potential consequences of chromatin instability

... face a risk of being placed under inadequate control measures The assumption of a common risk of AS in farms is supported by the homogenous distribution of the disease and similarities of prevalence ... Quantitative estimation of genetic risk for atypical scrapie in French sheep and potential consequences of the current breeding programme for resistance to scrapie on the risk of atypical scrapie ... least one AS case out of 200 animals tested for TSEs would be 10% Discussion This study was aimed at estimating the genetic risk for AS in French sheep and potential consequences of the current breeding...

Ngày tải lên: 14/08/2014, 13:21

... replicative potential under the different oxidative conditions To clarify the effect of oxidative stress on the replicative potential of chondrocytes, we analyzed the cellular replicative potential of ... tissue sample The results of the assay were calculated as mmol/l uric acid equivalents, and expressed as a ratio of antioxidative potential of the degenerating region to that of the corresponding ... over-production of nitric oxide (NO) and other reactive oxygen species (ROS) may be involved in the pathogenesis of OA [20-23] However, because of the highly reactive nature of these oxygen reactive...

Ngày tải lên: 09/08/2014, 06:22

... B Age at the time of infection is a strong determinant of chronicity, the earlier the acquisition of infection, the higher probability of developing chronic infection Levels of viremia in chronic ... incidence of hepatic decompensation was 16%, the incidence per 100 person years was 3.3 and the mean interval between the time of diagnosis of cirrhosis and the onset of first episode of decompensation ... primary infections are self-limited with clearance of virus and development of immunity However, an estimated 3% to 5% of adults and up to 95% of children develop chronic HBV infection Persistent...

Ngày tải lên: 02/11/2012, 11:17

... and maintenance of transgenes Several of the studies report the subsequent generation of viable progeny animals, the cells of which contain transgene DNA sequences While a minority of studies have ... the transgene following injection of naked DNA into the vas deferens [60], with a follow-up report claiming detection of the transgene in the cells of 7.5% of offspring animals produced following ... animals, via a variety of routes including pronuclear microinjection and SMGT [74, 75, 76] In the context of human germline gene therapy, such vectors offer the potential advantage of eliminating the...

Ngày tải lên: 03/11/2012, 10:01

... Feast and harvesters of crops, as well as caretakers of the home and caregivers to the children.4 Men, previously hunters, were now often herdsmen, providing more in the way of leisure time to ... around 3000 BCE, at the beginning of the Bronze Age, that human society emerged into the light of recorded history – having accomplished the domestication of most of the vegetables, fruits, and ... those foods But clearing the land for the cultivation of grasses and tubers and the herding of animals brought a whole train of ecological consequences to the planet Plant and animal species were...

Ngày tải lên: 01/11/2013, 11:20

... a result of these decisions The state of Texas has sued CMS to prevent the loss of federal funds and a group of Planned Parenthood clinics has sued the state to prevent implementation of the affiliate ... Evaluation of Florida’s Family Planning Waiver Program: Cost Effectiveness of First Eight Years 1998-2006, University of Florida College of Medicine.; Sills, S (2007) Cost Effectiveness of Medicaid ... source of medical care Paper presented at National Survey of Family Growth Research Conference; Hyattsville, MD 21 Table 2: Comparisons of Texas and US women on rates of diseases and receipt of health...

Ngày tải lên: 13/02/2014, 06:20

... some of the weaknesses and problems that can affect the quality of studies investigating the potential causes of cryptorchidism and hypospadias Quality assessment of the various studies and of ... measure of exposure but may allow calculation of exposure or, more commonly, enable identification of sub-groups of individuals with different levels of ‘relative exposure’ to groups/classes of ECs ... Disorders and the Potential Role of Environmental Chemical Exposures EC exposure and hormone levels In view of the potential importance of fetal androgen levels/exposure in relation to risk of TDS disorders,...

Ngày tải lên: 13/02/2014, 10:20

... sealed had no signs of closure Of the three main ethnic groups, 98% of Mandinkas, 4% of Wollofs and 32% of Fulas had signs of genital cutting The socio-demographic characteristics of cut and uncut ... 643±653 august 2001 L Morison et al Long-term consequences of FGC in The Gambia secondary level education (3% of Mandinkas, 6% of Fulas and 1% of Wollofs) During interviews with a ®eldworker 58% ... Three of these women reported being `sealed' (WHO type III) Of the 1157 women who were examined by a gynaecologist 668 (58%) had signs of genital cutting The frequency of the different types of...

Ngày tải lên: 13/02/2014, 16:20

... health consequences of smoking have been submitted: The Health Consequences General, 1972 of Smoking, A Report of the Surgeon The Health Consequences of Smoking, 1973 The Health Consequences of Smoking, ... M.D - Professor, Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA and Chief of Pulmonary McLean, Ross, M.D - Professor of Medicine Gray School of Medicine, ... M.D., F.R.C.P - Professor, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Ml Hoffmann, Dietrich, Ph.D - Member, and Chief, Division of Environmental Carcinogenesis,...

Ngày tải lên: 14/02/2014, 13:20

... Adopting a Label: Heterogeneity in the Economic Consequences of IFRS Adoptions Working paper, University of Frankfurt, University of Pennsylvania, University of Chicago, and MIT Daske, H., L Hail, C ... 2000 The Economic Consequences of Increased Disclosure Journal of Accounting Research 38 (Supplement): 91-124 27 Muller, K 1999 An Examination of the Voluntary Recognition of Acquired Brand Names ... suggesting adoption of IAS 40 should play a critical role in “leveling the playing field” by requiring provision of previously unknown fair values of these core assets for a subset of firms This leads...

Ngày tải lên: 18/02/2014, 01:20

... loss -of- function mutations in the predominantly neuronal P-type ATPase gene ATP13A2 are the cause of Kufor–Rakeb syndrome [33] The clinical features of Kufor–Rakeb syndrome are similar to those of ... maintenance of the ideal pH in the lysosome This function, albeit potentially implying a much broader effect of mutations, might also mean that ATP13A2 may be related to the recycling pathways of ceramide ... that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism One shortfall of the present theory is the lack of neuropathological...

Ngày tải lên: 18/02/2014, 14:20

... of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 catalysis came from experiments with metalloporphyrin models [5,6,77] Of ... of the crystal structure of NDO as well as spectroscopic data provide a rationale for the catalytic mechanism of this class of enzymes Naphthalene 1,2dioxygenase is a heterohexamer composed of ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse...

Ngày tải lên: 19/02/2014, 16:20

... substitution of the PCI domain of CSN2 by the PCI domain of Rpn6 has consequences for the complex integration of the chimerical CSN2-Rpn6 protein The cDNA encoding the first 343 amino acids of human ... results indicate an association of the CSN and the 26S proteasome, the exact mode of this interaction, the role of PCI domains, and its consequences for the stability of cellular proteins is not ... Permanent expression of Flag-CSN2 causes de novo assembly of the CSN complex in B8 cells connected with degradation of endogenous p53 and stabilization of c-Jun (A) Lysates of B8 cells (controls),...

Ngày tải lên: 20/02/2014, 01:20

... analyses of growing daughter strands A fast increase of the DNA synthesis rate either reflects release of replicon initiations or stimulation of elongation, or both To determine the cause of the ... profile consists of 31 fractions (B) Comparison of the profiles of 15 (m) or 40 (d) reoxygenated cells (same as in Fig 2A) in percentage of total c.p.m ·, Matured 14C-labeled bulk DNA of T24 cells ... staining of total cellular and chromatin- bound PCNA T24 were grown and incubated on coverslips Two sets of hypoxic cells and of cells reoxygenated for 10 and 30 were prepared One set of cells...

Ngày tải lên: 21/02/2014, 00:20

... Stomatal density- Number of stomata per mm2 in the abaxial surface - Thickness of palisade tissue (µm) - Thickness of mesophyll tissue (µm) - Mean number of cells in unit length of the palisade layer ... 26.04 31.3 Transverse section of one year old twig of wild Hevea accession MT 1623 having maximum number of IXP PX IXP X 16 X4 14 Transverse section of one year old twig of wild Hevea accession MT ... section of one year old twig of wild Hevea accession MT 1584 having minimum number of IXP X4 X 16 15 Potential accessions for structural traits along with twig diameter Accession/ No of primary...

Ngày tải lên: 21/02/2014, 04:20

... coercion, of abduction, of fraud, of deception, of the abuse of power, or of a position of vulnerability or of the giving or receiving of payments or benefits to achieve the consent of a person having ... member of the Italian research team, Professor Franca Bimbi (of the University of Padova), who is currently a Member of Parliament In addition to her sociological perspective, Professor Bimbi offered ... health Perceptions of conditions of women’s personal life and effects on health Perceptions of conditions of women’s personal life and effects on health Perceptions of conditions of women’s personal...

Ngày tải lên: 05/03/2014, 13:20

... report are those of the Institute of Medicine Committee on Responding to the Psychological Consequences of Terrorism and are not necessarily those of the funding agencies Library of Congress Cataloging-in-Publication ... president of the National Academy of Sciences The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding ... achievements of engineers Dr Wm A Wulf is president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of...

Ngày tải lên: 06/03/2014, 05:20

... conceptual clarity about the nature of the consequences of these activities As knowledge stands, neither of those requirements is fulfilled Estimates of the extent of illicit drug production, distribution ... If profits due to dilutions are included, an average of three quarters of the total value added is generated in the country of final destination Figure VIII Generation of "value added" of heroin ... abuse, creating something of a vicious circle D Trade and balance of payments The effects of the illicit drug industry on both the balance of trade and the balance of payments of a producer country,...

Ngày tải lên: 08/03/2014, 06:20

... merits of cropping systems, consisting of input management methods and levels of cropping diversity Input treatments consisted of (i) high input (HI)—conventional tillage with recommended rates of ... Livestock contributed an average of 36% of total emissions, while fields contributed about 39% Of the GHGs, N2O and CH4 dominated, accounting for an average of 49% and 42% of total farm emissions GHG ... the case of organic farming are: (1) lack of input of synthetic N-fertilizers (which require a high energy consumption for production and transport and can account for more than 50% of the total...

Ngày tải lên: 08/03/2014, 23:20