parathyroid hormone related protein pthrp in tumor progression
Báo cáo y học: " Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation" pps
... [19] ATLL cells express factors such as interleukin-1, tumor necrosis factor β, parathyroid hormone- related protein (PTHrP) , macrophage inflammatory protein- 1α (MIP-1α) and receptor activator of ... detectable by RT-PCR There was no increase in PTHrP mRNA or protein expression in unstimulated PBMCs during culture in vitro IL-2 stimulation up-regulated PTHrP mRNA expression in the first week (3.8 to ... competing interests Enzyme Linked Immunosorbant Assays p19 Gag protein in the culture supernatant was measured using a commercially available ELISA kit (Zeptometrix, Buffalo, NY) MIP-1α protein in...
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Báo cáo y học: "Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis" pptx
... factor receptor superfamily)-interacting serine-threonine kinase and 2; TNFAIP, tumor necrosis factor alpha-induced protein; TNFR, tumor necrosis factor receptor; TNFRSF, tumor necrosis factor receptor ... Gauthereau X, Klein C, Pairault J, Fève B, Chambaut-Guérin AM: Tumor necrosis factor-alpha-induced adipose -related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis ... upregulated in joints and spleens in mice with GPIinduced arthritis Administration of anti-TNFα mAb reduced TIARP mRNA in splenocytes In arthritic mice, TIARP mRNA was expressed mainly in CD11b+ cells in...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... determinant behind its signaling capacity The existence of a C-terminus domain (C-domain) emerged from a prediction of the 3D structure of a single-chain heparanase enzyme [73] In this protein 3894 ... primary tumor [102] The possible involvement of heparanase in tumor selfseeding is supported by the timing of its induction during tumorigenesis and its prometastatic function Using the RIP-Tag2 tumor ... variant Almost all protein- coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
... from proteins involved in melanin synthesis such as MelanA/MART-1, tyrosinase related protein (TRP) -1, TRP-2, gp100 and tyrosinase [59] Unfortunately, there has been limited success in vaccination ... to TAMs in other parts of the tumor [8,30] In summary, inflammation and the immune system play critical roles in both tumor suppression and tumor progression Understanding the complex interactions ... tumor progression 96 Figure 23: Diagram illustrating the progression of tumors in RETAAD mice 99 Figure 24: In silico modeling of tumor growth in non-vascularised tumors...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
... disseminated cancer cells by 80% (reduction seen in primary tumor) Therefore (4) 𝑘𝑘 𝑑𝑑 = 0.2𝑘𝑘 𝑐𝑐 By combining (2), (3) and (4), one finds (5) 𝐷𝐷𝐷𝐷𝐷𝐷 𝑐𝑐 � 𝐷𝐷𝐷𝐷𝐷𝐷 = 𝑑𝑑 Therefore, even an 80% inhibition ... 2: Immune profiling gating strategy Identification of immune subsets in single-cell suspension of RETAAD tumors The figure shows the strategy used to enumerate immune cells in tumors E Appendix ... 5: Alternate inhibitors of HGFR, EGFR and TGF-βR1 Alternative Inhibitors block PMN-MDSC induced EMT Alternative inhibitors block PMN-MDSC induced EMT in NBT-II cells AG1478 – EGFR inhibitor, SGX523...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 1
... maintenance of persisent iMTOCs at nuclear envelope 44 3.1.1 Lack of microtubule binding protein Mia1p results in fewer interphase Microtubules 44 3.1.1.1 Mia1p is a microtubule binding protein ... Mto1p and Mto2p 12 1.2.3 Organizing microtubule bundles 13 1.2.3.1 Minus-end-directed motor protein Klp2p 14 1.2.3.2 Bundling protein Ase1p 14 1.2.3.3 Model of maintaining ordered microtubules 15 ... poles and NE division fails in Mia1p-overexpressing cells 80 3.2.3 Spindles in Mia1p-overexpressing cells are bipolar and require the microtubule-crosslinking protein, Ase1p, for their assembly...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 2
... thus contributing to maintenance of the antiparallel linear microtubule arrays in interphase cells 1.2.3.2 Bundling protein Ase1p Another protein which functions in organizing antiparallel microtubule ... tips by depositing the kelch-repeat protein, Tea1p, at the cell tips There, Tea1p functions in polarity establishment by recruiting a complex, forminbinding protein Bud6p and the formin, For3p, to ... system identified a partner of D-TACC protein, another centrosomal protein -Minispindles (Msps), making a breakthrough in understanding normal function of TACC protein (Lee et al., 2001) Msps belongs...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 3
... 1mM GTP] containing 5% milk and then with taxol-stabilized bovine brain 3X microtubules (50μg/ml) in the same buffer, followed by washing and immunoblotting withTAT1 anti-tubulin antibodies 2.2.5 ... Imaging, Sunnyvale, CA) For imaging of microtubule dynamics, S pombe cells expressing αtubulin-GFP were grown in appropriate selective medium and placed in sealed growth chambers containing 2% ... was spun down at 14,000rpm for 10min at 4oC The pellet was air dried for 10min and resuspended in 40μl TE buffer containing RNAse and incubated at 37oC for 20min DNA was stored at -20oC 2.3 Construction...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 4
... the spindle midzone in 43% of Mia1p-overexpressing cells, and I found it localizing to kinetochores in 15% of cells (see Figure 3.2.3F) Another midzone marker is the microtubule-binding protein ... are single maximum intensity projections of zstacks obtained by epifluorescence imaging 50 3.1.2.2 Microtubules remained attached to the SPB in alp14Δ cells Interestingly, I found that in the ... preexisting microtubules in mia1Δ cells Since mia1Δ cells exhibited reduced numbers of microtubule bundles, I was interested in finding out whether mia1Δ cells are defective in nucleating microtubules...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 5
... dissociation, indicating that in addition to Mia1p, other protein( s) is/are function in parallel pathway to anchor microtubule to the SPB during interphase One possible candidate involving in anchoring minus ... pombe cells overexpressing the TACC -related protein, Mia1p, were capable of organizing spindle-pole like structures While formation of intranuclear microtubule bundles in interphase S pombe cells ... microtubule-stabilizing proteins In fission yeast, Mia1p was revealed as the coiled-coil protein that is predicted to be the homologue of TACC 4.5.1 Mia1p interacts with Alp14p but not Dis1p In fission...
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Roles of TACC related protein, mia1p in MTOCs and microtubule dynamics in schizosaccharomyces pombe 6
... pericentriolar material proteins Dev Cell 7, 815-829 19 Demeter, J., Morphew, M., and Sazer, S (1995) A mutation in the RCC1 -related protein pim1 results in nuclear envelope fragmentation in fission yeast ... characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development Mech Dev 97, 13-26 66 Samejima, I., Lourenco, P.C., Snaith, H.A., and Sawin, K.E (2005) Fission ... with the kinesin-like protein pkl1p Mol Biol Cell 11, 1225-1239 60 Pardo, M., and Nurse, P (2005) The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission...
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Báo cáo khoa học: A unique vertebrate histone H1-related protamine-like protein results in an unusual sperm chromatin organization pot
... is indicated in the right margin of the tree and the group including the protamine-like proteins and the germinal H1 histones is highlighted in gray in the tree, where the protamine-like protein ... specificity resides in the intrinsically disordered domains of their N- and C-terminal tails In the case of the PL-I proteins, there is a substantial increase of arginine within these regions (see ... binding energy, greater flexibility and faster binding, that favor the selection of intrinsically disordered proteins (IDPs) over highly folded proteins, especially when the specificity of binding...
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Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot
... (ionizing radiation and UV radiation) Sensing and activation of the DDR is coordinated by proteins of the phosphatidylinositol 3-kinase-like protein kinase family: ATM, Bacterial genotoxins and ... intoxication with genotoxins, may allow cells carrying genomic instability to break through the tumorigenesis barrier, resulting in an increased risk of tumor development vated protein kinase [57] (Fig ... mitogen-activated protein kinase-acti- Bacterial genotoxins and genomic instability Fig Possible role of bacterial genotoxins in cancer development Chronic infection with CDT or colibactin-producing bacteria...
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Báo cáo khoa học: Role of the structural domains in the functional properties of pancreatic lipase-related protein 2 pot
... obtained using human or porcine lipase and colipase The proteins bearing the C-terminal domain of PL were efficient inhibitors of the lipase activity, whereas the proteins bearing the C-terminal ... N2Cc In conclusion, the accessibility of the active site was better in the protein bearing the N2 domain than in the protein bearing the Nc domain Thus, the accessibility of the active site in ... the N2 proteins was independent of the nature of the C-terminal domain, in contrast to the situation with Nc proteins Indeed, the C2 domain induced sensitivity of the Nc active site to E600 inhibition...
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Báo cáo y học: "Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases" pps
... play central roles in reabsorption of proteins and endocytosis More than 30 ligands for LRP2 have been reported so far, including vitamin-binding proteins, apolipoproteins, hormones, and other ... pMAL-eHis-LRP2F7, respectively The inserted cDNA fragments were expressed as a hybrid protein with maltose-binding protein (MBP) Recombinant CD69 as an MBP fusion protein was similarly prepared, as ... of human LRP2 were obtained by RT-PCR They were then expressed as a maltose-binding protein (MBP) fusion protein EGF, epidermal growth factor; LDL, low-density lipoprotein without anti-LRP2 autoAbs...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30 ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... Hs01911452_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT3) Hs00382744_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT5) Hs00202721_m1 Interferon, alpha-inducible protein...
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Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx
... patients, remained unchanged in one, and increased in three, rendering the authors’ results statistically insignificant HMGB1 mRNA expression remained unchanged after infliximab therapy as indicated ... rHMGB1 administration [7] Systemic administration of either neutralizing HMGB1 antigen-affinity purified polyclonal antibodies or the anti-inflammatory domain of HMGB1, termed the A-box protein, significantly ... arthritis in animals and shares key histological features observed in RA, including pannus formation, synovial membrane hypertrophy, and mononuclear cell predominance within synovial tissue [7] The injection...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30 ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... Hs01911452_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT3) Hs00382744_m1 Interferon-induced protein with tetratricopeptide repeats (IFIT5) Hs00202721_m1 Interferon, alpha-inducible protein...
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Báo cáo y học: "Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release" pps
... molecular chaperones in the folding of oxidized proteins Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein J Biol Chem 2001, 276:21337-21342 ... individual thioredoxin-like domains of protein disulfide isomerase Biochem 1995, 34:11725-11735 Freedman RB, Hirst TR, Tuite MF: Protein disulphide isomerase: building bridges in protein folding Trends ... adrenomedullin and adrenomedullin-binding protein- 1 in sepsis: down-regulation of proinflammatory cytokines Crit Care Med 2002, 30:2729-2735 Darby NJ, Creighton TE: Functional properties of the individual...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... compensate for the decrease in circulating T levels In this scenario, an increase in 5α-reductase enzyme activity is observed in the PCa cells, resulting in an increase in the rate of conversion ... Table 20a Interday Validation of Dimethoxycurcumin in Mouse Serum Table 20b Intraday Validation of Dimethoxycurcumin in Mouse Serum Table 21a Interday Validation of Dimethoxycurcumin in 1g/L PBS/BSA ... to heat shock proteins and other proteins where DNA binding cannot occur (Hoimes & Kelly, 2010) Androgens such as the newly converted DHT preferentially bind to AR, causing the initially bounded...
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