oxidative stress in diabetes mellitus ppt
Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
... toapplied ROS. Interestingly, upregulation of pes1expression was not observed following H2O2-induced oxidative stress in cultures of A. fumigatus 293.1 grown in either Sabouraud or 5% FBS in MEM ... Infect Dis21, 161–172.4 Denning DW (1996) Therapeutic outcome in invasiveaspergillosis. Clin Infect Dis 23, 608–615.5 Denning DW (1998) Invasive aspergillosis. Clin InfectDis 26, 781–805.6 ... this strain in subsequent gene-disruption experi-ments. In order to find whether pes1 was expressed duringfungal infection in G. mellonella, A. fumigatusATCC 26933 conidia were injected into larvae...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... brain Aβ amyloidosis model.Previously, we have shown that a full dose ofindomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress ... inflammation when combined with indomethacin. In summary, our findings support the hypothesis that oxi-dative stress and inflammation represent important butdistinct therapeutic targets in AD-like amyloidosis. ... burden in the hippocampus of these mice [16].However, recent studies indicate that a subset of NSAIDs,including indomethacin, also possesses a direct, COX-independent Aβ-lowering capacity in cell...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... global inhibitionof src-family tyrosine kinases or inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream ... has been investi-gated with the use of specific protein kinase inhibitorsrevealing that protein kinase C (PKC) [37-39], p21-acti-vated kinase-1 (PAK1) [40], mitogen-activated proteinkinase (MAPK) ... Peroxynitrite-induced alterations in synapto-somal membrane proteins: insight into oxidative stress in Alzheimer's disease. J Neurochem 1999, 72:310-317.87. Bonfoco E, Krainc D, Ankarcrona...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... origin, wasobtained from ATCC (Manassas, USA) and cultured Ham’sF-12 media (Gibco) containing 2 mM L-glutaminesupplemented with 0.01 mg/ml bovine pituitary extract(Gibco, USA), 0.005 mg/ml insulin ... study,PM2.5 induced more MDA formation than PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total ... protein in the PM2.5 - and PM10 -treated rat lung epithelial cell was determined by WesternBlotting. The lower shows the ratio of Nrf2/actin usingcalculatging by densitometor. In the...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b) recycling of citrulline...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... oxidative stress. Our findings show that pilocarpine induces SE,which can produce alterations in superoxide dismutaseand catalase activities in different areas, thereby pro-tecting the brain ... [2,19,20], immediatelyafter pilocarpine administration, animals persistentlyshow behavioral changes, including initial akinesia,ataxic lurching, peripheral cholinergic signs (miosis,piloerection, ... Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res112, 77–83.3 Treiman DM (1955) Electroclinical features of statusepilepticus. J Clin...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease in [Ca2+]c, probably coincides with ... functions, in addition tohaving supporting functions for oxidative defences [79],involving the thioredoxin system [40]. Aconitase actsalso as an iron-responsive element binding protein, iso-citrate ... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons...
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Báo cáo khoa học: Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana ppt
... equilibrated with theurea-binding buffer. After washing the cartridge with theurea-binding buffer, the luminal domain of At SEL-1Lwas eluted with the urea-binding buffer containing 1 mimidazole, and ... 7.9, containing 5 mm imidazole, 0.5 m NaCl and 1 mmCaCl2(binding buffer), and then centrifuged at 10 000 gfor 30 min at 4 °C. The pellet was suspended in the bind-ing buffer containing 6 m ... phosphorylating the specific serine resi-due of eIF2a [51] to protect cells from the stress. P58IPKinhibits PKR-mediated translational arrest byinactivating the kinase by binding to the domain ofPKR...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalyticallyindependent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymesand fluxes under oxidative stress Recently, we reported that amebas incubated for30 min in ... bindclose to the Fe–S clusters, blocking the access of ROS. In this regard, a preliminary docking analysis withcoenzymes in the 3D model of EhPFOR suggested thatthe CoA-binding site was, indeed,...
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Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
... mice. Fasting induced a significant increase in bothgenotypes; however, this was more evident in theVLCAD KO mice (Fig. 3A). Interestingly, the MCTdiet also induced AOX gene expression in WT mice.After ... observed in human VLCADD [5]. In fact, in both mice and humans, clinical symptoms becomemainly evident as a consequence of triggers suchas fasting, resulting in the accumulation of long-chainacylcarnitines, ... quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.S. Tucci et al. Oxidative stress in VLCAD KO miceFEBS Journal 277 (2010)...
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Stress in longer words ppt
... Stress in longer words Khi thêm các tiền tố và hậu tố vào các từ gốc, dường như trọng âm câu...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidative stress is involved in the ... National Cancer Institute. Using a reverse-phase pro-tein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lungcancer cell line after treatment...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... (BUN) and creatinine, urine amount, and the ratio of urine protein tocreatinine. Serum levels of blood urea nitrogen (BUN) and creatinine and the ratio of urine protein to creatinine in three groups ... for estimating daily urine volume andmeasuring the ratio of urine protein to urine creatinineexcretion. Quantification of urine protein, BUN, andcreatinine level was performed using standard ... Creatinine and BUN,Urine Amount and the Ratio of Urine Protein toCreatinine after IR ProcedureThree time points (i.e. 24 h, 72 h, and day 14 after theIR procedure) were chosen for determining...
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báo cáo hóa học: " Pictorial Representation of Illness and Self Measure Revised II (PRISM-RII) – a novel method to assess perceived burden of illness in diabetes patients" pptx
... research into the content validity of PRISM-RII iswarranted, including cognitive debriefing sessions. It isnot clear if using a single question on degree of suffering in this context is indeed ... suffering. In The nature of suffering andthe goals in Medicine Edited by: Cassell EJ. New York: Oxford Univer-sity Press; 1991:31-47. 2. Cassell EJ: Diagnosing suffering: A perspective. Ann Intern ... valid instrument for measuring suffering in people with diabetes. Diabetes was chosen, since this con-dition is a highly prevalent chronic disease that is knownto cause considerable distress,...
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Physiological and biochemical responses to salt stress in the mangrove pptx
... 50% inhibition of nitrite formation from hydroxylamine in the presenceof xanthineoxidase.A steep increase in the activity of SOD began immediately following the transfer of theplant grown in ... a reduction in stomatal opening. The likely sequenceof events was thought to be increased salinity, water stress, stomatal closure, decrease in intracellular CO2, and decrease in photosynthesis. ... carbohydratesas the dominant osmoregulating compounds. Glycinebetaine, the most common compatiblesolute, has also been found in A. marina (Ashihara et al., 1997).The active oxygen species including superoxide,...
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