optimising the development of antibodies as treatment for cancer
báo cáo khoa học: "From basic research to clinical development of MEK1/2 inhibitors for cancer therapy" pot
... strong rationale for the clinical development of drugs targeting the ERK1/2 MAP kinase pathway in cancer, the effectiveness of this approach in cancer therapy remains to be validated The first and ... than 40% of melanomas [57] The majority of these mutations are clustered in the kinase domain of B-Raf and lead to the stimulation of ERK1/2 activity in cells [58] It is noteworthy that RAS and ... proliferation of specific cell types [34-37] ERK1/2 signaling is required for the progression of cells from the G0/G1 to S phase [20,38] Activation of the ERK1/2 pathway is associated with induction of the...
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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx
... would be the "nanofilter" that serves as the main point of resistance to the transvascular passage of spherical particles larger than 12 nm in diameter across the BBTB Therefore, in the physiologic ... estimated by the in vivo measurement of tumor tissue MRI signal at baseline (T10) and then again following the intravenous infusion of the Gd-dendrimer (T1), and the in vitro measurement of the molar ... first-pass drug delivery across the BBTB [44-46], and the temporary opening of the junctions between endothelial cells of the BBTB to enhance the permeation of drugs across the BBTB[34,47,48] The...
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Báo cáo khoa học: " Development of a sandwich ELISA for the detection of Listeria spp. using specific flagella antibodies" potx
... (PBS-T) was added and incubated for 30 at room temperature (RT) After Development of a sandwich ELISA for the detection of Listeria spp using specific flagella antibodies 43 washing, 100 µl of each ... antibody (MAb) was diluted in carbonate buffer (pH 9.6) to the concentration of 10 µg/ml and 100 µg of diluted MAb was added into ELISA plate (Costar, Netherlands) The plate was incubated for h at 37oC ... ELISA was used to monitor the development of the antibody level using the yolk diluted 1,000 times with PBST The yolk antibody also showed no cross reaction to any other bacteria (Table 1), and the...
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Báo cáo khoa học: "Development and evaluation of indirect ELISA for the detection of antibodies against Japanese encephalitis virus in swine" pptx
... sisongaid -ores eht ni esu laitnetop sti rof detagitsevni saw ASILE-I VEJ eht rof depoleved saw dohtem lacigolores tneinevnoc dna elpmis a ,nosaer siht roF selpmas fo rebmun detimil a htiw noitazidradnats ... cificeps-suriv sitilahpecne esenapaJ gnitceted rof metsys yassa noitanitulgga elcitrap a fo tnempoleveD I enaruK ,M orihsaT ,T ikasakaT ,T awagO ,H awasaraK ,K oguS ,Y awasoruK ,M amayakaN ,A otomamaY 81 961-951 ... lacigoloreS ASILE -I rof desu erew snegitna deifirup eht ,)SBP( enilas dereffub etahpsohp ni sisylaid retfA sreyal esorcus owt eht neewteb ecafretni eht morf derevocer saw negitna ehT )ASU ,namkceB(...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... of illness, and the duration of the current episode, and the number of visits with a psychiatrist over the last six months There are limitations of the present study The sample of patients was ... among the high and the poor knowledge-performers in the three groups for age, durations of illness, the duration of the current episode, and the number of visits with a psychiatrist over the last ... to understand the need for maintenance treatment Q25 Knowledge of different kinds of treatments Q18 Knowledge of the magnitude of therapeutic efficacy of treatments Q20 Knowledge of common side-effects...
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Application of recombinant antibody technology for the development of anti lipid antibodies for tuberculosis diagnosis
... ulcerations of the soft tissue of the skin respectively (15,16) M leprae on the other hand is well known for its association with the historical disease leprosy (17) However, there is a large group of ... individuals) of the world’s population has LTBI (1) However, there is a 5% chance of active disease within the first 18 months of infection and a further 5% chance of disease reactivation over the person’s ... months of antibiotic therapy) and the lack of specificity for active TB for diagnosis on the basis of symptomology, X-rays or TST/IGRAs alone (35) This is evidenced by the low proportion of microbiologically...
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Development of cell sheet constructs for layer by layer tissue engineering using the blood vessel as an experimental model 1
... approach The aim of the present thesis was to investigate the use of PCL films as scaffolds in layered tissue engineering, using the blood vessel as a model The scope covers the engineering of microthin ... transplantation has become increasingly common in the past 30 years and has saved many lives, while having improved the quality of lives of thousands of other patients Paradoxically, the advent of reliable ... his energy, dedication and passion for research I would like to thank the students and staff of BIOMAT Centre, past and present, for their help and the pleasure of their company: Chee Kong, Fenghao,...
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Development of cell sheet constructs for layer by layer tissue engineering using the blood vessel as an experimental model 2
... cultured in the same medium, fibroblastic cells quickly grew out from fetal liver mononuclear cells, and failed to express endothelial phenotype 122 Chapter Isolation and Characterisation Of Vascular ... Chapter Isolation and Characterisation Of Vascular Progenitors Figure 4-3: Primary culture of haemopoietic tissue in EGM Following culture in endothelial cell media, outgrowth colonies were ... Characterisation Of Vascular Progenitors (a) (b) (c) (d) (e) (f) Figure 4-4: CFU assay Adherent colonies appeared after ten days of culture, and were stained with crystal violet to facilitate visualization...
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Development of cell sheet constructs for layer by layer tissue engineering using the blood vessel as an experimental model 3
... vWF was sporadically expressed on the cells A functional assay of acLDL uptake was performed to confirm the endothelial nature of the cells In contrast to the immunostaining results, acLDL was ... of the cells to semi-solid cultures for haematopoietic colony forming assays as an assessment of the retention of haematopoietic character following expansion As seen in Figure 4-10, Colony forming ... medium, the adhered fibroblasts and MSC quickly outgrew the EPC population To verify the presence of haematopoietic and endothelial lineage cells in the liver, I studied the expression profile of the...
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Development of cell sheet constructs for layer by layer tissue engineering using the blood vessel as an experimental model 4
... Frequency Glow Discharge (RFGD) Plasma after thorough repeated washing My results confirm the feasibility of the use of plasma based methods for the surface modification of µXPCL films without affecting ... increased O:C ratio following PAAc grafting, and then the introduction of an N1speak following the conjugation of the CD34 antibody, indicating presence of the protein High resolution surveys of the ... 5.2.1.4 Assessment of tensile properties The choice of the plasma-based method to modify the µXPCL surface was made on the basis of its advantageous low depth of penetration However, bioresorbable...
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SOME SOLUTIONS FOR THE DEVELOPMENT OF CONSUMER LENDING AT TECHCOMBANK HOANG QUOC VIET
... used to assess the efficiency of THQV’s consumer loans and find out the strength, the weakness as well as the reason for its shortcomings Then, based on the limitations, this report puts forward ... Step 3: The director of the branch will responsible for approving the loan application form or not if the value of the loan does not exceed 500 million In case of an exceed, the director of the branch ... be formed from loan capital or other assets The borrower only has gives the bank the legal papers, proof of legal ownership of the mortgaged property It does not need to transfer the lien of...
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The Potential of Biofumigants as Alternatives to Methyl Bromide for the Control of Pest Infestation in Grain and Dry Food Products
... effective tool for the control of stored-product insect pests In view of the scheduled phaseout of methyl bromide under the Montreal protocol, the role of phosphine in grain protection has increased and ... were performed to evaluate the activity of the fumigants The first screening of the compounds was space fumigation in glass chambers of 3.4-L capacity (for details see Shaaya et al., 1991) The highly ... on the rates of sorption of homologous series of ITCs on wheat, we could show that the rate of sorption decreases with increasing molecular weight (Shaaya and Desmarchelier, 1995) In the case of...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... is the common name for the flowering plant, Hypericum perforatum L (Gaster and Holroyd, 2000), a member of the Hypericaceae family Its yellow flower has been gathered for the feast of St John the ... disease outcome), except for the treatment exposure If neither the investigators nor the study subjects know who was allocated into the treatment group or the control group, then the RCT was “double-blinded.” ... constant increasing pattern of the G1 /S index was observed in the treatment group, whereas the G1 /S ratio of the control group decreased concomitantly between 10 and 24 h of treatment Following...
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Tài liệu Báo cáo khoa học: Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse pdf
... University of Tokyo, Japan) for help in performing endothelial tube formation experiments This work was supported by grants from the Japan Society for the Promotion of Science (to T I.) and the Ministry ... examine the endothelial cell biology of the mouse, and will accelerate the molecular and cellular analysis of ECs and their heterogeneity in various vascular beds 1994 Construction of the transgene ... sequence of the Pgk gene, and a portion of the multiple cloning site of pMCS5 XhoI–EcoRI-digested tsA58T Ag cDNA was blunted and cloned into the SwaI site of pCGX, and the direction was verified...
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Tài liệu The Development of the Feeling for Nature in the Middle Ages and Modern Times doc
... in the Gargaric grove Nature has made nothing dumb; the birds of the air and the beasts of the earth are not silent, the snake has its hiss, the fishes of the sea as they breathe give forth their ... wherein all the beasts of the forest creep forth 'The young lions roar after their prey, and seek their meat from God 'The sun ariseth, they gather themselves together, and lay them down in their dens ... rivers, their force is increased Therefore, felling down the trees on both the banks, they, like unchaste women, are going quickly towards the ocean 'The heat of the forest has been removed by the...
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Báo cáo " Development of climate change scenarios for small areas in Vietnam by using the MAGICC/SCENGEN software in combination with statistic correction" docx
... through: + Assumption testing the magnitude of the correlation coefficient Rxy + Assumption testing the magnitude of the coefficient of regression equation + Assumption testing the efficiency of regression ... for small areas of Vietnam such as the Red River basin, the Lao Cai area, Thua Thien Hue region, and other climatic regions of Vietnam as well [5] and most recently climate change scenarios for ... products of MAGICC/SCENGEN 5.3 software need more consideration In the study, the temperature and rainfall scenarios are built in the monthly form of decades of the 21st century However, within the...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
... the literature In the feedback process, the opinions of the industrialists and academics were obtained based on their knowledge and experience Methodology for review of the related articles The ... prove this assertion, the distribution of published articles per year extracted from the Web of Science database is demonstrated in Figures to Therefore, in order to determine the formation of active ... (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production stage and...
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Báo cáo khoa học: " The Development of Lexical Resources for Information Extraction from Text Combining Word Net and Dewey Decimal Classification" potx
... taken from the DDC The development WN-PDDC as generic resource (see figure 2) Before starting the development, the set of field labels relevant for the application must be identified Then the Core ... guarantee the system from noise caused by spurious entries in the lexicon The BL could be seen as the complementary set of the FL with respect to the generic language, i.e it contains all the words of ... to the use of generic dictionaries with respect to the IE needs First there is no clear way of extracting from them the mapping between the FL and the ontology; this is mainly due to a lack of...
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novel semiconductor materials for the development of
... technology Based on these facts it was clear that the precise control of the surface chemistry was mandatory for the final optimization of the device performance For this reason there are some basic ... CHEMFET of BIOFET In all of these devices, the surface potential developed at the surface of the semiconductor is based on the direct interaction of the ligand with the exposed atoms of the semiconductor, ... the case of a GaN-based CHEMFET, the interaction of Lewis bases with the surface will drastically influence the internal band structure of the semiconductor As a result, the carrier density in the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25