pathogenic mechanisms in asthma and copd

... matrix proteins may play a role in the remodelling of airways and blood vessels in COPD In COPD patients, as compared to non -COPD patients an increased staining for fibronectin in the neointima, ... changes in the bronchial wall in both asthma and COPD, there are distinct differences in detail between these situations Angiogenesis seems to be a typical finding in asthma, while, in COPD, little ... combination of haematoxylin-eosin, Masson trichrome, PAS, alcian blue-PAS and orcein, and evaluated microvessels in the supepithelial lamina propria, showing an increase in vessel number and...

Ngày tải lên: 12/08/2014, 11:22

... sources included in the model were: road traffic, shipping, aviation, railroad, industries and larger energy and heat producers, small scale heating, working machines, working vehicles, and working ... especially in relation to the prevalence of COPD/ chronic bronchitis Results discussion Although asthma and COPD have many risk factors in common and often coexist in clinical settings, and there ... restricting the groups to those with asthma but not COPD, and COPD but not asthma, to exclude confounding by comorbidity This process was also followed for symptoms Relative risk was estimated using...

Ngày tải lên: 06/03/2014, 19:20

... * HRQoL, COPD, and asthma In the current analyses, we chose to join self-reported asthma and spirometrically defined COPD in one group Firstly, aging is an established risk factor for COPD [17,30,31] ... shortness of breath in the last 12 months Woken by attack of coughing in the last 12 months Usually cough first thing in the morning in winter? Usually cough in day or night during winter? Voll-Aanerud ... Questionnaire information Information on respiratory symptoms was obtained in ECRHS II by questions 1-11 listed in appendix Asthma was defined as ever having had asthma, question 12 in appendix...

Ngày tải lên: 20/06/2014, 16:20

... from the remaining samples after routine blood examination was performed according to DEM procedures Routine tests undertaken include full blood examination, electrolyte examination and ECG measurement ... between QTc interval and albuterol levels Recorded QTc interval and (R)-, (S)- and total albuterol levels and are shown in (a), (b) and (c) respectively (R)-, (S)- and total albuterol levels in subjects ... function and QTc interval in patients with acute severe asthma and COPD in the emergency department International Journal of Emergency Medicine 2011 4:30 Submit your manuscript to a journal and benefit...

Ngày tải lên: 21/06/2014, 03:20

... useful in monitoring asthma and COPD patients during infectious episodes, but this clearly requires further investigation Decreased pH values in EBC in patients with inflammatory diseases like asthma ... (HC), asthma, COPD and cold Comparison of pH in EBC obtained by either RTube or ECoComparison of pH in EBC obtained by either RTube or ECoScreen in healthy controls (HC), asthma, COPD and cold ... manuscript SD helped in acquiring patient data PH, PS, CV, RB, RS and KR were involved in drafting and revising the manuscript SG carried out the logistics and appointed all included study patients...

Ngày tải lên: 12/08/2014, 14:20

... We combined polythymidine and F508del genotypes [1], and examined associations between 11 different genotype combinations, and annual FEV1 decline and risk of asthma or COPD We also examined whether ... decline of 14 ml in 9T/9T, 3.8 ml in 7T/9T, 61 ml in 6T/ 7T, 23 ml in 5T/9T, ml in 5T/7T, 31 ml in 9T/9T F508del, ml in 7T/9T F508del, 72 ml in 7T/7T F508del, and 72 ml in 5T/9T F508del individuals ... Intron-8 polythymidine tract and ∆F508 genotype Figure thymidine tract spirometry genotype Odds ratios for and F508deldefined COPD by intron-8 polyOdds ratios for spirometry defined COPD by intron8...

Ngày tải lên: 12/08/2014, 18:22

... and maintained data records CK and JBL were members of the external advisory committed and worked with JW in planning and interpreting the studies JFD confirmed dosimetry and treatment planning ... MartinCaballero J, Marshall GM: The cyclin-dependent kinase inhibitor, p21 (WAF-1), promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein in cancer cells Carcinogenesis ... The data in the right hand show four lines response in a relatively linear pattern (R2 = 0.7271) but the cell lines in the right hand panel not The best fit correlation line for the data in the...

Ngày tải lên: 09/08/2014, 09:20

... CD25 in COPD and smokers, suggesting the presence of regulatory T-cells [6] It is of importance to verify and evaluate regulatory T cells in COPD in more detail, as these cells may play a role in ... and Lee et al reported similar findings in patients with emphysema [9] Recently, we found a decreased proportion of CD4+CD25bright cells in ex-smoking subjects with COPD compared to smoking COPD ... would restrain cigarette smoke-induced inflammatory activation and, thus, the development of COPD [10] In contrast, in smokers who develop COPD, the T regulatory response is supposed to be inappropriate,...

Ngày tải lên: 12/08/2014, 13:22

... iron-containing haem proteins, including cytochromes and NADPH oxidases, were proposed some time ago as potential O2 sensors in a variety of cellular systems In NEBs, a number of lines of evidence point ... [25], suggesting a potential interaction of different ROS-generating systems acting on different timescales Identity of the O2-sensing K+ channels An interesting parallel has arisen in CB and NEB ... K2P channel; TWIK, tandem of P-domains, weakly inward rectifying K2P channel In NEBs, a similar controversy has arisen, in part owing to the vexed nature of consistently isolating native NEB cells...

Ngày tải lên: 12/08/2014, 18:20

... polymorphisms in candidate genes for asthma/ atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate ... of inconsistent findings, it is intriguing that chromosomal regions linked to asthma have also shown evidence for linkage to other inflammatory and autoimmune diseases (such as psoriasis, inflammatory ... other genes involved in the allergic inflammation (e.g IL-4Rα [21], β2AR [24]) We can therefore speculate that inconsistent findings in the genetic studies of asthma and atopy summarized in this...

Ngày tải lên: 12/08/2014, 18:20

... countries, and reactivation of latent infection in elderly persons who lived in Singapore during the high incidence period may be factors involved in maintaining the TB incidence in Singapore 2-3 ... only to understanding the immunology of host-pathogen interactions in this disease, but also clinically for risk stratification of TB contacts and in assessing vaccine efficacy in clinical trials ... key findings 155 8-2 Future work 156 8-2.1 Investigating if in vitro mycobacterium inhibition and cytokine profiles correlate with longterm protection against TB infection...

Ngày tải lên: 14/09/2015, 14:05

... studies indicate that proinsulin and VSV G protein are segregated into distinct vesicles from those containing the ER retrieval KDEL receptor.46 Interestingly, the proinsulin-containing vesicles ... Hormones in the Secretory Pathway Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing Prohormone cleavage and activation continues in the ISG, the vesicular intermediate linking ... Proenkephalin Processing Enzyme in Chromaffin Granules 92 Participation of PC1/3 and PC2 Subtilisin-Like Proteases, and 70 kDa Aspartyl Protease (PCE) in Proenkephalin Processing in Chromaffin Granules...

Ngày tải lên: 03/10/2016, 12:15

... Powers L, Gerke A, Hunninghake GW: Vitamin D decreases respiratory syncytial virus induction of NF-kappaBlinked chemokines and cytokines in airway epithelium while maintaining the antiviral state ... authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: ... http://respiratory-research.com/content/12/1/31 96 Leandro AC, Rocha MA, Cardoso CS, Bonecini-Almeida MG: Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Tolllike receptor 2, nitric oxide synthase 2, and interferon-gamma...

Ngày tải lên: 12/08/2014, 13:22

... for inducing and maintaining psoriasis It is also envisaged that CD8+ T-cells are involved in the control of the Th1 polarization that is observed in psoriasis lesions, and that fluctuations in ... vessel and underlying tissue Also, inflammatory cells roll along the blood vessel wall by the interaction between selectins (E and P-selectin) expressed by endothelial cells and selectin ligands ... of pro-inflammatory cytokines by the keratinocytes In this fashion, the cytokine network in psoriasis can become a self-sustaining process Thus, the production of pro-inflammatory cytokines together...

Ngày tải lên: 25/10/2012, 11:40

... phosphatidylethanolamine (PtdEtn) and the mixture of phosphatidylserine (PtdSer), PtdIns and sphingomyelin The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns of brain, heart, spleen, kidney and ... 1-stearoyl-2-arachidonoyl-PtdIns is the predominant molecular species even in codfish roe [26] and salmon sperm [27], salmon liver [28] and rainbow trout retina [29] If molecular conservation of PtdIns is found in marine ... PtdIns origin [25] In general, lipids from terrestrial mammals are rich in n)6 series PUFAs, such as linoleic acid and arachidonic acid In contrast, the predominant PUFAs in lipids from marine...

Ngày tải lên: 08/03/2014, 08:20

... modulated by lumican-evoked signaling, including vinculin and focal adhesion kinase [82] Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhesion ... detail In analogy to decorin, lumican inhibits tumor cell growth in soft agar by increasing the expression of the cyclin-dependent kinase inhibitor p21WAF1 [72] Again, similar to decorin, these ... overlapping with the EGF-binding domain [32] The structural constraints of the EGFR binding region support a stochiometry of : for the decorin protein core and EGFR, suggesting that decorin is biologically...

Ngày tải lên: 15/03/2014, 23:20

... protein aggregation, played an important role in the protein function Our approach to the study of protein structure and dynamics in such media has been focused on understanding how proteins are ... 13 Halling PJ (1990) High-affinity binding of water by proteins is similar in air and in organic solvents Biochim Biophys Acta 1040, 225–228 14 Yang PH & Rupley JA (1979) Protein–water interactions ... more complete understanding of the structural properties of this enzyme in organic solvents is shown in Fig Cutinase was simulated in five different organic solvents of increasing dielectric constant...

Ngày tải lên: 16/03/2014, 10:20

... animal dander, etc • Ensuring proper maintenance of heating and air conditioning systems • Installing HEPA filters—which trap very small particles • Planning for ongoing improvement of the indoor ... partners in the planning and decision making involved in the child’s welfare Both IDEA and “504” outline student evaluation procedures and stipulate the creation of individual health plans—an Individualized ... care to students and staff by responding to complaints, dealing with problems (establishing or disproving causation between, for example, poor IAQ and health complaints), and foreseeing potential...

Ngày tải lên: 23/03/2014, 23:20

... increasingly important role in the survey as a means of enhancing topic coverage in the Core section The unintended result was an increasingly unwieldy survey instrument and longer interviewing ... Association Asthma Clinical Research Centers found that the inactivated influenza vaccine is safe to administer to adults and children with asthma, including those with severe asthma. 3 Influenza ... asthma mortality and morbidity rates continue to plateau and/ or decrease Mortality figures due to asthma have been continuing declining for the past years The number of deaths due to asthma in...

Ngày tải lên: 23/03/2014, 23:20

... the glucose tolerance and insulin sensitivity of the ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and obesity-related metabolic ... association between ApoE4 phenotype and insulin and glucose levels became stronger with increasing body mass index [60,61] These findings again raise the interesting possibility that, although hyperplastic ... suggesting that, in the absence of ApoE, decreased plasma lipid delivery to insulin sensitive tissues improves insulin sensitivity and prevents the development of diet induced obesity Using an...

Ngày tải lên: 29/03/2014, 22:21