optimization techniques in pharmaceutical formulation and processing

... b-hexosaminidase content in SG+ ⁄ + cells at day 33 is set as 100% Results are expressed as means of triplicate determinations ± SD detected in SG– ⁄ – cells, indicating that pro-CPA processing into ... lack of SG also results in defective cathepsin E storage and that this, in turn, results in defective pro-CPA processing, leading to an accumulation of pro-CPA Next, we investigated the possibility ... and protein analysis (A) Total RNA was prepared from serglycin (SG)+ ⁄ + and SG– ⁄ – bone marrow-derived cells after different durations (days 0–33) of culture in medium containing interleukin...

Ngày tải lên: 07/03/2014, 11:20

... Materials, and Techniques in the Archaic and Classical Periods Edited by Olga Palagia Frontmatter More information GREEK SCULPTURE egh FUNCTION, MATERIALS, AND TECHNIQUES IN THE ARCHAIC AND CLASSICAL ... Cataloging in Publication Data Greek Sculpture : function, materials, and techniques in the Archaic and classical periods / edited by Olga Palagia p cm Includes bibliographical references and index ... Oxford and a Fellow of the British Academy He has specialized in the study of Greeks and Greek culture overseas, burial customs, and in ancient gems and finger rings He has written several handbooks...

Ngày tải lên: 23/03/2014, 11:21

... where distinguished within Chapter 6: - Coated printing and writing paper as for instance coated fine paper used for printing, writing and copying Uncoated printing and writing paper as for instance ... elsewhere or may be integrated with the pulping operations on the same site That is to say, the activities involved in pulping and recovered paper processing and those involved in papermaking may be undertaken ... separately or in combination on the same site Both pulp mills and paper mills are operated in non-integrated and integrated ways Mechanical pulping and recycled fibre processing is usually an integrated...

Ngày tải lên: 01/04/2014, 00:20

... Wireless Communications and Networking Precoding in Wireless Systems, and Optimization Techniques for Scheduling in Wireless Systems Three papers are included in each of the first and the second categories, ... Lagrange optimization approach Optimization Techniques for Precoding and Beamforming in Wireless Systems In this part, it is demonstrated how the optimization techniques can be used for developing ... enjoy reading the carefully selected papers on the exciting research area of Optimization Techniques in Wireless Communications Sergiy A Vorobyov Shuguang Cui Yonina C Eldar Wing-Kin Ma Wolfgang...

Ngày tải lên: 21/06/2014, 22:20

... dotted line: same conditions as in Fig 1a (i.e., with cooling and without stirring) but the 10-fold diluted EL Dashed line: RT, no stirring Continuous line: RT, stirring Thick line: cooling, no ... was maintained in all the anodizations and for all the process time period, a linear relationship between J and h was expected [5, 22] However, after the initial increase in h with increasing J ... by hand brushing ([10 s) with acetone-wet lens paper, sonicating in warm (60 °C) acetone, rinsing in de-ionized (DI) water, sonicating another in warm (60 °C) ethanol, and thoroughly washing...

Ngày tải lên: 22/06/2014, 00:20

... fibroin fiber scaffolds containing bone morphogenetic protein (BMP-2) and/ or nanoparticles of hydroxyapatite (nHAp) using electrospinning, and showed its ability in inducing in vitro bone formation ... of connected polymer chains Crosslinking can be done either through physical (UV irradiation, freeze drying and heating) and chemical means such as ionic crosslinking in presence of divalent ... morphogenetic proteins, plays an important role in the development of bone and cartilage It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction...

Ngày tải lên: 14/09/2015, 08:41

... processes (for instance emulsification and electrospinning as well as post -processing conditions like scaffold handling and incubation) that may result in partial removal of amino acid groups and conformation ... load BMP-2 into three dimensional fibrous scaffolds using an electrospinning method, including encapsulating into fibers or coating on fiber surface, and revealed that BMP-2 encapsulated into fibers ... control The results were obtained by rinsing and removing the scaffolds from their respective plate wells hours after seeding, and by counting the cells remaining inside the plate well, the attachment...

Ngày tải lên: 14/09/2015, 08:41

... BMP-2 into three dimensional fibrous scaffolds using an electrospinning method, including encapsulating into fibres or coating on fibre surface, and the results revealed that BMP-2 encapsulated into ... treatment of IHC staining, vWF can be stained as brown color Therefore brown color staining detected in bone fragments can be seen as the formation and growth of new blood vessels H&E staining analysis ... color staining is observed for control and F1, but F2-F4 show more of brown staining The observations demonstrate that the cells in bone fragments treated by F2-F4 are refreshing and growing, accompanied...

Ngày tải lên: 14/09/2015, 08:41

... distinct bands present on the gel (Figure 5.6) In other words, the released DNA has survived both the electrospinning process and postprocessing conditions (handling of scaffold, incubations, and ... hypodermic syringe, Popper & Sons, Inc., New Hyde Park, NY US) fitted with a 29-g needle and set up in the elecontrospinning apparatus The flow rate of polymer solution from the syringe into the spinneret ... and C) For group A, an initial burst shows up suddenly from the starting point till days 7-9 for samples A1, A2 and A3 In contrast, when the cumulative DNA release reached 80-85%, the remaining...

Ngày tải lên: 14/09/2015, 08:41

... B3, and C1 Furthermore, this also confirms that during the progress of bone healing, tissue reabsorbing/remodeling, and the in growth of blood vessel are interactively together rather than being ... graft In a previous study (Nie and Wang, 2007), PLGA/HAp composite scaffolds with different HAp contents (0%, 5% and 10%) were fabricated by electrospinning method and DNA was incorporated into ... of new bone and the healing of segmental defects in vivo Groups A, B and C released DNA or DNA nanoparticles in different ways and time frames, thus, their performances in bone healing were not...

Ngày tải lên: 14/09/2015, 08:41

... are maintained after going through the processes of spray drying, supercritical CO2 foaming and post -processing conditions (handling of scaffold, incubations, and lyophilization) As shown in Figure ... course of the spray drying process, high-pressure supercritical CO2 foaming process, and post -processing conditions (handling of scaffold, incubations, and lyophilization) Comparing the results for ... after and 30 days retained its original structural integrity as evidenced by the distinct bands present on the gel (Figure 7.5b) This shows that the plasmid DNA integrity could be maintained in...

Ngày tải lên: 14/09/2015, 08:41

... Lysine-based peptides modified foams for tissue engineering and DNA delivery Toward realizing an effective dual system for tissue engineering and DNA delivery, our work presents intriguing findings ... regarding their applications in tissue engineering and it has been proved that polymeric foams are promising candidates for tissue engineering (Chun et al., 2004; Nie et al., 2008a; Takahashi and ... protein is too low, especially in the initial stage (Figures 7.5a and 7.7b) Therefore, an initial and significant release of DNA is demanded in order to optimize this kind of devices Lysine,...

Ngày tải lên: 14/09/2015, 08:41

... PLGA/chitosan and PLGA/Lysine composites is in form of naked DNA and its transfection efficiency is extremely low, which would hinder their applications in biomedical engineering In future investigations, ... cytotoxicity and sustained expression of DNA, which is favorable for DNA delivery and tissue engineering applications In conclusion, this research has shown potential applications of electrospinning and ... electrostatic interaction and hydrophilic interaction between DNA and the surface of Lysine pepetide modified foams The sustained release of DNA from PLGA/chitosan and PLGA/Lysine foams led to...

Ngày tải lên: 14/09/2015, 08:41

... Advances in Process Systems Engineering – Vol STOCHASTIC GLOBAL OPTIMIZATION Techniques and Applications in Chemical Engineering 7669 tp.indd 4/22/10 10:35:38 AM Advances in Process Systems Engineering ... achieving sustainable processes and manufacturing In view of its importance and usefulness, optimization has attracted the interest of chemical engineers and researchers in both industry and academia, ... Multi-Objective Optimization: Techniques and Applications in Chemical Engineering, World Scientific, Singapore Ravindran, A., Ragsdell, K.M and Reklaitis, G.V (2006) Engineering Optimization: Methods and...

Ngày tải lên: 01/04/2014, 11:36

... learners gain success in teaching and learning listening skill Classroom listening Class-room listening may be divided into intensive listening and extensive listening Intensive listening Intensive ... UFFP in learning listening skills and the possibility of applying bottom-up techniques to teach these skills at the university; - Investigating the effects of using bottom-up techniques in teaching ... rising intonation contour in or falling intonation Place a check in column (rising) or column sentences (falling), depending on the pattern you hear Discriminating between phonemes Listening...

Ngày tải lên: 07/09/2013, 13:48

... properly before processing is among the main reasons for contamination in fruit juice Washing and brushing fruit before the juicing step is common in juice processing According to one industry survey, ... production, including preharvest practices of planting, growing of fruit, harvesting, postharvest handling, washing, and cooling and storage PREVENTIVE MEASURES IN THE ORCHARD Contamination of ... seagulls,9 and cattle and other ruminants10 in the orchard by direct or indirect contact should be prevented, and fertilizing orchards with manure should be avoided 11 Using “drops” and damaged fruit increases...

Ngày tải lên: 25/10/2013, 21:20

... linguistic, metalinguistic, and extralinguistic knowledge The system is constructed by combining a "closed" system, based only on linguistic knowledge (a lingware written in ARIANE-78), and two "open" ... others with the definition and use of specification formalisms ("static grammars") and verification tools Gran~atical knowledge processing Just as in current software engineering, we have long ... function) between strings and trees~ or trees and trees : many trees may correspond to one string, and, conversely, many strings may correspond to one tree Lexical knowledge processin~ In the long run,...

Ngày tải lên: 08/03/2014, 18:20

... Milling Pasta Number of case studies 3 1 1 1 Innovations in Minimizing Waste and Wastewater Effluent From Food and Beverage Processing Operations >> Case Studies Innovations in Minimizing Waste and ... Contact Information Jay Mullin, Project Analyst OCETA 905-822-4133 ext 238 Innovations in Minimizing Waste and Wastewater Effluent from Food and Beverage Processing Operations Cheese Processing: Pine ... measures and projects undertaken in Canada, the USA, and internationally They cover a number of sub-sectors including dairy, brewing, meat and seafood processing, dry and baked goods, and other...

Ngày tải lên: 08/03/2014, 23:20

... of clean water for processing, such as for washing raw material and products, cleaning of machines, containers or flushing the working floor, de-icing, thawing and salt soaking All the water used ... shrimp processing in Soc Trang province, using an industrial ecology perspective Soc Trang is one of the Vietnamese provinces with large production of shrimp in terms of farming and processing industries ... 4.7 Networks embedding shrimp processing industry in Soc Trang province (main relations for eco-industrial clusters in bold lines) 98 Figure 5.1 Provincial pangasius production in Vietnam 106 Figure...

Ngày tải lên: 13/03/2014, 18:58