phần 1 trình bày đồ án
Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... -1. 06 0. 317 11 .19 2 0.35 0 .19 –0.65 10 mg/day 2. 71 0.65 17 .2 15 .03 4 .18 –54.08
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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx
... References 10 11 12 13 14 15 16 17 18 R824 Schmidt AM, Yan SD, Yan SF, Stern DM: The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses J Clin Invest 20 01, 10 8:949-955 ... NS 2200 18 00 Soluble RAGE (pg/ml) Blood sRAGE (pg/ml) Figure 2000 18 00 16 00 P < 0.05 14 00 12 00 10 00 800 600 400 200 RA blood 976 ± 14 2 (787) 777 ± 81 (699) RA synovial fluid 5 01 ± 81 ( 414 ) 306 ... (n) 19 26 Age (years ± standard deviation) 63.8 ± 14 .3 60.8 ± 14 .0 Sex (male/female) 5 /14 8 /18 Disease duration (years ± standard deviation) 13 .1 ± 9.6* 8.2 ± 8.3 Rheumatoid factor (+/-) 12 /7 14 /12 ...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... -0.53 to -0 .11 S100A8a -0.06 0.03 -2. 51 0. 01 -0 .11 to -0. 01 S100A9a -0.08 0.04 -1. 94 0.06 -0 .15 to 0.002 S100A12a -0.08 0.05 -1. 70 0.09 -0 .18 to 0. 01 Carriage of RAGE 82S -0.33 0 .12 -2.88 0.005 ... sRAGEa -0.77 0. 31 -2. 51 0. 01 -1. 37 to - 016 1. 45 0.28 5 .12 < 0.0 01 0.89 to 2. 01 Multivariate analysis: RF ACPA 1. 22 0.29 4.24 < 0.0 01 0.65 to 1. 79 S100A9a 0.34 0 .10 3.42 0.0 01 0 .14 to 0.54 Adjusted ... -1. 94 0.06 -0.78 to 0.009 S100A8a 0.20 0.06 3.65 < 0.0 01 0.09 to 0. 31 S100A12a 0.54 0 .10 5.46 < 0.0 01 0.34 to 0.73 Multivariate analysis: Body mass indexa 0.86 0. 41 2 .10 0.04 0.05 to 1. 67 S100A8a...
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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx
... Arthritis Research & Therapy 2 011 , 13 :R 113 http://arthritis-research.com/content /13 /4/R 113 Received: October 2 010 Revised: May 2 011 Accepted: 12 July 2 011 Published: 12 July 2 011 References Schmidt AM, ... IL -17 or inhibitor-treated cells Heo et al Arthritis Research & Therapy 2 011 , 13 :R 113 http://arthritis-research.com/content /13 /4/R 113 Page 10 of 12 Figure Act1 shRNA completely inhibited IL -17 -induced ... Therapy 2 011 , 13 :R 113 http://arthritis-research.com/content /13 /4/R 113 Page of 12 Figure IL -17 and IL-1b increased RAGE mRNA expression in RA-FLS (a) RA-FLS were cultured with 10 ng/ml IL -17 , ng/ml...
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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt
... concentration 0h 3h 6h 9h 10 0 lM mM mM Not detectable Not detectable Not detectable 1. 58 · 10 )4 2.00 · 10 )3 6.42 · 10 )3 6.37 · 10 )4 8.36 · 10 )3 1. 55 · 10 )2 1. 54 · 10 )3 9.95 · 10 )3 1. 94 · 10 )2 FEBS Journal ... 338 – 10 6 338 – 14 9 Intensity (cps) 14 00 12 00 CEd GA 10 00 800 CE dGB 600 400 200 B 8.0E+05 1. 2E+06 Intensity 10 11 Time (min) 12 13 14 17 8 [M- CO2-dRib - H] 15 338 [M-CO2-H]- Fig LC-MS ⁄ MS analysis ... plasmid as compared to the unmodified plasmid DNA (Fig 7) (cfu·mL 1) A 1. E+09 1. E+08 1. E+07 1. E+06 1. E+05 1. E+04 1. E+03 1. E+02 1. E+ 01 1.E+00 Quantification of plasmid transcription Control In order...
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Báo cáo y học: " Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study" potx
... smoker 10 3 638 492 -10 63 >48 96 628 449 -10 55 ≤48 10 4 669 484 -10 76 ≥50
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Báo cáo y học: "Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation" pdf
... 9 :11 46 -11 55 Poon BY, Raharjo E, Patel KD, Tavener S, Kubes P: Complexity of inducible nitric oxide synthase: cellular source determines benefit versus toxicity Circulation 2003, 10 8 :11 07 -11 12 ... cells/mm2, non-ventilated sepsis 2 .1 ± 0.6 cells/mm2, P < 0.05) and RV (LTV 11 .3 ± 1. 9 cells/mm2, HTV 12 .2 ± 2 .1 cells/mm2; non-ventilated sepsis 5.5 ± 1. 5 cells/mm2, P < 0.0 01; Figure 3) In general, the ... Signal 2007, 9:2003-2 012 19 Slutsky AS, Tremblay LN: Multiple system organ failure Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 19 98, 15 7 :17 21- 1725 20 Syrkina O, Jafari...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
... (ng·mL 1) * 12 5 * 10 0 pg·mL 1 AGE-HSA LPS 2400 * 3000 2500 2000 15 00 10 00 500 * * 50 * 25 50 12 .5 25 50 10 0 HSA AGE-HSA (µg·mL 1) * * 4000 3200 * * * 800 10 10 0 10 00 LPS (ng·mL 1) 10 00 * * 600 * 10 ... pg·mL 1 800 2000 AGE-HSA LPS 600 MCP -1 IL-8 IL-6 A J Liu et al AGE-HSA LPS 16 00 3000 12 00 18 00 800 200 12 00 400 600 0 400 24 12 Incubation time (h) * 10 00 800 pg·mL 1 B * 600 * 400 * 200 C 10 10 0 10 00 ... * 10 10 0 10 00 LPS (ng·mL 1) 2500 * 2000 * 15 00 10 00 400 24 12 Incubation time (h) 16 00 200 0 2400 800 75 24 12 Incubation time (h) * * 50 12 .5 25 50 10 0 HSA AGE-HSA (µg·mL 1) * 500 0 * 50 12 .5...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... Sci 2002, 59:45-53 Available online http://arthritis-research.com/content /11 /5/R136 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Fuchs S, Skwara A, Bloch M, Dankbar B: Differential induction and ... stimulation: TNF-α 12 .7 ± 2.0 versus 6.2 ± 0.5 pg /10 5 cells; IL-6 17 3 ± 38 versus 81 Page 11 of 19 (page number not for citation purposes) Arthritis Research & Therapy Vol 11 No Franke et al Figure ... http://arthritis-research.com/content /11 /5/R136 Figure 11 Stimulation of TNF-α and Il-6 by AGE-BSA (a) Transcripts for TNF-α were significantly increased after one and two days (*P < 0. 01, n = 15 ) (b) ILAGE-BSA...
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Báo cáo y học: " Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats" pot
... biosynthesis J Biol Chem 20 01, 276(52):49 310 -49 319 Page of (page number not for citation purposes) Respiratory Research 2009, 10 :55 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Nakai A, Satoh M, ... 2004, 16 5(6):2033-2043 Razzaque MS, Nazneen A, Taguchi T: Immunolocalization of collagen and collagen-binding heat shock protein 47 in fibrotic lung diseases Mod Pathol 19 98, 11 (12 ) :11 83 -11 88 Razzaque ... The FASEB Journal 2004, 18 : 816 -827 Izbicki G, Segel MJ, Christensen TG, Conner MW, Breuer R: Time course of bleomycin induced lung fibrosis Int J Exp Path 2002, 83 :11 1 -11 9 Chaudhary NI, Schnapp...
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báo cáo hóa học: " Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes" docx
... Page of 9 10 11 12 13 14 15 16 17 18 Competing interests The authors declare that they have no competing interests Received: 15 February 2 011 Accepted: June 2 011 Published: June 2 011 References ... angiogenesis in swine model of hibernating myocardium J Am Coll Cardiol Img 2008, 1: 500- 510 doi :10 .11 86/ 219 1- 219 X -1- 3 Cite this article as: Tekabe et al.: Imaging the effect of receptor for advanced ... integrin after murine hindlimb ischemia Circulation 2005, 11 1:3255-3260 Tekabe et al EJNMMI Research 2 011 , 1: 3 http://www.ejnmmires.com/content /1/ 1/3 Page of 22 Meoli DF, Sadeghi MM, Krassilnikova...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... of 13 (page number not for citation purposes) Arthritis Research & Therapy Vol 11 No Rasheed et al RT-PCR To analyze the transcription of type-2 collagen (COL2A1), type -10 collagen (COL10A1), ... number EK 112 1; Panomics, Fremont, CA, USA) The color intensity was read at 450 nm using the Synergy HT ELISA plate reader (Biotek) Available online http://arthritis-research.com/content /11 /3/R 71 In ... days (passage 1) Expression of (a) type-2 collagen (COL2A1) and (b) aggrecan (ACAN), type -10 collagen (COL10A1) and SRY-box containing gene (SOX-9) was determined by RT-PCR M, 10 0 bp DNA ladder;...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... receptor for Page 19 of 21 (page number not for citation purposes) Journal of Translational Medicine 2009, 7 :17 14 5 14 6 14 7 14 8 14 9 15 0 15 1 15 2 15 3 15 4 15 5 15 6 15 7 15 8 15 9 16 0 16 1 16 2 advanced glycation ... stage, then downregulated S100A9 1q 21 See S100A8 See S100A8 See S100A8 S100A10 1q 21 Not observed Several tissues, highest in lung, kidney, and intestine S100A 11 1q 21 Yes – inflammation induced ... http://www.translational-medicine.com/content/7 /1/ 17 10 11 12 13 14 15 16 Acknowledgements This report was funded, in part, by PO1 CA 10 1944-01A2 (Lotze, Michael T) Integrating NK and DC into...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... count 19 ± 12 19 ± 11 ± 11 ESR (mm/hour) 44 ± 27 46 ±33 36 ±30 34 ±29 CRP (mg/dl) 1. 8 ± 1. 8 2 .1 ± 2.2 1. 9 ± 3.0 1. 7 ± 2.2 Hemoglobin (mg/dl) 13 ± 1. 5 13 ± 1. 7 13 ± 1. 4 13 ± 1. 6 10 9 ± 53 99 ± 19 ... 51 ± 38* 36 ± 27 45 ± 30 37 ± 30 CRP (md/dl) 2.5 ± 3 .1* 1. 5 ± 1. 8 1. 7 ± 2.0 1. 8 ± 2.3 12 .5 ± 1. 5 12 .7 ± 1. 5 12 .9 ± 1. 6 Hemoglobin (mg/dl) Glucose (mg/dl) 13 .0 ± 1. 9 10 0 ± 30 10 2 ± 40 99 ± 25 10 2 ... (mg/dl) 14 27 ± 529* 11 82 ± 378 12 52 ± 369 12 26 ± 443 IgM (mg/dl) 13 9 ± 61 152 ± 88 17 3 ± 61* 14 0 ± 88 IgA (mg/dl) 285 ± 13 9 236 ± 10 4 282 ± 12 6 232 ± 10 6 19 (40%) 69 (36%) 45 (69%)* 25% (n) 18 (26%)...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf
... GCC 16 /12 0.45 13 /8 0.28 12 /9 0. 51 GCT 28/ 31 0.7 21/ 27 0.39 22/26 0.56 GTC 12 /11 0.83 10 /7 0.47 9/7 0.62 TCC 20/ 21 0.88 18 /20 0.75 18 /19 0.87 Linkage disequilibrium: TLR1_SNP1 (rs5743 618 ) – TLR1_SNP2 ... >1. 80 ( +13 .4%) 2.03 ( +11 .4%) 1. 76 ( +13 .9%) 1. 76 ( +13 .9%) 1. 78 ( +13 .7%)
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Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf
... 1. 03 (0.67 1. 59) 81/ 287 1. 55 (0.94–2.56) 21/ 348 0. 51 (0.25 1. 03) haplotypec 1. 0 Yes/no 1. 0 51/ 123 1. 0 29 /14 4 1. 0 18 /15 6 1. 0 One aT haplotyped 77 /19 1 0.98 (0.62 1. 54) 56/ 213 1. 43 (0.84–2.42) 14 /254 ... ApaIb AA 51/ 123 1. 0 29 /14 5 1. 0 18 /15 6 1. 0 Aa 77 /19 1 0.98 (0.62 1. 54) 56/ 212 1. 43 (0.84–2.42) 14 /254 0.46 (0. 21 1. 00) aa 32/69 1. 20 (0.67–2 .15 ) 25/76 1. 93 (1. 00–3.70) 7/94 0.65 (0.24 1. 75) 'A' ... carriage 12 8/303 0.82 (0.49 1. 37) 85/357 0.65 (0.37 1. 13) 32/ 410 1. 01 (0.40–2. 51) 'a' allele carriage 10 9/260 1. 03 (0.67 1. 59) 81/ 288 1. 55 (0.94–2.56) 21/ 348 0. 51 (0.25 1. 03) tt 20/44 1. 00 11 /53 1. 0...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt
... GCC 16 /12 0.45 13 /8 0.28 12 /9 0. 51 GCT 28/ 31 0.7 21/ 27 0.39 22/26 0.56 GTC 12 /11 0.83 10 /7 0.47 9/7 0.62 TCC 20/ 21 0.88 18 /20 0.75 18 /19 0.87 Linkage disequilibrium: TLR1_SNP1 (rs5743 618 ) – TLR1_SNP2 ... >1. 80 ( +13 .4%) 2.03 ( +11 .4%) 1. 76 ( +13 .9%) 1. 76 ( +13 .9%) 1. 78 ( +13 .7%)
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Báo cáo y học: " Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis" doc
... colonization at yrs* Impaired glucose tolerance Diabetes 11 .1 ± 5 .1 1.4 ± 2.3 13 4 /12 1 13 6 (53%) 91 (36%) 28 (11 %) 63 ± 3% 60 ± 3% 21 (8%) 15 (6%) Abbreviations: yrs: years; P aeruginosa: Pseudomonas ... 0.4) -1. 7 (± 0.6) -1. 6 (± 0.9) 0.8 92 .1 (± 3.7) 95.2 (± 5.0) 92.8 (± 7.8) -1. 8 (± 0.6) -2.2 (± 0.8) -1. 8 (± 1. 3) 0.9 ER22/23EK GG AA + AG 95.6 (± 9.7) 86.4 (± 9.5) -2 .1 (± 1. 4) +1. 0 (± 1. 4) 0 .1 93.8 ... (± 4 .1) 88.8 (± 6.7) -2.5 (± 0.5) -2.9 (± 0.7) -1. 6 (± 1. 1) 0.7 89.2 (± 4 .1) 98.7 (± 5.4) 94.4 (± 8.4) -2.2 (± 0.7) -3.8 (± 0.9) -2.2 (± 1. 3) 0.4 ER22/23EK GG AA + AG 95.2 (± 11 .2) 92.6 (± 11 .0)...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Health 5PO1HL57278-O7 and 5RO1HL 412 50 -12 References Leslie, C.C (19 97) Properties and regulation of cytosolic phospholipase A2 J Biol Chem 272, 16 709 16 712 Balsinde, J & Dennis, E.A (19 97) Function ... J.-L., Yokomori, K & Tjian, R (19 95) Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II Cell 81, 11 15 11 25 47 Arnold, H.H & Winter, B (19 98) Muscle differentiation: ... Clin Invest 88, 3 31 335 11 Gross, R.W (19 85) Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum Biochemistry 24, 16 62 16 68 12 Hazen, S.L., Zupan,...
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Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts pot
... GT 11- 12 20 (5.4) 25 (6.8) 0.79 (0.43 -1. 45) 0.442 0.636 GT13 65 (17 .7) 70 (19 ) 0. 91 (0.63 -1. 33) 0.634 0.749 GT14 -18 GT19 (1. 9) 26 (7 .1) (1. 1) 16 (4.3) 1. 77 (0. 51- 6.08) 1. 67 (0.88-3 .17 ) 0.362 0 .11 2 ... 72 (39 .1) Del/Del 20 (10 .9) 21 (11 .4) Ins 257(69.8) 254 (69) Del 11 1 (30.2) 11 4 ( 31) TT 13 1 ( 71. 2) 12 1 (65.8) TC 45 (24.5) 55 (29.9) CC T (4.3) 307 (83.4) (4.3) 297 (80.7) C 61 (16 .6) 71 (19 .3) ... value 11 3.9/254 .1 ( 31) 0.8 (0.58 -1. 1) 0 .16 6 0.573 66.4/3 01. 6 (18 ) 75 .1/ 292.9 (20.4) 0.85 (0.59 -1. 23) 0.399 0.573 37 .1/ 330.9 (10 .1) 38.8/329.2 (10 .5) 50 .1/ 317 .9 (13 .6) 27.7/340.3 (7.5) 7.0/3 61 (1. 9)...
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