paraneoplastic neurological syndromes nejm

... in 30–50% of patients with thymoma or sclerotic myeloma. Table 97-1 Paraneoplastic Syndromes of the Nervous System Syndromes of the brain, brainstem, and cerebellum Focal encephalitis ... Paraneoplastic cerebellar degeneration Opsoclonus-myoclonus Syndromes of the spinal cord Subacute necrotizing myelopathy Motor neuron dysfunction Myelitis Stiff-person syndrome Syndromes ... nerve hyperexcitability Autonomic neuropathy Syndromes of the neuromuscular junction Lambert-Eaton myasthenic syndrome Myasthenia gravis Syndromes of the muscle ...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 097. Paraneoplastic Neurologic Syndromes (Part 2) Pathogenesis Most PNDs are mediated by immune responses triggered ... the resistance of many of these conditions to therapy. Table 97- 2 Paraneoplastic Antineuronal Antibodies, Associated Syndromes and Cancers Antibody Syndrome Associated Cancers Anti-Hu...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

... 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 1) Harrison's Internal Medicine > Chapter 96. Paraneoplastic Syndromes: Endocrinologic/Hematologic Paraneoplastic Syndromes: ... the prevalence of paraneoplastic syndromes indicate that they are more common than is generally appreciated. The signs, symptoms, and metabolic alterations associated with paraneoplastic disorders ... in a patient with cancer should prompt consideration of a paraneoplastic syndrome. The most common endocrinologic and hematologic syndromes associated with underlying neoplasia will be discussed...

Ngày tải lên: 07/07/2014, 04:20

... Table 96- 1 Paraneoplastic Syndromes Caused by Ectopic Hormone Production Paraneoplastic Syndrome Ectopic Hormone Typical Tumor Types a ... lung, pancreas, ovary a Only the most common tumor types are listed. For most ec topic hormone syndromes, an extensive list of tumors has been reported to produce one or more hormones. b hCG...

Ngày tải lên: 07/07/2014, 04:20

... osteolytic cytokines and inflammatory mediators. Clinical Manifestations Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 3) Etiology Humoral hypercalcemia of malignancy...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 4) Etiology Vasopressin is an antidiuretic...

Ngày tải lên: 07/07/2014, 04:20

... Unfortunately, many patients will eventually progress despite medical blockade. Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 5) Rarely, corticotropin-releasing hormone...

Ngày tải lên: 07/07/2014, 04:20

... subtype 2. Octreotide scans may also be useful to detect these tumors. Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 6) Tumor-Induced Hypoglycemia Caused by...

Ngày tải lên: 07/07/2014, 04:20

... underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic ... these tumors (Table 96- 2). The extent of the paraneoplastic syndromes parallels the course of the cancer. Table 96-2 Paraneoplastic Hematologic Syndromes the serum erythropoietin level ... mass. If the red cell mass is elevat ed, Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 7) Hematologic Syndromes: Introduction The elevation of granulocyte, platelet,...

Ngày tải lên: 07/07/2014, 04:20

... in 40% of patients with lung and gastrointestinal cancers, 20% of patients Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 8) Granulocytosis Approximately 30% of ... 400,000/àL) have an underlying diagnosis of cancer. IL-6, a candidate molecule for the etiology of paraneoplastic thrombocytosis, stimulates the production of platelets in vitro and in vivo. Some ... advanced-stage disease are more likely to have granulocytosis than those with early-stage disease. Paraneoplastic granulocytosis does not require treatment. The granulocytosis resolves when the...

Ngày tải lên: 07/07/2014, 04:20

... Further Readings Cutaneous paraneoplastic syndromes are discussed in Chap. 54. Neurologic paraneoplastic syndromes are discussed in Chap. 97. Al-Tourah AJ et al: Paraneoplastic erythropoietin- induced ... Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 9) Clinical Manifestations Patients with ... lymphocytic lymphoma. J Clin Oncol 24:2388, 2006 [PMID: 16710039] DeLellis RA, Xia L: Paraneoplastic endocrine syndromes: A review. Endocr Pathol 14:303, 2003 [PMID: 14739488] Emel EA et al:...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 13/07/2014, 20:20