operation design and construction of impulse generators
kuffel, e. (2000). high voltage engineering - fundamentals (2nd ed.)
... As such, an understanding of these methods leads to clearer understanding of the basis of insulation coordination Similarly, an understanding of the operation and application of metal oxide arresters ... the concepts of power transmission, voltage stress, and testing with various types of voltage Chapter provides a description of the apparatus used in the generation of a.c., d.c., and impulse voltages ... electrical breakdown of gases The breakdown of liquid and solid dielectrics is presented in Chapter of the current edition Chapter of the new text represents an expansion of Chapter of the previous...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance ... Popliteal and pedal pulses were absent bilaterally with poor capillary refill The left foot was red and inflamed up to and including the medial malleolus The lateral aspect of the great toe and second ... continued to improve and heal, and her remaining gangrenous toes eventually fell off Her blood pressure at admission was 166/53 with use of Lisinopril, which was dropped and eventually ceased...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... A_3 of the left hole of the link, and then pick the axis A_12 of the pin at arm 45 For Translation constraint, select the back face of the link, and then pick the front face of the arm Click OK ... of top hole of the arm_asm sub-assembly with the axis A_2 of post – see figure below 40 For Translation constraint, 41 Pick the circular face in the back of arm as shown Pick the front face of ... another Pin connection between link and eccentric 43 As Axis alignment constraint, select the axis A_4 of the right hole of the link, and then pick the axis A_4 of the pin at eccentric For Translation...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... depth of 160m in the central part of basin This is a product of tectonic activities of the Dien Bien - Lai Chau fault zone in Pliocene-Quaternary time and is one of the bases for determining age of ... structure and formation of the Dien Bien basin The geological structure of the Dien Bien basin is composed of main parts: the basement consists of Triassic sedimentary bedrock and the cover consists of ... of pebble, granule, sand and boulder in the low part, silt, clay mixed with some sand layers in the upper part The last one is composed of pebble, granule mixed with silt and clay Mechanism of...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... A-chain and B-chain of nPS, and in the case of His37, the v1 torsion angle changes from 63.34° to )67.80° and )52.11° for the A-chain and B-chain of nPS, respectively The imidazole ring of His34 ... Protein–ligand and water-mediated protein–ligand hydrogen bond interactions (broken lines) that stablize the pantoate molecules in site I and site II of nPS Oxygen atoms of pantoate and water ... expanded view of the superposed substrate-binding sites of nPS (green) and M tuberculosis PS (magenta) In nPS, the pantoate molecule takes the position of the adenine ring of ATP The carbon and...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... chains of Pro34 and Leu38 N1 and N6 of the base of A20 lie close to Nd2 and Od1 of the side chain of Asn87 in the S4 strand, with ˚ ˚ distances of 2.82 A and 2.97 A, respectively The plane of the ... aromatic ring of Tyr587 at the C-terminal end of H23 and the hydrophobic side chains of Ile517 of H19 and Pro591, Val592 and Leu593 of the loop between H23 and H24 (Fig 5C) N4H2 and O2 of C35 are ... N-terminal domain and the bases of G19 and A20 in the complex of P horikoshii ArgRS are shown in Fig 5B The bases of G18 and G19 of the D-loop form hydrogen bonds with the bases of U55 and C56 of the T-loop,...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... inhibition and TRAIL in osteoarthritic disease and chondrocyte apoptosis, and the hypoxic inhibition of cartilage and chondrocyte degeneration Results Macroscopic and radiographic examination of the ... chondrocyte apoptosis and may suppress the progression of arthritis Materials and methods Induction of OA Beagle dogs (n = 20) with a mean ± SD age of 1.4 ± 0.4 years and a mean ± SD weight of 10.2 ± 1.4 ... surfaces of natural killer (NK) cells, as well as on CD4+ and CD8+ T cells It promotes apoptosis, which may aid in the resolution of infection and the attenuation of the development of streptoxotocin-induced...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... 35, and 70 after the addition of the enzyme The top spectrum is that of DHMP for comparison Only the NMR signals of the 2¢ and 3¢ protons of DHNP and DHMP are shown The chemical structures of ... NP and MP and 2248 between HP and HPO in accordance with the similar shapes and sizes between NP and MP and between HP and HPO The different Kd values are proportional to the different values of ... emission wavelength of 430 nm and an excitation wavelength of 330 nm for HP and at an emission wavelength of 446 nm and an excitation wavelength of 360 nm for HPO The emission and excitation slits...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... detailed sequence of zinccoordination changes during catalysis and the mode of inhibition of anions such as fluoride and phosphate Experimental procedures Purification of SGAP The cloning of the SGAP ... range of the expected ioniza- Mechanism of an aminopeptidase from S griseus tion of a zinc-bound water ⁄ hydroxide in solution, DHion of 20–30 kJÆmol)1 [52] The enthalpy of ionization of a carboxylic ... for both SGAP and the catalytic mutant E131D, resulting in solvent isotope effects of 1.67 and 2.52, respectively, at pH 8; and 2.10 and 2.92, respectively, at pH 6.5 (Table 1) The profound solvent...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths of ... 79 Analysis of the fungicidal effect of viscotoxin A3 M Giudici et al excitation and emission wavelengths were 360 ⁄ 425 and 362 ⁄ 450 nm for observation of the fluorescence of DPH and TMA-DPH, ... potential and volume homeostasis of mitochondria Cell 91, 627–637 27 Haugland RP (1996) Handbook of Fluorescent Probes and Research Chemicals, 6th edn Molecular Probes, Inc, Eugene, OR 28 Chandra...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... parts of sequences of the mutants of M luteus B-P 26 UPP synthase (EKE, RAKDY) and of Srt1p (Srt1p-delta) are shown (B) TLC autoradiograms of polyprenyl alcohols corresponding to products of cis-prenyl ... structure of E,EFPP complex of UPP synthase from E coli (Protein Data Bank No 1V7U) Then, structures of E,E-FPP and IPP, which were identified from the complex structure of IPP and the D26A mutant of ... been described [29] In order to understand the molecular mechanisms of chain length determination, we built structural models of Rv1086 and of LLLH mutant of M luteus UPP synthase using the E coli...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... light path of the cuvette], which considers the decrease of the concentration of oxaloacetate in equilibrium with L-malate during the formation of NADH (the concentrations of malate and NAD+ remain ... Determination of intracellular propionyl-CoA and acetyl-CoA Concentrations of acyl-CoA were determined by the use of citrate synthase from pig heart and purified methylcitrate 3230 M Brock and W Buckel ... cell-free extract and water to a final volume of 980 lL The reaction was started by the addition of 20 lL of a 100 mM ATP solution (final concentration mM) and the reduction of NAD was monitored...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... glucose units of pullulan (Fig 4A) IPU is an anomer-inverting enzyme Comparison of the active sites of the model of IPU and Dex49A The active site structures of the model of IPU (Fig 4A) and Dex49A ... reducing end side of these substrates (Fig 5B) The activities of IPU for 32 mM of IMTG, panose and MM were assayed, and mg of the enzyme liberated 18.5, 14.0 and 7.37 lmolÆ min)1 of glucose, respectively ... cleft In the model of IPU, several aromatic and charged residues, Trp277, Tyr349, and Asp371, are present in the vicinity of Gly350, and could be favourable for binding of Glc +2 of the a-(1fi4)-linked...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... EAD is off the reaction pathway responsible for the principal transformation Values of KSH and kf(H) correspond to KD and kf for the reaction of nondeuterated substrate, and KSD, kf(D) and kr(D) ... statistical factor taking account of the ratio of protons and deuterons on the considered group when the latter is polyprotic; (c) the degree of restriction of the free rotation of the considered group ... concentration of L-Met and TPL being 95.23 mM and 2.64 unitsÆmL)1, respectively One-milliliter aliquots were withdrawn after 108, 250, 360, 568, and 754 and treated as above The theoretical values of isotopic...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... survey of the absorption features of MPO, LPO and their intermediates The absorption spectrum of MPO is characterized by an intense Soret peak at kmax ¼ 430 nm and weaker bands at 570, 620 and 690 ... effect of H2O2 or be part of a vestigial enzymatic pathway, now abandoned O’Brien suggests its role is in the oxidation of physiologically relevant substrates, drugs and in the etiology of some ... reducing effect of superoxide ions, in the form of Cpd III, is shown in steps 5, and and goes along with dioxygen release The optical absorption peaks of each intermediate are shown on top of the scheme...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... dithiothreitol [19] This hyperreactivity is a feature also of the mixed disuldes formed by Cys31 and Cys32 with glutathione [12], and of the mixed disuldes of MSSAE (unpublished results) To verify the hypothesis ... manner, and is ể FEBS 2003 Disuldes and antitumor action of BS-RNase (Eur J Biochem 270) 1983 Fig Time-course of dimerization of the labelled monomeric derivative of BS-RNase 125I-labelled MSSAE ... of the SDS/PAGE runs of 125I-labelled MSSAE detached by high salt from PM D and M mark the electrophoretic mobilities of BS-RNase and monomeric BS-RNase, respectively IAM and incubated for 16...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... formation and decomposition of superoxide in the system Superoxide is formed via reaction and decomposed via reactions and The rate of formation depends on the concentration of NAD and oxygen and ... Kinetics of the formation of p-670 and of the decay of compound III of horseradish peroxidase Arch Biochem Biophys 327, 279284 39 Hawkins, C.L & Davies, M.J (2001) Generation and propagation of radical ... concentrations of compound II and the aromate The consumption of Per3+ occurs via reactions 2, 6, and 10 The rates of reactions and should be smaller during oscillations, while the rate of reaction...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... positions of other Fig Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the modelled structures of wild-type and D153N mutant forms of E coli ... aligned with the sequences of 1CEV and 1RLA and pasted into the structural alignment The alignment was then corrected by hand Since the sequences of the two arginases and agmatinase greately differ ... modeling of the active site The modelled structure was very similar to the template, with respect to the number and arrangement of structural elements (a-helix and b-sheets), and one of the major...
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Tài liệu Báo cáo Y học: Dynamic mechanism of nick recognition by DNA ligase ppt
... moiety of the nick [19,25] Two of them, Lys238 and Lys240 of T7 DNA ligase (Lys188 and to a lesser extent Lys186 of Chlorella virus DNA ligase) were shown to be essential for the transadenylation and ... 5¢-phosphate of the nick and backwards in the 5¢-direction of the nicked strand Fig Illustration of the proposed mechanism of dynamic nick recognition by DNA ligase Positioning of the reacting ... template-primer, and ddCTP Science 264, 1891– 1903 41 Li, Y., Korolev, S & Waksman, G (1998) Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus...
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