the incidence of cervical intraepithelial ... countries indicate that the age-adjusted risk of cervical carcinoma developing after a renal transplant was 1.65.7 times that in the control group [4,16-18] Early screening seems mandatory and screening...
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Báo cáo khoa học: "Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinoma" pps
... to 3DCRT [8,16,17] In our study, in addition to these findings, we found IMRT capable of reducing small bowel volumes receiving potentially toxicity-inducing intermediate- and low-dose irradiation, ... Furthermore, reduction in the small bowel V45Gy using IMRT may lead to lower rates of late gastrointestinal toxicity [20] Again, in the comparison between IMRT and classic bony landmark-derived 3FBB ... methods were employed for final dose calculations The final IMRT plans were independently reviewed and deemed clinically acceptable by both a gastrointestinal clinical physicist and radiation oncologist...
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Báo cáo khoa học: " The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay" pptx
... and oxaliplatin have radiosensitizing properties on tumor cell lines in vitro [12,13], while the additional effect of oxaliplatin in vivo is more uncertain [13,14] The main dose-limiting acute side ... published results from randomized trials on whether the addition of oxaliplatin further increases gastrointestinal toxicity, but the combination of 5-FU (or capecitabine), oxaliplatin and radiotherapy ... decisive factor in the repair of the bowel after cytotoxic therapy The pioneering work of Withers and Elkind presented in 1970 has given us the opportunity to study this in the mouse intestinal mucosa...
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Báo cáo y học: "Cholesterol-crystal embolism presenting with delayed graft function and impaired long-term function in renal transplant recipients: two case reports" potx
... immunosuppression consisting of a calcineurin inhibitor, prednisone and mycophenolate mofetil in addition to induction therapy with an interleukin-2 receptor antagonist Within 48 hours after transplant surgery, ... effect on renal function during longterm use of fluvastatin in renal transplant recipients in the Assessment of Lescol in Renal Transplantation (ALERT) study Clin Transplant 2006, 20:732-739 ... performed on day 13 post -transplant revealing cholesterol-crystal embolism (CCE) acute asthma attack In addition, he had a history of smoking and needed insulin therapy while in the intensive care unit...
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giudelines on small bowel enteroscopy and capsule endoscopy in adults 2008
... examine the small bowel in most situations These guidelines are intended to provide an evidence based document describing endoscopic investigation of small bowel disorders for capsule endoscopy includes ... gastrointestinal bleeding In most patients who present with gastrointestinal haemorrhage, prompt investigation by way of clinical assessment and endoscopy of the upper or lower gastrointestinal ... diagnosing sites of chronic intestinal bleeding Am J Surg 1989;157:137–44 Lewis BS, Wenger JS, Waye JD Small bowel enteroscopy and intraoperative enteroscopy for obscure gastrointestinal bleeding...
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Báo cáo y học: " Model of end stage liver disease (MELD) score greater than 23 predicts length of stay in the ICU but not mortality in liver transplant recipients" ppt
... failure and subsequent need for RRT is associated with increased mortality in ICU patients in general [29] and in particular in liver transplant recipients, varying from 27% to 67% depending on ... increased incidence in viral and bacterial infections, activation of inflammatory and coagulation pathways, and immunologic reactions [45-47] In patients after liver transplantation, intraoperative ... patients and to outline and predict major clinical risk factors regarding length of stay in the ICU and mortality Therefore, data from all consecutive liver transplants performed in our institution over...
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Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
... calcineurin inhibitor and is used in combination with other immunosuppressant for the prophylaxis of liver and kidney transplant rejection [6] Like another calcineurin inhibitor cyclosporine, ... point in organ transplantation [3] Cyclosporine, a calcineurin inhibitor, is a primary immunosuppressive drug used in renal transplant to prevent acute transplant rejection Cyclosporine acts by inhibiting ... rate and improve the outcome of the transplant Patient’s allograft survival rates become higher by lowering circulating plasma concentrations while maintaining efficacy and minimizing toxicity and...
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Báo cáo y học: "A k2A-positive Klebsiella pneumoniae causes liver and brain abscess in a Saint Kitt’s ma"
... ampicillin and intermediate to ampicillin/sulbactam It was sensitive to the cephalosporins (cefazolin, cefotaxime, and cefepime), the fluoroquinolones (ciprofloxacin, levofloxacin), the aminoglycosides ... bacterial liver abscesses and metastatic infections with a predominance of cases in Taiwan [2] This syndrome has several distinguishing characteristics from traditional liver abscesses including its ... origin, absence of underlying hepatobiliary diseases, and the presence of other invasive complications including endophthalmitis, suppurative meningitis, brain abscess, necrotizing fasciitis, and...
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Báo cáo y học: "Characterization of erythrovirus B19 genomes isolated in liver tissues from patients with fulminant hepatitis and biliary atresia who underwent liver transplantation"
... diseases including liver diseases in different countries is now planning and we shall report on further investigations in the future In conclusion, we found a high prevalence of B19 infection in livers ... patients, transplant recipients, and hydrops fetalis and fetal death by intrauterine infection Aplastic anemia, which occurs in 33% of children and 5% of adult patients who undergo orthotopic liver transplantation ... major viral proteins: VP1 and NP2, the viral capsid proteins, and NS1, a nonstructural protein Both VP1 and VP2 are derived from overlapping reading frames and share substantial amino acid sequences...
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Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx
... neutrophils, and eccrine glands [13] Cathelicidins kill Gram-positive and Gram-negative bacteria and Trypanosoma cruzi Similar to defensins, cathelicidins participate actively in linking innate and adaptive ... numbers in the locus of b-defensin in chromosome As a result of this deficiency in a-defensins and b-defensins, luminal microbes invade the mucosa and trigger in ammation [104] Concluding remarks Initially ... b-defensins induce the release of histamine and prostaglandin D2 in a G-protein– phospholipase C-dependent manner [62] [71]; HPN1–3 bind C1q and activate the classic complement pathway [72], increase...
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Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... significant increase in integrin alpha6 and decrease in integrin alpha v and beta4 expression levels In the presence of fibronectin and/ or HGF, a significant increase in integrin alpha3 and alpha5 expression ... sphingosine-1-phosphate and sphingosylphosphorylcholine can mobilize calcium from internal sources, that sphingosine kinase binds to and is possibly regulated by calmodulin, and that sphingosine is an inhibitor ... signalling events, involving small GTPases, phosphotinositide 3-kinases, protein tyrosine kinases and MAP kinases (MAPKs) In this study, immature and mature DCs (iDCs and mDCs) were generated in vitro...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... modulated by lumican-evoked signaling, including vinculin and focal adhesion kinase [82] Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhesion ... detail In analogy to decorin, lumican inhibits tumor cell growth in soft agar by increasing the expression of the cyclin-dependent kinase inhibitor p21WAF1 [72] Again, similar to decorin, these ... overlapping with the EGF-binding domain [32] The structural constraints of the EGFR binding region support a stochiometry of : for the decorin protein core and EGFR, suggesting that decorin is biologically...
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Báo cáo khoa học: Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver pot
... to cations and anions, uncoupling and swelling, and inhibition of respiration in state [3,4] Furthermore, it has been suggested that Cu2+ ions inhibit SDH [10] Cd2+ and Cu2+ ions induce cell ... Cd2+ and Cu2+ ions on the kinetics of the CoQ-reducing and CoQoxidizing modules Effect of Cd2+ on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B) Effect of Cu2+ on the kinetics ... fumarase and succinate dehydrogenase; and (b) CoQ oxidizing, comprising cytochrome bc1, cytochrome c oxidase (COX) and the rest of the oxidative phosphorylation system, including proton leak and 3658...
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Báo cáo khoa học: Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation pdf
... major enzyme involved in 7-OEt coumarin O-deethylation in human Apparent intermolecular noncompetitive kinetic isotope effects in human liver microsomes and a baculovirus-based recominant system ... H2O:CH3CN (55 : 45, v ⁄ v) containing 10 mm HClO4, a flow rate of 1.0 mLÆmin)1, and monitoring at A330 [19] Kinetic parameters (Km and kcat) were determined using nonlinear regression analysis with ... secondary kinetic isotope effects [19,27–29] The existence of a gem secondary kinetic isotope effect has the effect of attenuating the rate of C-H bond-breaking, so in principle the intrinsic kinetic...
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How Banks Construct and Manage Risk A Sociological Study of Small Firm Lending in Britain and Germany pptx
... forms of lending, such as leasing, factoring and asset financing, their central role in financing SMEs has been maintained (Cruickshank 2000) Risk Handling and Risk Management in British and German ... considerable losses in corporate lending, and more specifically in small firm lending German banks, in contrast, reported no or only minor losses in corporate and small business lending during the last ... remaining risk involved in lending to SMEs in their decision-making processes on such lending, as reflected in their organisational 12 structures, informal routines and rule systems The focus in...
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Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I pdf
... Actin, b, cytoplasmic NSFL1 (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A-I Abhydrolase domain containing 14b D-Amino ... indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase activities In the rat, gluconeogenesis ... in reducing buffer containing 50 mm Tris ⁄ HCl, pH 8.8, 30% glycerol, m urea, 2% SDS and 1% dithiothreitol, followed by a blocking step in similar buffer containing 2.5% iodoacetamide instead...
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Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc
... maintained in DMEM alone However, in cultures maintained in DMEM containing 100 and 1000 lgÆmL)1 heparin, the percentage of 35S-labeled proteoglycans remaining in the matrix after 10 days in ... tendon cultures maintained in the Table Incorporation of [3H]serine into macromolecules of bovine tendon explants maintained in DMEM containing varying concentrations of CaPPS or heparin The proximal ... 3481 Inhibition of proteoglycan catabolism in tendon T Samiric et al small proteoglycans remained in the matrix that had been maintained in DMEM alone, but in cultures maintained in DMEM containing...
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Báo cáo khóa học: Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon pot
... system is involved in the appearance of free [35S]sulfate in the culture medium, tendon cultures were maintained in DMEM containing 10 mM ammonium chloride following days in culture in DMEM alone ... processing of decorin core protein It is possible that newly synthesized decorin contains an intact aminoterminal propeptide which is removed with time in culture by the action of proteinases ... core proteins released into the medium of explant cultures after and days in culture, respectively A number of distinct bands of over 250 kDa and a series of bands ranging between 75 and 160 kDa...
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