pi3k akt signaling pathway and prostate cancer

Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"

Ngày tải lên : 31/10/2012, 14:59

... to review and evaluate associations between genes in the NER pathway and lung cancer risk, focusing on genes encoding five key enzymes in this pathway: XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG ... (Thr241Met) polymorphism and lung cancer risk Cancer Epidemiol Biomarkers Prev 2001; 10: 911-2 26 Chen S, Tang D, Xue K, et al DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese ... polymorphism and risk of primary lung cancer Carcinogenesis 2003; 24: 1677-81 57 Cui Y, Morgenstern H, Greenland S, et al Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and...

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Nutrition, Exercise and Prostate Cancer potx

Ngày tải lên : 22/03/2014, 16:21

... of Contents Nutrition, Exercise and Prostate Cancer Introduction Understanding the Links Between Nutrition, Exercise, and Prostate Cancer Effects of Oxidation and Inflammation The Contribution ... understanding of the roles of diet and exercise in the prevention of age-related diseases, as well as in the recurrence and progression of prostate cancer Nutrition, Exercise and Prostate Cancer ... Exercise and Prostate Cancer tissue that is removed surgically, and have found that inflammation leads to the atrophy, or wasting away, of normal prostate tissue adjacent to precancerous and cancerous...

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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc

Ngày tải lên : 11/08/2014, 08:22

... cytokines and inhibit iNOS expression and NO release in LPS-stimulated RAW264.7 macrophages by targeting the NFB activation pathway Materials And Methods Cell Culture and Sample Treatment The RAW264.7 ... phosphorylation and degradation (Fig 2D-F) and inhibited NFkB nuclear translocation (Fig 3C-D) The molecular pathways involved in the regulation of iNOS expression occur largely at a transcriptional level and ... AIDS and Immunology Research, The Dr Tovi Comet-Walerstein Research Program, The Dave and Florence Muskovitz Chair in Cancer Research, The Jaime Lusinchi Research Institute in Applied Sciences and...

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Báo cáo y học: "Can a single model explain both breast cancer and prostate cancer?" pps

Ngày tải lên : 13/08/2014, 16:21

... Protects Prostate Cancer Cells from Apoptosis in Vitro and Confers Resistance to Androgen Depletion in Vivo Cancer Res 1995, 55:4438-4445 López-Otín C, Diamandis EP: Breast and Prostate Cancer: ... androgen ablation by "offcycle" maintenance with finasteride in LNCaP prostate cancer xenograft model Prostate 2006, 66:495-502 Murthy S, Agoulnik IU, Weigel NL: Androgen Receptor Signaling and ... upregulating telomerase activity in prostate epithelial cells and PC However, Table 2: Extended E-D model of breast cancer and prostate cancer Hormone receptor Property Membrane androgen receptor ↑apoptotic...

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NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity

Ngày tải lên : 12/10/2015, 17:35

... ATM- and ATR-mediated signaling pathways are highly interconnected ATM and ATR communicate with each other to coordinate and modulate the cellular outputs in respond to DNA strand breaks and stalled ... pathway and the intrinsic pathway Although rarely reported, ATM and ATR are also involved in mediating apoptosis signaling pathways by phosphorylating their downstream targets (Kaina and Roos ... ataxiatelangiectasia mutated (ATM)- and ataxia-telangiectasia and Rad3-related (ATR)dependent DNA damage signaling pathways NBS1 deficiency led to a decrease in the phosphorylation level of ATM and ATR as well as...

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NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity

Ngày tải lên : 26/11/2015, 22:49

... ATM- and ATR-mediated signaling pathways are highly interconnected ATM and ATR communicate with each other to coordinate and modulate the cellular outputs in respond to DNA strand breaks and stalled ... pathway and the intrinsic pathway Although rarely reported, ATM and ATR are also involved in mediating apoptosis signaling pathways by phosphorylating their downstream targets (Kaina and Roos ... ataxiatelangiectasia mutated (ATM)- and ataxia-telangiectasia and Rad3-related (ATR)dependent DNA damage signaling pathways NBS1 deficiency led to a decrease in the phosphorylation level of ATM and ATR as well as...

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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx

Ngày tải lên : 10/08/2014, 10:21

... The PI3K/ Akt is one of the most important signaling pathways in regulating cell growth, proliferation and apoptosis, and Akt is a major downstream target of PI3K [18] The PI3K/ Akt signaling pathway ... Bcl-2related proteins in breast cancer cells Breast Cancer Res 2005, 7:R940-52 33 Luo J, Manning BD, Cantley LC: Targeting the PI3K- Akt pathway in human cancer: rationale and promise Cancer Cell 2003, 4:257-62 ... arrest and apoptosis in lung cancer A549 cells by modulating PI3K/ Akt pathway Journal of Experimental & Clinical Cancer Research 2011 30:33 Submit your next manuscript to BioMed Central and take...

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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

Ngày tải lên : 09/08/2014, 09:20

... p -Akt may be required for the anti-neoplastic action of small molecule inhibitors of the PI3K/ Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer ... p -Akt levels Because ErPC3 and LY294002 act at two distinct levels of the PI3K/ Aktpathway to reduce Akt- activity, the distinct potency of ErPC3 and LY294002 to inhibit Akt- activity in PC3 and ... survival pathways including the PI3K/ Akt pathway This pathway is frequently deregulated in prostate cancer patients It has been shown earlier that the antineoplastic action of ErPC3 and related...

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Báo cáo y học: "Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway" ppsx

Ngày tải lên : 10/08/2014, 10:20

... correlated with the metastatic potential and malignant degree of lung and stomach cancer [9,10] It was also reported that Rab5a was involved in EGF signaling pathway and migration in hepatocellular carcinomas ... control cell adhesion events, and then affect cell motility [17-19] However, the link between Rab5a and integrinmediated signaling pathway and the exact roles of Rab5a in cancer progression remain ... signaling pathway, and induce the cancer cell migration and invasion Page of Figure Rab5a regulates the activity of Rho GTPases and reorganization of actin cytoskeleton in HeLa cells (A) The Control and...

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Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"

Ngày tải lên : 26/10/2012, 09:48

... Murray T, Xu J, and Thun MJ Cancer statistics 2007 CA Cancer J Clin 2007; 57: 43-66 Li Y, and Cozzi PJ Targeting uPA/uPAR in prostate cancer Cancer Treat Rev 2007;33(6):521-7 Catalona WJ and Smith ... step in the prostate tumorigenesis [59] C-myc is localized at chromosome [60] and its overrepresentation is associated with prostate cancer progression [61] Due to the fact that prostate cancer is ... permanent seed implants for localized prostate cancer BJU Int 2007; 99: 497-501 Sharifi N, Gulley JL, and Dahut WL Androgen deprivation therapy for prostate cancer JAMA 2005; 294: 238-244 Bloomfield...

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Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

Ngày tải lên : 18/02/2014, 06:20

... consisting of a-defensins-1 and -2, induced activation of the p38 MAP kinase and PI3K ⁄ Akt pathways in human monocytes (U937) The mixture of HNP activated only the PI3K ⁄ Akt pathway in human lung ... kinase and PI3K ⁄ Akt and increase phosphorylation of GSK3b on Thr390 and Ser9 SB203580 and LY294002 prevented a-defensin-induced increases in the protein contents of Thr390-phosphorylated and Ser9-phosphorylated ... MAP kinase and PI3K ⁄ Akt The Wnt ⁄ b-catenin signaling pathway is required for proper lung mesenchymal growth and vascular development [12,28] Up-regulation of the Wnt ⁄ b-catenin pathway was...

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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt

Ngày tải lên : 21/02/2014, 01:21

... from ERK1 and bands were added up to generate one single ERK1/2 value) serum-cultured ECV304 cells exposed to PD98059 (Fig 5B) Interestingly, both the inhibition of MEK/ERK pathway and the exposure ... immunoreactivity of ERK1/2 and phospho ERK1/2 (A,B), and MEK1/2 and phospho MEK1/2 (C,D) The lower part of each panel reports the quantitative analysis of phospho ERK1/2 (A,B), and phospho MEK1/2 (C,D) ... Ras/ Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase Src, and Shc Rapid dissociation of GRB2/ Sps-Shc complex...

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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Ngày tải lên : 07/03/2014, 03:20

... change in the PI3K/ Akt pathway in gastric cancer cells lines, and conﬁrmed that PrPC regulates the expression of p -Akt in vitro, consistent with the above in vivo ﬁndings PI3K/ Akt is involved ... inhibition of the PI3K/ Akt signaling pathway leads to inhibition of PrPC-induced cell drug resistance in gastric cancer cells PI3K/ Akt is involved in the activation of P-gp by PrPC in gastric cancer To ... positive upstream regulator of PI3K/ Akt in gastric cancer cells By inhibiting the PI3K/ Akt pathway using LY294002 or co-transfection with Akt siRNA, the drug sensitivity and accumulation in SGC7901/PrPC...

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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot

Ngày tải lên : 07/03/2014, 04:20

... a In this article, we describe a novel S cerevisiae signaling pathway that implicates Bud32p and Sch9p (yeast homologs of mammalian PRPK and Akt ⁄ PKB, respectively) in modulating the phosphorylation ... exponential phase, and then incubated for 30 in galactose medium to activate the GAL regulon Total mRNAs were extracted and subjected to standard northern blot analysis GAL1 mRNA, and ACT1 mRNA (considered ... C Peggion et al Role of Bud32p in a new signaling pathway in yeast A B Fig Genetic interaction between BUD32 and SCH9 (A) The double deletion of BUD32 and SCH9 is lethal for yeast Heterozygotic...

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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx

Ngày tải lên : 07/03/2014, 12:20

... wild-type Akt (Akt- WT), membrane-targeted active Akt (Akt- myr), dominant-negative Akt (Akt- K179M) or empty vector control (pUSEamp) Forty-eight hours later, whole cell lysates were produced and analyzed ... the phosphatidylinositol 3-kinase (PI3K) pathway and its downstream effectors [23] This pathway is a key signal transducer of many growth factors and cytokines and has been implicated in the regulation ... to induce HO-1 in a PI3K ⁄ Akt- dependent and Nrf2dependent manner HO-1 induction by PI3K ⁄ Akt or Nrf2 activation requires further delineation in models of transplantation and may represent an...

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Prostate cancer: diagnosis and treatment docx

Ngày tải lên : 15/03/2014, 00:20

... Prostate cancer: diagnosis and treatment ii Chapter Title Prostate cancer: diagnosis and treatment February 2008 iii Prostate cancer: diagnosis and treatment Published ... Intelligence unit and Surveillance (WCISU) Between 1996 and 2004 the age standardised incidence rate of prostate cancer increased in all cancer networks in England and Wales1 In England the average ... Source: cancer registries of England and Wales Data Source: Office of National Statistics and Ordnance Survey Prostate cancer: diagnosis and treatment 1.4 Survival In most cases prostate cancer...

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Prostate cancer - Diagnosis and treatment pot

Ngày tải lên : 15/03/2014, 00:20

... guideline .38 Introduction Prostate cancer is one of the most common cancers in men Every year there are 34,986 new cases in England and Wales and 10,000 deaths Prostate cancer is predominantly ... die with prostate cancer and those who might die from prostate cancer Why this is important The greatest uncertainties in managing prostate cancer are around the identification of which cancers ... professionals and men with prostate cancer is essential It should be supported by evidence-based written information tailored to the man's needs Treatment and care, and the information men with prostate cancer...

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Questions & Answers About Prostate Cancer, Bone Metastases, and Treatment-Related Osteoporosis pot

Ngày tải lên : 15/03/2014, 01:20

... with prostate cancer and 27,050 men will die from prostate cancer in the U.S Q How is prostate cancer diagnosed? A Prostate cancer is most often diagnosed by needle biopsy of the prostate gland ... urinary bladder in men Q How common is prostate cancer? A Prostate cancer is the most common form of cancer in men (except for skin cancer) and a leading cause of cancer death worldwide In 2007, close ... General Information about Prostate Cancer Q What is prostate cancer? A Prostate cancer is an abnormal (malignant) growth of the prostate, a walnut-sized gland at the base of the urinary...

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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

Ngày tải lên : 16/03/2014, 11:20

... vitro analysis of NF-jB signaling pathway 46 Peet GW & Li J (1999) IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin J Biol ... (rhIKK2) and Nandini Kishore for providing the SC-514 inhibitor We thank also Paul Hayter, Sasha Sreckovic and Matthew Strawbridge with help in growing and analyzing the A549 cells and nally ... and inammatory responses and also genes involved in apoptosis and cell proliferation [36] In this paper, we report the results of cell-based, in vitro and in silico experiments on the NF-jB pathway...

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Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx

Ngày tải lên : 30/03/2014, 02:20

... expression in the androgen responsive prostate cancer cell line LNCaP It is an oncogene overexpressed in prostate, breast and ovarian cancer, as demonstrated by DNA microarray analysis and high density ... Because the PKB ⁄ Akt pathway is the central pathway involved in prostate cancer progression, activation of PKB ⁄ Akt by its phosphorylation is a possible mechnism of cell survival and migration ... et al (2004) PrLZ, a novel prostate- speciﬁc and androgen-responsive gene of the TPD52 family, ampliﬁed in chromosome 8q21.1 and overexpressed in human prostate cancer Cancer Res 64, 1589–1594 Byrne...

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