possible role of acyl glucuronides in the toxicity of drugs

... in the process of DNA laddering (as is the case with EndoG) rather than in the production of large-sized DNA fragments, considering the timing of uptake of the mitochondria in the autophagosome, ... stained the degenerating parental macronucleus, but not the other nuclei (Fig 3C–E) Moreover, the density of staining was high around the degenerating macronucleus, presumably corresponding to the ... which appear to be involved in the final resorption of the parental macronucleus during PND in T thermophila, and suggested the involvement of mitochondria in this process [19] In mammalian apoptosis,...

Ngày tải lên: 20/02/2014, 03:20

... suggested the importance of a-LA in the treatment of peripheral nerve injuries, but further studies are needed to explain the mechanisms of its neuroprotective effects and before the use of a-LA in ... nerve injury [1] The activities of SOD and CAT were found to be high in sciatic tissue of rats indicating high production of superoxide anion radical Therefore, the increase of SOD and CAT activities ... activities may be a response against oxidative stress The results of Senoglu and colleagues correlated with our recent findings in which the combined employment of a-LA and g-linolenic acid with a rehabilitation...

Ngày tải lên: 10/08/2014, 10:20

... by the specificity of the probes The contradiction lies in the expression of Diva in the adult testis and the E15 17 embryo between these two papers, indicating that the expression of Diva in ... family members, the possible involvement of Diva in the regulation of cell cycle has never been investigated Our present study intended to identify the possible role of Diva during the microglia ... by the early loss of plasma membrane integrity following the plasma membrane leakage and leading to 10 increase in the content of intracellular fluid and subsequent swelling The organelles of the...

Ngày tải lên: 12/09/2015, 08:19

... as a single-chain precursor (preproinsulin) and folded as proinsulin, in which a connecting peptide of 35 residues links the C terminus of the B chain and N terminus of the A chain After digestion ... of protein enzymes in the B-cell granule, proinsulin is converted into insulin and C-peptide of 31 amino acids [26] Previous studies completed on the unfolding process of insulin or proinsulin ... to the increased entropic penalty associated with fixing the end positions of longer linkers Considering the passive role of the linker in proteins like Rop, we may question whether the role of...

Ngày tải lên: 19/02/2014, 12:20

... evaluating the tumor suppressive effects of MSCs on the in vivo progression of HCC, and to investigate the possible role of Wnt signaling in tumor tissues by assessing the gene expression profile of ... mimicking the one of resident cells in the host tissue Insults trigger the release of chemokines from the endothelium inducing adhesion and migration of circulation BMDC into the liver parenchyma The ... development of HCC seems to be the abnormal regulation of the transcription factor b-catenin, a key component of the Wnt signaling pathway [58] In the normal state, the binding of members of a family of...

Ngày tải lên: 10/08/2014, 10:21

... according to the manufacturer's instructions This technique is based on the incorporation of the pyrimidine analogue 5-bromo-2'-deoxyuridine (BrdU) instead of thymidine into the DNA of proliferating ... characterized by the infiltration of inflammatory leukocytes including eosinophils with an enhanced lung expression of proinflammatory cytokines and chemokines, with a possible link to the activation of signal ... lungs Histological findings of the periodic acid Schiff (PAS)-stained Histological findings of the periodic acid Schiff (PAS)stained lungs The groups of mice were intratracheally inoculated with...

Ngày tải lên: 12/08/2014, 14:20

... those of the Metaviridae The position of the median is shown as a gray bar in the box that delimits the boundaries of the lower and upper quartiles Data points more than 1.5 times the inter-quartile ... heterochromatin The major source of differences was the distribution of solo LTRs in the Metaviridae Age of insertions LTR retroelements have a built -in clock that can be used to estimate the age of given ... accurate of the two deposited research Our data on the genomic distribution of retroelements can be considered in the light of theoretical work predicting the distribution of TE populations within...

Ngày tải lên: 14/08/2014, 14:21

... crucial role in stabilizing the proteinprotein interface [31] All of the interactions reported in Fig in the range between and 6.0 A are identical in the major and minor fractions of the holoprotein ... between the two proteins (as indicated by the values of DGwater, Cm and Tg) hence arise from the changes in the surface of the protein because of the interactions of the cofactor with the protein ... slightly; there is a difference of almost C between the Tg values of the proteins, the value being higher for the holo form There have been contrasting reports about the interaction of the 4Â-PP...

Ngày tải lên: 16/03/2014, 10:20

... volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site To test the ... aromatic phenylalanines and the phenyl ring of the substrate play an important role in substrate binding The large effect of the mutations on the acylation rate indicate that these residues are ... results indicate that mutating bF57, which is located ˚ at the bottom of the binding pocket at A from the nucleophilic serine, does in uence the rate of formation of the acyl- enzyme, as judged by the...

Ngày tải lên: 17/03/2014, 23:20

... block of tissue (incorporating AF and NP in continuity) was fixed in 10% neutral buffered formalin and processed to paraffin wax Sections were taken for haematoxylin and eosin staining to score the ... decrease in MTL of 0.85 kbp per decade of life in non-degenerate discs (Figure 1a) Interestingly, the MTL differed according to the degree of degeneration in two discs from the same individual ... cells into the degenerate disc to achieve success Competing interests 10 11 The authors declare that they have no competing interests 12 Authors' contributions CLM participated in the design of the...

Ngày tải lên: 09/08/2014, 10:20

... happened in patients receiving IF Acrolein proved to be the causative factor in the urotoxicity of IF Mesna reacts specifically with acrolein in the urinary tracts and prevents urotoxicity of IF ... of MRP4/ABCC4 in vitro Further studies are needed to explore the effect of MRP4/ABCC4 on the transport of oxazaphosphorines and CFB It would also be interesting to investigate the effect of the ... capable of conferring resistance to several families of natural product drugs like PgP/ABCB1, including Vinca alkaloids (vincristine and vinblastine), anthracyclines (e.g daunorubicin and doxorubicin),...

Ngày tải lên: 14/09/2015, 14:06

... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure of the economy, thus eliminating discontinuities in the transmission of information ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...

Ngày tải lên: 24/10/2012, 09:33

... advantageous in serving transport in the Mekong Delta linking to Cambodia The total length of the inland waterway (IW) system is about 40,998 km, mainly in the Red River Delta and the Mekong Delta In the ... forwarding activities of the S.R of Vietnam, and on this basis to integrate with such professional colleagues on the world The Association has the role of coordinating the activities of the members ... conditions for business associations, as well implemented strategies on developing and increasing the quality of trade services of the Ministry of Trade and the Ministry of Transport Being the intermediary...

Ngày tải lên: 27/10/2012, 16:42

... English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the ... is for the most part the preserve of the few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which...

Ngày tải lên: 05/11/2012, 16:27

... categories of business-to-business advertising are industrial and professional advertising b.1 Industrial advertising Advertising targeted at individuals who buy or influence the purchase of industrial ... development of the industry also fosters the other industries in society, which contributes to the development of the economy as a whole In Vietnam, spending for advertising is rather lower than that in ... advertising industry Since the opening policy and law of foreign investment, advertising industry has seen remarkable changes The growth rate of advertising service is the highest in economy, in which...

Ngày tải lên: 16/04/2013, 11:05

... raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One of the off shoots of the ... enabling of others to help achieve the goals of the organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...

Ngày tải lên: 08/10/2013, 15:56

... relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process of the financial markets has rendered the dominance of the banking sector in the financial ... in turn contributed to the financial stability not only in Asia but also in the whole world Role of the international financial institutions ( IFIs ) The IFIs have played an active role in financial...

Ngày tải lên: 18/10/2013, 07:15

Ngày tải lên: 25/10/2013, 05:20

... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... consumed in place of saturated fatty acids It is possible to increase the content of vitamin E, a natural antioxidant, and to insert the capability of producing plant-based omega-3 fatty acids into ... commercially introduced in the U.S in 1996 and have been rapidly adopted by farmers It has been estimated that 24% of the corn and almost 70% of the soybeans and cotton grown in the U.S in 2001 were...

Ngày tải lên: 25/10/2013, 21:20

... establishment of the Faculty of Arts and the Faculty of Medicine in 1935, the Faculty of Economics and Law in 1936, the Faculty of Theology in 1942 and, finally, the Faculty of Science in 1954 The main ... the Folketing, on the role of the University as the principal shareholder in Cheminova The listing of Cheminova on the Stock Exchange in 1986 and the establishment of the first science park in ... behind the economic upswing and increase in employment in Denmark since the start of the economic boom at the beginning of 1994 The Greater Copenhagen area together with the Municipalities of...

Ngày tải lên: 16/01/2014, 16:33