pathophysiology of allergic diseases

Ngày tải lên: 08/08/2014, 21:20

... Transcription factors of Th2 cytokines Mechanism Inhibition of synthesis of transcription factors on the level of transcription Inhibition of synthesis of transcription factors on the level of translation ... mechanisms of allergic sensitization allows the development of novel immunomodulatory strategies aimed at primary prevention of allergen-mediated diseases These are based either on the inhibition of ... al, Primary Prevention of Allergic Diseases Table Immunomodulatory Concepts for Prevention of Allergen-Mediated T Helper Immune Response No in Figure 1 Principle Inhibition of Th2 cytokine synthesis...

Ngày tải lên: 08/08/2014, 21:20

Ngày tải lên: 08/08/2014, 21:20

... allergic diseases 1.1.1 Definitions 1.1.2 Epidemiology of Allergic Diseases in Childhood 1.1.3 Immunological basis of atopy and allergic diseases 1.1.4 The microflora ... development of sensitization and allergic diseases during early infancy The primary aim of this study is therefore to assess the effect of administration of probiotics from birth on the prevention of allergic ... suggested that disruption of gut microbiota could drive the development of allergic airway response without any previous systemic priming The ‘microflora hypothesis of allergic diseases has been postulated...

Ngày tải lên: 11/09/2015, 21:39

... allergy It offers an in-office, rapid, and sensitive assessment of allergen sensitization General considerations of skin testing should be discussed first before exploring the specific details of food ... biological potency of these extracts often occurs between lots Fruits and vegetables produce extracts that contain particularly labile allergens, and thus the use of fresh produce may offer increased ... Children less than year of age may have IgE-mediated allergic disease related to a particular food in the absence of skin test reactivity [13] While the diagnostic sensitivity of negative puncture...

Ngày tải lên: 08/08/2014, 21:20

... effect of probiotics in allergic diseases The therapeutic and preventive role of probiotics in atopic dermatitis has been extensively studied Prevention of atopic dermatitis The prevention of allergic ... composition of gut microbiota of allergic infants a target of bifidobacterial therapy at weaning? Gut 2002, 51(1):51-5 Kirjavainen PV, et al.: Characterizing the composition of intestinal microflora ... of these studies show a slight benefit over placebo for the treatment of atopic dermatitis However, several of the studies show no benefit b) The role of probiotics in Asthma A small number of...

Ngày tải lên: 08/08/2014, 21:20

... significant Onset of respiratory allergic diseases Respiratory allergic diseases appeared in 66 cases out of 176 (37.5%) Of the 66 cases, 36 patients out of 176 (20.5%) developed only RC, 18 out of 176 ... of AD into respiratory allergic diseases Methods A Study design A.1 Phases of the study This study consisted of two phases: 1) a retrospective analysis of children affected by AD at the age of ... mean age of appearance of asthma was 3.33 years Out of 66 cases with respiratory allergic diseases, 30 (17%) had asthma, which in 18 cases was isolated and in 12 associated with RC All of the participants...

Ngày tải lên: 13/08/2014, 13:22

... STUDY OF GENE AND PROTEIN VACCINES FOR ALLERGIC DISEASES IN MICE TAN LI KIANG (B.Sc Hons., University of Edinburgh, UK) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PAEDIATRICS ... RT-PCR analysis of cytokine expression profiles of splenic 87 CD4+ T cells Figure 2.8 Effect of IL-13 blockade in mice primed with 10 μg of rDer p 88 protein Figure 3.1 Monitoring of target preparation ... extracts of mites are capable of inducing allergy symptoms of the respiratory tract Inhalation of dust mite allergens by sensitive individuals can cause allergy diseases such as bronchial asthma, allergic...

Ngày tải lên: 14/09/2015, 14:20

... and incidences of allergic asthma particularly in children are increasing worldwide The role of interleukin-13 (IL-13) as one of the major players in the genetics of allergic diseases have been ... leading to a release of a host of pro-inflammatory mediators, thus causing mucosal inflammation and the physical manifestation of the disease The role of IgE in the development of allergic disorders ... shown the importance of IL-12 in the prevention of Th-2 immune responses in murine in vivo models of allergic diseases [46, 49], and adds evidence that endogenous production of IL-12 is protective...

Ngày tải lên: 30/09/2015, 14:23

... birth In Hungary 25.2% of congenital abnormalities were prevented by these methods Previously the selective abortion, i.e termination of pregnancy after the prenatal diagnosis of severe fetal defects ... Hungary about 20% of major congenital abnormalities (8.7% in the total group) were terminated after the prenatal diagnosis of defects Tertiary prevention: complete recovery of congenital abnormalities ... for their prevention Conflict of interest The author has declared that no conflict of interest exists References Czeizel AE, Intődy Z, Modell B What proportion of congenital abnormalities can...

Ngày tải lên: 02/11/2012, 11:12

... robust allergic lung inflammation Induction of allergic lung inflammation Naïve mice were injected i.p at day and day with 10 µg chicken egg ovalbumin (Sigma) in 100 µl of PBS mixed with 100 µl of ... [26] Most of the inflammatory responses described above arguably fall into the category of Th1-mediated effector mechanisms Moreover, they are often associated with local development of lymphoid ... transfer of a small number of antigen specific Th2 cells combined with antigen challenge [28, 31-33] These results suggested that lung allergic inflammation was not dependent on any “conditioning” of...

Ngày tải lên: 03/11/2012, 11:24

... conditions of license 326 Therapy of Selected Diseases Allergic Disorders IgE-mediated allergic reactions (p 72) involve mast cell release of histamine (p 114) and production of other mediators (such ... treatment of acute myocardial infarction Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license yes 312 Therapy of Selected Diseases ... Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 314 Therapy of Selected Diseases Hypotension The venous side of the circulation,...

Ngày tải lên: 15/12/2013, 13:15

... because of an increased risk of valve thrombosis, of haemorrhagic complications, and of offspring complications Pregnancy is associated with increased maternal risk The character and magnitude of ... assessment of the risk–benefit ratio Estimates of expected health outcomes for larger populations were included, where data exist The level of evidence and the strength of recommendation of particular ... Group Valvular Heart Disease of the ESC,4 the guidelines of the German Society of Cardiology (German Society of Cardiology),5,6 and the ESC Task Force on the Management of Valvular Heart Disease...

Ngày tải lên: 12/02/2014, 12:20

... imaging technique (SENSE factor of 2) Imaging time of DWI was 90 s for 20 slices Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue On the other hand, ... They showed that the ADC value of the 752 Table DWI studies with ADC values in ovarian diseases Authors of Study Year of Publication Journal Tumour & Tissue (no of subjects) b-values Moteki et ... usefulness of DWI for the detection of metastatic bone tumor Current status and future directions of DWI for gynecological diseases Figure 12 shows a decision-making diagram in the MRI diagnosis of gynecological...

Ngày tải lên: 13/02/2014, 06:20

... Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School and Institute of Public Health of the University of Porto (ISPUP), Al Prof Hernâni ... 4200-319, Portugal Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School and Institute of Public Health of the University of Porto (ISPUP), Porto, ... cause of death in 2006, followed by cancer, and these two groups of diseases were responsible for more than half of all deaths [6] Portugal is characterized by a very higher contribution of cerebrovascular...

Ngày tải lên: 15/02/2014, 04:20

... a ­  • Activation of macrophages  • Infection controlled  Weeks  Th1+ IL­4  • TNF­a becomes toxic  • NECROSIS  • Failure to control bacterial growth  Toxicity of TNF­a;  role of IL­4 ?  TNF­a ... Moreira et al. (1993) J. Exp. Med. 177, 1675­1680 The use of IL­4 gene knockout Balb/c mice to  look at the role of IL­4 in necrosis and fibrosis in  pulmonary TB  Hernandez­Pando et al  (2004) Eur J Immunol 34, 174­183  • Role of IL­4 in necrosis confirmed  ... strong “Th1” response  … so why does anyone get the disease ?? The Th1 response of the tuberculosis patient fails to eliminate  The problem of “compliance”.  The patient feels better too soon!  “  compliance ...

Ngày tải lên: 15/02/2014, 13:20

... Shimano Physiology and pathophysiology of the SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different regulatory ... Triglyceride 617 Physiology and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth and the ... summarize, SREBP-1c is a physiological regulator of lipogenesis, and activation of SREBP could contribute to obesity-related pathophysiology through modification of tissue-specific gene expression as shown...

Ngày tải lên: 18/02/2014, 13:20

... numerous topics See Table of Contents for location of specific information This document replaces all previous versions of the “Prevention and Control of Communicable Diseases, A Guide for School ... Mark Jenkerson Bureau of HIV, STD, & Hepatitis Melissa Van Dyne Office of Veterinary and Public Health Karen Yates Section for Child Care Regulation Sue Porting Section of Epidemiology for Public ... individual cases require professional judgment beyond the scope of this document Practitioners and users of this manual should not limit their judgment on the management and control of communicable disease...

Ngày tải lên: 05/03/2014, 10:20

... THE ENCYCLOPEDIA OF ENDOCRINE DISEASES AND DISORDERS THE ENCYCLOPEDIA OF ENDOCRINE DISEASES AND DISORDERS William Petit Jr., M.D Christine Adamec The Encyclopedia of Endocrine Diseases and Disorders ... risk of developing some dangerous and often fatal forms of cancer, particularly tumors of the ovary and the pancreas Older individuals are also more likely to develop belownormal levels of calcium ... Symptoms of Acromegaly There are many different indicators of the presence of acromegaly Some signs and symptoms of this disorder are as follows: • Oily skin • Headaches (in 60 percent of patients)...

Ngày tải lên: 06/03/2014, 00:20

... 179 Of the Jaundice, 206 Of Tumours of the Breast, 216 Of Paralytic Complaints, 219 Of an Incontinency of Urine, 223 Of a Stoppage of Urine, 227 Of the Epilepsy, 237 Of the Small-Pox, 243 Of Erisypilatous ... PAGE Of the Malignant and Petechial Fever, Of the Dysentery, 57 Of the Cholera Morbus, 97 Of the Inflammatory Fever, 104 Of the Angina, 109 Of the Pleurisy, 111 Of the Peripneumony, 115 Of the ... 124 An Account of the Diseases which were most by Donald Monro Of the Epidemical Catarrhal Fever of April 1762, 137 Of the Rheumatism, 141 Of the Autumnal Remitting Fever, 154 Of the Intermitting...

Ngày tải lên: 06/03/2014, 20:20