pg txl and pg cpt from the laboratory to the clinic
nanotechnology for cancer therapy, 2007, p.810
Ngày tải lên :
04/06/2014, 14:30
... biodistribution and selective localization of the nanovector and its cytotoxic and/ or imaging agent Although the first type of molecules used to enhance the selective localization and delivery of nanovectors ... nanotechnology and performs preclinical efficacy and toxicity testing of nanoscale devices and materials The goal of the NCL is to support the rapid acceleration of preclinical development of nanovectors to ... Cancer Therapy infrastructure to characterize nanoplatforms and to ensure that the rapid translation of discoveries in this area proceeds from preclinical to clinical use The recognition by the...
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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY
Ngày tải lên :
24/08/2014, 13:10
... to enhance cytotoxicity of laboratory and clinical chemotherapeutic agents The survival of SF767 human glioblastoma cells will be monitored after treatment with the compounds singly as will the ... these compounds to enhance the cytotoxicity of laboratory and clinical chemotherapeutic agents (Methyl methane sulfonate (MMS) and Temozolomide (TMZ)) known to induce DNA damage repaired by the ... cytoplasm may be important to maintain these transcription factors in a reduced state prior to their transport to the nucleus (44) Ape1 has also been shown to accumulate in the nucleus and mitochondria...
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Báo cáo sinh học: " Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy" pptx
Ngày tải lên :
18/06/2014, 22:20
... of the study and coordination of the work as lead investigator All authors contributed to the interpretation of the results and the drafting of the manuscript, and they read and approved the ... mainly due to the oil contained inside the NCs' core The release data of Doc from the NCs (Figure 6) were fitted to the Higuchi model [38] to determine the drug release mechanism The drug release ... Hansen modified the Hildebrand approach and divided δ into three components that take into account the force of the dispersion [δd], the polarity [δp], and the hydrogen bonds [δh] Therefore, δ is...
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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy" doc
Ngày tải lên :
20/06/2014, 07:20
... gorilla and chimpanzee were together, which left cow, rat, and mouse in the other group In the first sub-group, the gorilla and chimpanzee PTTG1 cDNA sequences showed 98.85% identity The PTTG1 ... regulated in vivo and in vitro by estrogen and that its induction levels coincide with bFGF and vascular endothelial growth factor (VEGF) The bFGF and other growth factors are known to modulate angiogenesis ... their studies, these investigators found an absence of the antiapoptotic marker bcl-2 in these animals, suggesting that there might be a different mechanism other than inhibition of the apoptotic...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
Ngày tải lên :
11/08/2014, 00:22
... attributable to the saturated protons of the polymeric network The broad resonance peak at δ = 0.8–1.0 ppm are from the methyl protons of the isopropyl group The signal peaks for the methyne proton (>CH-) ... at 1642 and 1540 cm-1 correspond to the amide carbonyl group and the bending frequency of the amide N-H group respectively The absorptions bands in the region 1443–1457 cm-1 are due to the bending ... place The water attached in the process of hydration of the polymer and proton exchange with the solvent gives rise to a broad and intense peak at 3300 cm-1 The – CH- stretching vibration of the...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
Ngày tải lên :
11/08/2014, 00:23
... apoptosis and autophagy Further, higher cytotoxicity in the MCF-10A breast normal cell line was noted than in the 4T1 and MCF-7 breast cancer cell lines Nonetheless, the Magh-Rh (H cit) and Lip-Magh-Rh ... of the molecules [4] The cytotoxic activity of some rhodium carboxylates is given by their ability to bind covalently to DNA bases, unpairing them, and subsequently inhibiting DNA replication and ... chromatin to nuclear periphery and the remarkable presence of vacuoles and condensed mitochondria when compared to the MCF-7 and 4T1 control cells (Figure 5C-F and 6C-F), respectively These morphological...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
Ngày tải lên :
30/09/2015, 05:59
... discovery The NCCSC established the necessary tests and indicators for the discovery, development, toxicology and clinical evaluation of candidate drugs Later in the 1960s, Frank Schabel and Howard ... safe and effective therapy The differences in therapeutic windows of different drugs are related to their functions, as in whether they inhibit the essential of non-essential functions of the ... antagonistic if the effect is larger, equal to, or lower than the summed effects of the single drugs [36] The addition of drug to another can modulate the therapeutic activities of the partner drug...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
Ngày tải lên :
18/06/2014, 15:20
... -H19 or the LucSV40 plasmid The values represent the luciferase activity of the H19 promoter relative to the activity of the control vector LucSV40 B The killing potential of the DTA-H19 vector in ... 7:69 The H19 regulatory sequences were able to drive DTA expression in the ovarian cancer cell lines that led to cell death Therefore, we further investigated the therapeutic potential of the toxin ... differs from that of the constructs transfected into the cells Thus, transcription factors may be able to induce transcription from the plasmid, but not from the endogenous gene We have shown the...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
Ngày tải lên :
18/06/2014, 16:20
... XbaI and NcoI, and the insert of the luciferase gene (luc) was replaced by the Diphtheria toxin A chain (DTA) coding region to yield the H19-DTA construct The DTA gene was prepared from the pIBI30-DT-A ... assumption, the first stage was to explore the expression level of each of the mentioned regulatory sequences and then compare it to the combined expression level (from the two regulatory sequences) ... products (containing T7 and Sp6 promoters) were purified from the gel, sequenced and found to be identical to the relevant published sequences in the gene bank 100 to 200 ng from the purified products...
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Improvement of different vaccine delivery systems for cancer therapy pptx
Ngày tải lên :
06/03/2014, 02:21
... of the vector DNA into the host genome and their high cost [48,49] Non-viral or synthetic vectors have many advantages over their viral counterparts as they are simple, safe and easy to manufacture ... adeno-associated virus and pox virus have been modified to eliminate their toxicity and maintain their high gene transfer capability Due to the limitations correlated to viral vectors, non-viral vectors have ... effectively and directly transferred into the cytosol This system has been applied to deliver proteins into cells [24], but not yet to deliver antigens into DCs for cancer immunotherapy In vitro and...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
Ngày tải lên :
28/03/2014, 23:20
... at high levels in the targeted tumor cells The delivery of the vectors in normal and malignant cells from the targeted tissue results in the deletion of the STOP signal and the transcription ... factors and chemokines, and amplify the synthesis of HA and proteoglycans such as versican The interaction of the anti-adhesion molecule versican with HA and CD44 promotes the expansion of the ... vehicles to the site of angiogenesis rather than to the quiescent vasculature [105] On the basis of these observations, it is possible to deliver immune-activating cytokines ⁄ secreted proteins to the...
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recombinant antibodies for cancer therapy, methods and protocols
Ngày tải lên :
11/04/2014, 10:25
... held together by the constant domains CH1 and CL (70) To stabilize the association of the VH and VL domains, they have been linked with peptides (71,72), disulfide bridges (70) and “knob-into-hole” ... (6–8) The main factors responsible for these initial shortcomings were related to the immunogenicity of the murine protein, to modulation of targeted antigens, and to the poor ability of these ... determined by the conformation of the individual CDRs, by the relative disposition of the CDRs, and by the nature and disposition of the side chains of the amino acids comprising the CDRs (21)...
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nanocarriers as an emerging platform for cancer therapy
Ngày tải lên :
28/05/2014, 15:07
... of drugs from the surrounding environment, and the ability to entrap both hydrophilic and hydrophobic drugs Through the addition of agents to the lipid membrane or by the alteration of the surface ... necessary to improve the therapeutic efficacy of an anti-ErbB2-targeted liposomal doxorubicin relative to its nontargeted counterpart15 The binding of certain ligands to their receptors may cause ... cell-specific recognition and binding The nanoparticles can (i) release their contents in close proximity to the target cells; (ii) attach to the membrane of the cell and act as an extracellular...
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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx
Ngày tải lên :
06/08/2014, 19:21
... Anti-angiogenic factors are not stable on their own and they are not cytotoxic, and to be effective they would require chronic administration Anti-angiogenic factors could be made more reliable through the ... used to deliver gene therapy vectors into tumors For example, RGD Burton and Libutti: Journal of Biology 2009, 8:85 85.3 Table Angiogenesis factors Factors affecting endothelial proliferation and ... disease To overcome the problem, researchers are now developing targeted TNF-α delivery systems These involve either direct targeting of the TNF-α protein to the tumor and delivery by gene therapy...
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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
Ngày tải lên :
09/08/2014, 02:21
... subsequent logical therapy following resistance to other endocrine agents However, if the patient is unfit to receive any further anti-estrogen therapy then it is very likely that they would not ... withdrawal therapy as is being tested in the adjuvant setting in the SOLE trial Conclusions Our data therefore provides some clinical evidence and emphasises the relevance of withdrawal therapy The ... drafted, revised and finalised the manuscript KLC and JFR revised and approved of the contents of the manuscript All authors read and approved the final manuscript Conflict of interests The authors...
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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf
Ngày tải lên :
09/08/2014, 04:21
... metabolites 4-OH-tamoxifen and endoxifen which both have a greater affinity to the estrogen receptors and ability to inhibit cell proliferation when compared to the parent drug The key enzyme in this ... tailor treatment to patients, community and tumor factors (based on clinical, pathological and biological factors) b) To address economic considerations, cost-effectiveness and quality of life ... of innovative clinical research that address the needs of LMCs • To identify key components and infrastructure needs in LMCs to support research • To determine the key barriers to pharmaceutical...
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