organ specific regulation of immune responses
Báo cáo y học: "DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma model" pps
Ngày tải lên :
13/08/2014, 18:22
... suggest that organ- specific reactions are responsible for these organ- and time-dependently deviant regulation patterns in the two organ types investigated This might contribute to a specific sequence ... final concentration of ethanol amounted to 0.1% This is important as ethanol per se can modulate immune responses Animals of the vehicle group received a once daily injection of saline including ... ethanol Collection of organ samples For PCR analysis, liver and lung were collected immediately after the mice were euthanized One lobe of each organ was excised and put into a microfuge tube The...
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THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS
Ngày tải lên :
16/10/2015, 11:59
... Master studies I TABLE OF CONTENTS Acknowledgements I Table of Contents II Summary VII List of Tables VIII List of Figures IX List of Abbreviations XI Chapter Introduction 1.1 The Immune System 1.2 ... self and non-self In doing so, the immune system will then be able to induce appropriate and yet specific immune responses towards the specific pathogens The immune system in mammals can be classified ... occurrence of adverse immune response in autoimmune diseases, allergy and allograft rejection The antigen presenting cells (APCs) of innate immunity provide the activating signals through regulation of...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... repressive Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol 11 No Lee et al Figure Network-based analysis ofof upregulated genes in the functional category of immune ... expression profiles of immune response-related molecules in vivo Despite an additional proportion of granulocytes (mainly neutrophils), our results showed that there was an overexpression of several ... effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating experiments did not show any strong evidence of...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
Ngày tải lên :
09/08/2014, 01:23
... the inhibition of APCs or pathogenic T cells, by maintenance of the TR cell population and/or by enhancement of their function (reviewed in [54]) Elucidation of the mechanism of TR cell suppression ... Society for the Promotion of Sciences 19 20 References 24 Cohen IR: Regulation of autoimmune disease physiological and therapeutic Immunol Rev 1986, 94:5-21 Arnold B: Levels of peripheral T cell tolerance ... sex-linked dysgenesia of the gonad after neonatal thymectomy in mice Science 1969, 166:753-755 Sakaguchi S, Sakaguchi N: Organ- specific autoimmune disease induced in mice by elimination of T cell subsets...
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Báo cáo khoa học: " Water flux in boreal forest during two hydrologically contrasting years; species specific regulation of canopy conductance and transpiration" pps
Ngày tải lên :
09/08/2014, 04:20
... in a stand To enable species -specific analyses, we expressed water uptake of pine and spruce trees separately to represent a flux of hypothetical monospecific stands of either pine or spruce These ... amount of leaf biomass, it was estimated that a monoculture of pine with the basal area of the present stand ) (29.3 m would have LAI of 2.0, whereas a pure spruce stand would reach LAI of 5.8 ... the goodness of fit were standard error of the estimate and coefficient of deter- ) mination (r 2.5 Effect of soil drought on water and carbon fluxes - quantification The effect of drought on...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
Ngày tải lên :
09/08/2014, 08:22
... tissue -specific and inflammation -specific regulation of fibroblast function Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol No Hardy et al Figure Expression of ... the effect of cortisone being abrogated by glycyrrhetinic acid (data not shown) Discussion Fibroblasts and endothelial cells are able to influence immune responses through expression of specific ... Willebrand factor staining) Page of 10 (page number not for citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow,...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 13:22
... repressive Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol 11 No Lee et al Figure Network-based analysis ofof upregulated genes in the functional category of immune ... expression profiles of immune response-related molecules in vivo Despite an additional proportion of granulocytes (mainly neutrophils), our results showed that there was an overexpression of several ... effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating experiments did not show any strong evidence of...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
Ngày tải lên :
11/08/2014, 08:21
... pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV Journal of Immune Based Therapies and Vaccines 2011 9:2 Page of Submit your next manuscript ... delivery of attenuated Lmdd-HIV-gag is immunogenic and can induce Gagspecific cellular immune responses, even in the presence of multiple prior Lmdd exposures Anti-vector and anti-HIV Gag antibody responses ... Certainly the ability of Lm to direct immune responses to mucosal regions is an attractive feature of this vector [22] Thus, this technology should be considered a part of a heterologous prime-boost...
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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs" pot
Ngày tải lên :
12/08/2014, 04:21
... approved by The Animal Research Ethics Committee of Umeå University, Sweden Evaluation of immune response To evaluate and compare the immune responses after vaccination and infection, eight animals ... carbencillin to OD A600 of 0.7 Expression of the antigens was induced by the addition of isopropyl-beta-D-thiogalactopyranoside (IPTG) at a final concentration of 0.5 Page of 10 (page number not ... presentation of antigens [37], but interestingly, while the sera of immunised mice recognized the amino-terminal part (aa 1–100) of the Nprotein, sera of the infected animals did not The lack of reactivity...
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Báo cáo y học: "Antigen-presenting particle technology using inactivated surface-engineered viruses: induction of immune responses against infectious agents" pptx
Ngày tải lên :
13/08/2014, 09:21
... cell CD28 receptor, and fragment C of tetanus toxoid Implantation of these cells in mice resulted in successful in vivo induction of tetanus toxoid specific immune responses [25] Although successful, ... supports the premise that the observed inhibition of HIV replication is not due to massive apoptosis of CD4-positive cells Induction of specific antibody responses Unlike HIV-1, HSV-2 does not replicate ... performed by the addition of 1.2 g of PEG (MW = 3,350) and 2.2 g of NaCl per 100 ml of culture supernatants, resulting in a 6% final concentration that would favor the recovery of particles relative...
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Báo cáo y học: "Dynamic models of immune responses: what is the ideal level of detail" pptx
Ngày tải lên :
13/08/2014, 16:20
... tracking a larger number of immune components are often desirable when studying the progression of an infection or disease Given our need to study the dynamics of immune responses to infection ... can parameterize the continuous change of immune components as a function of time The model reveals specific parameters defining the dynamics of the host’s immune processes that are important in ... Cattadori, I M., Immune regulation of a chronic bacterial infection and consequences for pathogen transmission”, submitted] Since the immune responses involve interactions at the site of infection,...
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Mapping targets of immune responses in complete dengue viral genomes
Ngày tải lên :
10/11/2015, 12:27
... 13 2.1.2 Immune responses to dengue virus infection 13 2.1.3 Targets of immune responses in dengue viral genome 15 2.2 Antigenic diversity of targets of immune responses in ... B-cell epitopes on the surface of dengue virus Cellular immune responses, such as cytotoxic and helper T-lymphocyte responses, are an essential part of the specific immune responses to DENV infections ... capable of producing an immune response 14 2.1.3 Targets of immune responses in dengue viral genome The principal targets of cellular immune response to DENV are shown in Table 2.1 The T cell responses...
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Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
Ngày tải lên :
09/08/2014, 06:23
... negative regulation of LPS responses Immunity 2002, 17:677-687 Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ: Re-examination of the role of suppressor of cytokine signaling (SOCS1) in the regulation ... weeks of age about 50% of the SOCS7-deficient mice died as a result of hydrocephalus that was characterized by cranial distortion, dilation of the ventricular system, reduced thickness of the ... the expression of IFN-responsive genes in SOCS3- Regulation of lipopolysaccharide (LPS) signaling by STAT3 (signal transduction and activators of transcription 3) and suppressor of cytokine signaling...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
Ngày tải lên :
05/03/2014, 23:20
... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases ... amount of damage to host tissues and organs Interestingly, both sides of this equation co-evolved several mechanisms that mediate pathogen recognition, initiation and expansion of immune responses, ... in regulation of the immune response.” Annu Rev Immunol 22: 503–29 Aliberti, J., S Hieny, et al (2002) “Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
Ngày tải lên :
30/03/2014, 15:20
... effects of leptin and progesterone in the immune system This differential regulation of FAAH suggests that the same factors can lead to a cell-specific control of the tone [24] and the activity of ... presence of 100 nM ÔcoldÕ leptin (data of the ÔcoldÕ leptin experiment with CHP100 cells were superimposable to those of U937 cells, and were omitted for the sake of clarity) Western blot analysis of ... were increased by treatment of U937 cells, but not of CHP100 cells, for 24 h with lM progesterone (Fig 3B) Quantitative analysis of phospho-STAT3 and of total Ikaros isoforms by ELISA corroborated...
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Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx
Ngày tải lên :
18/06/2014, 16:20
... functionality of monocytes after treatment, we considered the upregulation of the expression of any one of these independent markers by more than 50% to be a gain of function In the 1.25 mg-group, 28% of ... Page of 11 The a priori level of significance was a p-value of < 0.05 Data was computed using JMP® software Results Safety Two out of the 33 enrolled patients were removed from the 1.25 mg arm of ... we saw a doubling of the objective response rate which suggests that IMP321 is a potent agonist of effective anti-cancer cellular immune responses in this clinical setting Page of 11 Table Patients...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
Ngày tải lên :
18/06/2014, 16:20
... likely reflects ongoing autoimmune responses towards b-islets Although still under development, assays of immune responses, and in particular antigen -specific T cell responses could become an alternative ... onset and severity of T1 D, as well as reduced susceptibility to other organ- specific autoimmune disorders, such as experimental autoimmune encephalomyelitis (EAE) and autoimmune ovarian dysgenesis ... variation influences immune selection and/or activation of antigen -specific, pathogenic T cells, leading to a breakdown of self tolerance in a given organ These two scenarios are of course non mutually-exclusive...
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báo cáo hóa học: " The impact of shift work induced chronic circadian disruption on IL-6 and TNF-a immune responses" pot
Ngày tải lên :
20/06/2014, 00:20
... Mark et al Journal of Occupational Medicine and Toxicology 2010, 5:18 http://www.occup-med.com/content/5/1/18 deprivation and thereby an induction of proinflammatory immune responses [7-9] Cytokine ... shift schedules The mean age of shift workers was 36.4 yrs (SD 9.34) and the mean age of daytime workers 40.1 yrs (SD 7.77; p < 0.001) 86.9% of the shift workers and 75.7% of the day workers were ... influence of chronic sleep debt and circadian disruption on the immune system we compared cytokine production and lymphocytes count in a morning blood sample of shift workers with Table Influence of...
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Báo cáo hóa học: " Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine" pot
Ngày tải lên :
20/06/2014, 01:20
... innate and cellular responses (NK, NKT, and CD8+ T cell responses) associated with clearance of influenza viral infected cells [23] The role of innate and adaptive cellular responses to influenza ... epitopes of influenza proteins in the context of a highly immunogenic, non-infectious structure VLPs elicit immune responses and protection at low doses (HA content) and without the use of an exogenous ... efficient immune responses Curr HIV Res 2006, 4:475-484 McBurney SP, Young KR, Ross TM: Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses...
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báo cáo hóa học:" Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Chi Zhang" pptx
Ngày tải lên :
20/06/2014, 04:20
... (IGF-1) can Zhang Journal of Orthopaedic Surgery and Research 2010, 5:37 http://www.josr-online.com/content/5/1/37 Page of Figure3 The proposed model of coordinated regulation of osteoblast differentiation ... multifunctional determinant of craniofacial patterning and osteoblast differentiation Cell 2006, 125:971-986 11 Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH: Regulation of adult bone ... as: Zhang, Transcriptional regulation of bone formation by the osteoblast -specific transcription factor Osx Journal of Orthopaedic Surgery and Research 2010, 5:37 Page of ...
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