proteins including the ferlins are involved in lipid binding and fusion
Báo cáo khoa học: Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans pot
Ngày tải lên :
16/03/2014, 03:20
... either direct or indirect, in lipid metabolism and respiration, it stills remain unclear One hypothesis might be that GST kappa plays a role in the folding of proteins involved in lipid synthesis ... BM883827.1) *Residues involved in glutathione binding site #Residues involved in dimer interface GSTK-1 and GSTK-2 are localized in peroxisomes and mitochondria, respectively The analysis of GST ... was observed in the body wall muscles (Fig 2C) and in the rectal gland cells in larvae and adults (Fig 2D) The presence of a peroxisomal targeting signal in its C-terminus (Fig 1) and the punctate...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
Ngày tải lên :
22/03/2014, 21:20
... conservation of the tryptophan in binding site II and an aromatic residue (mainly tryptophan or tyrosine) in binding site I [22] We have shown that the tryptophan residue involved in binding site II ... interaction between the N- and C-terminal domains of SSIII in vitro Mapping of the CD -binding region in the N-terminal SBDs In order to identify the SBD region required for the SBD–CD interaction, we ... the D2 domain and D(495–535) in the D3 domain, are involved in the interaction with CD, and that this interaction enhances the catalytic activity of the enzyme Our results show that the interaction...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
Ngày tải lên :
09/08/2014, 10:22
... edema and erythema from the ankle to the tarsal bone, and = edema and erythema from the ankle to the entire leg The sum of the values from three legs, excluding the hind leg into which CII–incomplete ... tolerance and immune inhibition in the induction of oral tolerance in the murine CIA model We examined the change in the expression of IDO in CD11c+ DCs of Peyer's patches after repeated oral administration ... with incomplete Freund's adjuvant was injected into a hind leg as a booster injection The mean arthritis index was significantly lower in the tolerance group than in the CIA group throughout the...
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báo cáo khoa học: " Small chloroplast-targeted DnaJ proteins are involved in optimization of photosynthetic reactions in Arabidopsis thaliana" potx
Ngày tải lên :
12/08/2014, 03:21
... the photosynthetic capacity of respective mutants, we next investigated whether the DnaJ proteins are involved in regulation of the stability of the photosynthetic pigment protein complexes in ... the DnaJ mutants At first, the H 2O levels in the leaves of the DnaJ mutants and WT were detected using DAB (diaminobenzidine) as a substrate Notably, the staining intensity and accordingly the ... those induced in WT by HL treatment, including upregulation of several distinct genes encoding transcription factors, heat shock proteins, DnaJ proteins as well as antioxidant and redox proteins, ...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
Ngày tải lên :
16/02/2014, 09:20
... all-alpha domain, STAT protein DNA -binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3 In addition, for stat6 and foxp3, there were ... implicated in other protein–protein interactions, a STAT protein DNA -binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... was found between the two organisms for the regions containing the t-bet and foxp3 genes Around t-bet, the genes TBK1 -binding protein 1, oxysterol -binding protein-like (OSBPL7) and mitochondrial...
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Báo cáo khoa học: Eukaryotic class 1 translation termination factor eRF1 ) the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis pptx
Ngày tải lên :
07/03/2014, 05:20
... of the protein during the docking to the binding site on the ribosome or other ligands Strikingly, the second most flexible part of the protein (if one does not take into account the N-terminal ... competitive inhibition at the ribosome -binding site [32] Together, the M and C domains of human eRF1, in the absence of the N domain, are able to bind to the mammalian ribosome and induce GTPase ... effective binding of the protein to the ribosome The second, and more plausible, is that 4232 the loop is situated at the interface between the M and N domains of eRF1, and this flexibility may be involved...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
Ngày tải lên :
07/03/2014, 12:20
... implicated in retraction of the PilA4-comprising DNA translocator transporting the DNA through the periplasmic space Binding of the DNA to the DNA -binding protein ComEA on the surface of the inner ... fragments of the PilM, PilN, PilO, PilW, PilQ and PilA4 competence proteins and raised antisera against these proteins to visualize the proteins in the T thermophilus wild-type strain This is the first ... fatty acylation and, thereby, be involved in membrane anchoring of the pilin Since PilA4 is similar to the meningococcal pilin and contains several central serine residues, it is tempting to speculate...
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Báo cáo khoa học: Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation doc
Ngày tải lên :
07/03/2014, 15:20
... Fig Dm-eIF4B-L and Dm-eIF4B-S are RNA -binding proteins (A) Filter -binding assay showing the titration curves of Drosophila eIF4B proteins against 32P-labeled 38-nucleotide single-stranded RNA (0.25 ... shown) Nevertheless, the lower values for Dm-eIF4B determined in our assays are consistent with the weak binding observed for human the eIF4B RRM domain [53] The RNA -binding activity of Dm-eIF4B ... using cap-FLuc reporter mRNA in the absence or presence of increasing amounts of the indicated proteins (B) Functionality of the Ubx-IRES in a dicistronic reporter mRNA in vitro The effect of the...
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Báo cáo khóa học: Phospholipase C, protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells ppt
Ngày tải lên :
16/03/2014, 16:20
... not involved [23,24] To determine whether PLC activity or G-protein-mediated signaling was involved in EGCG-induced PLD activation in U87 cells, we examined the effects of pertussis toxin and the ... protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing ... cell types [36], and the inhibitor attenuated EGCG-induced increases in PLD activity, PLC probably regulates PLD through stimulation of this kinase Interestingly, the increase in PLD activity...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
Ngày tải lên :
23/03/2014, 07:20
... are released into the extracellular space and interact with type and type cannabinoid (CB1 and CB2) receptors, non-CB1 ⁄ non-CB2 receptors, and noncannabinoid receptors, including the type vanilloid ... which cleaves the amide bond to form arachidonic acid and ethanolamine [5] Taken together, AEA, its congeners and the proteins that bind, synthesize or transport them form the ‘endocannabinoid system’ ... CB1 binding in the striatum, but not in the cortex ipsilateral to the ischemic insult (data not shown) Instead, CB1 receptor content was not affected by the hormone treatment (Fig 3), and neither...
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Báo cáo khoa học: Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells pptx
Ngày tải lên :
23/03/2014, 17:21
... transcription These sites bind Sp1 and Sp3, and protein levels and binding of Sp1 and Sp3 are increased in PMAtreated cells These findings indicate that Sp1 and Sp3 play a pivotal role in the transcriptional ... anti-Sp3 IgG, indicating they contain proteins other than Sp1 or Sp3 It is not clear whether these unknown factors interact with Sp1 or Sp3, facilitating their binding to GC-I and enhancing their transcriptional ... and Sp3 are able to bind to the GC boxes and that binding of Sp1 forms complex C1 and binding of Sp3 forms complexes C2 and C3 PMA treatment increases Sp1 and Sp3 protein expression in HL-60...
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Báo cáo hóa học: " Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding" pot
Ngày tải lên :
20/06/2014, 01:20
... CD81 binding classifying then as group I mutants and implicating them as being directly involved in E2 binding to CD81 In conclusion, we have determined that the second and third putative CD81 binding ... wt, including all the mutations in the putative CD81 binding region (Y474A, D481A, R483A, Y485A, W487A, H488A, Y489A, and R492A) suggesting that this region is not directly involved in binding ... retained the ability to bind CD81, indicating that these specific residues are also not directly involved in the E2 and CD81 interaction, eight of the substitution mutants in these domains did not bind...
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Báo cáo sinh học: " Research Article An Upper Bound on the Critical Value β∗ Involved in the Blasius Problem" pot
Ngày tải lên :
21/06/2014, 17:20
... t, and hence Az t −Az t ≤t 1−t for t ∈ t, Integrating the last inequality for t to and using Az 2.18 0, we know that Az t ≤ s − s ds ≤ s − s ds t 2.19 √ √ And then z √ Az t ≤ 3/3 This, together ... China, for their guidance and the referees for their valuable comments and suggestions This research is supported in part by the Training Fund of Sichuan Provincial Academic and Technology Leaders ... Journal of Inequalities and Applications Theorem 2.2 The problem 1.1 - 1.2 has at least a solution for β ∈ −18733/105 −0.18733 β, and then β∗ < Proof We first prove that the function z obtained in Lemma...
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Báo cáo y học: " Mitogen-activated protein kinases and NFκB are involved in SP-A-enhanced responses of macrophages to " pdf
Ngày tải lên :
12/08/2014, 14:20
... killing, both in the presence and absence of SP-A, as evidenced by the increase in labelled BCG These results suggest that tyrosine kinases are involved in induction of nitric oxide and subsequent ... targets, mediated in part by the MAP kinase family In addition, binding of the transcription factor NFκB to the iNOS promoter is known to be involved in nitric oxide production In the current study ... evading host defense, including limitation of the ability of the host cell to trigger important signalling pathways In the lung, during the first insult by mycobacteria, SP-A may play a role in the...
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Báo cáo y học: " Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment" pot
Ngày tải lên :
12/08/2014, 18:22
... epithelial cell surface in the alveolus Together these studies showed that the β2integrin/ICAM-1 interaction between AM and lung epithelial cells are important in the chemotaxis of AM in the ... stimulating factors and chemokines are released from lung cells following the inhalation of atmospheric particles and that these mediators are critically important in the production and the release ... M-CSF and MIP-1β, to this list of these mediators involved in the marrow production, mobilization and recruitment of monocytes that are increased in response to PM10 exposure reinforces the hypothesis...
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Characterization of the molecular mechanisms involved in ethionamide activation in mycobacteria
Ngày tải lên :
09/09/2015, 08:14
... localization into: 1, Lipid and fatty acid metabolism; 2, cell envelope proteins which include cell wall proteins, lipoproteins and secretion systems; 3, macrophage-interacting proteins; 4, protein kinases; ... strain than a clinical isolate Regardless, the numerous handling and in vitro passages of these individual strains in various labs could translate into the acquirement of stable mutations in these ... of these drugs against Mtb are further summarized in Table (87) Unique amongst other general antibiotics, several of the anti-TB drugs in use today including INH, ETH, and pyrazinamide (PZA) are...
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Single DNA studies of architectural proteins involved in bacterial pathogenesis and meiosis in saccharomyces cerevisiae
Ngày tải lên :
09/09/2015, 11:25
... dynamics of their DNA -binding Therefore, my objective of finding the characteristics of protein binding to single DNA molecules needs the aid of singlemolecule manipulation During the last twenty ... the expression of diverse virulence genes The Nterminus of SsrB contains the site of phosphorylation and the C-terminus consists of a DNA -binding domain Dimerization occurs upon DNA binding and ... anti-silencing proteins (Figure 1.12) (56) The activities of the anti-silencing proteins play crucial roles in activating pathogenic genes in Salmonella, E.coli and Yersinia, while their anti-silencing...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
Ngày tải lên :
14/09/2015, 14:04
... associated proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and ... 116 kDa intact form into 85 kDa and 25 kDa fragments This process separates the aminoterminal DNA -binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss ... bind their lipid ligands with much lower affinities (>1 to 10 uM), and therefore are now believed to be affected by change in dietary levels of lipids, and are important in maintaining lipid...
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Distribution of secretory phopholipase group XIIA in the CNS and its role in lipid metabolism and cognition
Ngày tải lên :
04/10/2015, 17:04
... hippocampus including CA1-3 fields, dentate gyrus and brainstem (Shirai and Ito, 2004) The significance of PLA2 in maintaining membrane lipid homeostasis of the brain is evident in all these studies ... modified into eicosanoids via the action of cyclooxygenases, thereby releasing inflammatory regulators such as prostaglandins and leukotrienes (Dennis, 1994) On the other hand, phospholipids including ... acetylcholine, dopamine and norepinephrine During signal transduction, the movement of calcium ions into the axon terminals induces the docking of neurotransmitter filled vesicles onto the pre-synaptic...
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