oxygen dependent browning of soy sauce
Tài liệu Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation pdf
Ngày tải lên :
20/02/2014, 23:20
... mechanism of regulation of both domains involves a common iron dependent process [74,75,79] Regulation of HIFa subunits by oxygen- dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... reaction requires oxygen (in the form of dioxygen O2), iron (Fe2+) and the cofactor 2-oxoglutarate The hydroxylation reaction is inherently dependent on ambient oxygen because the oxygen atom used ... reaction scheme for oxygen- dependent hydroxylation by PHD/HPH and FIH-1 hydroxylases The hydroxylation of target substrates requires dioxygen (O2), iron [Fe(II)] and the cofactor 2-oxoglutarate...
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Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx
Ngày tải lên :
13/08/2014, 13:20
... TGF-β dependent production of reactive oxygen species upon transdifferentiation of derivatives of hepatic stellate cells (M1-4HSC line) to M-HTs The data provide evidence that (i) the increase of ... involvement of NADPH oxidase in the TGF- dependent increase of oxidative stress in M1-4HSC was obtained by measurements of ROS content in cells that have been treated with TGF-β in the presence of DPI ... translocation of Smad2/3 as visualized by confocal immunofluorescence analysis (C) Confocal immunofluorescence images after staining of cells with antidesmin antibody ferentiation of M1-4HSCs,...
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Identification of antioxidants in dark soy sauce
Ngày tải lên :
09/10/2015, 10:49
... and blended soy sauce were produced Semi-chemical soy sauce is produced by further fermentation of acid hydrolyzed products; while blended soy sauce is produced by mixing fermented soy sauce with ... 1.1 A brief history of soy sauce 1.2 The methodology of preparation of soy sauce 1.3 The functional components of soy sauce 1.4 The balance of free radicals/reactive species and antioxidants Chapter ... sauce The history of soy sauce goes back over three thousand years The origin of soy sauce is generally considered to be in China, where soy sauce is called jiang-you, the extract of jiang Jiang was...
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Báo cáo y học: "Allele dependent silencing of COL1A2 using small interfering RNAs"
Ngày tải lên :
03/11/2012, 11:52
... 82% (Figure 5B), of which 75%, 75% and 73% could be attributed to silencing of the targeted T-allele, respectively Assessment of relative allele abundance of COL1A2 mRNA The software PeakPicker ... used for allele specific silencing irrespective of the location of the actual mutations In this study we have examined the allele dependent effects of seven tiled siRNAs targeting a region surrounding ... allele of rs1800222) 72 hours post-transfection with three different concentrations of siRNA3 Colours of bars indicate the SNP used to calculate allele ratios from cDNA chromatograms in the software...
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Approach to Zero Emission Processes in Food Industry - Case Study for Soy-Sauce Production Process -
Ngày tải lên :
05/09/2013, 08:40
... elements Figure presents the input and output of soy- sauce producing plant based on t production of soy- sauce Main emission from the plant is -2- Journal of Water and Environment Technology, Vol.2, ... (soy- sauce lees) remaining after the filtration of the fermented broth (Moromi mash) The inputs through salt water and conditioning occuies a large fraction of soy- sauce mass The thickness of ... Ori,2 TOC [kg] Soy- Sauce, 1t Membrane filtration 17 Ori,5 58 Celite filtration 46 Soy- Sauce, 63(in 1t) Fig.4 Detailed material flow of total organic carbon Fig.3 Detailed material flow of total mass...
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Tài liệu Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 refined models suggest environment-dependent induction of alternative bent ⁄extended resting states doc
Ngày tải lên :
18/02/2014, 04:20
... rotation of the bTD module at the main chain of D606 to dock it against the calf-2 domain with its C-terminus in proximity of the N-terminus of the b3 open TM helix Overall evaluation of the models ... swing-out, of $ 6, of the hybrid domain was present in this conformation, consistent with that of $ 10 observed in the avb3 ectodomain tted in the TEM map [7] Finally, after introduction of the mature ... (involving the swing-out of the b3 hybrid domain [6]) taking place without the requirement of full separation of the TM helices Since then, crystallographic structures of the aIIbb3, avb3 and...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
Ngày tải lên :
19/02/2014, 02:20
... core of the particle from lysosomal esterases, or that impaired lipolysis of LDL lipids may block proteolysis of apoB [36] This may arise as a result of the failure of hydrophobic regions of apoB, ... inhibition of the thiol -dependent lysosomal cathepsins by glycated proteins may be of particular importance in apoB turnover The accumulation of glycated apoB within HMDMs may be related to that of the ... experiments The rates of uptake of both the lipid and protein components are not matched by the rate of cellular metabolism of these species, resulting in the accumulation of both unmodified cholesteryl...
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Tài liệu Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling pptx
Ngày tải lên :
19/02/2014, 05:20
... sustained activation of Rac by overexpression of the Rac-specific activator, Tiam1, or overexpression of V12-Rac1, strongly induces transcriptional upregulation of tissue inhibitor of metalloproteinase ... four different isoforms Of these, the prototype member of the TIMP family, TIMP-1, is of particular interest, because in addition to its classic role as a broad specific inhibitor of active matrix ... well-established roles of (a) AP-1 in regulating the transcription of numerous genes, and (b) of TIMP-1 as an inhibitor of tumor invasion and metastasis as well as a regulator of cell proliferation...
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Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
Ngày tải lên :
19/02/2014, 06:20
... properties of GLD2 are similar to those of the enzymes purified from A niger [1] and A nidulans [2]; that is, the enzyme catalyses the reversible reduction of DHA to glycerol using 4232 Fig SDS ⁄ PAGE of ... 20 gÆL)1 of the main carbon source, as specified, at 28 °C To make mycelial or cell extracts of H jecorina or S cerevisiae, about 100 lg of fresh mycelia or cells were mixed with 300 lL of glass ... Characterization of a glycerol kinase mutant of Aspergillus niger J Gen Microbiol 136, 1299–1305 14 Asako H, Wakita R, Matsumura K, Shimizu M, Sakai J & Itoh N (2005) Purification and cDNA cloning of NADPH-dependent...
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Tài liệu Báo cáo khoa học: Insulin-dependent phosphorylation of DPP IV in liver Evidence for a role of compartmentalized c-Src ppt
Ngày tải lên :
19/02/2014, 07:20
... concentration of the soluble form of DPP IV may result in an increased proteolysis of GLP-1 peptides and thus decreased insulin secretion [20] The insulin -dependent phosphorylation of DPP IV observed ... Results are representative of three independent experiments elements by 0.1% Triton X-100 is possible, we were still in a position to address the question of the orientation of c-Src We used the endosomal ... representation of the three major domains (sinusoidal, lateral, bile canalicular) of the hepatocytes present in the PM fraction [50] To the best of our knowledge, tyrosine phosphorylation of DPP IV...
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Tài liệu Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells pptx
Ngày tải lên :
19/02/2014, 18:20
... assay of Ras -dependent outgrowth of neurites from PC12 cells [14] These results indicate that even though phosphorylation of Ser916 may contribute to stimulation of the Ras-GEF activity of Ras-GRF1, ... kDa isoform of Ras-GRF1 seems to be expressed at a higher level than the 140 kDa isoform The serotonin-induced increase in phosphorylation of both isoforms was reduced by the coexpression of hPDE4D2 ... mechanism of Ras activation through Gs-coupled receptors is not fully understood In the present study, we show endogenous expression of the Ca2+ -dependent 140 kDa and shorter isoforms of RasGRF1...
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Báo cáo khoa học: Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A⁄C pot
Ngày tải lên :
07/03/2014, 01:20
... [3] One of the clones corresponded to the N-terminal region of JNK-associated leucine zipper (JLP) protein (amino acids 1–141), which is the most recently identified member of the JIP group of scaffold ... Identification of JLP as a partner of hsMOK2 using the yeast two-hybrid screen and identification of the hsMOK2 interaction domain (A) Constructs expressing full-length or the indicated domains of hsMOK2 ... Harper et al Phosphorylation -dependent binding of MOK2 A D B E C Fig The N-terminal domains of JLP and JSAP1 bind to hsMOK2 in vitro (A) Mapping the interaction region of JLP using GST pull-down...
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Báo cáo khoa học: Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells docx
Ngày tải lên :
07/03/2014, 02:20
... of P2X7 receptors in the regulation of neuritogenesis and in the fine control of the balance between proliferation ⁄ differentiation of neuroblastoma cells Results Molecular characterization of ... formation Moreover, we linked the activation of the P2X7 receptor with the regulation of Ca2+ ⁄ calmodulin -dependent kinase II (CaMKII) activity and some of its downstream effectors, including focal ... structures that showed high levels of P2X7-positive immunostaining, suggesting the implication of P2X7 receptors in the control of neuritogenesis (Fig 5G,H) Knockdown of the P2X7 receptor induces neurite...
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Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
Ngày tải lên :
07/03/2014, 16:20
... structural analysis of F45W mutants of the yeast protein confirms this We have explored the context -dependent effects of proline on ubiquitin stability by introducing a number of substitutions at ... van’t Hoff analysis are close to %5000 JÆK)1Æmol)1 [58,59] It is not entirely clear whether burial of 66–71% of the hydrophobic surface area of the native state should account for all of the ... capacity and entropy of formation of the TSE for folding (U-à) Reported errors reflect the quality of the nonlinear least squares fit to the experimental data We have used the F45W mutant of yeast ubiquitin...
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Báo cáo khoa học: Photosynthetic acclimation: Structural reorganisation of light harvesting antenna – role of redox-dependent phosphorylation of major and minor chlorophyll a/b binding proteins pot
Ngày tải lên :
16/03/2014, 06:20
... the quantity and spectral quality of incident light, often leading to imbalanced excitation of the two photosystems In order to ensure an optimal quantum yield of oxygen evolution during photosynthesis, ... Mechanism of state transitions General mechanism The process of state transitions represents a short-term adaptation of the photosynthetic apparatus to the conditions of imbalanced illumination of PSII ... screening assays for identification of mutants affected in the signalling cascade of this process These types of screening have led to isolation of the series of stm [58] and stt [59] mutants deficient...
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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt
Ngày tải lên :
16/03/2014, 10:20
... direction of expression levels of these two a2,3-sialyltransferase genes for enzymes of similar substrate specificity for N-glycans may act in a compensatory manner, the reduction of gene expression of ... New function of p16INK4a ´ S Andre et al Fig Effect of sialidase treatment on the cell-surface binding of plant lectins Semilogarithmic representation of fluorescent surface staining of mock-transfected ... ⁄ nuclear run-off experiments, by proteomic profiling and by flow cytofluorometry Identification of up-regulation of galectin-1 expression Quantitative determination of the presence of galectin1-specific...
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Báo cáo khoa học: Mutual effects of proton and sodium chloride on oxygenation of liganded human hemoglobin Oxygen affinities of the a and b subunits potx
Ngày tải lên :
16/03/2014, 14:20
... (1999) Photodissociation of oxygenated forms of the native hemoglobin HbA and its isolated a- and b-subunits and kinetics of molecular oxygen rebinding Dokl Biophys (translation of Dokl Akad Nauk) ... Taking advantage of the photosensitivity of the heme Fe–ligand bond [8–14], flash photolysis has been used extensively in kinetic studies of oxygenated hemoglobins Recently, the rates of O2 association ... based on determination of the bimolecular association rate constant of O2 rebinding and the quantum yield of BR, c The latter value is defined as the ratio of the number of O2, which succeed in...
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Báo cáo khoa học: Atrial natriuretic peptide-dependent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A pptx
Ngày tải lên :
16/03/2014, 23:20
... ANP -dependent photolabeling of DGC The inset indicates the curve slope and the 50% inhibitory concentration (IC50) of ATP Each data point represents the average arbitrary units of photolabeling of ... effect of ATP on NPR-A Our results, showing co-operativity of ATP inhibition of 8-azido-ATP-B photolabeling, characterized by a Hill coefficient of 2.2, suggest a mechanism by which binding of one ... as the percentage binding of specific 125I-labeled ANP and represents the mean ± SEM of duplicates This figure is representative of three identical experiments 5575 ANP -dependent ATP binding on...
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Báo cáo khoa học: "Learning Correlations between Linguistic Indicators and Semantic Constraints: Reuse of Context-Dependent Descriptions of Entities" doc
Ngày tải lên :
17/03/2014, 07:20
... call the set of all descriptions related to the same entity in a corpus, a profile of that entity Profiles for a large number of entities were compiled using our earlier system, PROFILE (Radev ... variety in the size of the profile (number of distinct descriptions) for different entities Table shows a subset of the profile for Ung Huot, the former foreign minister of Cambodia, who was ... covers a variety of pre-modifier and appositional noun phrases For each word wi in a description, we use a version of WordNet to extract the synset offset of the immediate parent of wi 4.2 Finding...
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Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression potx
Ngày tải lên :
17/03/2014, 09:20
... actions of MIBG result from its ability to prevent Rho -dependent activation of SRF Discussion The results of this study indicate that an arginine -dependent mART is activated upon stimulation of SMC ... are representative of three independent experiments, each of which exhibited similar results labeling of the 140, 133, 116, 95, 82 and 73 kDa proteins, while the labeling of several proteins ... (MIBG), a decoy substrate of arginine -dependent mono-ADP-ribosylation that consequently reduces modification of endogenous protein targets [29], for 10 prior to addition of various growth stimulating...
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