parkinsons disease oxidative stress and therapeutic approaches

... al Particle and Fibre Toxicology 2011, 8:20 http://www.particleandfibretoxicology.com/content/8/1/20 RESEARCH Open Access Ambient particulate air pollution induces oxidative stress and alterations ... resistance, oxidative stress, alteration of vasomotor tone, vascular and visceral inflammation, adiposity, and Page of 14 atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice and other several ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis

Ngày tải lên: 06/03/2014, 19:20

... peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases Peripheral neuropathy is a common disorder seen by many specialists and can pose ... PERIPHERAL NEUROPATHY – ADVANCES IN DIAGNOSTIC AND THERAPEUTIC APPROACHES Edited by Ghazala Hayat Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Edited by Ghazala Hayat Published ... Diagnostic and Therapeutic Approaches 2.2.2 Neural stem cells (NSCs) Neural stem cells (NSCs) have the ability to differentiate into neurons, astrocytes and oligodendrocytes (Parker, Anderson et

Ngày tải lên: 17/03/2014, 02:20

... and blood urea nitrogen levels and the degree of histological abnormalities were markedly lower in group than in group (all p < 0.03) The mRNA expressions of inflammatory, oxidative stress, and ... protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury Methods: Adult male Sprague-Dawley (SD) rats (n = 24) were equally randomized into group (sham ... anti-inflammatory, anti -oxidative, and anti-apoptotic biomarkers were higher in group than in group (all p < 0.03) Immunofluorescent staining showed a higher number of CD31+, von Willebrand Factor+, and heme

Ngày tải lên: 18/06/2014, 19:20

... against oxidative stress [7] was verified by testing the correla- tion between levels o f 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a def ense against oxidative ... cardiovascular and pulmonary diseases [1]. Among the different mechanisms proposed to explain these adverse effects, the production of reactive oxygen species (ROS) and the generation of oxidative stress ... days. We collected urine samples before and after each shift, and quantified an oxidative stress biomarker (8- hydroxy-2’-deoxyguanosine), the reducing capacity and a biomarker of PAH exposure (1-hydr

Ngày tải lên: 20/06/2014, 00:20

... refined our understanding of the etiology and pathogenesis for both peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases. Peripheral ... – ADVANCES IN DIAGNOSTIC AND THERAPEUTIC APPROACHES Edited by Ghazala Hayat Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Edited by Ghazala ... advances in therapeutic approaches. Gene and cell therapy is the future of many disorders, especially in peripheral nervous system disorders. Cell therapy in diabetic neuropathy and ischemic

Ngày tải lên: 27/06/2014, 10:20

... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... I: Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy Pharmacol Ther 2006, 111:476-494 Rahman I, Biswas SK, Kode A: Oxidant and antioxidant balance in the airways and ... vitro and in rat lungs in vivo Am J Physiol Lung Cell and Mol Physiol 2006 (Epubmed) Rahman I, MacNee W: Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease

Ngày tải lên: 12/08/2014, 16:20

... complex, two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, 2007). ... both pro-survival role and pro-death role (White and DiPaola, 2009). On the one hand, autophagy functions as a tumor suppressor maintaining cellular integrity and genomic stability (Liu and Ryan, 2012;

Ngày tải lên: 22/10/2015, 21:19

... fragmentation and Comet assay on isolated splenocytes and their prevention by resveratrol (5 and 10 μM), catechin (10 and 20 μM), curcumin (5 and 10 μM) and α-tocopherol (5, 10 and 20 μM) In ... molluscicidal and weedicidal activities and is employed for control of bacterial and fungal diseases of fruits, vegetables, nuts and field crops, algae in domestic lakes and ponds and in gardening ... concentrations of flubendiamide and copper alone, and also along with the antioxidants- resveratrol (5 and 10 μM), curcumin (5 and 10 μM), catechin (10 and 20 μM) and α-tocopherol (5, 10 and 20 μM) Solutions

Ngày tải lên: 30/05/2020, 21:22

... peroxidation and H2O2 and NO levels as a marker of oxidative and nitrosative stress were estimated in testicular tissue Previous studies authenticated the prominence of oxidative stress in the ... antioxidants and oxidative stress markers in testis Development of testicular impairment followed by CP exposure is mainly ascribed to free radical intervened oxidative distress and attenuation ... enzyme levels in the welfare of oxidative trauma in vivo AHE treatment significantly ameliorated the increased levels of oxidative stress markers, i.e TBARS, H2O2 and NO, and pre-treatment restored

Ngày tải lên: 23/07/2020, 23:46

... context of oxidative stress and mineral imbalance and immuno regulations are equally important and remain less explored Accumulating evidence indicates a close bidirectional communication and regulation ... phagocytosis and reactive oxygen species generation) Mast cells can modulate thyroid function Therefore, evaluation of oxidative stress and mineral imbalance along with mast cell activity and neuroendocrine ... mineral profile (Iron, Zinc, Copper and Manganese), oxidative stress markers (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, CatalaseCAT and total antioxidant capacity-TAC),

Ngày tải lên: 20/09/2020, 19:30

... CPT-induced oxidative stress and not reduced DNA damage Our results also reveal the novel finding that knockdown of ATG5 protein reduces both basal oxidative stress and drug-induced oxidative stress ... CPT-induced oxidative stress Autophagy inhibition also reduced basal oxidative stress level To our knowledge, this is the first report of autophagy inhibition-mediated reduced basal oxidative stress ... autophagy [22] and we suspect that autophagy inhibition may affect levels of endogenous antioxidants With observed CPT-induced oxidative stress in this study and reports of oxidative stress induced

Ngày tải lên: 05/11/2020, 05:24

... NH2-terminal kinases (JNK), and p38 kinases, are MAPK cascades activated by cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress [9, 10] As a ... role against oxidative stress- mediated diseases like diabetes, obesity, cardiovascular disease, etc [13] However, the molecular mechanism by which curcumin decreases the oxidative stress remains ... effective in the management of diet-induced oxidative stress and could be explored as a therapeutic adjuvant against complications associated with obesity and diabetes Keywords Glutathione peroxidase

Ngày tải lên: 01/11/2022, 09:55

... preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice Methods and results: Eight-week-old C57BL/6 J mice (n=24) were ... Access Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, ... obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, weeks) Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected

Ngày tải lên: 02/11/2022, 09:23

... of oxidative stress [6,7] To determine whether the enhanced IL-8 expression in palmitatetreated Gi HepG2 cells was due to oxidative stress, the ROS level of Sc and Gi HepG2 cells in control and ... oxidative stress Modulation of IL-8 production by glutathione peroxidase and curcumin To corroborate that oxidative stress is a causative agent of IL-8 up-regulation in palmitate-treated Sc and ... relationship between NF-κB signaling and G6PD deficiency-derived oxidative stress in inflammation Antioxidants have been shown to exert the inhibitory effect on oxidative stress and inflammatory response

Ngày tải lên: 02/11/2022, 10:43

... (ARD), traffic cops (TC) and office workers (OW) Higher levels of oxidative stress and inflammation markers in serum of ARD subjects were observed as compared to OW and TC Uni and multivariate analyses ... this study, we monitored serum oxidative stress and immunological markers and untargeted urine metabolic profiling of ARD subjects as case and office workers: OW and traffic cops: TC as controls, ... existence of exposure specific metabotypes in biofluids of ARD, OW and TC groups Monitoring serum oxidative stress and inflammation markers and urine metabolites by NMR may be useful to characterize

Ngày tải lên: 19/11/2022, 11:46

... 09 August 2016 Inhibition of Autophagy Enhances Curcumin United light irradiationinduced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells Tianhui Niu1, Yan Tian2, Zhusong Mei1 ... apoptosis, proliferation and autophagy in human melanoma A375 cell The results showed that red united blue light irradiation efficaciously synergized with Cur to trigger oxidative stress- mediated cell ... approach4 So far, the combination of phototherapy and chemotherapy is considered to be an efficient method to lessen the dose of chemotherapeutic drugs and reduce the harmful side effect5,6 Phototherapy

Ngày tải lên: 04/12/2022, 14:58

... pronounced susceptibility to oxidative stress and to radicals due to their low levels of anti-oxidants and radical scavangers11,12 In primary cultured OPCs, oxidative stress caused by exposure to ... expression of MBP and CNP, similar to that observed at 21% O2 These data indicate that culturing OPCs at 21% O2 negatively affects development and maturation Both enhanced oxidative stress and reduced ... (A2B5, O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors

Ngày tải lên: 04/12/2022, 15:55

... MDA, NO, DNAF, Ca2+ and XO activity, while it decreased GSH level, SOD and CAT activities as compared to the C groups; γ-radiation increased oxidative stress (OS), LPO, apoptosis and induced testes ... γ-radiation (HR and RH groups, respectively) decreased the levels of MDA, NO, DNAF and Ca2+ but increased GSH level and the activities of SOD, CAT and XO as compared to R group and this indicates ... fruits and vegetables as well as in food products and beverages derived from plant, such as tea and olive oil [9] It is the predominant flavonoid in lemons and oranges while the peel and membranous

Ngày tải lên: 04/12/2022, 16:05

... orders@intechopen.com Oxidative Stress and Diseases, Edited by Volodymyr Lushchak and Dmytro V. Gospodaryov p. cm. ISBN 978-953-51-0552-7 Oxidative Stress: Cause and Consequence of Diseases 17 ... complex I associated with Oxidative Stress: Cause and Consequence of Diseases 15 enzymes of these two big groups may lead to oxidative stress and consequent diseases, among which cancer, ... understanding and advise them quite novel and non-standard approaches to find and decipher mechanisms of diseases. Finally, we would like to thank all authors for their contributions and hard...

Ngày tải lên: 12/02/2014, 16:20

... The Basal Levels of Active and Inactive Plasma Renin Concentration in İnfancy and Childhood. Clin Sci 67:383-387. Hemodynamics – New Diagnostic and Therapeutic Approaches 14 pathology. ... Zubarev, 2001). Hemodynamics – New Diagnostic and Therapeutic Approaches 12 observed. In benign neoplasia, on the other hand, no specific and measurable Doppler flow spectrum has been reported. ... Hemodynamics – New Diagnostic and Therapeutic Approaches 24 Chang YJ, Chan IP, Cheng FP, Wang WS, Liu CP & Lin SL. (2010). Relationship between Age, Plasma Renin Activity, and Renal Resistive Index...

Ngày tải lên: 19/02/2014, 23:20