non contact mechanical characterization and testing of drug tablets

... MECHANICAL CHARACTERIZATION AND MODELING OF POLYMER/CLAY NANOCOMPOSITES SONG SHAONING (B.ENG) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MECHANICAL ENGINEERING ... List of Figures Figure 5.5 Dependency of elastic modulus of explicit RVE and effective RVE on diameter of clay particle, (for ECNs) Figure 5.6 Dependency of elastic modulus of explicit RVE and ... dependency of elastic modulus on the number of clay particles Figure 3.6 Effect of particle size on (a) elastic modulus and (b) tensile strength of epoxy/clay nanocomposites; Effect of number of silicate...

Ngày tải lên: 09/09/2015, 11:20

... DEPARTMENT OF MECHANICAL ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2005 Abstract Name: Xue Zhengjun Degree: Master of Engineering Dept: Mechanical Engineering Thesis Title: Characterization and Testing ... Summary of Al2O3-water Nanofluids……………… 138 Table 5.5 Summary of Simulation Results of Al2O3-water Nanofluids…… 138 Table 5.6 Property Summary of Al2O3-water Nanofluids……………… 143 Table 5.7 Summary of ... Advisors: Dr Andrew A.O Tay, Professor, Department of Mechanical Engineering, National University of Singapore Dr Zhang Hengyun, Senior Research Engineer, Institute of Microelectronics viii List of Tables...

Ngày tải lên: 03/10/2015, 20:31

... These samples, and samples of fresh unsulfided and sulfided catalyst, were characterized by nitrogen adsorption and SEM The results of textural characterization by nitrogen adsorption of the catalyst ... related to the intensity of emission of the characteristic Ka line of each element White corresponds to a high concentration of a given element, and black to the absence of this element, while ... Fig SEM-EDX maps of distribution of elements: red mud after h run time The brightness of every pixel of the EDX maps, B, can be quantified on a scale of (black) to (maximum degree of brightness)...

Ngày tải lên: 23/09/2012, 14:46

... factors and when asked about the history of their pregnancy, give a long list of supposed agents On the other hand the mothers of healthy babies are thinking of the present and future of their ... first occurrence and recurrence of neural-tube defects [52] Conflict of interest None declared References Jones KL, Smith DW, Ulleland CL et al Pattern of malformations in offspring of chronic alcoholic ... severe (non life-threatening) diseases such as acne and psoriasis Int J Med Sci 2005 2 It is necessary to select non- teratogenic drugs instead of teratogenic drugs during pregnancy if possible and...

Ngày tải lên: 02/11/2012, 11:12

... Huo et al Characterization of respiratory complex II Fig Sequencing of porcine heart mitochondrial complex II Total RNA was extracted and purified from the fresh porcine heart, and genes of four ... G250, and the four bands corresponding to subunits of porcine complex II were cut out and N-terminal sequenced by the Edman degradation method and amino acid analyzer in the Department of Biology, ... the left, and the positions of molecular weight standards are indicated on lane FEBS Journal 274 (2007) 1524–1529 ª 2007 The Authors Journal compilation ª 2007 FEBS 1525 Characterization of respiratory...

Ngày tải lên: 19/02/2014, 02:20

... spectrometry and the lability of the sulfogroup in mass spectrometry analysis allows recognition of the modification, and differentiation of sulfotyrosine and phosphotyrosine [38] Characterization of the ... mechanisms of incorporation of PTMs in the biosynthesis of conopeptides Appropriate methods of analysis need to be addressed to ensure recognition of these PTMs, if present, in the course of characterization ... Amidation of C-terminus Sulfation of tyrosine Hydroxylation of proline Carboxylation of glutamic acid Cyclization of N-terminal Gln O-Glycosylation Bromination of tryptophan Isomerization of tryptophan...

Ngày tải lên: 19/02/2014, 12:20

... mapping On the basis of the assumptions of Hiromi [30] that the intrinsic rate of hydrolysis (kint) in the productive complex is independent of the length of the substrate, Km and Vmax were used ... Hiromi K (1970) Interpretation of dependency of rate parameters on the degree of polymerization of substrate in enzyme-catalyzed reactions Evaluation of subsite afnities of exo-enzyme Biochem Biophys ... PelB contains a few inserted b-strands (1a in Fig 2), and one large insert of 15 amino acids is present before the rst b-sheet of coil 3, which is on the edge of the pronounced substrate-binding...

Ngày tải lên: 20/02/2014, 03:20

... pattern and extent of stimulation of the membrane and soluble yeast PtdEtnPLD activity by Ca2+ and their inhibition by other divalent cations is highly comparable The mechanism of action of Ca2+ ... purification of the cytosolic PtdEtn-PLD resulted in rapid loss of activity Ó FEBS 2002 Characterization and regulation of yeast PtdEtn-PLD activity (Eur J Biochem 269) 3823 Table Effect of different ... concentrations of 10)6 to 10)5 M and a Membrane-bound None Ca2+ Mg2+ Co2+ Ba2+ Mn2+ Zn2+ Fig Effect of increasing Ca2+ concentration on membrane and cytosolic PtdEtn-PLD activity Cytosolic and membrane-bound...

Ngày tải lên: 22/02/2014, 07:20

... Aceite de la Comunitat Valenciana Aceite de Madrid Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Andalucía Extremadura Extremadura Castilla-La ... Construction of Data Matrices and MLR Models 9.5 Prediction of OFA Concentration in VOOs Using FTIR and MLR 9.5.1 Description of FTIR Spectra and Construction of Data ... Construction of the Monolithic Columns and Optimization of the Separation Conditions 8.1.2 Characterization of the Phenolic Compound Profiles 8.1.3 Construction of Data Matrices and LDA Models...

Ngày tải lên: 07/03/2014, 21:20

... facilitate identification of the key substrates of individual SVMPs and enable a better understanding of the molecular mechanism of action of P-III SVMPs Functional role of the non- enzymatic proteins ... activity and toxicity of the basic subunit, is a product of divergent evolution of the catalytically active and toxic PLA2 The salt bridge between Asp48 of the PLA2 molecule and Lys60 of the acidic ... ternary complex of enzyme, substrate and oxygen and that reduction of the flavin involves formation of a semiquinone [42] As the protein is a flavoenzyme oxidase, the reduced FAD cofactor is reoxidized...

Ngày tải lên: 14/03/2014, 22:20

... number of phosphate containing substrates, and it has a high specificity for nucleotide monophosphates and, in particular, UMP and GMP The structure of NagD has been determined and the occurrence of ... Fig Overproduction and purification of recombinant AraL-His6 (A) Analysis of the soluble (S) and insoluble (P) protein fraction (20 lg of total protein) of induced cultures of E coli Bl21(DE3) ... family of NagDlike phosphatases to be characterized at the level of gene regulation Results and Discussion The araL gene in the context of the B subtilis genome and in silico analysis of AraL...

Ngày tải lên: 14/03/2014, 23:20

... Rensland, H., Lautwein, A., Geyer, M., Scheffzek, K., Goody, R.S., Kalbitzer, H.R., Pai, E.F & Wittinghofer, A (1993) Three-dimensional structures and properties of a transforming and a nontransforming ... methanol and repeated evaporation under reduced pressure, yield of the pure GTPcNH2 was 50–60% One gram of GTP triethylammonium salt was added to a stirred solution of 2.5 mL tributylamine and 1.2 ... )5.51 )5.30 – – 0.91 0.97 – – Preparation of NMR samples and NMR spectroscopy 31 P and 19F NMR spectra of free nucleotides were recorded in aqueous solution of 90%/10% H2O/D2O Typically the lyophilized...

Ngày tải lên: 18/03/2014, 01:20

... in its pathogenesis and an understanding of 6150 their mode of action could be useful in exploring them as drug targets Results Figure shows the sequence and putative domains of M tuberculosis ... ClpC1 and its deletion mutants (A) SDS ⁄ PAGE of purified full-length ClpC1 and deletion mutants, ClpC1D1 and ClpC1D2 (B) Full-length ClpC1 and deletion mutants, ClpC1D1 and ClpC1D2; the first and ... interest to understand the mode of action of these proteins in M tuberculosis In this study, we functionally characterized the ClpC1 protein of M tuberculosis, and investigated the role of its N-terminal...

Ngày tải lên: 23/03/2014, 06:20

... cDNA, and lanes 1, 3, and show the same using genomic DNA of C roseus Primer pairs were: #GSP-4 and #PFLF1 (lanes and 2); #GSP-2 and #GSP-4 (lanes and 4); #GSP-2 and #PFLR-1 (lanes and 6); and ... #PFLF-1 and #PFLR-1 (lanes and 8) (B) Schematic organization of the CrPrx gene The asterisk indicates the position of the codon encoding the first amino acid of the mature protein, and the regions of ... membranes of the central vacuole, and the wall thickening of xylem cells (fi) common with other plant peroxidases [18,21,22] The inclusion of Ser96 and Asp99 in a salt bridge motif at the beginning of...

Ngày tải lên: 23/03/2014, 09:21

... focussed particularly on structural characterization, elucidation of mechanism of action, kinetics, sequencing and cloning of lipase genes, and general characterization of performance (Alberghina et ... channelblocking drugs such as diltiazem Lipases are used in synthesis of these drugs (Berglund and Hutt, 2000) This review reports on the production, purification, and characterization of lipases ... synthesis of lipid membranes and prostaglandins Microbial lipases are used to obtain PUFAs from animal and plant lipids such as menhaden oil, tuna oil, and borage oil Free PUFAs and their mono- and...

Ngày tải lên: 24/03/2014, 05:20

... indicates the position of the ssDNA in the absence of SSB protein and the subsequent retardation of the band with an increasing amount of SSB is also shown *Position of the double-stranded control DNA ... Effect of HpSSB on ATPase activity of HpDnaB in the presence of ssDNA The release of radiolabeled Pi from (c-32P)ATP was monitored in the absence and presence of different concentrations of HpSSB ... Wt and DC20 SSB protein in varying concentrations (0, 0.45, 0.9, 1.8, 2.7 and 3.6 lg, respectively) with 300 ng of M13mp18 single-stranded circular DNA and ⁄ or 300 ng of pUC18 double-stranded...

Ngày tải lên: 30/03/2014, 02:20

... mass of the compounds in the venom and the masses of rAgTx2 (used as a control toxin) and rPBTx3 were determined with MALDI-TOF MS on a VG Tofspec (Micromass, UK) operating in the linear and in ... disulfide pairing [44] and is also conserved throughout these sequences of all the members of subfamily of a-KTx, including PBTx3 Because of these similarities and conservation of the consensus sequence, ... nM of rAgTx2 different in the range of test potentials from )30 to +20 mV Recombinant PBTx3 (500 nM) blocked the Kv1.2 and Kv1.3 peak currents by 54% and 53% at )30 mV (n ¼ 3), and by 53% and...

Ngày tải lên: 31/03/2014, 09:20

... Coordinate Description of the Pendubot l1 is the length of link one, lc1 and lc2 are the distances to the center of mass of the respective links and q1 and q2 are the joint angles of the respective ... the software package Simnon [4] Appendix E lists the source code of three implemented controllers Finally, Appendix F reproduces the mechanical drawings of the components of the linkage 2 MECHANICAL ... mass of link one the length of link one (See Figure 3.1) the distance to the center of mass of link (See Figure 3.1) the moment of inertia of link one about its centroid the total mass of link...

Ngày tải lên: 31/03/2014, 23:20

... certainly mechanically heterogeneous and anisotropic This raises the question of the influence of pre-existing rheological heterogeneities and mechanical anisotropy on the deformation of continents ... orientation of the [010] and [100] axes of olivine, respectively perpendicular and close to the strike of the orogen (Mainprice and Silver, 1993) These measurements hint at the existence of a crystallographic ... dependence of the dominant deformation mechanisms (dislocation glide and climb) on temperature The geotherm controls the depth of the brittle– ductile transition, and the viscosity of both crustal and...

Ngày tải lên: 31/03/2014, 23:20

... C/min, and held for 10 250  C at 25  C/ min, and held The flow rate of hydrogen was 30 ml/min and the flow rate of air was about 400 ml/min Temperatures of the injector and detector were 280 and ... weight of the internal standard, AB ¼ peak area of FAME, ftricaprylin ¼ response factor, Atricaprylin ¼ peak area of the internal standard, and ms ¼ weight of the sample Determination of sulfur ... When increasing the amount of loading catalyst, the slurry (mixture of catalyst and reactants) was become too viscous giving rise to a problem of mixing and a demand of higher power consumption...

Ngày tải lên: 05/05/2014, 08:42