potential diagnostic markers and therapeutic targets

... idea that N-α-PGP and PGP are novel biomarkers and therapeutic targets for COPD Necessary future directions include measuring N-α-PGP and PGP in a larger cohort of COPD patients and controls, correlating ... were at 270-70 and 270-116 for PGP and 312-140 and 312-112 for N-α-PGP The R2 value for the calibration curves for PGP was 0.988 and the detection limit was 10 pg/ml The intra- and inter-assay ... recently described a potentially new pathway that signals neutrophil infiltration followed by damage to the airways and may represent a novel etiology as well as diagnostic and therapeutic target...

Ngày tải lên: 12/08/2014, 14:20

... identification of tumoral biomarkers and potential therapeutic targets in the most common human neoplasias including glioblastoma, oral squamous cell carcinoma, and breast, lung, prostate, and colorectal cancers ... were obtained (157) Oncogenomics and Cancer Proteomics – 28 Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer 7.4 Statistical and and bioinformatic challenges The experimental ... Oncogenomics and Cancer Proteomics – Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer http://dx.doi.org/10.5772/1745 Edited by César López-Camarillo and Elena Aréchaga-Ocampo...

Ngày tải lên: 30/03/2014, 09:20

... distribution and metabolism of cholesterol and triglycerides APOE-ε is less efficient than E2 and E3 variants for the reuptake and efflux of cholesterol in neurons and astrocytes On the other hand, APOE-ε4 ... Ermio and Antonietta Fava Chapter 20 Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles Suzanne de la Monte, Ming Tong and Jack R Wands ... of the subdisciplines, and therefore will satisfy the needs and interests of both newcomers to the field, and specialized experts interested in understanding concepts and approaches to Alzheimer’s...

Ngày tải lên: 28/06/2014, 05:20

... leukotriene and prostaglandin isoforms (e.g., leukotriene E4, Page of prostaglandin D , and prostaglandin 9a,11bPGF ) Together with a characteristic clinical presentation, abnormal markers can be of diagnostic, ... useful markers fairly specific to mast cells include serum chromogranin A (in the absence of cardiac and renal failure, neuroendocrine cancer, and proton pump inhibitor use) and serum and urinary ... C-findings) and a progressive clini-cal course, cytoreductive drugs are recommended and are prescribed together with anti-mediator-type drugs [46,47] Potential therapeutic options are interferon-a and...

Ngày tải lên: 10/08/2014, 21:23

... neovascularisation include ADAM9 [22] and ADAM15 [23,24] ADAMs as Biomarkers in Cancer Biomarkers are potentially useful in cancer detection (screening and aiding diganosis), asssessing prognosis, ... The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? Clinical Proteomics 2011 8:9 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... expected to weaken cell:cell interaction and thus allow dissociation of potential invasive and metastatic cells in the primary cancer Such dissociation could potentially place a malignant cell or...

Ngày tải lên: 13/08/2014, 13:20

... Zapol and K J Falke 25 Gas Mixing and Distribution in the Lung, edited by L A Engel and M Paiva 26 High-Frequency Ventilation in Intensive Care and During Surgery, edited by G Carlon and W S Howland ... further our understanding of the causes of sleep-related breathing disorders Parts Three and Four also emphasize the potential opportunities for developing improved diagnostic and therapeutic strategies ... made in our understanding of these disorders with respect to epidemiology and risk factors, pathogenesis, clinical and behavioral consequences, and appropriate diagnostic and treatment strategies...

Ngày tải lên: 14/02/2014, 17:20

... settings are standardized, and should include a minimum wall filter setting of 50 Hz and a Doppler sample volume between and mm (Szatmari et al., 2001) 4 Hemodynamics – New Diagnostic and Therapeutic ... flow, and concluded that a comparison between venous flow levels in the obstructed and unobstructed kidneys might result in enhanced diagnostic accuracy 20 Hemodynamics – New Diagnostic and Therapeutic ... complex 16 Hemodynamics – New Diagnostic and Therapeutic Approaches interactions between several regulatory pathways (renin–angiotensin, kallikrein–kinin, and prostaglandin–thromboxane) are in fact...

Ngày tải lên: 19/02/2014, 23:20

... sedatives and analgesics specifically for a diagnostic and/ or a therapeutic procedure require specific credentials for this practice It is the intent of Sedation and Analgesia for Diagnostic and Therapeutic ... of safety and standards of care These guidelines are not all the same, however, and it is instructive and important to understand the differences between them and to recognize their potential ... Neuroscience: Sedation and Analgesia for Diagnostic and Therapeutic Procedures Edited by: S Malviya, N N Naughton, and K K Tremper © Humana Press Inc., Totowa, NJ Lydic, Baghdoyan, and McGinley During...

Ngày tải lên: 07/03/2014, 15:20

... settings are standardized, and should include a minimum wall filter setting of 50 Hz and a Doppler sample volume between and mm (Szatmari et al., 2001) 4 Hemodynamics – New Diagnostic and Therapeutic ... HEMODYNAMICS – NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES Edited by A Seda Artis Hemodynamics – New Diagnostic and Therapeutic Approaches Edited by A Seda Artis Published ... flow, and concluded that a comparison between venous flow levels in the obstructed and unobstructed kidneys might result in enhanced diagnostic accuracy 20 Hemodynamics – New Diagnostic and Therapeutic...

Ngày tải lên: 14/03/2014, 10:20

... cancer, and others 785 After a diagnosis of active pulmonary TB had been made and medication started, all patients were seen one week after medication start by a physician and monthly thereafter, and ... correspond to those of Alvarez et al (6) and Van den Brande (15) but contrast with those of Katz et al (17) and Umeki (8), who found that malignancies and immunosuppressive drug intakes were higher ... limit), Fernandez-Villar et al (30) found an 18.2% incidence of hepatotoxicity in the risk factor group (advanced age, chronic liver disease, abuse of alcohol, and others), and van den Brande et...

Ngày tải lên: 15/03/2014, 03:20

... provide, in overview, a summary of the potential application of miRNAs as diagnostic and therapeutic targets in cancer TranslaƟonal repression Fig miRNA generation and gene regulation [9] Mature miRNAs ... unique targets for diagnostic imaging in vivo for taxonomic classification of tumors [24] The emerging role of miRNAs in neoplasia highlights their potential value as mechanism-based therapeutic targets ... potential value as mechanism-based therapeutic targets and biomarkers for diagnosis, prognosis of disease-specific outcomes and prediction of therapeutic responses [25] While there are numerous detailed...

Ngày tải lên: 16/03/2014, 01:20

... peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases Peripheral neuropathy is a common disorder seen by many specialists and can pose a diagnostic ... muscle wasting in the hands Symptoms in the advanced cases may include muscle waste in the hands and fore arms, neck and shoulder, vocal cords, which leads to scoliosis and malfunction in chewing, ... 2005) 8 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Dynamin is phosphorylated by several kinases including PKC and CDK5, and dephosphorylated by carcinerurin Dynamin-dependent...

Ngày tải lên: 17/03/2014, 02:20

... Science and Therapeutic Potential, second edition, useful as a reference and a valuable tool for the improvement of reproductive medicine from the cell biology perspective ´n Carlos Simo and Antonio ... protein and employed retinoic acid (RA) to induce differentiation of ESCs They detected expression of male germ cell– specific markers in the differentiated EBs and markers of Leydig and Sertoli ... Differentiation and Placental Morphogenesis 126 Maria Giakoumopoulos, Behzad Gerami-Naini, Leah M Siegfried, and Thaddeus G Golos 13 Reproductive Stem Cells of Embryonic Origin: Comparative Properties and Potential...

Ngày tải lên: 22/03/2014, 20:21

... Medicine, Vol 40: Diagnostic and Therapeutic Antibodies Edited by: A J T George and C E Urch © Humana Press Inc., Totowa, NJ 23 24 Ritter possible; for commercial reagents rabbit, goat, and sheep are ... Methods in Molecular Medicine, Vol 40: Diagnostic and Therapeutic Antibodies Edited by: A J T George and C E Urch © Humana Press Inc., Totowa, NJ 35 36 Verma and Boleti Fig Reduction of immunogenicity ... patients when used for immunodiagnostic and immunotherapeutic purposes, and is seen in almost 50% of patients treated with mAb (40) Repeated exposure to the 42 Verma and Boleti murine antibody...

Ngày tải lên: 10/04/2014, 22:38

... DH: Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I CNS Neurol Disord Drug Targets 2009, 8:1-6 Cribbs DH, Agadjanyan MG: Active and passive ... potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease Journal of Translational Medicine 2011 9:127 Submit your next manuscript to BioMed Central and ... significantly higher than that elicited by WSN-WT Anti-Ab and anti-influenza antibodies are therapeutically potent To show the therapeutic potential of dual chimeric vaccine we first analyzed binding...

Ngày tải lên: 18/06/2014, 22:20

... peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases Peripheral neuropathy is a common disorder seen by many specialists and can pose a diagnostic ... muscle wasting in the hands Symptoms in the advanced cases may include muscle waste in the hands and fore arms, neck and shoulder, vocal cords, which leads to scoliosis and malfunction in chewing, ... 2005) 8 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Dynamin is phosphorylated by several kinases including PKC and CDK5, and dephosphorylated by carcinerurin Dynamin-dependent...

Ngày tải lên: 27/06/2014, 10:20

... Musculoskeletal Imaging: Diagnostic and Therapeutic Procedures, with the fixed purpose of assisting residents in radiology, orthopaedics, and neurosurgery in their diagnostic and therapeutic procedures ... imaging Musculoskeletal Procedures: Diagnostic and Therapeutic, edited by Jacqueline C Hodge ©2003 Landes Bioscience 2 Musculoskeletal Procedures: Diagnostic and Therapeutic Equipment • • • • • ... sponsor and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice...

Ngày tải lên: 29/06/2014, 11:20

... may limit the therapeutic potential of adult NSCs in vivo and ex vivo On the other hand, it may interact with the neurogenic niches to promote the regenerative potential in vivo, and the integration ... and confocal microscopy analysis of autopsies for markers of the cell cycle and neuronal differentiation, like proliferating cell nuclear antigen and β-tubulin, show that cell proliferation and ... has the potential for self-repair and that newborn neuronal cells may contribute to the functioning, and physioand pathology of the CNS [36] However, adult NSCs remain elusive cells and to be...

Ngày tải lên: 08/08/2014, 17:20

... activate and induce the proliferation of T cells and activate macrophages Activated macrophages expand and infiltrate the reticuloendothelial tissues (including bone marrow, liver, spleen, and lymph ... us that T cells and NK cells are the trigger for HS, and gaining better control of T- and NK-cell activation is the best way to manage and control the disease Clinical, Biologic, and Pathologic ... Activated lymphocytes secrete high levels of INF-␥ and induce a feedback loop on macrophage and T cells, which continuously activate each other and expand High levels of inflammatory cytokines are...

Ngày tải lên: 08/08/2014, 21:20