nutrient and genetic regulation of lipoprotein metabolism
Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx
... via the activation of orexin- and ⁄ or NPY-expressing neurons, and that long-term body weight loss is a result of the promotion of energy expenditure GALP in feeding and energy metabolism ported ... alternate transcript of the GALP gene Further elucidation of the function of GALP and alarin will provide the necessary basis for the treatment and prevention of obesity and related disorders ... neuromediator of food intake and body weight via a specific receptor for alarin 5008 Regulation of GALP mRNA expression GALP mRNA gradually increases between postnatal days and 14, and markedly...
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Genetic and signal regulation of quorum sensing in agrobacterium tumefaciens
... regulation of the TraR receptor 22 1.3.3.4 Regulation of QS by degradation of the quorum sensing signals 25 1.4 Variations in genetic regulation of QS 27 1.5 Aims of present ... committee members A/Prof Mingjie Cai in Institute of Molecular and Cell Biology (IMCB) and A/Prof Yuan Kun Lee in Department of Microbiology (NUS), for their expert suggestions and critical evaluations ... 1.3.3 Regulation of quorum sensing in A tumefaciens 17 1.3.3.1 Regulation of the TraI synthase 17 1.3.3.2 Positive regulation of the TraR receptor 17 1.3.3.3 Negative regulation...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... understand the genetic, biochemical and cell biological mechanisms involved in the coordinated regulation of peroxisomal and mitochondrial lipid metabolism, chemical energy production and thermal ... at 50 °C and 10 at 95 °C, followed by a total of 40 twotemperature cycles (15 s at 95 °C and at 60 °C) For the generation of standard curves, serial dilutions of a cDNA sample were used and mRNA...
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Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
... mRNA signal To obtain relative TRAF4 and L32 expression values the ratio between the signal intensities of bands of treated cells and the corresponding band of the untreated group were calculated ... volumes of molecular mass standards are indicated above Ó FEBS 2002 Localization and transcriptional regulation of TRAF4 (Eur J Biochem 269) 4823 the microscope stage To prevent the synthesis of ... induction, of TRAF4 mRNA by these stimuli However, in the T-cell lines Jurkat (Fig 9A) and D23II-7 (Fig 9B) both TNF and PMA/Ionomycin, induced a significant and reproducible up -regulation of TRAF4...
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Báo cáo khoa học: Functional and genetic characterization of the promoter region of apolipoprotein H (b2-glycoprotein I) ppt
... of the complexity of regulation that occurs in vivo The regulation of human gene expression is a critical, highly coordinated and complex process The core promoter is generally within 50 bp of ... expressed in the liver and sporadically in intestinal cell lines and tissues [8] The plasma concentration of b2GPI is 20 mgÆdL)1, of which a small portion is bound to lipoproteins and the rest exists ... that the effect of the )1190G>C and )32C>A SNPs is dependent upon Trp316Ser polymorphism None of the individual haplotypes harboring less common alleles for the )643T>C (H2 and H9) and )1219G>A...
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Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
... downregulation of the miR-29 family members (miR-29a, miR-29b and miR-29c) in the border zone of murine and human hearts during myocardial infarction [25] This study also showed down -regulation of ... collagen production and the development of diabetic nephropathy through the down -regulation of PTEN and the subsequent activation of Akt (Fig 1) [43] Increased expression of miR-377 is also thought ... reasons, and knowing the multitude of pathways that miRNAs can affect, it is envisaged that investigating the roles of miRNAs in fibrosis could not only advance our understanding of the pathogenesis of...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... DNA damage is usually handled through induction of cell cycle arrest through the upregulation of cyclin-dependent kinase inhibitors, such as p21, and subsequent repair of the lesions To achieve ... p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage-induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... chemotherapeutics adriamycin, etoposide and cisplatin), the levels of Itch become reduced and allow the accumulation of p73 [53] p73 displays functions in apoptosis induction, and many of its pro-apoptotic target...
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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... respond to the presence of IPTG, and such clones were indeed found at a frequency of 22% of the second cross over event Southern blot analysis and DNA sequencing of one of these clones in the ... of gyrase activity and gyrase expression for supercoiling are negative (i.e the activity and expression of DNA gyrase is inhibited not stimulated by higher levels of supercoiling) and those of ... study the regulation of cell function both comprehensively and fairly quantitatively Yet it is of crucial importance to evaluate how much of a given regulation is effected at the level of gene...
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Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
... the refolding of misfolded proteins Loss of function of protein homeostasis genes also causes accumulation of damaged proteins and activation of gpdh-1 expression Green arrows and red lines indicate ... process of interest, allows genes to be ordered into pathways, and can provide important and novel mechanistic insights into the molecular structure and function of proteins In addition to forward genetic ... proteins [11] Mutant alleles of three of these genes, osr-1, osm-7 and osm-11, have been characterized and shown to cause constitutive accumulation of glycerol [25,29] osr-1 and osm-7 are expressed...
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Báo cáo sinh học: " Genome structure and transcriptional regulation of human coronavirus NL63" docx
... (-) strand synthesis Fine-tuning of the efficiency of the strand-transfer processes may be modulated by many other features, including the local sequence and structure of the core body TRS and its ... during (-) strand synthesis, and that the actual strand transfer within the E sequences occurred after copying of the core TRS and the next 13 nucleotides Evidence for such a "delayed" strand transfer ... nested set of (-) strand sg mRNAs are subsequently copied into a set of (+) strand sg mRNA Other factors besides the sequence similarity between body and L TRS influence the efficiency of transcription...
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báo cáo hóa học: " Leader (L) and L* proteins of Theiler''''s murine encephalomyelitis virus (TMEV) and their regulation of the virus'''' biological activities" docx
... cleavage of the p220 component of the cap-binding protein complex [32], resulting in the shut off of host protein synthesis On the other hand, the function of L of the cardioviruses is not well ... iron/ferritinmediated activation of NFκB [34] The functions of L of Page of (page number not for citation purposes) Journal of Neuroinflammation 2006, 3:19 TMEV and the other cardioviruses remain ... L of DA strain has been reported to inhibit the transcription of IFN α/β [36,40], the replication of virus is suppressed under pressure of IFN α/β L prevents transcription of IFN α/β because of...
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báo cáo hóa học:" Genome structure and transcriptional regulation of human coronavirus NL63" ppt
... (-) strand synthesis Fine-tuning of the efficiency of the strand-transfer processes may be modulated by many other features, including the local sequence and structure of the core body TRS and its ... during (-) strand synthesis, and that the actual strand transfer within the E sequences occurred after copying of the core TRS and the next 13 nucleotides Evidence for such a "delayed" strand transfer ... nested set of (-) strand sg mRNAs are subsequently copied into a set of (+) strand sg mRNA Other factors besides the sequence similarity between body and L TRS influence the efficiency of transcription...
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CLINICAL AND GENETIC ASPECTS OF EPILEPSY doc
... hyperactivation and release of toxic factors, such as nitric oxide (NO), Clinical and Genetic Aspects of Epilepsy leading to over production of excess peroxynitrite, and reactive oxygen and nitrogen ... cells of the CNS and comprise the major mechanism of self-defense against brain injury, infections and disease Activation of microglia occur as a response to these insults, and both neurotoxic and ... brain homeostasis, nutrient supply, and protection of the brain from endogenous and exogenous toxins Influx transporters that maintain CNS homeostasis and nutrient supply include A -and Nsystem amino...
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Báo cáo lâm nghiệp: "ISSR and AFLP identification and genetic relationships of Chinese elite accessions from the genus Populus" ppt
... explores the potential of adopting AFLP and ISSR for high throughput fingerprinting of poplar accessions and the determination of their genetic relationships MATERIALS AND METHODS 2.1 Plant materials ... rapid and accurate identification of large numbers of poplar accessions and for the determination of their genetic relationships Although it is sometimes more difficult to compare from lab to lab and ... structure of natural populations [1] and construct genetic linkage maps [37] Inter-simple sequence repeat polymorphism (ISSR) analysis overcomes many of the technical limitations of RFLP and RAPD...
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báo cáo khoa học: "Genetic study of Dandarawy chickens: I. Heritabilities and genetic correlations of body weight and weight gain" ppt
... characters of Kinney T B (1969) A Summary of Reported Estimates of Heritabilities and of Genetic and Phenotypic Correlations for Traits of Chickens Agriculture Handbook No 363, U.S Department of Agriculture, ... elimination of sex effect and ranged from 0.0 to 0.76 after elimination of sex effect from the sire, dam, and sire-dam components of variance The values of heritability of the combined sexes before and ... to 16 wk of age The genetic and environmental correlations were estimated according to the general formula of correlations : half sibs; remainder of after substitution of the genetic and environmental...
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Báo cáo y học: "iagnostic Markers based on a Computational Model of Lipoprotein Metabolism" ppsx
... information contained in a lipoprotein profile, may be of added value in the clinic Lipoprotein metabolism of VLDL, IDL, and LDL comprises three main processes The lipoproteins are produced by ... apolipoprotein B to obtain lipoprotein fluxes [12] These techniques are costly and labor-intensive A good characterization of the status of lipoprotein metabolism is, therefore, an extensive and ... Size and Shape Characterization of Blood Lipoproteins Clin Chem 2007, 53:2026-2029 Olivecrona T, Hultin M, Bergö M, Olivecrona G: Lipoprotein lipase: regulation and role in lipoprotein metabolism...
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báo cáo khoa học: " Trust and the regulation of pharmaceuticals: South Asia in a globalised world" ppt
... (NMA) Association of Pharmaceutical Producers of Nepal (APPON) ’To uplift and preserve the professional standard, values and freedom of the NMA’; ‘carry out academic activities ’; and ‘ improve the ... Central board of excise and customs Ministry of Law & Justice Foreign MNCs OPPI NIPER Ministry of Commerce &industry, Dept of Industrial Policy and Planning, Pharmexcil, India Patent Office, Trade ... insights of discussions in anthropology of global assemblages and in political economy of global commodity chains; and by integrating ‘bottom-up’ and ‘top-down’ approaches to the local and global...
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báo cáo khoa học: " Molecular characterisation and genetic mapping of candidate genes for qualitative disease resistance in perennial ryegrass (Lolium perenne L.)" doc
... the experimental work and the majority of analysis, prepared the tables and figures and the primary drafts of the manuscript, and contributed to finalisation of the text and journal-specific formatting ... validation and genetic mapping Association of SNPs with resistance loci in perennial ryegrass and cereal species Figure Schematic representation of empirical and bioinformatics-based discovery of perennial ... both rice and Arabidopsis thaliana, and are distributed non-randomly throughout the genome [30-32] Clustering of R genes is known to facilitate tandem duplication of paralogous sequences and generation...
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Báo cáo y học: "Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor" ppsx
... Arhem, The Netherlands) with a cutoff level of 25 arbitrary units per milliliter in accordance with the instructions of the manufacturer The range of measurement was to 1,600 U/ mL, and all values ... analysis and participated in the design of the study MAL-N and JLV carried out the HLA determination, analyzed and interpreted the data, and helped in the manuscript preparation All authors read and ... article as: Balsa et al., Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor Arthritis...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... central to the regulation and expression of stress-response genes in the face of inflammatory and oxidative challenge [13,14,16– 19,27,54,55,58] Oxygen and redox regulation of HIF-1α and NF-κB will ... Stephen C Land, Department of Child Health, University of Dundee, Scotland, UK) and the National Institutes of Health (NIH; Bethesda, USA) (Professor Philip E Bickler, Department of Anesthesia and Perioperative ... hand, is relatively quick and violent, characterized by the swelling of the cytoplasm, the rupturing of cell membranes, the dilation of the mitochondria and the disintegration of subcellular and...
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