poly alkyl cyanoacrylate nanoparticles for delivery of anti cancer drugs
nanotechnology for cancer therapy, 2007, p.810
... infections; localized delivery of cytotoxic and anti- angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles; intracellular delivery systems for drugs and genes using ... PLGA/PLA Nanoparticles for Anti- cancer Therapy 243 Sanjeeb K Sahoo and Vinod Labhasetwar Chapter 15 Poly( Alkyl Cyanoacrylate) Nanoparticles for Delivery ... categories, including polymer conjugates, polymeric nanoparticles, and polymeric micelles Polymeric conjugates that have been investigated for use as nanovector systems for delivery of anti- tumor agents...
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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY
... Repair as a Target in Cancer 19 Consequences of Inhibiting the BER Pathway Proteins in Cancer 19 Inhibition of the DNA Repair Function of Ape1 as a Target in Cancer 22 Existing ... Inhibitors of Ape1’s Repair Activity 28 Pharmacophore Mediated Models to Identify Inhibitors of Ape1 29 Identification of Pharmacological Inhibitors of Ape1 29 Need for Specific Inhibitors of ... network of Ape1 23 Figure 6: Consequences of Inhibition of the Repair Function of Ape1 25 Figure 7: Principle of the High-Throughput Screening (HTS) Assay 36 Figure 8: Principle of the...
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Báo cáo sinh học: " Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy" pptx
... Several polymers have been proposed as nanocarriers for drug delivery systems For example, poly( d,l-lactic acid) and poly( ε-caprolactone) [PCL] have been extensively used as nanocarriers because of ... effects [22] One of the reasons could be ascribed to the composition of the formulation and the poor control of the drug release rate Therefore, the development of compatible polymer-based nanocarriers ... of four biodegradable polymers, including PLA R206, PLA R207, PLA R208, and PCL, was used to obtain a suitable formulation based on the size of the obtained blank NCs An amount of 200 mg of polyesters...
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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy" doc
... that down regulation of PTTG1 in cancer results in suppression of tumor growth and progression Therefore, down-regulation of PTTG1 or inactivation of its tumorgenic function in cancer may become ... overexpression of this gene was reported in many other tumors including esophageal cancer [63], thyroid cancer [55], small cell lung cancer and non-small cell lung cancer [18,64,65], testicular cancer ... fzy-mediated APC/C activity is required for the degradation of securin during the onset of anaphase, while fzr-mediated APC/C activity is essential for the degradation of mitotic cyclins, fzy, and other...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
... profile of void polymeric nanoparticles Toxicity6 Toxicity profile of void polymeric nanoparticles A) A series of eight pancreatic cancer cell lines were exposed to a 20fold range of void polymeric ... Figure transform infra-red (FTIR) spectrum of copolymeric nanoparticles Fourier Fourier transform infra-red (FTIR) spectrum of copolymeric nanoparticles The FTIR spectrum of (NIPAAM-VPPA) copolymer ... of co-polymeric nanoparticles Figure Synthesis strategy for NIPAAM/VP/PEG-A co-polymeric nanoparticles Synthesis strategy for NIPAAM/VP/PEG-A co-polymeric nanoparticles Please refer to text for...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... a continuous development of drugs that may effectively treat breast cancer patients In point of fact, there is a wide field of research concerning antitumor activity of metal complexes such as ... toxicity of Rh2(H2cit)4 for normal cells while enhancing the efficacy in carcinoma therapy, we proposed its association with magnetic nanoparticles Doses of 50 μM of Rh2(H2cit)4-loaded to maghemite nanoparticles ... injection of 262 μL of maghemite nanoparticles with rhodium (II) citrate into PBS was performed at Page 14 of 17 56°C, under magnetic stirring at a flow rate μL/s to a final concentration of 1.96...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... various anti- cancer drugs and therapeutic proteins for improved cancer therapy The first part of this thesis focuses on the evaluation of these cationic nanoparticles as carriers for the delivery of ... Biodistribution of P(MDS-co-CES )nanoparticles In vivo anti- tumor efficacy studies of P(MDS-co-CES) nanoparticles Distribution of nanocomplexes within tumors INVESTIGATION OF CATIONIC POLYMERIC NANOPARTICLES ... INVESTIGATION OF CO -DELIVERY OF THERAPEUTIC PROTEN AND ANTI- CANCER DRUG USING CATIONIC POLYMERIC NANOPARTICLES 4.1 Introduction 4.2 Results and Discussion 4.2.1 Characterization of Pac-loaded nanoparticles...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... Determination of the level of RNA products of the H19 gene The PCR reactions were carried out in 25 μl volumes in the presence of ng/μl of each of the forward and the reverse primers using 0.05 units/μl of ... work shows the use of the regulatory sequences of the H19 gene for the development of DNAbased therapy for human ovarian cancer related ascites The successful development of anti- tumor gene therapy ... with three antibody preparations: 1) primary antibody- the CA-125 monoclonal antibody, 2) linking antibody used to bind the primary antibody, 3) labeling Page of 11 (page number not for citation...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... of 94°C for 30 sec, 59°C for 45 sec and 72°C for 60 sec, and finally 72°C for The PCR reactions were carried out in 25 μl volumes in the presence of ng/μl of each of the forward and the reverse ... provides a more relevant tool for the investigation of the biology and therapy of bladder cancer than subcutaneous implantation of bladder cancer cells (heterotopic model) Therefore, a mouse model was ... additive activity of the double promoter vector versus combination of two single promoter vectors was never demonstrated Therefore the presence of an additive anti- cancer effect of the double promoter...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... developed antigen delivery tools based on the cross presentation theory of exogenous antigens for DCs In these studies, various types of antigen delivery carriers such as liposomes [98,99], poly- (g-glutamic ... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti- cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... The most widely studied polymers for gene therapy include poly (L-lysine) (PLL) and polyethylenimine (PEI) The nature of PEI polymers enables the targeting ligands and/or polyethylene glycol (PEG)...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... we highlight the relevance of CD44v isoforms in cancer which seem to be suitable targets for anti- cancer therapy In several primary and cancer cells, CD44v6 forms a ternary complex with HGF and ... persist for week because of a lack of transfer of siRNA or the dilution of siRNA concentration after each cell division, or a lack of stability of siRNA, which limits their use in the inhibition of ... hallmarks of cancer with altered tumor cell-intrinsic metabolism, proposing the avoidance of immunosurveillance as a result of metabolic reprogramming of tumor cells as another hallmark of cancer...
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recombinant antibodies for cancer therapy, methods and protocols
... One of the major limitations in using monoclonal antibodies as therapeutic agents for treating cancer has been the immnunogenicity of murine antibodies The development of human anti- mouse antibodies ... recombinant antibodies to date Finally, we will focus on future prospects for antibody-based therapeutic concepts in oncology The Development of Recombinant Antibodies for Cancer Therapy 2.1 Chimeric Antibodies ... (tumor) antigens of choice results in the clonal activation of B lymphocytes producing human antibodies Upon rechallenge of the mice with the antigen of interest, affinity maturated antibodies...
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nanocarriers as an emerging platform for cancer therapy
... nanoparticle-based drug carriers One of the earliest reports of their use for cancer therapy dates back to 197962 when adsorption of anticancer drugs to polyalkylcyanoacrylate nanoparticles was described ... Adsorption of anti- neoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum J Pharm Sci 68, 1521–1524 (1979) 63 Couvreur, P et al Tissue distribution of anti- tumor drugs ... associated with polyalkylcyanoacrylate nanoparticles J Pharm Sci 69, 199–202 (1980) 64 Couvreur, P., Kante, B., Grislain, L., Roland, M & Speiser, P Toxicity of polyalkylcyanoacrylate nanoparticles...
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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx
... targeting of TNF alpha to cancer vasculature PLoS One 2009, 4:e4972 Hofmeister V, Vetter C, Schrama D, Brocker EB, Becker JC: Tumor stroma-associated antigens for anti- cancer immunotherapy Cancer ... Characterization of a specific phage-displayed peptide binding to vasculature of human gastric cancer Cancer Biol Ther 2004, 3: 1232-1235 Feldman AL, Libutti SK: Progress in antiangiogenic gene therapy of cancer ... identification of antiangiogenesis targets opens up a wide new field of study New areas of study, together with further research in gene therapy, will hopefully improve and prolong the lives of patients...
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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
... Dodwell DJ, Anderson H, Redford J: Response after withdrawal of tamoxifen and progestogens in advanced breast cancer Annals Of Oncology: Official Journal Of The European Society For Medical Oncology/ ... development of resistance to tamoxifen itself due to clonal selection of breast cancer cells that grow in the presence of tamoxifen [4,6] An in vitro study of cells derived from tumors of postmenopausal ... this article as: Agrawal et al.: Clinical relevance of “withdrawal therapy” as a form of hormonal manipulation for breast cancer World Journal of Surgical Oncology 2011 9:101 Submit your next manuscript...
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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf
... five percent of the global resources for cancer control [1] Breast cancer is the most frequent cancer among females Globally the incidence of breast cancer is increasing, and the rate of increase ... increased cost of treatment, it can be safely assumed that the cost of novel anticancer drugs will continue to expand as an insurmountable obstacle to care for an ever greater proportion of cancer patients ... accessibility of first-line systemic anticancer treatments as part of the comprehensive breast cancer control plan for underserved countries An example of novel chronology and mode of drug administration...
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Báo cáo khoa học: "Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence" ppsx
... Frequency of lymph nodal metastasis of pancreatic cancer Page of 13 treatment of pancreatic cancer has not been addressed With more effective chemotherapy for systemic treatment of pancreatic cancer, ... 13 Figure Flowchart of studies to final number of eligible studies Table Classification of regional lymph nodes of the pancreas No of Study Studies Year Location of Tumors No of Patients LN Positivity ... subgroups of lymph nodes We also analyzed the metastatic rates of several subgroups of lymph nodes based on tumor locations The metastatic rates of subgroups of lymph nodes for Page of 13 patients...
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
... previously Figure MLC head Dosimetric verification of accuracy of field junctions of a Dosimetric verification of accuracy of field junctions of a MLC head White and black levelled regions represent ... constraints as recommended for safe 3D-treatments some years ago: a dose of ≥ 20 Gy should not exceed 50% of the volume of a single lung and ≥ 25 Gy should not exceed 30% of the volume of both lungs together ... After 45 Gy (elective dose for not macroscopically involved nodes) the upper jaws of the upper volume are closed asymmetrically for a length of cm After 55,8 Gy (dose for macroscopically involved...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25