nmr of solid phase synthesis resins

... Solution -Phase Synthesis of Substituted Amines by N-Alkylation with %-Halocarbonyl CNLONSMDQZZZZZZZZZZZZZZZZZZZZ'''13 1.3 Examples of Solid- Phase Synthesis of Substituted AminesZZZZZZ'ZZZ.18 1.3.1 Solid- Phase ... August 2010, Solid- Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids Major Professor: Martin J 9^/NMMEKl, Ph.D A novel route has been developed for the solid- phase synthesis of Ncarboxyalkyl ... Title of Thesis/Dissertation: Solid- Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids Master of Science For the degree of I certify that in the preparation of...

Ngày tải lên: 24/08/2014, 13:46

... Solution phase synthesis of 3-36 124 3.7.2 Solid- Phase library synthesis of 3-38, 3-39, 3-44, 4-45 and 3-47 126 3.7.3 Experimental Section 132 3.7.3.1 Solution Phase Synthesis 132 3.7.3.2 Solid- Phase ... 1.2.2 Synthesis of 1,3,5-Triazine Derivatives 14 1.2.2.1 Solution phase synthesis of 2,4,6-trisubtituted-1,3,5-triazine 14 1.2.2.2 Solid- Phase Synthesis of 1,3,5-Triazine Derivatives 17 Purpose of ... Solution -phase reactions leading to N, N’-alkylaryl carbodiimide 59 3-12 Scheme 3.9 Revised synthesis of 3-7 60 Scheme 3.10 Solid- phase Synthesis of 3-7 63 Scheme 3.11 Traceless solid- phase synthesis...

Ngày tải lên: 14/09/2015, 08:25

... xiv LIST OF PUBLICATIONS CHAPTER 1: INTRODUCTION 1.1 Solid- phase synthesis (SPS) 1.1.1 Solid supports 1.1.2 Linkers 1.1.3 Reaction monitoring in solid- phase synthesis 13 1.1.4 Solid- phase synthetic ... from the solid support (Figure 1.1) Figure1.1 Illustration of a solid- phase synthesis This concept of solid- phase synthesis was first raised by R B Merrifield in 1963 for efficient peptides synthesis. [1] ... thesis reports the development of novel methodologies for the solid- phase synthesis of purine derivatives The first project involves the solid- phase synthesis of 2,9-disubstituted-6-oxopurines...

Ngày tải lên: 15/09/2015, 17:09

... Abstract—a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described In both ... 1).1,2 To investigate this hypothesis we sought a solid phase synthesis of which would be sufficiently general to allow production of a library of compounds for biological screening Figure a-Acylamino-a,a-disubstituted ... anhydride of 6a, prepared in situ by treatment of 6a with 0.5 equiv of DIC in a mixture of CH2Cl2 and DMF (entry 9).27 Submitting the resin to a second cycle of coupling increased the level of conversion...

Ngày tải lên: 26/08/2016, 11:29

... Ph Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis ... Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene Resin Synthesis of Functionalized Polystyrene ... (PS) resins 1.2 Polyacrylamide resins 1.3 Polyethylene glycol (PEG) grafted resins 1.4 PEG-based resins Surface-type surports Composites and supported gels Brush polymers 1.1 Polystyrene (PS) Resins...

Ngày tải lên: 17/04/2015, 09:11

... 23 iv TABLE OF CONTENTS 2.2.3 Solid phase crystallization (SPC) of a-Si:H films 30 2.2.4 Rapid thermal annealing of poly-Si thin films 31 2.2.5 Hydrogenation of the poly-Si thin ... 131 6.3.1 Effect of SiH4 gas flow rate on the deposition rate of a-Si:H films 131 6.3.2 Effect of RF power density on the deposition rate of a-Si:H films 134 6.3.3 Effect of SiH4 gas flow rate ... representation of the interdigitated metallisation scheme of poly-Si thin-film solar cells on glass (b) Schematic xii LIST OF FIGURES cross-section of an emitter finger, the sloped sidewalls, and parts of...

Ngày tải lên: 09/09/2015, 11:21

... values) Synthesis of benzodiazepines Rachedine Kaoua et al Molecules 2011, 16, 92-99 Synthesis of benzodiazepines Sternbach et al J Org Chem 1962, 27, 3788 Lednicer et al Organic Chemistry of Drug Synthesis; ... New York, 1998 Lednicer et al The Organic Chemistry of Drug Synthesis; Wiley-Interscience: New York, 1977 Ellman’s solid- phase synthesis of 1,4-benzodiazepines Ưu điểm Tổng hợp Pha rắn? Không ... PHA RẮN TỔNG HỢP PHA RẮN SOLID PHASE SYNTHESIS • The scale SPS is limited and restricted by the amount of the solid support and its loading capacity • The preparation of multi-milligram quantities...

Ngày tải lên: 12/10/2016, 14:11

Ngày tải lên: 14/11/2014, 06:36

... 15] Synthesis of nanostructures via simple wet-chemical method is one of the most favoured routes towards the cost-effective large-scale production of nanobuilding blocks Chemical synthesis of ... with a very few number of spheres The histogram of nanodiscs distribution (Fig 2b) shows that majority of discs have a diameter of *55 nm On the other hand, HR-TEM photograph of green-coloured silver ... 1c), obtained by using mM of sodium citrate, shows the presence of only silver nanorods of different aspect ratios (R = 3–7) The histogram of particle distribution of corresponding silver nanorods...

Ngày tải lên: 21/06/2014, 17:20

... serum of α1AGP and of haptoglobin, and also of mRNAs of acute phase proteins to a level as found in the control animals Furthermore, that the BDL cirrhosis model itself triggered the synthesis of ... models The acute phase response consists of changes in the serum concentration of multiple proteins due to a reorganization of hepatic protein synthesis favouring "the acute phase proteins" and ... mortality of patients with cirrhosis exposed to infection is rooted in a decreased liver function in the form of a decreased synthesis of acute phase proteins In addition, that the function of the...

Ngày tải lên: 13/08/2014, 13:20

... technique can be used for solution as well as solid phase synthesis diversification reaction divide diversification reaction Split-pool Synthesis • Optimization of reactions leads to compounds • Each ... the β-elimination of resin-bound leaving groups has been used as a cleavage strategy for the release of alkenes from supports Preparation of Alkenes by β-Elimination Preparation of Alkenes by β-Elimination ... C-Vinylation The Heck, Stille, and Suzuki couplings Synthesis of tetrahydroisoquinolines Parallel Library Synthesis • Optimization of 12 reactions provides compounds • The library members...

Ngày tải lên: 17/04/2015, 08:58

... effects of pH of the aqueous Table Because the flow rates of sample solution and eluent solutions are two important parameters for the quantitative retention of analytes on the solid phase extraction ... is not used for the solid phase extraction studies In this work, a simple and accurate procedure for cadmium(II) and lead(II) ions that is based on solid phase extraction of cadmium(II) and lead(II) ... Natural and synthetic solid phase extractors that have high surface area and adsorption capacity, stable for acidic and basic media are preferred for solid phase extraction of metal ions Zeolites,...

Ngày tải lên: 02/09/2015, 13:45

... described here: solid phase crystallization (Section 1.3.1), seed layer approach (Section 1.3.2), and liquid phase crystallization (Section 1.3.3) 1.3.1 Solid phase crystallization The solid phase crystallization ... Investigation of impact of HF:HNO3 acid ratio on scattering efficiencies of AIT glass 47 3.2.4 Up-scaling of the AIT process to pilot line-scale borosilicate glass sheets 50 3.3 Fabrication of ... Figure 6-3: (a) SEM tilt view of sample RST4, (b) SEM cross-sectional view of RST4 111 Figure 6-4: The AFM measured height profiles of the rear Si surface of (a): sample RST4 after...

Ngày tải lên: 09/09/2015, 11:16

... Liquid-liquid extraction LOD Limit of detection LOQ Limit of quantification muSPE Micro solid phase extraction using mixed matrix membrane μ-SPE Membrane bag micro solid phase extraction MPME Membrane ... 46 3.3.2 Preparation of surface modified sorbents 3.3 44 47 3.3.2.1 Preparation of APS 47 3.3.2.2 Preparation of UPS 47 3.3.2.3 Preparation of ZIPS 47 3.3.3 Characterization of sorbents and sorbent-containing ... Determination of EWC 48 References 49 RESULTS AND DISCUSSION 50 Preparation of sorbents 51 4.1.1 Preparation of APS and UPS 51 4.1.2 Preparation of ZIPS 53 4.2 EWC 54 4.3 Comparison of sorbents...

Ngày tải lên: 10/09/2015, 09:12

... successful realization of this thesis iii TABLE OF CONTENTS ACKNOWLEDGEMENT i TABLE OF CONTENTS iii SUMMARY vii LIST OF PUBLICATIONS x LIST OF TABLES xi LIST OF FIGURES xiii LIST OF SYMBOLS xv CHAPTER ... Application of the silica monolith as solid phase extraction cartridge for the extraction of epinephrine, metanephrine and normetanephrine from urine  Application of the silica monolith as solid phase ... dealt with the solid phase extraction and this thesis is dedicated to explore the potential of monolith as a solid phase extraction cartridge Chapter 24 1.6 MONOLITH: AS A SOLID PHASE EXTRACTOR Sample...

Ngày tải lên: 10/09/2015, 15:50

... Figure 1.2 Evolution of number of transistors packed into each of Intel’s new generation of microprocessors, describing Moore’s law [2] .3 Figure 1.3 Cost of fabrication of transistors, DRAM ... leakage profile of the various diodes fabricated The change in the slope of the leakage profile at a bias larger than 2V is due to the onset of GIDL current 83 Figure 5.8 XTEM images of the ... half that of the influenza virus or about 2000 times smaller than a strain of human hair For a sense of the physical size of the transistor, Fig 1.7 shows a micrograph image of a strand of hair...

Ngày tải lên: 12/09/2015, 09:28

... behavior of solid materials is largely dependent on the mineralogical characteristics of the solid phase (Ettler et al 2003), the second objective involves identification of possible mineralogical phases ... variety of phases, namely phases with high Zn-Ni-P-Fe and phases with high Al-Si content The coexistence of Zn, Ni, P, and Fe, as observed in the map, suggests that Fe and PO43−-rich phases are ... SE) and therefore supports in direct solid phase characterization The results of solid phase characterization can be used to account for the leachability of some HMs (e.g., Ni and Zn in sample...

Ngày tải lên: 18/08/2016, 15:47

... portion of body or tail of the pancreas For tumors of SPT located in the neck and body of the pancreas, resection of the midportion of the pancreas and the mass with preserving the rim of the ... Malignant potential of solid pseudopappillary neoplasm of the pancreas Br J Surg 2006;93:733-37 de Castro SMM, Singhal D, Aronson DC, et al Management of Solid- pseudopapillary Neoplasms of the pancreas: ... analysis of solid- pseudopapillary tumor of the pancreas: report of 15 cases Hepatobilliary Pancreat Dis Int 2008;7(2):196-200 Yu CC, Yeh CN, Hwang TL, Jan YY Clinicopathological study of solid and...

Ngày tải lên: 25/10/2012, 11:40

... regardless of SHW feeding rate The most important impact of the SHW feeding was on the free lime content of the clinker Replacement of 20% of the coal energy in the rotary kiln burner (3 t/hr of SHW ... inlets for solid and liquid alternative fuels and one annular inlet for coal, see Figure 1(b) The solid alternative fuel is fed via a Pfister feeder system designed to control mass feeding of solid ... distribution 4.2 Analyses of raw meal, precalcined meal and clinker The variation of the measured raw meal properties during the test period was insignificant The degree of calcination of the precalcined...

Ngày tải lên: 05/09/2013, 15:28

Ngày tải lên: 24/10/2013, 15:20