poly alkyl cyanoacrylate nanoparticles in drug delivery and vaccine development
Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc
Ngày tải lên :
18/02/2014, 16:20
... activity and a polymerizing ⁄ polycondensing activity (silica polymerase) At present, we are working on elucidation of the molecular switch controlling these dual enzymatic functions; initial data indicate ... M & Hanada K (1982) l-transEpoxysuccinyl-leucylamido(4-guanidino)butane and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L Biochem J 201, 189–198 25 Muller ... of silicatein in spicules and in intra- and extracellular vesicles by TEM immunogold labeling (i) Association of silicatein with spicules (A) Strong antibody reactions are seen within the axial...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
Ngày tải lên :
07/03/2014, 05:20
... overexpressing SMO cells further confirmed the increased SMO activity, with decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and ... Correlations between polyamine analogue-induced increases in spermidine ⁄ spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines Cancer Res ... 3-aminopropanal and H2O2 2796 observed in specific tumor cell types following treatment with antitumor, polyamine catabolism-inducing polyamine analogues [2,12,24–26] The finding that spermine...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
Ngày tải lên :
28/03/2014, 10:20
... chlorination) some drugs and physiological substrates Depending on the remaining structure, the formed radical products of drugs can yield quinones, quinone imines, diimines, dimers (and other polymeric ... Drug- Metabolizing Enzymes, Transporters, and Drug Drug Interactions 83 Steven W Louie and Magang Shou Experimental Models of Drug Metabolism and Disposition 151 Gang Luo, Chuang Lu, Xinxin Ding, ... issues in drug design Chapter provides an overview on metabolizing enzymes, transporters, and their involvement with drug drug interactions In vitro experimental approaches to assess and predict drug ...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
Ngày tải lên :
29/03/2014, 08:20
... data reported in the present study, and obtained in living cells, confirm the finding obtained in reconstituted proteoliposomes [11,12] and isolated membranes [29,30] indicating that Pgp and a bacterial ... anthracyclines, are positively charged and therefore bind to acidic groups in proteins and membranes Thus, their movement into the cell can be envisaged as a series of binding and releasing events ... is expected to handle incoming drugs more efficiently compared to drugs already present in the cell interior By contrast, in the case where drug concentrations in the cytoplasm and the cytoplasmic...
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Báo cáo hóa học: " FTIR and Raman Spectroscopy of Carbon Nanoparticles in SiO2, ZnO and NiO Matrices" pdf
Ngày tải lên :
22/06/2014, 01:20
... different results: extremely high scattering intensity and an increasing background intensity as the Raman shift increases Due to the increasing background intensity, the phonon confinement model ... types by maintaining the same deposition parameters In Fig 3a, the dips in the spectra between and lm are due to water absorption (O–H bending vibrations at 1,600 cm-1) [6, 9] The O–H bending vibrations ... However, asymmetry in the G peak was observed in all samples indicating that the nano-carbon is graphitic in structure In Figs 5–7, we have re-drawn the G peak in a separate graph in order to demonstrate...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... Chromatography IC Intra-cerebral ICV Intracerebroventricular IFN-Ȗ Interferon gamma IL-1ȕ interleukin-1 beta IL-2 interleukin-2 IL-4 interleukin-4 IL-6 interleukin-6 IR infrared XIV iNOS inducible Nitric ... obstacle and deliver the antibiotic drugs to brain Drug delivery into the brain Since the BBB represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic ... although nanoparticles and liposomes are relatively complex and large structures This may be applied in the drug delivery targeted the brain Nanoparticles in the brain drug delivery Nanoparticles...
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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization
Ngày tải lên :
13/09/2015, 20:39
... as involved in purifying and standardizing make these natural polymers more expensive (Hanker and Giammara, 1988) In contrast, synthetic polymers are more easily purified and standardized and ... conventional drug delivery systems such as injections, capsules and tablets, which necessitates frequent dose administration to maintain the drug concentration in the body within the therapeutic window In ... of polymers in the formulation of controlled drug delivery systems has over the years become an important area of research and development The present trend points to an increasing interest in...
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Land quality indicators and their use in sustainable agriculture and rural development pdf
Ngày tải lên :
06/07/2014, 08:20
... viewpoint of inland fisheries and aquaculture J Kapetsky and U Barg 127 Indicators for Sustainable Development in Fisheries S Garcia 131 SESSION 3: THEMATIC ISSUES IN DEVELOPING INDICATORS 163 Land ... issues and participatory approaches Land quality indicators and their use in sustainable agriculture and rural development 11 CONCEPTS, DEFINITIONS AND PRINCIPLES "Land", the "functions of land", ... and their use in sustainable agriculture and rural development 19 Land quality indicators and their use in sustainable agriculture and rural development 19 The context of indicators in FAO THE CONCEPT...
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Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc
Ngày tải lên :
11/08/2014, 10:23
... and Vaccines 2004, Origin and developmental processes of dendritic cells DCs originate from hematopoietic stem cells in the bone marrow Recently, there have been great insights into the origins ... phagocytose, process, and present immunogenic peptides to T cells [1,16,17] Antigenic infectious agents including vaccines induce proinflammatory cytokines (e.g., TNF-α) These cytokines promote Langerhans ... the gut and express and release the immunogen in the intestine DCs in the mucosal site will then capture the immunogen via DC-binding peptide motifs They internalize the immunogen, process and present...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
Ngày tải lên :
21/06/2014, 02:20
... carboxylate ligands to bind Cu 2+ ; however, other metal/ligand/polymer combinations could be synthesized including those employing other polymers routinely used in targeted drug delivery, such ... characterization, and metal binding properties of our Cu-binding particles, as well as preliminary in vitro toxicity in cancer cells Page of 10 Results Synthesis and characterization of Cu-loaded polymeric nanoparticles ... the original loading solution determined Cu loading, resulting in values ranging between 12 and 16 wt.% based on these reactions conditions XPS was used to further confirm Cu loading and to probe...
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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx
Ngày tải lên :
11/08/2014, 00:22
... in the in vivo stability of such nanoparticles against opsonic capture by (a) shielding the high negative charge of the polymer and (b) forming a steric barrier against approaching opsonins and ... [23] PEG chains, covalently attached with PLGA nanoparticles using ring-opening polymerization method, results in increased residence in blood (intravenous) or airway (intranasal) and enhanced ... diseases, including COPD and CF Distinct etiologies and inflammatory responses drive mucous hypersecretion in these diseases In CF and COPD, the inflammatory response is neutrophilic and may be induced...
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Báo cáo khoa hoc:" Biodegradable Nanoparticles are Excellent Vehicle for Site Directed in-vivo Delivery of Drugs and Vaccines" pptx
Ngày tải lên :
11/08/2014, 08:20
... amount of the polymer carrier required for vaccine /drug delivery in the body The loading of drugs /vaccine into/onto nanoparticles is achieved by two methods: 1) by incorporating the drug at the ... Biodegradable Nanoparticles are Excellent Vehicle for Site Directed in- vivo Delivery of Drugs and Vaccines Anil Mahapatro1 and Dinesh K Singh2* Bioengineering Program & Department of Industrial and Manufacturing ... effects of using polyisohexylcyanoacrylate-nanospheres in the delivery of doxorubicin in mice The doxorubicin incorporated into poly (isohexylcyanoacrylate) nanopsheres and delivered in mice showed...
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SELF ASSEMBLY AND DRUG DELIVERY IN AMPHIPHILIC PEPTIDES MICROSCOPIC INSIGHTS FROM COARSE GRAINED SIMULATIONS
Ngày tải lên :
09/09/2015, 08:13
... in the group I would like to thank the internal and external examiners for spending precious time in examining my thesis and providing valuable comments I am thankful to A/Prof Yang Kun-Lin and ... and A/Prof Chen Shing Bor for being the panel examiners in my oral qualifying examination and thesis advisory committee Their suggestions and comments were helpful in improving my research I ... process of drug loading and release, and provide bottom-up guidelines towards the intelligent design of new amphiphilic peptides for drug delivery The main contents of the thesis contain four parts...
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In vitro and in vivo evaluation of transferrin conjugated lipid shell and polymer core nanoparticles for targeted delivery of docetaxel
Ngày tải lên :
09/10/2015, 11:18
... include the naturally occurring vinca alkaloids (e.g vincristine and vinblastine) and their semi-synthetic analogues (e.g vinorelbine) and the taxanes (e.g paclitaxel and docetaxol) They act on ... The vinca alkaloids prevent the protein from polymerizing into microtubules by binding specifically to β-tubulin In contrast, the taxanes prevent the microtubules from depolymerisation by binding ... administration of cabecitabine is almost 100% and the Tmax of 5‑FU is reached within 1.5–2 hours (Walko and Lindley, 2005) Figure 13: Ringsdorf‘s model for a polymeric drug containing the drug, ...
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Tài liệu Lipases and Phospholipases in Drug Development pptx
Ngày tải lên :
17/02/2014, 05:20
... 81 Mg2+-independent Neutral Sphingomyelinases 84 Alkaline Sphingomyelinase from the Intestinal Tract 85 Bacterial Sphingomyelinase-phospholipase C 85 Sphingomyelinase Mechanism 85 Binding of Magnesium ... Alonso Introduction and Scope Sphingomyelinases 80 Types of Sphingomyelinases 80 Acid Sphingomyelinase (aSMase) 80 Secretory Sphingomyelinase (sSMase) 81 Neutral, Mg2+-dependent Sphingomyelinases ... Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 Lipid Effects on Sphingomyelinase Activity...
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Tài liệu Negotiations in project sales and delivery process: An application of negotiation analysis pdf
Ngày tải lên :
18/02/2014, 11:20
... project parties in place, even the finest engineering solutions or most innovative contracting methods for organizing project activities will remain abstract and ineffective in achieving the ultimate ... settings enable only claiming, yielding or avoidance Whereas in integrative settings creating, or synonymously - 24 - problem solving is possible, but claiming, yielding and avoidance remain available ... signing of a contract Implementation phase: delivering and supervising the project; identifying and resolving of any The parties jointly select and commit to a problems, which may arise; training...
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Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
Ngày tải lên :
24/02/2014, 18:20
... befriending, and user participation in service planning and delivery Cultural sensitivity and understanding – perception, stigma, language, education and training Care provision – Talking therapies, ... about difficult things during this period User involvement User involvement was discussed both in terms of involvement in the planning and delivery of services and in terms of direct involvement or ... befriending, and user participation in service planning and delivery Cultural sensitivity and understanding – perception, stigma, language, education and training Care provision – Talking therapies,...
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Transdermal and Topical Drug Delivery Principles and Practice doc
Ngày tải lên :
05/03/2014, 22:21
... [hBD1], RNAse 7, and psoriasin) and inducible (e.g., hBD 2-4 and LL-37); (2) innate -in ammatory immunity, involving expression of proinflammatory cytokines and interferons; and (3) adaptive immunity ... bonds and N-(γ-glutamyl) lysine isopeptide bonds formed by transglutaminases Some of the structural proteins involved include involucrin, loricrin, small proline-rich proteins, keratin intermediate ... Skin and VD Center, Hyderabad, India William K Sietsema, INC Research, Cincinnati, OH, USA, and University of Cincinnati, Cincinnati, OH, USA Robert Turner, MedPharm Ltd., MedPharm Research and...
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Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
Ngày tải lên :
29/03/2014, 23:20
... that polymorphisms in CYP2D6 can significantly affect the activity of the enzyme, and therefore serve as an important guideline for determining the dose of antidepressant drugs and preventing drug- induced ... experiments in which total protein bound and imported into mitochondria is present; T, trypsin-treated mitochondria in which only the protein imported into mitochondria is present In the lanes marked In , ... compartment in isolated mitochondria and in COS-7 cells transiently or stably expressing the human protein Mutation of the putative mitochondrial targeting signal eliminates this targeting mechanism in...
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electrochemotherapy, electrogenetherapy and transdermal drug delivery
Ngày tải lên :
11/04/2014, 00:29
... in (29) (c in ), where symbolizes the macromolecules in the cell interior b the yet unoccupied binding sites in the cell and k b is the overall rate coefficient of binding The degree of binding ... solution and the membrane surfaces may be quanin tified by a single distribution constant according to: γ = c out /cout = cm /cin, where m out and cin = n in /V are the bulk concentrations inside and ... transformation and cell coloring suggest that the mechanism for the electroporative transport of both genes and drugs into 22 Neumann, Kakorin, and Toensing the cell interior has essential features in common...
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