pharmacology and side effects of specific anticancer drugs in elderly individuals

... regulating the activities of phosphotyrosine phosphatases [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin ... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... cell lines: lower invasive ability of LNCaP, medium invasive ability for DU145 and a higher ability for PC3 The varying expression of XAF1 suggests a causal changing of androgen dependency and invasiveness...

Ngày tải lên: 10/08/2014, 10:20

... presented in two chapters, each of which contains an independent introduction and discussion Chapter summarizes findings relevant to the genome-destabilizing effects of BIR (objectives through 4), and ... phosphoinositol-3-kinase-related kinase RDR Recombination-dependent replication RNR Ribonucleotide reductase SDSA Synthesis-dependent strand annealing SSA Single-strand annealing ssDNA Single-stranded ... variety of exogenous damaging agents, including environmental toxins, ultraviolet light, and gamma irradiation Primarily, all of these sources of damage affect one of the two strands of the DNA...

Ngày tải lên: 24/08/2014, 11:07

... 0.5% In some countries such as Switzerland, Portugal and Japan the reduction in asthma mortality have appeared by increasing use of inhaled corticoides 1.1.2 Epidemiology of asthma in Viet Nam In ... knowledge of parents on asthma was impaired Studying epidemiological characteristics of asthma and carrying out the interventions in communities to manage asthma and to improve quality of life of patients ... on prevalence and mortality of asthma is lack In 2003, the prevalence of asthma among children in Ha Noi was 12.56% in urban areas and 7.52% in rural areas In 2007, the prevalence of diagnosed...

Ngày tải lên: 04/12/2014, 03:48

... calcineurin inhibitor, hyperbilirubinemia, and hypoalbuminemia The incidence of kidney injury increased with an increase in the number of risk factors Hypoalbuminemia also was identified as an independent ... Society of Intensive Care Medicine: Prevention of acute kidney injury and protection of renal function in the intensive care unit Expert opinion of the Working Group for Nephrology, ESICM Intensive ... colistin, the use of colistimethate instead of colistin sulphate, more adequate dose adjustment according to renal function and significant improvement of ICU monitoring (in particular of the...

Ngày tải lên: 21/06/2014, 03:20

... administration of sclerosing agents [22] After the discontinuation of production of the injectable tetracycline hydrochloride by the manufacturer, alternative forms like doxycycline and minocycline ... oxytetracycline pleurodesis in the literature Şenyigit et al administered oxytetracycline at a dose of 35 mg/kg, and it was well tolerated by patients with minor side effects like nausea-vomiting and ... absorbtion of tetracycline and lidocaine following intrapleural instillation Chest 1988, 94:960-963 doi:10.1186/1749-8090-5-128 Cite this article as: Gözübüyük et al.: Comparison of side effects of oxytetracycline...

Ngày tải lên: 10/08/2014, 09:23

... participated in the design of the study VB worked on interpretation of statistical analysis and drafting of the manuscript RJ conceived of the study, and participated in its design and coordination and ... TM: Side effects of methylphenidate and desipramine alone and in combination in children J Am Acad Child Adolesc Psychiatry 1993, 32:1065-1072 19 Fine S, Johnston C: Drug and placebo side effects ... underlying therapeutic and side effects as well as correlation in parental assessment of therapeutic and side effects We also postulated that if the correlation between therapeutic and side effects...

Ngày tải lên: 11/08/2014, 15:22

... up point Pain decreased by points in the Activator group, points in the manipulation group, and points in the mobilisation group A reduction in pain of at least points is considered a clinically ... overestimating the effect of advertising and the lack of adequate time for screening and treating patients in the study We limited advertising to the major newspaper and magazines of the Bournemouth ... measurement of clinical pain intensity: a comparison of six methods Pain 1986, 27:117-126 67 Bolton JE, Wilkinson RC: Responsiveness of pain scales: a comparison of three pain intensity measures in chiropractic...

Ngày tải lên: 13/08/2014, 14:20

... reliable algorithms and validate existing methods The relevance of existing rules is uncertain [24] and additional factors such as co-factor binding and relative positions of target sites [25,26] ... number of targeted genes in the 'low' ranked group by the 'high' ranked group Instead of considering a range of tissues we ranked the targeted genes within a single expression dataset and for ... enable individual researchers to gain an indication of miRNA activity in their tissue/cells of interest This is a convenient approach to gain additional biological insight from gene expression profiles...

Ngày tải lên: 14/08/2014, 08:21

... the probability of major errors and failures in managerial actions It injects a measure of discipline in managerial thinking and organizational action It improves the capability of the organization ... efforts and cost incurred in sales and advertising will be wasted in following unrealistic objectives Thirdly, Lose control: A plan indicates you’ve had a bit of a think about your life and aren’t ... to begin to guide a business or even an individual, the end result is usually walking down the wrong path along with a lot of spraying and praying going on In order to succeed at anything you've...

Ngày tải lên: 23/03/2015, 10:58

... students; and - Formulating pedagogical implications and making suggestions for improving the teaching and learning of the listening skills at UFFP Scope of the study In this study, the investigator intended ... used in the type of listening is often within the students’ current ability so that they find it pleasing and interesting when they are listening With this type of listening, students are not reinforcing ... This includes talking to learner in the target language, raising learners’ awareness of their listening styles and strategies and introducing a range of materials, speaking styles and listening...

Ngày tải lên: 07/09/2013, 13:48

... thơng tin (cơng ty cung cấp thơng tin…) g ( g y g p g ) — Giải vấn đề “Free-rider problem” Quy định phủ gia tăng chất lượng thơng tin — Giải thích Puzzle Phát triển trung gian tài (Financial intermediation) ... họ khơng quan tâm đến lợi ích cổ đơng Giải G ả Principal-Agent Problem ế Giám sát: cung cấp thơng tin 2 Quy định phủ nhằm gia tăng thơng tin tin Phát triển trung gian tài Hợp đồng nợ Giải thích ... ka 12 Slide #14-12 Cấu trúc tài (Q (Quản trò tài chính) ò ) – Trong đo: đó: EBIT (Earnings before interest and taxes) T : Ta es Taxes EBIT x (1- T)= Lợi nhuận sau thuế nợ vàø vốán cổå phầàn h...

Ngày tải lên: 20/01/2014, 19:20

... mating throughout pregnancy and gestation Complete details of the study, including a description of reproductive effects in parents and offspring, are included in Section In the F1 offspring ... effects in F1 offspring included a decrease in live pups at birth and on pnd and a decrease in pup birth weight and weight gain in the high-dose group on pnd 0, 7, 14, and 21 for both sexes and also ... government found DIDP in of 18 toys in 1990, of 27 toys in 1991, of 16 toys in 1992, and of 29 toys in 1996 (7) In a Danish survey of 17 children’s toys, those without PVC did not contain phthalates...

Ngày tải lên: 13/02/2014, 10:20

... before the indulgence of this foolish habit To such an extent has it obtained, that we meet it in the kitchen, in the dining-room, and in the parlor; in every gathering of men of business; in every ... taverns and coffee-houses in England, and that taking snuff is becoming unfashionable and vulgar in France How much is it to be lamented, that, while the use of tobacco is thus declining in two of ... my opinion, without intending to wound the feelings of a single individual If your sentiments correspond with mine, you will assist in bringing this odious practice to the bar of public opinion...

Ngày tải lên: 17/02/2014, 22:20

... significant increases in the incidence of a variety of other ovarian and uterine proliferative lesions and cysts were also reported Replication of these findings and further study of the linkage of early ... (187) opment and are implicated in the initiation and early progression of prostate cancer due to their function in maintaining ductal integrity and regulating the differentiation of luminal epithelial ... production of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of...

Ngày tải lên: 05/03/2014, 16:20

... presence of polypyrimidine tract binding protein binding sites However, it would be wrong to conclude that evolutionary changes happening in human introns should be considered ‘bad’ because of a ... to demonstrate purifying selection at silent sites in the gene of interest and to demonstrate that such constraint is necessary to maintain correct splicing of the gene In fact, although we acknowledge ... but also induce the inclusion of a new exon in only a minor fraction of the mature transcript represent the best candidates in the creation of new splicing substrates for evolution In this way,...

Ngày tải lên: 06/03/2014, 09:22

... cause steric hindrance and does not confine orientations of the side chain to regions of space different from those permitted in the a-amino acid Thus, insertion of a single b-amino acid in a bioactive ... within the specific NK-1m binding site The CH2b of the pyrrolidine ring of [Pro9]SP probably fits within this hydrophobic subsite and thus compensates destabilizing interactions due to CH2c and ... and w and were subsequently refined by varying /, w angles in intervals of 10° and setting h angle to ) 60 ± 10° and 60 ± 10° Each /, h, and w-value was fixed by applying a harmonic potential and...

Ngày tải lên: 08/03/2014, 08:20

... ii Abstract The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California ... elderly individuals This study brings these issues together, describing, in a land use context, the transportation patterns and challenges of caregivers and care recipients The following findings ... counseling and training, mobility management, and coordination and brokerage services); 4) volunteer efforts (private automobiles, independent transportation networks, mobility counseling and training,...

Ngày tải lên: 14/03/2014, 17:20

... conditioned by the winter snow cover, being high in the summer and low in the winter; while the pre-Alpine and northern Apennine source rivers are mainly rain-fed and are only full in spring and autumn ... are those of the Tavoliere in Puglia and the Piana di Sibari in Calabria On the islands there are the plain of Catania in Sicily and that of the Campidano in Sardinia The islandsBesides the reliefs ... increased on the Alpine and Apennine peaks and this also continued in the Pliocene period, resulting in the depositing at the feet of the chains of huge deposits of sand, gravel and clay There then...

Ngày tải lên: 21/03/2014, 22:04

... alignment of the Artemia ANT protein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms ... role of ANT in the mammalian PTP, and (c) the absence of a Ca2+-induced PTP in mitochondria from the embryos of A franciscana, we investigated the effect of ANT ligands on Ca2+ uptake capacity in ... absence of the ANT inhibitory ligand cATR, and of the F0F1ATP synthase inhibitor oligomycin The results are shown in Fig In Fig 1A, ADP was present prior to the addition of mitochondria in all...

Ngày tải lên: 29/03/2014, 00:20

... treatment, and this caused an increase in cleaved caspase-3 in both RINm5F (Fig 8C) and INS-E1 cells (Fig 8D) In a different approach, apoptosis of RINm5F cells was determined by counting free floating ... staining; (B) Mitofluor Red 589 (mitochondria) staining; (C) anti-His (exogenous PHB)-FITC staining; (D) merge The arrows indicate staining of His-tagged PHB in (C) or both PHB and Mitofluor in ... (nuclei) staining; (B) Mitofluor Red 589 (mitochondria) staining; (C) anti-PHB ⁄ anti-rabbit-FITC staining; (D) merge Arrows indicate staining of PHB D proteins have been shown to be involved in endocytosis...

Ngày tải lên: 29/03/2014, 08:20