prognostic factors for outcome in metastatic renal cell carcinoma

... CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal- cell carcinoma N Engl J Med 2007, 356:115-124 Hiles JJ, Kolesar JM: Role of sunitinib and sorafenib in the treatment of metastatic ... clear cell renal carcinoma It has also provided the potential for developing novel targeted therapies, including specific vaccines In this pilot study we evaluated the feasibility of vaccination ... (buffer C) and incubated for 30 minutes at Page of RT in the dark Cells were washed two times in PBS/2% BSA and stained with anti-human FoxP3 antibody for 30 minutes at RT in the dark Cells were...

Ngày tải lên: 18/06/2014, 16:20

... Cancer vaccines: moving beyond current paradigms Clin Cancer Res 2007, 13:3776-3782 Pantuck AJ, Belldegrun AS, Figlin RA: Nephrectomy and interleukin-2 for metastatic renal- cell carcinoma N Engl ... Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma J Clin Oncol 2006, 24:1169-1177 Betts MR, Brenchley ... ED: Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma Clin Cancer Res 2007, 13:2075-2081 Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla...

Ngày tải lên: 18/06/2014, 15:20

... substantially improved outcomes for patients with advanced renal cell carcinoma [3,4] Sunitinib malate is an oral multi-kinase inhibitor targeting several receptor tyrosine kinases (PDGFRalpha and ... by the FDA in 2006 for treatment of metastatic renal cell carcinoma In a randomized phase III trial, sunitinib prolonged median progression-free survival (11 months) in comparison to interferon-alpha ... Nonetheless, in our case, CT findings were not sufficient for the diagnosis and the cause of imaging findings was unclear until laparotomy In summary, a case of an intra-abdominal abscess formation...

Ngày tải lên: 09/08/2014, 03:21

... Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese Carcinogenesis 2001, 22:1497-1503 Adelstein DJ, Li Y, Adams ... 10% buffered formalin embedded in paraffin and decalcified in 10% EDTA solution Representative blocks of the formalinfixed, paraffin-embedded tissues were cut to mm and deparaffinized with xylene ... cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clin Cancer Res 2000, 6:2166-2174 36 Nyati MK, Morgan MA, Feng FY, Lawrence TS: Integration of EGFR inhibitors...

Ngày tải lên: 18/06/2014, 19:20

... Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese Carcinogenesis 2001, 22:1497-1503 Adelstein DJ, Li Y, Adams ... 10% buffered formalin embedded in paraffin and decalcified in 10% EDTA solution Representative blocks of the formalinfixed, paraffin-embedded tissues were cut to mm and deparaffinized with xylene ... cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clin Cancer Res 2000, 6:2166-2174 36 Nyati MK, Morgan MA, Feng FY, Lawrence TS: Integration of EGFR inhibitors...

Ngày tải lên: 20/06/2014, 03:20

... Brenda A, Belldegrun AS: Evolving principles of surgical management and prognostic factors for outcome in renal cell carcinoma J Clin Oncol 2006, 24(35):5565-5575 Coppin C, Porzsolt F, Awa A, Kumpf ... of renal cell carcinoma: a pitfall in diagnosis of renal lesions Journal of Clinical Pathology 1998, 51(4):334-337 Lam JS, Shvarts O, Leppert JT, Figlin RA, Belldegrun AS: Renal Cell Carcinoma ... to the need for adjunctive nephrectomy in treating metastatic patients Removal of the malignant kidney may be of palliative benefit in some settings of metastatic renal cell carcinoma [5] There...

Ngày tải lên: 11/08/2014, 10:22

... Squamous Cell Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their outcome Aust N Z J Surg 1992, 62:697-701 Ames FC, Hickey RC: Squamous cell carcinoma of the skin of ... Squamous cell of the skin (excluding lip and oral mucosa) J Am Acad Dermatol 1992, 26:267-284 Chapelis BS, Marcusen C, Lang PG: Prognostic factors for metastasis is squamous cell carcinoma of the skin ... extremities Int Adv Surg Oncol 1980, 3:179-199 Mullen JT, Feng L, Xing Y, Mansfield PF, Gershenwald JE, Lee JE, Ross MI, Cormier JN: Invasive squamous cell carcinoma of the skin: Defining a high-risk...

Ngày tải lên: 09/08/2014, 07:21

... Surgical margin was affected in 23 patients (53.5%) Perineural invasion (PNI) was found in 30 patients (69.8%); There was no information regarding PNI, Lymphatic invasion (LI), Vascular invasion ... ng/ml) [9] In our analysis PSADT < months was strongly correlated with lower biochemical control (p = 0.01) reinforcing the importance of PSA kinetics to the outcome Gleason score, vascular invasion, ... patients In the EORTC 22911 radiotherapy was delivered using planning target volumes The first Planning Target Volume (PTV 1) was defined by the anatomical limits of the surgical bed including those...

Ngày tải lên: 09/08/2014, 10:21

... al ˜ Cholinesterases in renal carcinomas Results Cholinesterase activity in human kidney and renal tumours Butyrylcholinesterase activity predominated over acetylcholinesterase activity in healthy ... acetylcholinesterase and butyrylcholinesterase seem to play noncatalytic roles, which would explain their wide distribution in tissues and cells [16], including stem cells [17] Increasing evidence links ... Cholinesterases in renal carcinomas E Munoz-Delgado et al ˜ Introduction Renal cell carcinomas (RCCs), which account for 2% of adult malignancies, affect about...

Ngày tải lên: 06/03/2014, 22:21

... Bevacizumab for patients with metastatic renal cancer: an update Clin Cancer Res 10, 6367S–6370S Motzer RJ & Bukowski RM (2006) Targeted therapy for metastatic renal cell carcinoma J Clin Oncol ... factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice Clin Cancer Res 8, 3592–3600 13 Inoue K, Kamada M, Slaton ... peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis Clin Cancer Res 9, 1734–1740 19 Lawler J (2002) Thrombospondin-1 as an...

Ngày tải lên: 07/03/2014, 05:20

... differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule [10,11] Since ... screening of head and neck squamous cell carcinoma [49] as well as pancreatic carcinoma lesions and pancreatic carcinoma cells either left untreated or treated with demethylating agents [32,35] In ... ubiquitin-proteasome complex UCHL1 is involved in the control of the intracellular proteolysis, protein turnover and regulatory processes, which are important in maintaining normal cellular homeostasis [7]...

Ngày tải lên: 18/06/2014, 15:20

... Immunohistochemical staining for Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma Brown grains represent a positive signal (3, 3-diaminobenzidine staining) The positive expression ... with hypopharyngeal squamous cell carcinoma, suggesting that Oct4 expression may be a useful indicator for predicting the prognosis of hypopharyngeal squamous cell carcinoma Acknowledgements We ... and Sox2 was mainly localized in the nucleus of tumor cells (A) High Oct4 expression in tumor cells, (B) low Oct4 expression in tumor cells, (C) high Sox2 expression in tumor cells, and (D) low...

Ngày tải lên: 18/06/2014, 16:20

... was performed as follows: first cycle at 95°C for min, and then 30 cycles at 94°C for 45 s, 54°C for min, 72°C for and a final extension cycle of 72°C for The house-keeping gene b-actin was taken ... typically, several major cell types are used in vitro for testing including phagocytic, epithelial, endothelial and various cancer cell lines [20] Therefore, besides the renal cancer cell OS-RC-2, we ... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences...

Ngày tải lên: 18/06/2014, 19:20

... verified independently by reamplifying the corresponding fragment and repeating the sequencing procedure using both forward and reverse primers in the samples fixed in Bouin's solution Regarding the ... smoking, obesity, diuretic use and coffee consumption as risk factors for renal cell carcinoma J Natl Cancer Inst 1986, 77:351-356 Bruning T, Weirich G, Hornauer MA, Hofler H, Brauch H: Renal cell ... frequent event in sporadic clear -cell RCC [4,5] Trichloroethylene (TCE) is a solvent used in numerous industries, as degreaser in the metal manufacturing industry, solvent for oils and resins, or the...

Ngày tải lên: 20/06/2014, 00:20

... was performed as follows: first cycle at 95°C for min, and then 30 cycles at 94°C for 45 s, 54°C for min, 72°C for and a final extension cycle of 72°C for The house-keeping gene b-actin was taken ... typically, several major cell types are used in vitro for testing including phagocytic, epithelial, endothelial and various cancer cell lines [20] Therefore, besides the renal cancer cell OS-RC-2, we ... have a bright prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences...

Ngày tải lên: 20/06/2014, 03:20

... high at baseline, declined some from baseline to and weeks Pain, an important clinical indicator in metastatic disease, rose slightly over time This pattern of fluctuation in the individual items ... Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma J Clin Oncol 2000, 18:2972-2980 Yost KJ, Eton DT: Combining distribution- ... sunitinib (Sutent) Bevacizumab, approved for the treatment of metastatic colorectal cancer in 2004, has also shown clinical activity in metastatic RCC [4] Sorafenib, an oral multi-kinase inhibitor,...

Ngày tải lên: 20/06/2014, 16:20

... Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renal cell carcinoma Renal cell carcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni ... they enter the urinary collecting system It has been shown that fibrin glue and oxidized regenerated cellulose maintain a solid form when initially placed in direct contact with urine and then assume ... http://www.wjso.com/content/8/1/37 bleeding and nephrotoxicity, suggests a possible employ for FloSeal in the treatment of devastating renal injuries [14,15] Furthermore, a porcine model investigating on the use of...

Ngày tải lên: 09/08/2014, 03:21

... of cell kill in vivo via an anti-angiogenic pathway involving endothelial cell apoptosis [24] Coincidentally, apropos of the present clinical series, the preclinical studies initially suggesting ... Mohiuddin M: Radiation therapy in the treatment of metastatic renal cell carcinoma Int J Radiat Oncol Biol Phys 1985, 11:2007-2009 Halperin EC, Harisiadis L: The role of radiation therapy in the ... modality for controlling metastatic melanoma and RCC The LC rates achieved in our series are comparable to those obtained with SBRT for other tumor histologies, suggesting a dominant mechanism of in...

Ngày tải lên: 09/08/2014, 09:20

... TLR9-ligands, also induces invasion in TLR9 expressing cancer cells in vitro, the natural TLR9-ligand that might induce invasion for example in breast cancers, remains unknown [10,11] In the normal ... metastases from renal cell carcinoma: a case with 5-year followup J Urol 1992, 148(4):1247-1248 Finley DS, Pantuck AJ, Belldegrun AS: Tumor biology and prognostic factors in renal cell carcinoma Oncologist ... unspecific staining Expression of TLR9 has been previously detected in various cancer cell lines and in various clinical cancer specimens Synthetic TLR9-ligands induce cancer cell invasion in vitro...

Ngày tải lên: 10/08/2014, 10:21

... adhesion [11] Interestingly, PKCε contains an actin-binding domain [12] and promotes F-actin assembly in a cell- free system, indicating that PKCε modulates cell migration via actin polymers In addition, ... staining intensity and the percentage of positive tumor cells as follows [23,24]: no staining scored 0; faint or moderate staining in ≤ 25% of tumor cells scored 1; moderate or strong staining in ... PKCepsilon in renal cancer cells Int J Oncol 2004, 25:1157-1163 Engers R, Mrzyk S, Springer E, Fabbro D, Weissgerber G, Gernharz CD, Gabbert HE: Protein kinase C in human renal cell carcinomas: role in...

Ngày tải lên: 10/08/2014, 10:21