nmda tyrosine kinase fyn

Ngày tải lên: 20/06/2014, 01:20

... mitogen-activated protein kinase phosphatase-1 The activity of JNK, one of the MAPKs, is tightly controlled by both protein kinases, such as MAPK kinase 4 (MKK4) or MAPK kinase 7 (MKK7) and protein ... 321 cellular signal-regulated kinase (ERK)1 ⁄ 2, which is one of the three major groups of mitogen-activated protein kinases (MAPKs) in mammals, is activated by the EGFR tyrosine kinase and plays an essential ... factor receptor, mitogen-acti- vated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). Mol Cancer Ther...

Ngày tải lên: 16/02/2014, 09:20

... protein kinase subfamily of c-Jun kinases. Nature 369, 156–160. 21 Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR & Kufe DW (1995) Activation of the c-Abl tyrosine kinase ... EGFR results in receptor dimerization, activation of its tyrosine kinase and phosphorylation of its C-terminal tyrosine residues. The tyrosine- phosphorylated motifs of EGFR recruit various adaptors ... of tumors. Therefore, EGFR -tyrosine kinase is a promising therapeutic target. Although in vitro and in vivo studies have shown the anti-tumor activity of EGFR -tyrosine kinase inhibitors against...

Ngày tải lên: 18/02/2014, 13:20

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Ngày tải lên: 20/06/2014, 00:20

... and Fyn may play an important role in regulating the cellular localization of Fyn and tau. Results Tau interacts with Fyn- SH2 Because tau contains tyrosines that could be targeted by Fyn, and tyrosine ... expressing Fyn- SH3 and Fyn- SH2 were obtained from S. Anderson (University of Colorado Health Sciences Center, Denver, CO, USA). GST Fyn- SH2 and GST Fyn- SH3 were generated by subcloning Fyn- SH2 and Fyn- SH3 into ... variations in the affinity of Fyn- SH2 and Fyn- SH3 for GST beads. However, our data suggest that several-fold more tau binds to Fyn- SH3 than to Fyn- SH2. Tau binds predominantly to Fyn- SH3, which has a specific...

Ngày tải lên: 14/02/2014, 14:20

Ngày tải lên: 18/02/2014, 18:20

Ngày tải lên: 24/03/2014, 00:21

... Biochemical mechanism of action of tyrosine kinase Tyrosine kinases are enzymes that selectively phosphorylates tyrosine residue in different substrates. Receptor tyrosine kinases are activated by ligand ... action of tyrosine kinase. PK represents protein kinase and PP stands for protein phosphatase. 3. Classification Tyrosine kinases are primarily classified as receptor tyrosine kinase ... Oncogenic activation of tyrosine kinase Normally the level of cellular tyrosine kinase phosphorylation is tightly controlled by the antagonizing effect of tyrosine kinase and tyrosine phosphatases....

Ngày tải lên: 03/11/2012, 09:57

... S-transferase; HMW, high-molecular- weight; KIND, kinase noncatalytic C-lobe domain; KIND1, first kinase noncatalytic C-lobe domain; KIND2, second kinase noncatalytic C-lobe domain; MAP2, microtubule-associated ... nonreceptor-type protein tyrosine phosphatase 13 (PTPN13, or PTP-BL ⁄ PTP-BAS) [6,7], FERM and PDZ-domain-containing 2 (FRMPD2) [8] and Ras guanine exchange factor (RasGEF) very- KIND (v-KIND, or kinase noncatalytic ... protein kinase fold. Trends Biochem Sci 28, 349–352. 4 Otto IM, Raabe T, Rennefahrt UE, Bork P, Rapp UR & Kerkhoff E (2000) The p150-Spir protein provides a link between c-Jun N-terminal kinase...

Ngày tải lên: 14/02/2014, 19:20

... MAPK, mitogen-activated protein kinase; MAPKK, mitogen-activated protein kinase kinase; MBP, myelin basic protein; OXI1, oxidative signal-inducible 1; PDK1, 3-phosphoinositide-dependent kinase 1; PTI1, Pto-interacting ... (A) Recombinant kinase- inactive GST-lofMPK3 and GST-lofMPK6 were mixed with HIS-OXI1 in kinase buffer and [c- 32 P]-ATP. (B) Recombi- nant kinase- active GST-MPK3 and GST-MPK6 or recombinant kinase- inactive ... [8,9]. The AGC kinases were named on the basis of their homology to the mammalian cAMP-dependent protein kinase A, cGMP-dependent protein kinase G and phospholipid-dependent protein kinase C [8]....

Ngày tải lên: 14/02/2014, 19:20

... 3-phosphoglycerate kinase via an enzyme–substrate–enzyme complex. Biochemistry 21, 4189–4194. 10 Vas M & Batke J (1981) Evidence for absence of an interaction between purified 3-phosphoglycerate kinase and ... dehydrogenase and 3-phos- phoglycerate kinase. J Biol Chem 278, 5929–5940. 13 Singh P, Salih M, Leddy JJ & Tuana BS (2004) The muscle-specific calmodulin-dependent protein kinase assembles with the glycolytic ... phos- phoglycerate kinase. Eur J Biochem 149, 67–72. 8 Sukhodolets MV, Muronetz VI & Nagradova NK (1987) Interaction between D-glyceraldehyde-3-phos- phate dehydrogenase and 3-phosphoglycerate kinase labeled...

Ngày tải lên: 16/02/2014, 09:20

... ERK, extracellular signal-regulated kinase; JKAP, c-JUN N-terminal kinase pathway-associated phosphatase; JNK, c-JUN N-terminal kinase; JSP, c-JUN N-terminal kinase stimulatory phosphatase; JSP1-CS, ... signaling module in which MAPK kinase kinases phosphoryl ate MAPK kin- ases on Ser ⁄ Th r residues with con comitant activation . MAPK ki nases are d ual-specificity kinases, w hich, upon activation, ... Cavanagh J, Barrett T & Davis RJ (1997) Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci USA 94, 7337–7342. 8 Tournier C, Dong C,...

Ngày tải lên: 16/02/2014, 14:20

... TtAKb. Abbreviations AK, aspartate kinase; BsAKII, aspartate kinase II from Bacillus subtilis; CgAK, aspartate kinase from Corynebacterium glutamicum; CgAKb, regulatory subunit of aspartate kinase from Corynebacterium ... calorimetry; EcAKIII, aspartate kinase III from Escherichia coli; MAD, multiwavelength anomalous diffraction; MjAK, aspartate kinase from Methanococcus jannaschii; TtAK, aspartate kinase from Thermus thermophilus; ... aspartate kinase from Thermus thermophilus; TtAKb-free, Thr-free regulatory subunit of aspartate kinase from Thermus thermophilus; TtAKb-Thr, Thr-bound regulatory subunit of aspartate kinase from Thermus...

Ngày tải lên: 18/02/2014, 08:20

... recorded at an excitation wavelength of 492 nm. Spectra of reaction mixes lacking HSL or both HSL and kinase were subtracted from the spectra of the nonphosphorylated and phosphorylated HSL samples, ... & Belfrage P (1983) Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase. J Biol Chem 258, 15146–15152. 9 Anthonsen MW, Ronnstrand L, Wernstedt C, Degerman E & ... MR, Resjo S, Logan DT & Holm C (2008) Ser649 and Ser650 are the major determinants of protein kinase A-mediated activation of human hormone-sensitive lipase against lipid substrates. PLoS ONE...

Ngày tải lên: 18/02/2014, 11:20

... These include: (a) extracellular sig- nal-regulated kinases (ERKs); (b) c-Jun N-terminal kinases (JNKs); (c) p38 group MAPKs; and (d) ERK5 ⁄ big MAP kinase 1 [27]. JNKs act as negative regulators ... protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J ... hypoxia-inducible factor; IL, interleukin; JNK, c-Jun N-terminal kinase; LRH-1, liver receptor homolog 1; MAPK, mitogen-activated protein kinase; MRP, multidrug resistant-associated protein; NF-jB,...

Ngày tải lên: 18/02/2014, 13:20