probiotics and prebiotics in inflammatory bowel disease

... activation and increases IBb levels in vitro in intestinal epithelial cell lines [36] In gain of function mutations in the Nod2 gene, there is an induction of TH1 and IL-17 secreting T helper ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine ... twice for mins in PBS and incubated with biotinylated swine anti-rabbit immunoglobulin G (IgG, DACO), 1/200 dilution, for 45 Slides were washed in PBS, distilled water and counterstained in 20% Harris...

Ngày tải lên: 11/08/2014, 03:20

... activation and increases IBb levels in vitro in intestinal epithelial cell lines [36] In gain of function mutations in the Nod2 gene, there is an induction of TH1 and IL-17 secreting T helper ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine ... twice for mins in PBS and incubated with biotinylated swine anti-rabbit immunoglobulin G (IgG, DACO), 1/200 dilution, for 45 Slides were washed in PBS, distilled water and counterstained in 20% Harris...

Ngày tải lên: 11/08/2014, 06:22

... modulates the intestinal immune response, including the differentiation of T cells and the production and release of proinflammatory cytokines During the course of inflammatory bowel disease and experimental ... use (Hindryckx et al., 2011a) 4.2.2 Probiotics The normal intestinal microflora plays an important role in maintaining intestinal health These microflora protect against pathogens and maintain epithelial ... treatment goals in Crohn’s disease include reduction in bowel damage, prevention of complications and maintaining long term remission Combination therapy with X Preface infliximab and azathioprine demonstrated...

Ngày tải lên: 27/06/2014, 13:20

... therapy in inflammatory bowel disease Factors that may predispose to infectious complications in IBD Viral infections Bacterial infections Parasite and fungal infections IBD (disease type and extension, ... treatment of inflammatory bowel disease (IBD) has been marked by the increasing use of immunosuppressors, mainly azathioprine (AZA)/6-mercaptopurine (6-MP) and methotrexate (MTX), and by the advent ... infections, and cannot be recommended in routine practice Nevertheless, given the promising interest in this marker in other inflammatory diseases, its use should be also explored in IBD patients...

Ngày tải lên: 13/08/2014, 09:45

... s.mitton@sgul.ac.uk Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom Index Introduction Inflammatory Bowel Disease Management of Crohn’s Disease Management ... childhood inflammatory bowel disease in the British Isles Lancet 2001; 357: 1093-1094 [7] Sawczenko A, Sandhu B Presenting features of inflammatory bowel disease in Great Britain and Ireland Arch ... inflammatory bowel disease The British Society of Gastroenterology Initiative J Clin Path 1997; 50:93–105 [24] Scotiniotis I, Rubesin SE, Ginsberg G Imaging modalities in inflammatory bowel disease, ...

Ngày tải lên: 12/02/2014, 11:20

... estimated using the Quantitative Insulin Sensitivity Check Index (QUICKI), using the following formula: 1/(log insulin [µU/ml]) × log glucose (mg/dl) In accordance with our findings in a recent ... methotrexate Insulin resistance was estimated using the Homeostasis Model Assessment for Insulin Resistance (HOMA), using the following formula: insulin (µU/ml) × glucose (mmol/l)/22.5 Insulin sensitivity ... that, in IA patients with insulin resistance and/ or dyslipidemia, the use of DMARD in combination with dietary intervention was associated with a marked improvement in insulin resistance and sensitivity,...

Ngày tải lên: 09/08/2014, 06:22

... of the collectin family [such as the surfactant proteins A (SP-A)] and defensins (indicated by 1) In addition, SLPI and elafin have a role in modulating inflammation by inhibiting the neutrophil ... antiproteinase active site and the amino-terminal domain containing characteristic VKGQ sequences (in singleletter codes for amino acids) These sequences allow the elafin molecule to glue itself into ... encoding Toll-4) consistently expressed high levels of SLPI, in contrast with C3H/HeN, a strain sensitive to LPS reports Role of SLPI and elafin in innate immunity Role of SLPI and elafin in innate...

Ngày tải lên: 12/08/2014, 18:20

... it pertains to in ammatory bowel disease Once described as disabling and under-researched diseases, the in ammatory bowel diseases now attract intense interest from clinical and basic investigators, ... al In ammatory bowel disease and domestic hygiene in infancy Lancet 1994; 343:766–7 Jacobsen BA, Fallingborg J, Rasmussen HH et al Increase in incidence and prevalence of in ammatory bowel disease ... combined with what is learned in basic science research and is leading to a “personalized medicine” approach for managing in ammatory bowel diseases and is bringing the potential of prevention into...

Ngày tải lên: 22/03/2014, 21:20

... epithelial cells, an inhibitor of pro -inflammatory cyto‐ kine expression in the intestinal mucosa and an inductor of production of mucin and antimi‐ 11 12 Inflammatory Bowel Disease crobial peptides, ... Since we currently lack complete understanding of the mechanisms leading to the disease, this topic remains to be exceedingly interesting and enigmatic and most certainly a challeng‐ ing clinical ... Fujiyama Y In creased Expression of IL-17 in Inflammatory Bowel Disease Gut 2003;52(1):65-70 [51] Strober W, Fuss IJ Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases...

Ngày tải lên: 28/03/2014, 20:20

... measurements of fibrinogen-binding or expression of P-selectin Presented results are the mean-% of fibrinogen-binding and Pselectin expression ± SEM Reference values (obtained earlier during routine analysis ... function In this study, platelet adhesion to albumin, collagen and fibrinogen was investigated in the presence of soluble platelet activators including adenosine 5'-diphosphate (ADP), adrenaline, ... adhesion to albumin induced by simultaneous stimulation by LPA and adrenaline (a variable belonging to the LPA-factor in the present study) can be inhibited by inhibition of ADPsignalling in vitro [25]...

Ngày tải lên: 18/06/2014, 15:20

... Boehringer M, Hull M: Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogenactivated protein kinase and nuclear factor-kappaB ... differences in pathological disease state and investigated brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and ... Neuroinflammation 2005, 2:27 http://www.jneuroinflammation.com/content/2/1/27 Findings Aberrant expression of cyclins, cyclin dependent kinases (CDKs) and their inhibitors has been observed in...

Ngày tải lên: 19/06/2014, 22:20

... participated in the design of the study, was involved in collection of blood samples and performed ApoE genotyping; MC participated in the design of the study, was involved in clinical examinations and ... anti-oxidant depletion and clinical outcomes, such as cognitive deficit and patient survival, were not investigated Epidemiological studies considering dietary or vitamin supplement intake and the risk ... assessments using the Cambridge Examination for Mental Disorders in the Elderly (CAMDEX) [11], which includes the Cambridge Cognitive Examination (CAMCOG) and the mini-mental state examination (MMSE)...

Ngày tải lên: 19/06/2014, 22:20

... T cells in RA synovial tissues engrafted into mice with severe combined immunodeficiency In a murine model the intra-articular injection of IL-15 induced a local tissue inflammatory infiltrate ... patients with RA, inflammatory bowel disease, multiple sclerosis, and such HTLV-I-associated disorders including HAM/TSP and adult T cell leukemia Conclusions Our emerging understanding of the IL-15/IL-15R ... observed in patients with a series of inflammatory autoimmune diseases McInnes and colleagues reported abnormalities of IL-15 in RA and have suggested that IL-15 might precede TNF-α in the cytokine...

Ngày tải lên: 09/08/2014, 01:23

... Continuous Continuous Continuous Continuous Continuous Trichotomy Dichotomy Continuous Continuous Dichotomy Continuous Continuous Continuous Continuous Continuous Continuous Dichotomy Continuous ... Fransen and van Riel Table Disease activity instruments in the ACR guidelines Thresholds of disease activity Instrument Range Low Moderate High Disease Activity Score in 28 joints to 9.4 ≤3.2 >3.2 and ... pain rating Enthesitis Patient global rating Physical function Psoriasis extent Patient pain rating Joint damage by X-ray Nail involvement Physical function Patient pain rating Patient itching...

Ngày tải lên: 09/08/2014, 14:22

... metalloproteinases (MMPs) constitute a large family of proteolytic enzymes containing a metal in their organic structure playing key roles in degradation of proteins in extracellular matrix and in tissue ... C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis J Am Coll Cardiol 2006, 47:1369-78 Orbe J, Fernandez ... dissection, aortic aneurysm and myocardial ischemia Atherosclerosis is the main common pathologic finding in these disorders Clinical studies have investigated the role of MMP-1 in this pathologic process...

Ngày tải lên: 10/08/2014, 10:20

... falling in Stockholm and stable in Britain, Denmark, and Finland In the 1970s, the incidence of Crohn’s disease was thought to be rising in Britain and Denmark and falling or stabilized in Stockholm ... of inflammatory bowel disease: A Reappraisal Scand J Immunol 2000;51:10–17 74 Onderdonk A: The intestinal microflora and inflammatory bowel diseases In: Kirsner JB, ed Inflammatory Bowel Disease, ... Findings in Inflammatory Bowel Disease 91 Peter M MacEneaney and Arunas E Gasparaitis Inflammatory Bowel Disease Markers 107 Marla C Dubinsky and Stephan R Targan Medical Therapy of Inflammatory...

Ngày tải lên: 10/08/2014, 15:20

... biological functions into proinflammatory and antiinflammatory cytokines, Th1 and Th2 cytokines and chemokines Proinflammatory cytokines include IL-1, IL-6, IL-8, and TNF and contribute to many ... in initiating or maintaining IBD is also possible For example, common anerobes are capable of inducing inflammatory cytokines, including transforming growth factor beta (TGF β, which leads to intestinal ... antagonist in inflammatory bowel disease A novel mechanism of chronic intestinal inflammation J Immunol 1995;154(5):2434–2440 90 Cominelli F, Nast CC, Duchini A, Lee M Recombinant interleukin-1 receptor...

Ngày tải lên: 10/08/2014, 15:20

... testing in the evaluation of patients with IBD Inflamm Bowel Dis 1999;5(1):64–65 90 Dassopoulos and Hanauer Chapter / Radiological Findings in IBD 91 Radiological Findings in Inflammatory Bowel Disease ... anti -inflammatory drugs on the small and large intestine in humans Gastroenterology 1993;104(6):1832–1847 Miner PB, Jr Factors influencing the relapse of patients with inflammatory bowel disease ... the intestine and injure the From: Clinical Gastroenterology: Inflammatory Bowel Disease: Diagnosis and Therapeutics Edited by: R D Cohen © Humana Press Inc., Totowa, NJ 75 76 Dassopoulos and...

Ngày tải lên: 10/08/2014, 15:20

... patients maintained on azathioprine/6-MP compared to 75% for patients who discontinue medications following induction of remission with these agents In addition to inducing and maintaining remission, ... prognostic index Cytokines Concentrations of proinflammatory cytokines are increased in the intestinal mucosa in patients with active CD The evaluation of serum concentrations on intestinally produced ... Seidman EG, Dubinsky M, Patriquin H, Marx G, Theoret Y Recent developments in the diagnosis and Management of pediatric inflammatory bowel disease In: Inflammatory bowel disease therapy 1999 Kluwer...

Ngày tải lên: 10/08/2014, 15:20

... Emergency colectomy for inflammatory bowel disease Surgery 1982; 91:249–53 Colwell JC Enterostomal care in inflammatory bowel disease In: Kirsner JB, ed Inflammatory Bowel Disease W B Saunders, ... chronic inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are increasingly being recognized as a cause of chronic gastrointestinal disease in children and adolescents ... influencing the adjustment to colostomy J Wound, Ostomy and Contin Nurs 1999;26:298–305 Colwell JC Enterostomal care in inflammatory bowel disease In: Kirsner JB, ed Inflammatory Bowel Disease...

Ngày tải lên: 10/08/2014, 15:20