Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5) pdf

Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5) Specific Paraneoplastic Neurologic Syndromes (Table 97-3) Table 97-3 Antibody- Associated Paraneoplastic and Nonparaneoplastic Syndromesa Antibodies Paraneoplastic Syndrome Frequent Infrequen t Nonparaneopla stic Limbic encephalitis Ma2, Hu, CV 2 /CRMP5, anti- NR1/NR2 of NMDA receptor Tr, VGKC VGKC Cerebellar degeneration Yo, Tr, P/Q VGCC, Hu, Zic, Ri, CV 2 /CRMP5, Ma1-2 mGluR1; MAZ Gliadin, GAD Hypothalamic, brainstem encephalitis Ma2, Hu CV 2 /CRM P5 Encephalomye litis Hu, Zic CV 2 /CRM P5, Ri, amphiphysin Chorea CV 2 /CRM P5 Opsoclonus- myoclonus Ri Hu, Ma2, Yo, Stiff-person syndrome Amphiphy sin Gephyrin, Ri GAD PNH (neuromyotonia) VGKC VGKC Myasthenia AChR AChR, MuSK gravis LEMS P/Q-type VGCC MysB P/Q-type VGCC Sensory neuronopathy Hu Axonal sensorimotor neuropathy Hu, CV 2 /CRMP5 Monoclonal gammopathy (M protein) b Autonomic neuropathy Hu CV 2 /CRM P5, ganglionic AChR Ganglionic AChR Predominant sensory demyelinating MAG, ganglioside antibodies: often MAG, ganglioside antibodies, often present with neuropathy present with Waldenström's macroglobulinem ia MGUS Paraneoplastic retinopathy Recoverin (CAR), anti- bipolar cell antibodies (MAR), anti- enolase Tubby- like protein 1 , PNR Anti-enolase a Antibodies have been validated by more than one laboratory and/or the protein sequence of the target antigen is known. b The M protein usually does not have specific antibody activity. Note: Italics indicate that com mercial testing for these antibodies is not available. PNH, peripheral nerve hyperexcitability; CAR, cancer- associated retinopathy; MAR, melanoma-associated retinopathy; PNR, photoreceptor- specific nuclear receptor; MGUS, monoclonal gammopathy of uncertain significance; VGKC, voltage- gated potassium channel; GAD, glutamic acid decarboxylase; AChR, acetylcholine receptor; LEMS, Lambert- Eaton myasthenic syndrome; VGCC, voltage-gated calcium channel; MAG, myelin- associated glycoprotein; NMDA, N-methyl-D-aspartate. . Chapter 097. Paraneoplastic Neurologic Syndromes (Part 5) Specific Paraneoplastic Neurologic Syndromes (Table 97-3) Table 97-3 Antibody- Associated Paraneoplastic and Nonparaneoplastic. (Table 97-3) Table 97-3 Antibody- Associated Paraneoplastic and Nonparaneoplastic Syndromesa Antibodies Paraneoplastic Syndrome Frequent Infrequen t Nonparaneopla stic Limbic encephalitis. antibodies, often present with neuropathy present with Waldenström's macroglobulinem ia MGUS Paraneoplastic retinopathy Recoverin (CAR), anti- bipolar cell antibodies (MAR), anti- enolase