pediatric malignancies retinoblastoma and wilms tumor
RETINOBLASTOMA – AN UPDATE ON CLINICAL, GENETIC COUNSELING, EPIDEMIOLOGY AND MOLECULAR TUMOR doc
... Presentations of Retinoblastoma Onyekonwu Chijioke Godson Chapter Second Malignancies in Retinoblastoma: The Real Problem 23 Basil K Williams Jr and Amy C Schefler Chapter Ototoxic Hearing Loss and Retinoblastoma ... Yi-Jang Lee, Pei-Hsun Chiang and Peter C Keng 131 Viral Oncogenes and the Retinoblastoma Family M Geletu and L Raptis 155 Preface Retinoblastoma is the first ever discovered tumor suppressor gene that ... lesions The number of tumors Their position in the retina (posterior pole and anterior retina) The tumor size (diameter and thickness) The subretinal fluid and tumor seeds The vitreous...
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Báo cáo khoa học: "Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicitty" doc
... center of pediatric radiation oncology in the country In this article we report our initial experience of HT in the treatment of pediatric malignancies, focused on analysis of tumor response and acute ... Medulloblastoma CNS 16 (24%) Ependymoma and ependymoblastoma Glioma (12%) (11%) Pineoblastoma (3%) Teratoid/Rhabdoid tumor (3%) Germinal tumor (1%) Choroid plexus tumor Tumor site/histology Abdomen (1%) ... 293,2) Tumor bed CNS Glioma (7) Tumor/ tumor bed Abdomen Neuroblastoma (7) Tumor bed 21,0 21,34 ± 0,13 Thorax Rhabdomyosarcoma (1) Right pleura 50,4 50,11 ± 0,98 0,84 1,02 730,3 PNET (Askin’s tumor) ...
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Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt
... residues were found in both leukemia and lung cancer and one serine in both tumoral and normal pancreas ENOA in tumor cells is subjected to more acetylation, methylation and phoshorylation than in normal ... overexpression in tumors and its ability to induce a humoral and ⁄ or cellular immune response in cancer patients classify ENOA as a true TAA ENOA expression is increased in tumors The overexpression ... [107–115] Acetylation, methylation and phosphorylation are the main PTMs (Table 2) Acetylation was found in cervix and colon cancer, leukemia, normal pancreatic ducts and tumoral pancreatic cells Fourteen...
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Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
... Biophysical properties of hGBP5a ⁄ b and hGBP5ta M Wehner and C Herrmann hand, interact dynamically with the bound nucleotide, and usually bind nucleotides in the micromolar range ... Results and Discussion Hydrolytic activity of hGBP5a/b and hGBP5ta In light of previous observations for hGBP1 and other large GTPases, we analysed the enzymatic activity of hGBP5a ⁄ b and hGBP5ta ... cooperativity in specific activity, with Hill coefficients of 2.4 and 1.9 and dissociation constants (KdHill) of and lm for hGBP5a ⁄ b and hGBP5ta, respectively The proteins are very similar in terms...
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Báo cáo khoa học: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors ppt
... DNA binding and transcriptional activity [63,64] Moreover, Rb and Sp1 proteins are degraded by the same proteolytic enzyme, SPase, a nuclear and cytosolic protease with cathepsin B- and L-like ... the expression (transcription, mRNA and protein levels), of both Rb and Sp1 after CDK inhibition by the chemical inhibitors UCN-01, roscovitine and olomoucine, and by the intrinsic inhibitor p21 ... 5¢-GTGCCAAT GGCTGGCAGATCA-3¢ and 5¢-ACCATCCTGCTGCA CTTGGGC-3¢ for Sp1; 5¢-CTCCACACACTCCAGTT AGGA-3¢ and 5¢-CTGATTTAAGCATGGATTCCA-3¢ for Rb; and 5¢-CGCAGTTTCCCCGACTTCCC-3¢ and 5¢-GGCAGCGCACATGGTTCCTC-3¢...
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Oral Health Care – Pediatric, Research, Epidemiology and Clinical Practices Edited by Mandeep Singh Virdi ppt
... Oral Health Care – Pediatric, Research, Epidemiology and Clinical Practices, Edited by Mandeep Singh Virdi p cm ISBN 978-953-51-0133-8 Contents Preface IX Part Pediatric and Preventive Dentistry ... Blerta Xhemajli and Merita Berisha Chapter Pediatric Dentistry – A Guide for General Practitioner 51 Mandeep S Virdi Chapter Gingivitis in Children and Adolescents 69 Folakemi Oredugba and Patricia ... poor oral health and heart disease and between poor oral health and women delivering pre-term, low birth rate babies Caries and tooth supporting structures’ diseases (gingivitis and periodontitis),...
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hematologic malignancies, methods and techniques
... because of improper handling and/ or shipping It is important that FISH probes be stored at –20°C and handled with gloves and autoclaved pipet tips A change in sample type and sample degradation ... collected and transferred, transported, and preserved in the same way as for a BM specimen Lymph node and spleen: Lymph node and spleen biopsies or samples should be collected aseptically and transferred ... Switzerland 12 Heim, S and Mitelman, F (1995) Cancer Cytogenetics, 2nd ed., Wiley-Liss New York FISH Analysis 19 FISH Analysis Avery A Sandberg and Zhong Chen Introduction 1.1 History and Principles...
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pediatric hematology, methods and protocols
... FA and DC 3.3 ABI Gel Electrophoresis and Data Analysis Add an aliquot of the PCR product (4 µL) to 3.5 mL of formamide loading buffer (95% formamide in 1X TBE and mg of dextran blue/mL) and ... of the DKC1 and hTR Genes Oligonucleotide sequences and annealing temperatures for the PCR amplification of the 15 exons of the DKC1 gene and the hTR gene are given in Table The standard composition ... 1 40 32 16 16 12 280 1.5 1.5 (see Note 8) and flush the surface of the gel with TBE buffer using a syringe and bent needle Clean and invert the comb and insert it between the plates until the...
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Báo cáo hóa học: " Mutation or loss of Wilms’ tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination" ppt
... conception and design, acquisition of data, analysis and interpretation of data and wrote the manuscript; AL, AN and OS have made substantial contributions to acquisition of data, analysis and interpretation ... local ethics board Blood and bone marrow samples Bone marrow and peripheral blood samples have been collected before vaccination and during progression in heparinized tubes and mononuclear cells ... conception and design, interpretation of data and revising the manuscript critically for important intellectual content, ET has made substantial contributions to conception and design and was involved...
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Báo cáo hóa học: " Zinc in innate and adaptive tumor immunity" pot
... lung [83], colon, head and neck [84] and bronchus [83,85,86], and in the leukocytes and granulocytes of patients with bronchus and colon cancer [86] Serum and tumor zinc levels in human cancer are ... most tumor Prostate tumor cells and skin cancer are the exception to these findings, in that zinc levels are lower in prostate tumor tissue than in normal prostate cancer [86,88] Prostate glandular ... in peritumor tissue as compared to both normal tissue and tumor itself [86] Breast, lung (likely others except prostate) Increased zinc in tumor tissue [86,87] Prostate Decreased zinc in tumor...
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Báo cáo sinh học: "Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation" doc
... information and final writing of the manuscript VM, SS, PC and EB participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript MP and GVS ... Clinical parameters were compared and analyzed through coded data RNA extraction, cDNA synthesis and Qpcr RNA was extracted from 15-25 mg and 60-80 mg of tumor and normal lung tissue specimens, ... expression, patients’ clinicopathological features and survival was assessed Materials and methods Patients and samples Frozen primary lung tumor and corresponding non-neoplastic lung specimens...
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Báo cáo hóa học: " Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice" pptx
... consecutive intratumor injections of OncSyn and OncdSyn viruses or PBS (control) every four days as described in Materials and Methods At the onset of viral intratumor injections, tumor sizes appeared ... OncSyn and OncdSyn grown HSVComparative kinetics of viral replication of wild-type HSV-1(F) and mutant viruses OncSyn and OncdSyn grown on Vero and 4T1 cells Near confluent monolayers of Vero (a) and ... error bars represent means ± standard errors (b) Tumors were excised at 42 days post implantation and visually examined Panel shows representative tumors from virus and PBS treated animals itate...
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o cáo hóa học:" Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor " potx
... information and final writing of the manuscript VM, SS, PC and EB participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript MP and GVS ... Clinical parameters were compared and analyzed through coded data RNA extraction, cDNA synthesis and Qpcr RNA was extracted from 15-25 mg and 60-80 mg of tumor and normal lung tissue specimens, ... expression, patients’ clinicopathological features and survival was assessed Materials and methods Patients and samples Frozen primary lung tumor and corresponding non-neoplastic lung specimens...
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báo cáo hóa học:" Sphingosine-1 phosphate receptor (S1p1), a critical receptor controlling human lymphocyte trafficking, is expressed in hen and human ovaries and ovarian tumors" ppt
... hen and human tissue S1P1 immunoreactions are similar in hen and human ovaries and ovarian tumors Three bands at 47, 72, 108 kDa were observed The band at 47 kDa was faint, while bands at 72 and ... was expressed in human and hen ovaries and ovarian tumors with bands at 47, 72 and 108 kDa detected by Western blot (Figure 2) There were variations in the intensity of bands at each molecular ... years) Ovarian tumors were obtained from patients with malignant tumors (n = 5; mean age 64 ± 15 years) The tumor histology and tumor grade were determined by a pathologist using standard FIGO criteria...
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báo cáo hóa học:" A biregional survey and review of first-line treatment failure and second-line pediatric antiretroviral access and use in Asia and southern Africa" pdf
... and second-line paediatric antiretroviral access and use in Asia and southern Africa J Int AIDS Soc 2011, 14(1):7 doi:10.1186/1758-2652-14-17 Cite this article as: and : A biregional survey and ... failure and second-line pediatric antiretroviral access and use in Asia and southern Africa Journal of the International AIDS Society 2011 14:17 Submit your next manuscript to BioMed Central and ... transcriptase inhibitor and Journal of the International AIDS Society 2011, 14:17 http://www.jiasociety.org/content/14/1/17 Page of Switzerland and the School of Public Health and Family Medicine,...
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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx
... prolong exposure of tumor cells to antitumor drug, EPR effect [20], and subsequently increase the therapeutic effect of antitumor drug PEG offers the advantage that it is nontoxic and non-immunogenic, ... contributions Hou ZQ, Yi YF, and Zhang QQ conceived of the study and participated in the design of the study and performed the statistical analysis and drafted the manuscript Zhan CM and Jiang QW carried ... expressed on epithelial tumors of various organs such as colon, lung, prostate, Page of 11 ovaries, mammary glands, and brain [23,24] FA is known to be non-immunogenic, and FA-conjugated drugs...
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ORAL HEALTH CARE – PEDIATRIC, RESEARCH, EPIDEMIOLOGY AND CLINICAL PRACTICES pdf
... Oral Health Care – Pediatric, Research, Epidemiology and Clinical Practices, Edited by Mandeep Singh Virdi p cm ISBN 978-953-51-0133-8 Contents Preface IX Part Pediatric and Preventive Dentistry ... Blerta Xhemajli and Merita Berisha Chapter Pediatric Dentistry – A Guide for General Practitioner 51 Mandeep S Virdi Chapter Gingivitis in Children and Adolescents 69 Folakemi Oredugba and Patricia ... poor oral health and heart disease and between poor oral health and women delivering pre-term, low birth rate babies Caries and tooth supporting structures’ diseases (gingivitis and periodontitis),...
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Báo cáo y học: "Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients: a claims-based study" pps
... pituitary tumors, the first by expanding the patient base and the second, directly In this context, using claims data, we examined whether there was potential bias in the reporting of pituitary tumors ... pituitary tumors, particularly the benign and uncertain behavior types, were also more frequent among risperidone-treated patients (Table 4) Pituitary tumor frequencies were combined across types and ... atypical antipsychotic treatment generally (and risperidone treatment specifically), and pituitary tumors, it is important to recognize that pituitary tumors of clinical relevance may still occur...
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báo cáo khoa học: "Concomitant pulmonary and thyroid tumors identified by FDG PET/CT and immunohistochemical techniques" ppt
... and resection specimens of lung and thyroid were detected by hematoxylin eosin staining (HE) and IHC PET / CT: lung tumor SUVmax: 3.69, delay: 5.17; and thyroid tumor SUVmax 19.97 HE reveal papillary ... increased FDG uptake of the tumor in terms of the SUVmax in 3.69 and the delay SUV in 5.17 (Figure1:A and B), and no abnormal FDG uptake was found in the nodule-free lung tissues and mediastinum space ... thyroid Sensitive and reliable markers such as TTF-1, Tg, CK7 and CK20 were used to further ascertain the origin(s) of the two tumors co-existing in the lung and the thyroid TTF-1 and Tg are considered...
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Báo cáo khoa học: "Intraabdominal and retroperitoneal soft-tissue sarcomas - outcome of surgical treatment in primary and recurrent tumors" potx
... postoperative complications, and perioperative mortality, as well as longterm survival None of the tumors types (including GIST tumors) received neoadjuvant treatment R1 and R2 GIST tumors received Imatinib ... patients to the center for diagnosis, evaluation, and surgery Data on primary and recurrent tumor were collected including preoperative symptoms and diagnostic methods Patients with primary sarcoma ... primary tumor while 28 had a first recurrence of tumor 13 of the contacts had second- or more recurrencies and were excluded, so the population included in the analysis was 73 primary and 28 recurrent...
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