personalized computational models of the heart for cardiac resynchronization therapy

... chest extending over the edge The latency of the rats to turn away or withdraw from the edge was recorded If the pups fell from the platform or did not response within 60 seconds, the latency was ... recorded The maximum duration of recording was 90 seconds Rotarod performance test The rotarod test was used for evaluating the motor and coordination performance in animals [24] The test was performed ... P21 rats with the rolling rate of rpm Rats were placed on the rod and observed for The duration of rats holding on the rod without falling down was recorded as the day one trial On the following...

Ngày tải lên: 10/08/2014, 10:20

... had a seizure Further information from the partner suggested that the couple normally drank a lot of water between them, with the mother drinking up to litres of water a day The mother had recently ... those of eclampsia, the initial treatment of which was unsuccessful It is therefore important to consider other causes of fitting when dealing with these cases, and be aware of the effect of maternal ... assess the efficacy of treatment Blood tests in both mother and baby subsequently slowly normalised This improvement allowed the mother to be extubated the next morning It was noted that the mother...

Ngày tải lên: 11/08/2014, 19:21

... USA) The data of the competitive binding assays were represented graphically with the log of concentration of the competing drug on x-axis and percentage of the radioligand bound on the y-axis The ... of 11 curve has a slope less than 1.0 The concentration of competitor that competes for half the specific binding was defined as EC50, which is same as IC50 The affinity of the receptor for the ... The affinity for the first and second site for the competing drug is designated as Ki-1 (for high affinity) and Ki-2 (for low affinity) EC50 is the concentration of competitor that competes for...

Ngày tải lên: 10/08/2014, 05:21

... hemorrhage was noted in the single antiplatelet therapy group, and one subcutaneous hemorrhage was found in the combination therapy group As for the patient in the single antiplatelet therapy group who ... However, the patient who had recurrent thrombotic infarction in the combination of antiplatelet and anticoagulation therapy group showed an INR before the recurrence of 2.0, so the possibility of inadequate ... [3, 7] The purpose of the present study was to examine the effects of these regimens on recurrence of stroke So, the primary endpoint was occurrence of stroke This study was approved by the ethics...

Ngày tải lên: 26/10/2012, 09:48

... % of otherwise healthy children 6-60 months of age It is debated by experts whether it is the quickness of the rise in temperature or the height of the temperature which triggers the seizure The ... cool washcloths to the forehead and neck Sponge the rest of the body with lukewarm (not cold) water Loosen any restrictive clothing Don’t try to hold or restrain the child or stop the seizure movements ... another febrile seizure with a subsequent fever Of those who do, about ½ will have a 3rd seizure If there is a family history, if the first seizure happened before 12 months of age, or if the...

Ngày tải lên: 26/10/2012, 10:03

... transport for emergency referral) for the pregnant woman is done by IMNCS programme organizers in the presence of her husband and other members of the family to motivate them to follow the steps for ... study explores the knowledge of men on maternal and child health issues, their awareness of their wives’ practices and the preferred means of decision-making The objective of the study is to ... danger signs of ARI and Diarrhoea of under-5 children Page of Awareness on the use of oral rehydration therapy (ORT) during diarrhoea was universal However, around one-third of the respondents...

Ngày tải lên: 12/02/2014, 19:20

... Prevention of Mother to Child Transmission of HIV, Maternal, Neonatal, and Child Health and Pediatric HIV Services Objectives of the Guidance Supporting the integration of Prevention of Mother to ... committed to the goal of virtual elimination of mother-to-child transmission of HIV by 2015 These important goals have been adopted in the context of significant scientific advances that have the potential ... of ARV prophylaxis to the mother during labor, delivery, and the immediate postpartum period; and for the first time, (3) extension of prophylaxis, based on national guidelines, to either mother...

Ngày tải lên: 12/02/2014, 19:20

... identified by the yeast twohybrid system as a novel protein that interacted with the intercellular domain of the type tumour necrosis factor receptor [17] On the basis of the sequence of the homologue, ... or control vector by the addition of adenovirus to the cell culture at a multiplicity of infection of 10 After days of infection, the cells were serum starved for 12 h and then treated 1936 Protein ... channel consisting of several proteins that is usually in a low permeability or closed state Some models have proposed the presence of other molecular components of the pore, although there is still...

Ngày tải lên: 16/02/2014, 14:20

... extracellular matrix, thereby maintaining the equilibrium between synthetic and degradative processes in the cartilage [1] Therefore, the metabolic and structural changes of chondrocytes in the articular ... concentration of 60 lm (SigmaAldrich) suspended in a final volume of mL The tubes were incubated at 30 °C for 30 min, after which the reaction was terminated through the addition of mL of cold ethanol The ... hallmark of osteoarthritis (OA) is a decrease in the number of chondrocytes, as they are the only resident cells in articular cartilage Chondrocytes regulate the enzymatic breakdown of the extracellular...

Ngày tải lên: 18/02/2014, 14:20

... carrier and the GFP or b-Gal proteins for 30 at 37 °C These differences in the time courses of transduction may depend on whether the target protein is fused to the PEP-1 vector or mixed with the PEP-1 ... Fusion with the PEP-1 vector may alter the conformation, polarity or molecular shape of the target protein, improving transduction of the fusion proteins into cells To determine whether transduced ... administered 30 before ischemia At and days following ischemia, the protective effects of the fusion proteins were confirmed by immunohistochemistry The magnitude of the protective effect of PEP-1–HSP27...

Ngày tải lên: 18/02/2014, 17:20

... though the mothers’ reportage of the size of the infant is subjective, it can be a useful proxy for the weight of the child Hence, this paper attempts to estimate the factors that influence the ... at least one-third in the proportion of infants This target is in fact, one of the seven major goals for the current decade of the “A World Fit for Children” programme of the United Nations (UN, ... expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility is accepted for the accuracy of information contained in the...

Ngày tải lên: 19/02/2014, 22:20

... variety of clinical scenarios other than acute coronary syndromes The following is a list of some of the causes for the elevation of troponin in the absence of a thrombotic occlusion of the coronary ... medical therapy is a critical component of therapy for STEMI and confers benefit in addition to that gained by reperfusion therapies, regardless of method of reperfusion (Table 6) Ancillary therapy ... sensation The site of the discomfort is usually retrosternal, but radiation is common and usually occurs down the ulnar surface of the left arm; the right arm and the outer surfaces of both arms...

Ngày tải lên: 20/02/2014, 08:20

... cells The cells were prelabeled with [14C]Thd when seeded, 44 h before the start of the experiment The resulting [14C]Thd profile (Fig 2B, crosses) typically exhibits a peak in the last third of the ... important components of the prereplication complex as well as Cdk2, which is considered to be (one of) the activating kinase(s) of the complex, after medium renewal before and at the end of hypoxic gassing ... of replication proteins or regulators as well as high resolution 2D-gels With the aid of the T24 system presented here, we hope to characterize the special state of the protein equipment of the...

Ngày tải lên: 21/02/2014, 00:20

... data will be used In the domain of neonatal care it is in the form of knowledge about artifacts In the domain of meteorology it is in the form of knowledge of what is important For example, changes ... from the input data before summarizing The example data rithms In the domain of meteorology user thresholds have been used for determining stopping criterion for segmentation In the domain of gas ... are important in marine forecasts but not in public forecasts unless gales are predicted Finally in the domain of gas turbine it is in the form of important patterns For instance, damped oscillations...

Ngày tải lên: 22/02/2014, 02:20

... together with additional phosphorylation of RPA-34 after re-oxygenation (Fig 2) indicates the occurrence of single-stranded DNA [30–34] and therefore probably the beginning of unwinding of the ... in the form of a single-stranded DNAassociated RPA trimer complex Phosphorylation of the 34-kDa subunit of RPA is not essential for unwinding of the viral minichromosome As mentioned above, the ... different phosphorylation forms of the protein Rather, the lower band may be a degradation product of the upper Recently, Schumacher et al [29] isolated a N-terminal truncated form of polymerase d with...

Ngày tải lên: 22/02/2014, 04:20

... levels of NO produced by the endothelial isoform of this enzyme are beneficial by, among other mechanisms, sustaining blood flow in the periphery of the ischemic brain On the other hand, under normal ... may provide the basis for other failures in the future [6] Therefore, a better design of protective drugs and ⁄ or protocols for stroke treatment is needed, together with the discovery of new molecular ... molecular targets for the development of innovative and effective therapeutic agents During the last decade a great deal of interest has been devoted to dissecting the role of the endocannabinoid...

Ngày tải lên: 07/03/2014, 03:20

... mouse models of ischemic stroke [87,99,100] The mechanisms of brain damage involve gelatinasemediated disruption of the BBB integrity, of edema and hemorrhagic transformation, as well as of white ... mechanisms of recovery and repair The switch from detrimental to beneficial effects seems to depend on the strength and the duration of the insult and is crucial for determining the time-window for an ... active form of the cytokine by caspase-1, formerly referred to as interleukin-1b-converting enzyme (ICE) [131–133] Inhibition of caspase-1 by Ac-YVAD.cmk affords neuroprotection in rodent models of...

Ngày tải lên: 07/03/2014, 03:20

... transmission and maintenance of LTD in the hippocampus, whereas other members of the NF-jB family might be responsible for the induction of LTD and the late phase of long-term potentiation [42] ... to the downregulation of NF-jB-mediated transcription of the B-cell lymphoma (Bcl-2) family of anti-apoptotic genes [29,36] The apoptosis of cells deprived of NF-jB activity indicates that there ... produced by the fibrillar form of b-amyloid peptide in cultured neuronal models [75] The p50 ⁄ p65 dimer is activated in the first hour of exposure to b-amyloid and precedes the expression of a characteristic...

Ngày tải lên: 07/03/2014, 03:20

... mechanisms of action) and ‘synergistic combinatorial drug therapy emerge as key requisites for efficacious stroke treatment [4] Indeed, one of the possible reasons for the lack of clinical efficacy of ... [41] The key role of PARP-1 hyperactivation in endothelial dysfunction in experimental models of diabetes underscores the pathogenetic relevance of the enzyme to disorders of this key component of ... 4–6-day treatment This, of course, would reduce the risk of side effects The latter might be further reduced by the forthcoming development of PARP isoform-specific inhibitors [84] In conclusion,...

Ngày tải lên: 07/03/2014, 03:20