pharmacokinetics and pharmacodynamics of drugs delivered to the lungs
Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
Ngày tải lên :
16/03/2014, 16:20
... with the O atom of the main chain CO group of the TrpB240; Ng1 shares H bonding with O atom of the CO group of LeuB387 together with O atom of c-OH of SerB386; Ng2 is in H bonding with Od1 of AsnB241 ... within the S1¢-binding subsite O atoms of the main chain CO groups of LeuB387 and TrpB240, Od1 atom of AsnB241, and Oc atom of SerB386 and is expected to stabilize the positive charge of ArgB263 ... consists of O atoms of the main chain CO groups of LeuB387 and TrpB240, Od1 atom of AsnB241 and Oc atom of SerB386 and is expected to stabilize the positive charge of ArgB263 The possible nonsymmetrical...
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Tiểu luận: ADVANTAGES AND DISADVANTAGES OF CREDITS CARDS TO THE CUSTOMER ppt
Ngày tải lên :
13/07/2014, 15:20
... card and they have to discuss the reasons as to why the renewal has to be done To be able to transact the credit card, payments are supposed to be made to the bank directly on fixed dates and ... only handled by the bank and the bank can take this opportunity to take advantage of the naive customer and take a little more than they should during these transactions This puts the customer ... period of time it is being accessed When one goes past the limit, the charges are sometimes on top of the roof Another problem comes as a result of the unlimited use of the credit card The credit...
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Báo cáo y học: "Pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study" ppt
Ngày tải lên :
13/08/2014, 08:20
... intermediate (4 to 5) or high (6 to 8) probability of HIT With the exception of patient 2, all patients had positive antibodies against the heparin/PF4 complex Pharmacokinetics and pharmacodynamics of danaparoid ... within the normal range during the first hours To our knowledge, this is the first time the pharmacokinetics and pharmacodynamics of danaparoid have been studied during CVVH A limitation of this ... in the writing and critical appraisal of the manuscript, and all authors read and approved the final manuscript molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring,...
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Development of methods to improve sensitivity and portability of capillary electrophoresis for the analysis of stabilizers and drugs 1
Ngày tải lên :
14/09/2015, 10:36
... further enhancement of the stacking efficiency in the modified mode rested on the relative stability of the displacer-carrier complex to that of the solute-carrier complex Next, a new method to ... forward movement of the neutral sample associated with β-CD-NH2 and the backward movement of the neutral sample partitioned in the micelles of sodium dodecyl sulfate (SDS) Stability of the inclusion ... detection, the C4D method has the advantage that there is no need to custom-make a detection cell for each capillary The LOD was found to be 3ppm The linear range was between to 1000 ppm, and RSD...
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Development of methods to improve sensitivity and portability of capillary electrophoresis for the analysis of stabilizers and drugs 2
Ngày tải lên :
14/09/2015, 10:37
... though they migrate opposite to the direction of the EOF, are also transported to the detector (on the cathode side) Since their migration velocities are typically lower than the velocity of the EOF, ... increase the sensitivity, two approaches, either to increase the amount of analyte added to the capillary or to improve the sensitivity of the detector, may be applied However, due to the characteristics ... possible to detect cations and anions in the same run by controlling the EOF to elute more components of the sample There are several frequently used methods to change the EOF, such as adjustment of...
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A study on cultural obstacles to the teaching and learning of speaking skills in the classroom of grade 10 at nguyen tat thanh high school
Ngày tải lên :
07/09/2013, 13:00
... codes to speak and sometimes they translate on a word-by-words basis They apply the way they think in their mother tongue to form speech in English and pay no attention to the meaning beyond the ... affects the educational system of Vietnam Students at high school are not totally aware of the role of English in an open door and market economy They learn and expect to pass the exam at the end of ... aware of the importance of cultural factors in the teaching of speaking skills and, too , aware of the great influence of inferences between two cultures- target and learner’s cultures- on these...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
Ngày tải lên :
22/02/2014, 07:20
... both the Ea of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor ... 23 in the enzyme from the hyperthermophile Thermotoga neapolitana (optimal growth at 80 8C), and 46 in the XI from the mesophile Escherichia coli (optimal growth at 37 8C) The low Q (and, to some ... content relates to the enzyme’s functional temperature range and that BLXI thermostability is also directly related to the binding of specific metals as cofactors At the same time, the simple relationship...
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Báo cáo khoa học: Recruitment of transcription complexes to the b-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells docx
Ngày tải lên :
07/03/2014, 12:20
... recruitment of factors to the a-globin gene locus during the differentiation of erythroid cells The regulatory elements located upstream of the a-globin genes also appear to initiate the activation of the ... transcription 5¢ -to HS3 is directional and proceeds towards the HS3 core enhancer The RNA was isolated and reverse transcribed using a primer specific for the bottom strand (3¢)5¢) or for the top strand (5¢)3¢) ... dimethylation of H3K4 and recruitment of RNA Pol II and TBP to the LCR occurs before activation of any of the globin genes The presence of H3 dimethylated at K4 indicates that these elements...
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The Lady and Sada San A Sequel to The Lady of the Decoration potx
Ngày tải lên :
15/03/2014, 06:20
... If I went to the theater, church or concert, the call of that germ-ridden spot of the unholy name beat into my brain with the persistency of a tom-tom on a Chinese holiday The Lady and Sada San ... getting the best of the bare tablecloth and the empty house at home Some twenty years ago Sada’s father, an American, grew tired of the slow life in a slow town and lent ear to the fairy stories told ... one woman in the world! I struggled to make plain to her the attitude of American men and women and the semi-independence of the latter As well explain theology to a child To her mind the undeviating...
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Báo cáo khoa học: Recruitment of coregulator complexes to the b-globin gene locus by TFII-I and upstream stimulatory factor doc
Ngày tải lên :
23/03/2014, 07:20
... mutant of USF exhibited a reduction in Pol II loading to LCR element HS2 and to the b-globin gene promoter [20] At the same time, we observed a reduction in the recruitment of CBP and p300 to these ... shown to interact with CBP [27,28] Both of these proteins were shown to be required for histone acetylation of specific regions in the globin gene locus However, the recruitment of CBP ⁄ p300 to the ... recruits the histone acetyltransferase p300 to the b-globin promoter and this activity increases the accessibility for transcription factors TFII-I recruits HDAC3 and the PRC2 complex, which render the...
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Pricing and Hedging of Credit Derivatives via the Innovations Approach to Nonlinear Filtering pptx
Ngày tải lên :
29/03/2014, 03:21
... to determine π t , the current value of the process π On the other hand, the model parameters (the generator matrix of X and parameters of the functions a(·) and λi (·), i = 1, , m) need to ... Lt ) the full-information value of the default and the premium payment leg of the CDS index In our setup the value of the option at maturity U is then given by the following function of the market ... results and the innovations approach to nonlinear filtering By the same token we derive the dynamics of the market price of traded credit derivatives In Section these results are then applied to the...
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Đề tài " Existence and minimizing properties of retrograde orbits to the three-body problem with various choices of masses " potx
Ngày tải lên :
29/03/2014, 07:20
... methods on the existence of certain types of solutions to the planar three-body problem with various choices of masses There is a natural way of classifying orbits by their topological types in the ... orbits in the lunar theory Detailed descriptions are left to Section and Our main theorem (Theorem 1) shows the existence of many periodic and quasi-periodic retrograde solutions to the three-body ... homotopy class of the ˜ ˜ projection αφ of αφ in V \ Δ over t ∈ [0, 1] is one of the two generators for ˜ \ Δ) The left side of Figure depicts the path α over t ∈ [0, 1] ˜ ˜φ π1 (S A solution x of...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
Ngày tải lên :
30/03/2014, 04:20
... (b) to identify the active site residues involved in the binding of Glc to the super-open state (Fig 1C) of this two domain [large (L) and small (S)] enzyme, and thus the site of initiation of the ... revealed the structures of the unliganded (super-open) and Glc-bound (fully-closed) states of hGK [12], the residue contacts that make essential contributions to the binding of Glc to the super-open ... transition; and (c) to gain some insight into how the local torsional stresses at the contact residues in the super-open state propagate through the structure towards cleft closure and a 2468...
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state university of new york press the perils and promise of global transparency why the information revolution may not lead to security democracy or peace oct 2006
Ngày tải lên :
11/06/2014, 12:45
... document and publicize abuses of state power around the world International organizations monitor the behavior of governments and determine whether they are adhering to international agreements Together, ... availability of information, without respect to content.16 Five factors in particular have led to the rise of global transparency: the spread of democratic governments, the rise of the global media, the ... leaders to high standards, and punishing leaders who fail to meet them, mandates that citizens know what their leaders are up to Citizens pay taxes and have a right to see how they are spent They...
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knots groups and 3-manifolds papers dedicated to the memory of r h fox aug 1975
Ngày tải lên :
11/06/2014, 13:31
... generator of the center of the braid group B n , then the braid b· c k , k (Z and k -J- 0, closes to a nontrivial knot the trivial knot, and c f Proof First observe that if b l and b are n-stranded ... contradiction of Lemma 2, which is that g*(c k)
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Báo cáo hóa học: " Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys'''' pot
Ngày tải lên :
18/06/2014, 16:20
... administration, and to correlate PD activity with serum concentrations of these antibodies and the presence of an anti-product antibody response The PD assay used in this study was based on the ability of ... Andover MA and Pearl River, NY, respectively) were used Nine of these monkeys (males, Andover, MA) were enrolled into the in vivo study, based on the magnitude of IL-2RA gene expression and their ... Histogram for the RQ values (B) and log2-transformed RQ values (C) for 37 monkeys, as well as the fitting of these values into a Gaussian distribution (solid line) are shown RQcutoff = 2.3 and...
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báo cáo sinh học:" Non-European Union doctors in the National Health Service: why, when and how do they come to the United Kingdom of Great Britain and Northern Ireland?" pdf
Ngày tải lên :
18/06/2014, 17:20
... Remain) in the UK (18.9%), preference of living in the UK (7.4%) and the presence of family and friends in the UK (7.1%) (Figure 4) All respondents were asked to report their 'main' and 'other' reasons ... policy that fail to factor in the aspirations and needs of doctors who have already migrated to the UK are likely to disrupt the career paths of many non-European doctors, many of whom have spent ... of the European Working Time Directive, curtailing the working hours of doctors, along with the increased resource investment in the NHS at the end of the last century resulted in an influx of...
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Department of Business, Economic Development and Tourism State of Hawaii NOTES TO THE BASIC FINANCIAL STATEMENTS June 30, 2009_part4 ppt
Ngày tải lên :
19/06/2014, 17:20
... AUDITING STANDARDS To the Auditor Office of the Auditor State of Hawaii: We have audited the financial statements of the governmental activities and each major fund of the Department of Business, Economic ... (including torts) Claims under $10,000 are handled by the risk management office of the Department of Accounting and General Services All other claims are handled by the Department of the Attorney ... fund of the DBEDT may adversely affect the DBEDT's bUdget and financial statements NOTE M - RISK MANAGEMENT The DBEDT is exposed to various risks of loss related to torts; theft of, damage to, ...
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Department of Business, Economic Development and Tourism State of Hawaii NOTES TO THE BASIC FINANCIAL STATEMENTS June 30, 2009_part5 ppt
Ngày tải lên :
19/06/2014, 17:20
... consider to be material weaknesses, as defined above This report is intended solely for the information and use of the Office of the Auditor, the management of DBEDT, federal awarding agencies and ... the Auditor State of Hawaii: Compliance We have audited the compliance of the Department of Business, Economic Development and Tourism State of Hawaii (DBEDT) with the types of compliance requirements ... identified in the summary of auditors' results section of the accompanying schedule of findings and questioned costs Compliance with the requirements of laws, regulations, contracts, and grants...
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