pacap vip receptor expression in lut and modulation with cystitis
Tài liệu Bank Credit - A Study of the Principles and Factors Underlying Advances Made by Banks to Borrowers docx
Ngày tải lên :
15/02/2014, 01:20
... Currency, and banking periodicals Information embodied chiefly in chapters VII-XI and XVI, and unobtainable from the ordinary sources, was secured by extensive correspondence and interviews with bankers ... Cash on Hand and in Banks Accounts and Notes Receivable Merchandise or Inventory Real Estate, Machinery and Equipment Other Assets Stocks and Bonds Trade-Marks, Patents, Goodwill, etc Life Insurance ... of handling other works used jointly with Bank Credit may be passed over without comment except that a preliminary study of the bank balance sheet and of clearing and collection facilities and...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
Ngày tải lên :
18/02/2014, 04:20
... (PDZ) domain-containing protein PDZK3 ⁄ PDZD2 ⁄ PAPIN (plakophilin-related armadillo repeat protein-interacting protein) [61], decreased, but was still observed in HSF1-null MEF cells during heat ... is a master regulator of these genes Interestingly, the amino-terminal region of chicken HSF1 containing an alanine-rich sequence and the DNA-binding domain is sufficient to cause the functional ... domain during evolution Domains of mouse HSF3 were swapped with the corresponding domains of chicken HSF3, and the chimeras possessing the chicken HSF3 activation domain induced the expression...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
Ngày tải lên :
18/02/2014, 18:20
... involved in insulin signaling have been identified: (a) protein kinase Cf interacting protein (ZIP), an adaptor protein that binds to the PIR domain of Grb14 and mediates the assembly of a protein kinase ... Desbuquois et al Insulin-induced translocation of Grb14 in rat liver A H N B M LP S PM GE –ins Grb14 – ins Grb14 + ins –ins + ins + ins – ins EEA1 + ins Na+K+ATPase Calnexin + ins number: 10 11 ... [13], and tankyrase [15] The binding of ZIP to Grb14, by recruiting protein kinase Cf, enhances the serine phosphorylation of Grb14 and its inhibitory effect on IR kinase and insulin signaling...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
Ngày tải lên :
19/02/2014, 07:20
... contains all the SMAD proteins of the HTFN and APC and b-catenin-related factors Groups C and D involve smaller functional sets Group C contains the Rel family and CRE binding 6428 factors involved ... to interact with DNA based on protein dimerization [42] Zn finger domains are common in TFs, allowing them to bind DNA, but not to interact with other protein regions [42] This group of self-interacting ... certain protein domains and is a way of easily increasing the number of TFs, as appears to have occurred through evolution Functionality can be linked to structure, as is the case of DNA-binding and...
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the weakness of factors affecting sales activities at the website
Ngày tải lên :
19/02/2014, 14:53
... advertising services on website to trainers, who provide training courses The services include: - Advertising training courses with no pay within 30 days - Advertising training courses with special ... teaching content, pictures, tuition, and online registration with the trainer… - Choosing the most suitable trainer in the database, which includes hundreds of inland and foreign trainers and ... using phones instead of travelling, simplifying record-keeping form finding better call and routing plans, and supplying more and better customer information Salespeople often work alone, and...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
Ngày tải lên :
19/02/2014, 17:20
... cytokineresponsive genes contain putative Ets binding sites within their regulatory regions, including COX-2, iNOS, and MMP-13 We demonstrate here that endogenous COX-2 gene expression can be inhibited ... competes with intact endogenous ESE-1 for binding to target gene promoters The second dominant-negative mutant, Dominant Negative (DN2), encompasses the amino-terminal transactivation domain and Pointed ... factors in inflammation and in the regulation of cytokine-responsive genes has not been studied in detail However, several genes, including urokinase-type plasminogen activator, matrix metalloproteinase...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
Ngày tải lên :
06/03/2014, 00:21
... was injected into FC in a volume of 50 lL at a concentration of nmol ⁄ mL Interaction of TnrA with GlnK and GS in HBS buffer This resulted in increases in resonance units of 500 in FC and 800 in ... and after rigorous washing in nonionic detergent-containing buffer and elution of antibodybound protein, the samples were separated by SDS ⁄ PAGE and analyzed by immunoblotting In agreement with ... tightly to TnrA, preventing its binding to DNA, with the most effective feedback inhibitors of GS being glutamine and AMP [9] Mutations in TnrA that result in constitutive expression of the TnrA-activated...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
Ngày tải lên :
06/03/2014, 09:22
... L658, resulting in mutant receptors with no detectable EGFdependent tyrosine kinase activity but maintaining intact ligand-binding capacity [59–61] Significantly, no apparent aberrant intracellular ... Calmodulin and the EGFR prominent role in EGF-dependent activation and the fate of this receptor The EGFR CaM-binding domain The first report demonstrating that the EGFR is a CaM-binding protein arise ... membrane integrity could be a prerequisite for maintaining the tyrosine kinase of the EGFR in an auto-inhibited state in the absence of ligands This observation agrees perfectly with a model in which...
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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
Ngày tải lên :
07/03/2014, 12:20
... oxidative insult Insulin is a polypeptide hormone that regulates glucose, lipid and protein metabolism and promotes cell growth and differentiation On ligand binding, the insulin receptor tyrosine kinase ... was administered to establish the role of protein synthesis in insulin-induced HO-1 expression (Fig 2B,C) CHX abrogated HO-1 protein induction following insulin treatment but, in agreement with ... pretreated with actinomycin D (AD) followed by insulin (Fig 2A,C) Basal levels of HO-1 protein were reduced following AD treatment, and the HO-1 protein and mRNA response to insulin was abolished...
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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
Ngày tải lên :
08/03/2014, 08:20
... antibody with the MARCKS RNA-binding proteins was observed revealing that CstF64 is not involved in formation of the RNA:protein complexes C1 and C2 (Fig 5B, lanes and 6) The addition of increasing ... panel) and the UV-crosslinking results (Fig 5B) further supporting the finding that HuR is one protein binding the MARCKS 3¢-UTR in Swiss 3T3 cells In contrast to the Hu antiserum, no interaction ... Germany) containing the luciferase gene was digested with StuI and HindIII, and the luc-fragment was cloned into pcDNA3 (Invitrogen, Karlsruhe, Germany) via a filled -in EcoRI site and a HindIII site...
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Feasibility Study – The critical success factor in project management pot
Ngày tải lên :
14/03/2014, 19:20
... enterprises Each kind of project have different stages in development and implementation 10 Preparation for investment Implementation of investment Investment license Operation Payment Hand-over Supervision ... Detailed Feasibility Study ( F/S) • Business Plan : for short term • F/S is for long term including engineering design • F/S includes Project Execution Plan 13 III Outline of F/S • Cover sheet • Content ... 14 III Outline of F/S (Cont.) • Business administration model : production management, marketing and sale management, maintenance operation management operational cost of project in operational...
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Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx
Ngày tải lên :
17/03/2014, 03:20
... function without the mutation necessarily being located in the binding interface We selected eight amino acid residues in sTF for individual cysteine replacement and used the cysteines as handles ... in dark grey and the TF2 domain in light grey The Gla domain of FVIIa is shown in green; EGF1 in magenta; EGF2 in light blue; PD in dark blue The sTF residues highlighted in red are located within ... Residues E99 and L104 are located in the TF1 domain, and T197 is situated in the N-terminal portion of the TF2 domain, i.e close to the TF1 domain at the level of EGF1 in FVIIa in the sTF–FVIIa...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
Ngày tải lên :
17/03/2014, 11:20
... receptor kinase Our findings that Src colocalizes with Hrs and can phosphorylate Hrs in vitro and in vivo suggest that this kinase may be involved in the phosphorylation of Hrs On the other hand, ... the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive after internalization into ... Hrs in vitro and in vivo (A) Radioactive ATP was mixed with Hrs fused to maltose binding protein (MBP) (lane 3) or MBP alone (lane 2) An additional control containing buffer only was also included...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
Ngày tải lên :
18/03/2014, 01:20
... gp130 are involved in ligand binding: the Ig-like domain and the CBM [9–11] In the case of LIF-induced heterodimerization of LIFR with gp130, the cytokine first binds to the Ig-like domain of the ... affinity binding of the ligand is abrogated in this chimera, indicating that the reason for the missing signal transduction is not an incorrect spacing between the ligand binding epitopes of gp130 and ... against the 19 C-terminal amino acids of the receptor and thus does not interfere with ligand binding and extracellular receptor dimerization The immunoprecipitated proteins were separated by...
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Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
Ngày tải lên :
22/03/2014, 21:20
... sufficient for the interaction Aegyptin binds with low affinity to GPVI and integrin a2b1 binding sites in collagen Sequences involved in collagen interaction with GPVI and integrin a2b1 were tested ... Aegyptin binds with high affinity to the vWF binding site in collagen, independently of hydroxyproline In an attempt to identify the binding sites involved in collagen interaction with aegyptin, ... sequence involved in collagen interaction with vWF, and also interacts with GPVI and integrin a2b1 binding sites Aegyptin effectively inhibits carotid thrombus formation in vivo Results Aegyptin has...
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Báo cáo khoa học: Control of transferrin expression by b-amyloid through the CP2 transcription factor pdf
Ngày tải lên :
23/03/2014, 03:20
... as putative binding factors for transferrin promoter regions including CP2, specificity protein and p53 Interestingly, we found that the CP2 binding site was the most frequent motif in the conserved ... transferrin, and imply that CP2 binds to CP2 binding site I directly or through interaction with other transcription factors to enhance transferrin gene expression in cells CP2 binds to the transferrin ... Protein levels were verified by Western blotting using antibodies against transferrin, CP2 and b-tubulin (as a loading control) (bottom panels) The band intensity was measured, and transferrin protein...
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The Ubiquitous Triclosan A common antibacterial agent exposed ppt
Ngày tải lên :
23/03/2014, 10:20
... cleaning agents containing anti-bacterial agents and on industry to stop marketing and advertising the antibacterial qualities of their products, calling their use in households, “superfluous and ... seconds and then rinse of in warm water It is important to wash hands o�en, especially when handling food, before eating, a�er going to the bathroom, and when someone in your house is sick Dry hands ... correare not necessary in everyday use, and washing hands with lation between too much hygiene and increased allergies ordinary soap and warm water is an effective way to ward and asthma.28 This hypothesis...
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Báo cáo khoa học: The potyviral virus genome-linked protein VPg forms a ternary complex with the eukaryotic initiation factors eIF4E and eIF4G and reduces eIF4E affinity for a mRNA cap analogue ppt
Ngày tải lên :
23/03/2014, 10:21
... extract was incubated with recombinant VPgÆGst fusion and mixed with glutathione–Sepharose 4b beads After extensive washing, the proteins specifically retained on the resin were eluted with glutathione ... mimicking either strictly competitive binding or binding at two distinct but dependent sites Plots of residuals obtained from both fits showed unambiguously that VPg and m7GDP bind to distinct but interdependent ... the eIF4G-binding domain Results and discussion Interaction between VPg and eIF4E We initially evaluated the perturbation of the intrinsic fluorescence of eIF4E upon its interaction with VPg As...
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