paraneoplastic neurological syndromes emedicine
Chapter 097. Paraneoplastic Neurologic Syndromes (Part 1) potx
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... in 30–50% of patients
with thymoma or sclerotic myeloma.
Table 97-1 Paraneoplastic Syndromes of the Nervous System
Syndromes of the brain, brainstem, and cerebellum
Focal encephalitis ... Paraneoplastic cerebellar degeneration
Opsoclonus-myoclonus
Syndromes of the spinal cord
Subacute necrotizing myelopathy
Motor neuron dysfunction
Myelitis
Stiff-person syndrome
Syndromes ... nerve hyperexcitability
Autonomic neuropathy
Syndromes of the neuromuscular junction
Lambert-Eaton myasthenic syndrome
Myasthenia gravis
Syndromes of the muscle
...
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Chapter 097. Paraneoplastic Neurologic Syndromes (Part 2) potx
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... Chapter 097. Paraneoplastic
Neurologic Syndromes
(Part 2)
Pathogenesis
Most PNDs are mediated by immune responses triggered ...
the resistance of many of these conditions to therapy.
Table 97-
2 Paraneoplastic Antineuronal Antibodies, Associated
Syndromes and Cancers
Antibody Syndrome Associated
Cancers
Anti-Hu...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 1) docx
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... 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 1)
Harrison's Internal Medicine > Chapter 96. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
Paraneoplastic Syndromes: ... the
prevalence of paraneoplastic syndromes indicate that they are more common than
is generally appreciated.
The signs, symptoms, and metabolic alterations associated with
paraneoplastic disorders ... in a patient with cancer
should prompt consideration of a paraneoplastic syndrome. The most common
endocrinologic and hematologic syndromes associated with underlying neoplasia
will be discussed...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 2) ppt
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... Table 96-
1 Paraneoplastic Syndromes Caused by Ectopic Hormone
Production
Paraneoplastic
Syndrome
Ectopic Hormone
Typical Tumor
Types
a
... lung,
pancreas, ovary
a
Only the most common tumor types are listed. For most ec
topic hormone
syndromes, an extensive list of tumors has been reported to produce one or more
hormones.
b
hCG...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 3) pdf
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... osteolytic cytokines and inflammatory mediators.
Clinical Manifestations
Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 3)
Etiology
Humoral hypercalcemia of malignancy...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 4) pdf
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... Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 4)
Etiology
Vasopressin is an antidiuretic...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 5) doc
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...
Unfortunately, many patients will eventually progress despite medical blockade.
Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 5)
Rarely, corticotropin-releasing hormone...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 6) doc
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... subtype 2. Octreotide scans may
also be useful to detect these tumors.
Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 6)
Tumor-Induced Hypoglycemia Caused by...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 7) pdf
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... underlying disease rather than a paraneoplastic
syndrome. The paraneoplastic hematologic syndromes in patients with solid
tumors are less well characterized than the endocrine syndromes because the
ectopic ...
these tumors (Table 96-
2). The extent of the paraneoplastic syndromes parallels
the course of the cancer.
Table 96-2 Paraneoplastic Hematologic Syndromes
the serum erythropoietin level ... mass. If the red cell mass is elevat
ed,
Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 7)
Hematologic Syndromes: Introduction
The elevation of granulocyte, platelet,...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 8) ppt
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... in 40% of patients with lung and gastrointestinal cancers, 20% of patients
Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 8)
Granulocytosis
Approximately 30% of ... 400,000/àL)
have an underlying diagnosis of cancer. IL-6, a candidate molecule for the
etiology of paraneoplastic thrombocytosis, stimulates the production of platelets in
vitro and in vivo. Some ... advanced-stage disease
are more likely to have granulocytosis than those with early-stage disease.
Paraneoplastic granulocytosis does not require treatment. The
granulocytosis resolves when the...
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Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 9) docx
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...
Further Readings
Cutaneous paraneoplastic syndromes are discussed in Chap. 54. Neurologic
paraneoplastic syndromes are discussed in Chap. 97.
Al-Tourah AJ et al: Paraneoplastic erythropoietin-
induced ... Chapter 096. Paraneoplastic Syndromes:
Endocrinologic/Hematologic
(Part 9)
Clinical Manifestations
Patients with ... lymphocytic lymphoma. J Clin Oncol 24:2388, 2006
[PMID: 16710039]
DeLellis RA, Xia L: Paraneoplastic endocrine syndromes: A review.
Endocr Pathol 14:303, 2003 [PMID: 14739488]
Emel EA
et al:...
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