poly alkyl cyanoacrylate nanoparticles for delivery of anti cancer drugs

... infections; localized delivery of cytotoxic and anti- angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles; intracellular delivery systems for drugs and genes using ... PLGA/PLA Nanoparticles for Anti- cancer Therapy 243 Sanjeeb K Sahoo and Vinod Labhasetwar Chapter 15 Poly( Alkyl Cyanoacrylate) Nanoparticles for Delivery ... categories, including polymer conjugates, polymeric nanoparticles, and polymeric micelles Polymeric conjugates that have been investigated for use as nanovector systems for delivery of anti- tumor agents...

Ngày tải lên: 04/06/2014, 14:30

... Repair as a Target in Cancer 19 Consequences of Inhibiting the BER Pathway Proteins in Cancer 19 Inhibition of the DNA Repair Function of Ape1 as a Target in Cancer 22 Existing ... Inhibitors of Ape1’s Repair Activity 28 Pharmacophore Mediated Models to Identify Inhibitors of Ape1 29 Identification of Pharmacological Inhibitors of Ape1 29 Need for Specific Inhibitors of ... network of Ape1 23 Figure 6: Consequences of Inhibition of the Repair Function of Ape1 25 Figure 7: Principle of the High-Throughput Screening (HTS) Assay 36 Figure 8: Principle of the...

Ngày tải lên: 24/08/2014, 13:10

... Several polymers have been proposed as nanocarriers for drug delivery systems For example, poly( d,l-lactic acid) and poly( ε-caprolactone) [PCL] have been extensively used as nanocarriers because of ... effects [22] One of the reasons could be ascribed to the composition of the formulation and the poor control of the drug release rate Therefore, the development of compatible polymer-based nanocarriers ... of four biodegradable polymers, including PLA R206, PLA R207, PLA R208, and PCL, was used to obtain a suitable formulation based on the size of the obtained blank NCs An amount of 200 mg of polyesters...

Ngày tải lên: 18/06/2014, 22:20

... that down regulation of PTTG1 in cancer results in suppression of tumor growth and progression Therefore, down-regulation of PTTG1 or inactivation of its tumorgenic function in cancer may become ... overexpression of this gene was reported in many other tumors including esophageal cancer [63], thyroid cancer [55], small cell lung cancer and non-small cell lung cancer [18,64,65], testicular cancer ... fzy-mediated APC/C activity is required for the degradation of securin during the onset of anaphase, while fzr-mediated APC/C activity is essential for the degradation of mitotic cyclins, fzy, and other...

Ngày tải lên: 20/06/2014, 07:20

... profile of void polymeric nanoparticles Toxicity6 Toxicity profile of void polymeric nanoparticles A) A series of eight pancreatic cancer cell lines were exposed to a 20fold range of void polymeric ... Figure transform infra-red (FTIR) spectrum of copolymeric nanoparticles Fourier Fourier transform infra-red (FTIR) spectrum of copolymeric nanoparticles The FTIR spectrum of (NIPAAM-VPPA) copolymer ... of co-polymeric nanoparticles Figure Synthesis strategy for NIPAAM/VP/PEG-A co-polymeric nanoparticles Synthesis strategy for NIPAAM/VP/PEG-A co-polymeric nanoparticles Please refer to text for...

Ngày tải lên: 11/08/2014, 00:22

... a continuous development of drugs that may effectively treat breast cancer patients In point of fact, there is a wide field of research concerning antitumor activity of metal complexes such as ... toxicity of Rh2(H2cit)4 for normal cells while enhancing the efficacy in carcinoma therapy, we proposed its association with magnetic nanoparticles Doses of 50 μM of Rh2(H2cit)4-loaded to maghemite nanoparticles ... injection of 262 μL of maghemite nanoparticles with rhodium (II) citrate into PBS was performed at Page 14 of 17 56°C, under magnetic stirring at a flow rate μL/s to a final concentration of 1.96...

Ngày tải lên: 11/08/2014, 00:23

... various anti- cancer drugs and therapeutic proteins for improved cancer therapy The first part of this thesis focuses on the evaluation of these cationic nanoparticles as carriers for the delivery of ... Biodistribution of P(MDS-co-CES )nanoparticles In vivo anti- tumor efficacy studies of P(MDS-co-CES) nanoparticles Distribution of nanocomplexes within tumors INVESTIGATION OF CATIONIC POLYMERIC NANOPARTICLES ... INVESTIGATION OF CO -DELIVERY OF THERAPEUTIC PROTEN AND ANTI- CANCER DRUG USING CATIONIC POLYMERIC NANOPARTICLES 4.1 Introduction 4.2 Results and Discussion 4.2.1 Characterization of Pac-loaded nanoparticles...

Ngày tải lên: 30/09/2015, 05:59

... Determination of the level of RNA products of the H19 gene The PCR reactions were carried out in 25 μl volumes in the presence of ng/μl of each of the forward and the reverse primers using 0.05 units/μl of ... work shows the use of the regulatory sequences of the H19 gene for the development of DNAbased therapy for human ovarian cancer related ascites The successful development of anti- tumor gene therapy ... with three antibody preparations: 1) primary antibody- the CA-125 monoclonal antibody, 2) linking antibody used to bind the primary antibody, 3) labeling Page of 11 (page number not for citation...

Ngày tải lên: 18/06/2014, 15:20

... of 94°C for 30 sec, 59°C for 45 sec and 72°C for 60 sec, and finally 72°C for The PCR reactions were carried out in 25 μl volumes in the presence of ng/μl of each of the forward and the reverse ... provides a more relevant tool for the investigation of the biology and therapy of bladder cancer than subcutaneous implantation of bladder cancer cells (heterotopic model) Therefore, a mouse model was ... additive activity of the double promoter vector versus combination of two single promoter vectors was never demonstrated Therefore the presence of an additive anti- cancer effect of the double promoter...

Ngày tải lên: 18/06/2014, 16:20

... developed antigen delivery tools based on the cross presentation theory of exogenous antigens for DCs In these studies, various types of antigen delivery carriers such as liposomes [98,99], poly- (g-glutamic ... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti- cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... The most widely studied polymers for gene therapy include poly (L-lysine) (PLL) and polyethylenimine (PEI) The nature of PEI polymers enables the targeting ligands and/or polyethylene glycol (PEG)...

Ngày tải lên: 06/03/2014, 02:21

... we highlight the relevance of CD44v isoforms in cancer which seem to be suitable targets for anti- cancer therapy In several primary and cancer cells, CD44v6 forms a ternary complex with HGF and ... persist for week because of a lack of transfer of siRNA or the dilution of siRNA concentration after each cell division, or a lack of stability of siRNA, which limits their use in the inhibition of ... hallmarks of cancer with altered tumor cell-intrinsic metabolism, proposing the avoidance of immunosurveillance as a result of metabolic reprogramming of tumor cells as another hallmark of cancer...

Ngày tải lên: 28/03/2014, 23:20

... One of the major limitations in using monoclonal antibodies as therapeutic agents for treating cancer has been the immnunogenicity of murine antibodies The development of human anti- mouse antibodies ... recombinant antibodies to date Finally, we will focus on future prospects for antibody-based therapeutic concepts in oncology The Development of Recombinant Antibodies for Cancer Therapy 2.1 Chimeric Antibodies ... (tumor) antigens of choice results in the clonal activation of B lymphocytes producing human antibodies Upon rechallenge of the mice with the antigen of interest, affinity maturated antibodies...

Ngày tải lên: 11/04/2014, 10:25

... nanoparticle-based drug carriers One of the earliest reports of their use for cancer therapy dates back to 197962 when adsorption of anticancer drugs to polyalkylcyanoacrylate nanoparticles was described ... Adsorption of anti- neoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum J Pharm Sci 68, 1521–1524 (1979) 63 Couvreur, P et al Tissue distribution of anti- tumor drugs ... associated with polyalkylcyanoacrylate nanoparticles J Pharm Sci 69, 199–202 (1980) 64 Couvreur, P., Kante, B., Grislain, L., Roland, M & Speiser, P Toxicity of polyalkylcyanoacrylate nanoparticles...

Ngày tải lên: 28/05/2014, 15:07

... targeting of TNF alpha to cancer vasculature PLoS One 2009, 4:e4972 Hofmeister V, Vetter C, Schrama D, Brocker EB, Becker JC: Tumor stroma-associated antigens for anti- cancer immunotherapy Cancer ... Characterization of a specific phage-displayed peptide binding to vasculature of human gastric cancer Cancer Biol Ther 2004, 3: 1232-1235 Feldman AL, Libutti SK: Progress in antiangiogenic gene therapy of cancer ... identification of antiangiogenesis targets opens up a wide new field of study New areas of study, together with further research in gene therapy, will hopefully improve and prolong the lives of patients...

Ngày tải lên: 06/08/2014, 19:21

... Dodwell DJ, Anderson H, Redford J: Response after withdrawal of tamoxifen and progestogens in advanced breast cancer Annals Of Oncology: Official Journal Of The European Society For Medical Oncology/ ... development of resistance to tamoxifen itself due to clonal selection of breast cancer cells that grow in the presence of tamoxifen [4,6] An in vitro study of cells derived from tumors of postmenopausal ... this article as: Agrawal et al.: Clinical relevance of “withdrawal therapy” as a form of hormonal manipulation for breast cancer World Journal of Surgical Oncology 2011 9:101 Submit your next manuscript...

Ngày tải lên: 09/08/2014, 02:21

... five percent of the global resources for cancer control [1] Breast cancer is the most frequent cancer among females Globally the incidence of breast cancer is increasing, and the rate of increase ... increased cost of treatment, it can be safely assumed that the cost of novel anticancer drugs will continue to expand as an insurmountable obstacle to care for an ever greater proportion of cancer patients ... accessibility of first-line systemic anticancer treatments as part of the comprehensive breast cancer control plan for underserved countries An example of novel chronology and mode of drug administration...

Ngày tải lên: 09/08/2014, 04:21